- Must visit
The Getty Center
A renowned art museum in Los Angeles known for its impressive architecture and expansive art collection, including European paintings and decorative arts.
Cheapest price
$343
Average price
$427
Fastest journey
1 d 14 h 40 m
Average duration
1 d 14 h 50 m
Buses per day
2
Distance
2311 km
The best way to find a cheap bus ticket from Des Moines, IA to Los Angeles, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Los Angeles, CA will cost around $427 if you buy it on the day, but the cheapest tickets can be found for only $343.
Of the 2 buses that leave Des Moines, IA for Los Angeles, CA on Wed, May 20, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, May 20 the direct buses cover the 2311 km distance in an average of 1 d 14 h 50 m but if you time it right, some buses will get you there in just 1 d 14 h 40 m .
On Wed, May 20 the slowest buses will take 1 d 15 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the bus as it is the most popular option from Des Moines, IA to Los Angeles, CA among Omio's users. If you are prioritising price take the bus with prices starting from $169. For those with little time consider booking a flight which can get you there in 4h 54m. The ticket price range depends on the travel mode: a bus costs an average of $169, and a flight costs an average of $124.
Distance: 1435 miles (2311 km)
Most popular Bus | Flight | Driving |
|---|---|---|
$357 Average price Cheapest | $360 Average price | $345 Average price (fuel + tolls) |
44h 0m Average total duration 43h 30m Onboard + 30m Additional time* | 7h 54m Average total duration Fastest 4h 54m Onboard + 3h 0m Additional time* | 24h 14m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Des Moines, IA to Los Angeles, CA:
A bus is $4 (€3) less than a flight for this route with tickets for a flight from Des Moines, IA to Los Angeles, CA costing on average $360 (€291).
Other travel options to Los Angeles, CA take longer:
Bus takes on average 43h 30m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:15AM | Arrival Time 03:15PM | Duration 39h00 | Departure days Mon, Thu, Sat, Sun | Cheapest price $176 |
Operator Greyhound | Departure Time 12:35AM | Arrival Time 03:15PM | Duration 38h40 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price $330 |
Operator Greyhound | Departure Time 01:15AM | Arrival Time 01:05PM | Duration 59h50 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $169 |
Operator Greyhound | Departure Time 11:30AM | Arrival Time 11:00PM | Duration 59h30 | Departure days Mon | Cheapest price $257 |
Operator Greyhound | Departure Time 04:20PM | Arrival Time 03:30PM | Duration 49h10 | Departure days Thu | Cheapest price $282 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 08:15AM | Duration 38h40 | Departure days Thu | Cheapest price $244 |
Operator Greyhound | Departure Time 09:20PM | Arrival Time 10:30PM | Duration 49h10 | Departure days Fri | Cheapest price $362 |
The table below shows live departures for Des Moines, IA to Los Angeles, CA buses for today, Monday, May 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 11:30 AM Des Moines, IA | 59h30 | 11:00 PM Los Angeles, CA | 0 transfersDirect | |
| Tuesday, May 19 | |||||
![]() | 12:35 AM Des Moines, IA | 38h40 | 3:15 PM Los Angeles, CA | 0 transfersDirect | |
![]() | 1:15 AM Des Moines, IA | 39h00 | 4:15 PM Los Angeles, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Des Moines, IA to Los Angeles, CA run on average 2 times per day, taking around 43h 30m. Cheap bus tickets for this journey start at $169 (€136) but you can travel from only $124 (€100) by flight.
The earliest bus runs at 00:25, the last at 23:50. The fastest bus covers the 1435 miles (2311 km) distance in 38h 40m.
Distance 1435 miles (2311 km) |
Average bus duration 43h 30m |
Cheapest ticket price $169 (€136) |
Buses per day 2 |
Fastest bus 38h 40m |
First bus 12:25 AM |
Last bus 11:50 PM |
Cheapest Month Apr |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Sat |
Least Busy Day Sat |
Best time to book 91 days |
Discover the best of Los Angeles — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Los Angeles trip today.
A renowned art museum in Los Angeles known for its impressive architecture and expansive art collection, including European paintings and decorative arts.
The largest art museum in the western United States, offering a comprehensive view of art history.
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Los Angeles is generally expensive, especially in popular tourist areas and for accommodation.
15-20% in restaurants, round up or add a few dollars for taxis, not expected in cafes.
Find answers to the most common questions about traveling from Des Moines, IA to Los Angeles, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Los Angeles, CA, this guide helps you travel smarter and with confidence.

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