- Must visit
Portland Art Museum
World-class collections spanning Native American, Asian, and Northwest art. A cornerstone cultural stop in the South Park Blocks.
Cheapest price on Sep 30
$622
Average ticket price on Sep 30
$622
Fastest journey on Sep 30
2 d 20 h 55 m
Average journey duration on Sep 30
2 d 20 h 55 m
Buses on Sep 30
1
Distance
2369 km
The best way to find a cheap bus ticket from Des Moines, IA to Portland, OR is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Portland, OR will cost around $622 if you buy it on the day, but the cheapest tickets can be found for only $622.
It's difficult to get from Des Moines, IA to Portland, OR without transferring at least 4 times.


| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:15AM | Arrival Time 03:55PM | Duration 63h40 | Departure days Mon, Tue, Wed, Sun | Cheapest price $251 |
Operator Greyhound | Departure Time 12:35AM | Arrival Time 04:45AM | Duration 52h10 | Departure days Wed, Fri, Sat | Cheapest price $275 |
Operator Greyhound | Departure Time 01:15AM | Arrival Time 05:45AM | Duration 52h30 | Departure days Wed, Sat | Cheapest price $228 |
Operator Jefferson Lines | Departure Time 11:30PM | Arrival Time 08:25PM | Duration 68h55 | Departure days Wed | Cheapest price $622 |
The table below shows live departures for Des Moines, IA to Portland, OR buses for tomorrow, Wednesday, September 30. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 11:30 PM Des Moines, IA | 68h55 | 8:25 PM Portland, OR | 4 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Des Moines, IA to Portland, OR run on average 1 times per day, taking around 49h 25m. Cheap bus tickets for this journey start at $278 (€230) but you can travel from only $192 (€159) by flight.
The earliest bus runs at 02:00, the last at 20:00. The fastest bus covers the 1472 miles (2369 km) distance in 49h 25m.
Distance 1472 miles (2369 km) |
Average bus duration 49h 25m |
Cheapest ticket price $278 (€230) |
Buses per day 1 |
Fastest bus 49h 25m |
First bus 2:00 AM |
Last bus 8:00 PM |
Cheapest Month Feb |
Cheapest Day Sun |
High Season Jul - Sep |
Low Season Oct - Dec |
Discover the best of Portland, OR — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Portland, OR trip today.
World-class collections spanning Native American, Asian, and Northwest art. A cornerstone cultural stop in the South Park Blocks.
Hands-on museum famed for the USS Blueback submarine, science labs, and family-friendly exhibits on technology and nature.
Eclectic museum of movie props, oddities, and outsider collections in Northwest Portland. Fun, quirky, and uniquely local.
A 165-acre woodland park with serene paths, a rose garden, and Japanese Garden access. One of Portland's signature green spaces.
Beloved downtown square known as Portland's living room. Hosts events, people-watching, and easy access to major central sights.
Large urban forest with miles of trails for hiking and running. A local favorite for quick immersion in nature near downtown.
A toasted bread ring with a malty crust and chewy center. Portland shops helped make the city's bagel scene a modern local obsession.
Traditional regional chowder from the Pacific Northwest, usually with local clams, cream, potatoes, and herbs. A staple on many Portland seafood menus.
Fresh oysters from the Oregon coast, prized for their briny, clean flavor. Portland is a major city showcase for the state's shellfish culture.
Acclaimed bagel shop serving naturally leavened bagels with classic toppings in a casual neighborhood space.
Pioneering specialty coffee roaster with expertly brewed coffee and a minimalist café atmosphere loved by locals.
Iconic Portland brewery and pub pouring house beers with hearty pub fare in a lively, long-running local setting.
Moderate for U.S. city travel: hotels and dining are mid-priced, transit is reasonable, and budget food is easy to find.
Tip 18-20% at restaurants, more for great service. Taxis: 10-15%. Cafes: round up or tip $1-2 for drinks.
Find answers to the most common questions about traveling from Des Moines, IA to Portland, OR by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Portland, OR, this guide helps you travel smarter and with confidence.

Most Des Moines, IA to Portland, OR buses use the Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) to Portland, NW Station Way (Station Place Parking Garage) station pair. Use this guide to compare Des Moines, IA and Portland, OR bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) is 3 km from Des Moines city centre. Public transport options include:
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). ATMs are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Ticket office support is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Parking, Taxis, WC.
Accessibility facilities are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Wheelchair accessible buses available.
Portland, NW Station Way (Station Place Parking Garage) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Portland, NW Station Way (Station Place Parking Garage). ATMs are available at Portland, NW Station Way (Station Place Parking Garage).
Ticket office support is available at Portland, NW Station Way (Station Place Parking Garage).
Available at Portland, NW Station Way (Station Place Parking Garage): Parking, Taxis, WC.
Accessibility facilities are available at Portland, NW Station Way (Station Place Parking Garage): Ramp access available.
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