The cheapest and fastest buses from Des Moines, IA to Houston, TX
Cheapest price
$305
Average price
$311
Fastest journey
1 d 13 h 45 m
Average duration
1 d 13 h 45 m
Buses per day
2
Distance
1326 km
The best way to find a cheap bus ticket from Des Moines, IA to Houston, TX is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Houston, TX will cost around $311 if you buy it on the day, but the cheapest tickets can be found for only $305.
Of the 2 buses that leave Des Moines, IA for Houston, TX on Sun, Mar 22, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Mar 22 the direct buses cover the 1326 km distance in an average of 1 d 13 h 45 m but if you time it right, some buses will get you there in just 1 d 13 h 45 m .
On Sun, Mar 22 the slowest buses will take 1 d 13 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare bus and flight for Des Moines, IA to Houston, TX
Omio recommends booking the flight as it is the most popular option from Des Moines, IA to Houston, TX among Omio's users. If you are prioritising price take the bus with prices starting from $251. For those with little time consider booking a flight which can get you there in 3h 26m. The ticket price range depends on the travel mode: a bus costs an average of $251, and a flight costs an average of $232.
Distance: 823 miles (1326 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
$288 Average price Cheapest | $437 Average price |
38h 53m Average total duration 38h 23m Onboard + 30m Additional time* | 6h 26m Average total duration Fastest 3h 26m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Live departures
Des Moines, IA to Houston, TX bus times
The table below shows live departures for Des Moines, IA to Houston, TX buses for today, Saturday, March 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:30 PM Des Moines, IA | 37h45 | 5:15 AM Houston, TX | 0 transfersDirect | |
![]() | 3:45 PM Des Moines, IA | 37h45 | 5:30 AM Houston, TX | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Des Moines, IA to Houston, TX by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 22
Mar 23
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Mar 28
Journey information
Overview: Bus from Des Moines, IA to Houston, TX
Buses from Des Moines, IA to Houston, TX run on average 2 times per day, taking around 38h 23m. Cheap bus tickets for this journey start at $251 (€203) but you can travel from only $232 (€188) by flight.
The earliest bus runs at 00:15, the last at 23:45. The fastest bus covers the 823 miles (1326 km) distance in 37h 45m.
Distance 823 miles (1326 km) |
Average bus duration 38h 23m |
Cheapest ticket price $251 (€203) |
Buses per day 2 |
Fastest bus 37h 45m |
First bus 00:15 |
Last bus 23:45 |
Cheapest month Feb |
Cheapest day Sat |
High season Oct - Dec |
Low season Apr - Jun |
Best day to book ahead 1 day |
Bus providers: Jefferson Lines from Des Moines, IA to Houston, TXYou can travel by bus between Des Moines, IA to Houston, TX with Jefferson Lines for as low as $232 (€188). When you search for schedules and tickets, Omio will show you the best journey
Jefferson Lines
FAQs: Bus from Des Moines, IA to Houston, TX
Find answers to the most common questions about traveling from Des Moines, IA to Houston, TX by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Houston, TX, this guide helps you travel smarter and with confidence.

- Space Center Houston, an educational complex offering exhibits and tours related to NASA's space exploration
- Houston Museum of Natural Science, featuring extensive collections of fossils, gems, and ancient artifacts
- Houston Zoo, home to over 6,000 animals from around the world in a lush, 55-acre park
- Museum of Fine Arts, Houston, showcasing a diverse collection of art from antiquity to the present
- Buffalo Bayou Park, a 160-acre green space with trails, gardens, and views of the downtown skyline.
- Visit the Houston Livestock Show and Rodeo, the largest livestock exhibition and rodeo in the world, featuring concerts and carnival attractions
- Explore the vibrant street art and murals in the Houston Heights neighborhood
- Enjoy a performance at the Houston Symphony, offering a range of classical and contemporary music
- Discover the culinary scene with a food tour in the diverse neighborhoods of Houston
- Attend a game at Minute Maid Park, home of the Houston Astros, for an exciting baseball experience.
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Popular bus stations from Des Moines, IA to Houston, TX
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