Taking the bus is the cheapest way to travel from London to Edinburgh with next-day bus tickets starting from $31. National Express buses that travel from London to Edinburgh depart from Victoria station in central London. There are 4 direct buses per day from Monday to Friday and 3 on weekends. Buses depart in the morning and late at night with an additional evening bus departing during the week. Buses arrive at Edinburgh Bus Station in the city center and a typical journey takes between 9.5-10 hours. A Megabus service is also available with changes en route.

The fastest way to travel from London to Edinburgh is by taking a flight. A London to Edinburgh flight usually requires only 1:15 of flight time; however, when transport to and from the London and Edinburgh airports are taken into consideration, the journey will take approximately 3:30 hours. Flights traveling from London to Edinburgh depart from Heathrow, Gatwick, Stansted, London City and Luton Airports. Airlines traveling from London to Edinburgh include EasyJet, Ryanair, British Airways and Flybe with flights departing throughout the day. All flights land at Edinburgh Airport. Regular shuttle buses and trams traveling to the city center are available at Edinburgh airport.

Most travelers from London to Edinburgh who book with Omio choose to travel by train. Trains traveling from London to Edinburgh depart every day. During the week, Virgin East Coast trains depart approximately every 30 minutes from early morning until evening. All trains leave from Kings Cross Station and take between 4 to 5 hours to reach Edinburgh. There is an overnight sleeper train every night of the week except Saturday. ScotRail's Caledonian Sleeper takes about 7 hours to reach Edinburgh and departs from London's Euston station.