The cheapest and fastest buses from Des Moines, IA to Jacksonville, FL
Cheapest price
$245
Average price
$245
Fastest journey
1 d 13 h 15 m
Average duration
1 d 13 h 15 m
Buses per day
1
Distance
1648 km
The best way to find a cheap bus ticket from Des Moines, IA to Jacksonville, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Jacksonville, FL will cost around $245 if you buy it on the day, but the cheapest tickets can be found for only $245.
Of the 1 buses that leave Des Moines, IA for Jacksonville, FL on Tue, Feb 17, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Feb 17 the direct buses cover the 1648 km distance in an average of 1 d 13 h 15 m but if you time it right, some buses will get you there in just 1 d 13 h 15 m .
On Tue, Feb 17 the slowest buses will take 1 d 13 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus and flight for Des Moines, IA to Jacksonville, FL
Omio recommends booking the flight as it is the most popular option from Des Moines, IA to Jacksonville, FL among Omio's users. If you are prioritising price take the bus with prices starting from €231. For those with little time consider booking a flight which can get you there in 5h 55m. The ticket price range depends on the travel mode: a bus costs an average of €231, and a flight costs an average of €373.
Distance: 1024 miles (1648 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
€231 Average price Cheapest | €373 Average price |
33h 55m Average total duration 33h 25m Onboard + 30m Additional time* | 8h 55m Average total duration Fastest 5h 55m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Live departures
Des Moines, IA to Jacksonville, FL bus times
The table below shows live departures for Des Moines, IA to Jacksonville, FL buses for tomorrow, Tuesday, February 17. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 10:30 AM Des Moines, IA | 37h15 | 11:45 PM Jacksonville, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Des Moines, IA to Jacksonville, FL by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 17
Feb 18
Feb 19
Feb 20
Feb 21
Feb 22
Feb 23
Journey information
Overview: Bus from Des Moines, IA to Jacksonville, FL
Buses from Des Moines, IA to Jacksonville, FL run on average 1 times per day, taking around 33h 25m. Cheap bus tickets for this journey start at $291 (€231) if you book in advance.
The earliest bus runs at 05:30, the last at 21:40. The fastest bus covers the 1024 miles (1648 km) distance in 33h 25m.
Distance 1024 miles (1648 km) |
Average bus duration 33h 25m |
Cheapest ticket price $291 (€231) |
Buses per day 1 |
Fastest bus 33h 25m |
First bus 05:30 |
Last bus 21:40 |
FAQs: Bus from Des Moines, IA to Jacksonville, FL
Find answers to the most common questions about traveling from Des Moines, IA to Jacksonville, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Jacksonville, FL, this guide helps you travel smarter and with confidence.

Most popular bus connections from Des Moines, IA
More options for your journey from Des Moines, IA to Jacksonville, FL
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