The cheapest and fastest buses from Des Moines, IA to Milwaukee, WI
Cheapest price
$73
Average price
$73
Fastest journey
11 h 15 m
Average duration
12 h 22 m
Buses per day
3
Distance
495 km
The best way to find a cheap bus ticket from Des Moines, IA to Milwaukee, WI is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Milwaukee, WI will cost around $73 if you buy it on the day, but the cheapest tickets can be found for only $73.
It's difficult to get from Des Moines, IA to Milwaukee, WI without transferring at least once.
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Compare bus and flight for Des Moines, IA to Milwaukee, WI
Omio recommends booking the bus as it is the most popular option from Des Moines, IA to Milwaukee, WI among Omio's users. If you are prioritising price take the bus with prices starting from €40. For those with little time consider booking a flight which can get you there in 5h 21m. The ticket price range depends on the travel mode: a bus costs an average of €40, and a flight costs an average of €120.
Distance: 307 miles (495 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
€66 Average price Cheapest | €223 Average price |
10h 10m Average total duration 9h 40m Onboard + 30m Additional time* | 8h 21m Average total duration Fastest 5h 21m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Des Moines, IA to Milwaukee, WI Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:30AM | Arrival Time 05:05PM | Duration 11h35 | Departure days Fri | Cheapest price $73 |
Operator Greyhound | Departure Time 09:30AM | Arrival Time 11:45PM | Duration 14h15 | Departure days Fri | Cheapest price $73 |
Live departures
Des Moines, IA to Milwaukee, WI bus times
The table below shows live departures for Des Moines, IA to Milwaukee, WI buses for tomorrow, Friday, November 7. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
+ FlixBus | 11:30 AM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 11h15 | 10:45 PM Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI | 1 transfer | |
+ FlixBus | 11:30 AM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 11h35 | 11:05 PM Milwaukee, Intermodal Station | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Des Moines, IA to Milwaukee, WI by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 07
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Journey information
Overview: Bus from Des Moines, IA to Milwaukee, WI
Buses from Des Moines, IA to Milwaukee, WI run on average 2 times per day, taking around 9h 40m. Cheap bus tickets for this journey start at $49 (€40) if you book in advance.
The earliest bus runs at 03:20, the last at 09:30. The fastest bus covers the 307 miles (495 km) distance in 10h 45m.
Distance 307 miles (495 km) |
Average bus duration 9h 40m |
Cheapest ticket price $49 (€40) |
Buses per day 2 |
Fastest bus 10h 45m |
First bus 03:20 |
Last bus 09:30 |
Bus providers: Greyhound, Burlington Trailways from Des Moines, IA to Milwaukee, WIYou can travel by bus between Des Moines, IA to Milwaukee, WI with Greyhound, Burlington Trailways for as low as $49 (€40). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
Burlington Trailways
FAQs: Bus from Des Moines, IA to Milwaukee, WI
Find answers to the most common questions about traveling from Des Moines, IA to Milwaukee, WI by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Milwaukee, WI, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Des Moines, IA to Milwaukee, WI, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Des Moines, IA to Milwaukee, WI
Most popular bus connections from Des Moines, IA
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