- Must visit
Orlando Science Center
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
Cheapest price
$262
Average price
$262
Fastest journey
1 d 13 h 39 m
Average duration
1 d 13 h 39 m
Buses per day
1
Distance
1826 km
The best way to find a cheap bus ticket from Des Moines, IA to Orlando, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Orlando, FL will cost around $262 if you buy it on the day, but the cheapest tickets can be found for only $262.
Of the 1 buses that leave Des Moines, IA for Orlando, FL on Sun, Aug 02, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Aug 02 the direct buses cover the 1826 km distance in an average of 1 d 13 h 39 m but if you time it right, some buses will get you there in just 1 d 13 h 39 m .
On Sun, Aug 02 the slowest buses will take 1 d 13 h 39 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Buses from Des Moines, IA to Orlando, FL run on average 3 times per day, taking around 32h 30m. Cheap bus tickets for this journey start at $155 (€126) if you book in advance.
The earliest bus runs at 04:45, the last at 23:40. The fastest bus covers the 1134 miles (1826 km) distance in 34h 0m.
Distance 1134 miles (1826 km) |
Average bus duration 32h 30m |
Cheapest ticket price $155 (€126) |
Buses per day 3 |
Fastest bus 34h 0m |
First bus 4:45 AM |
Last bus 11:40 PM |
Cheapest Month Jan |
Cheapest Day Sun |
High Season Jan - Mar |
Low Season Apr - Jun |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 09:55AM | Arrival Time 09:20PM | Duration 35h25 | Departure days Fri | Cheapest price $296 |
Operator FlixBus | Departure Time 10:30AM | Arrival Time 03:59AM | Duration 41h29 | Departure days Tue | Cheapest price $386 |
Operator Greyhound | Departure Time 11:30AM | Arrival Time 01:25AM | Duration 37h55 | Departure days Wed | Cheapest price $425 |
Operator FlixBus | Departure Time 02:20PM | Arrival Time 03:59AM | Duration 37h39 | Departure days Tue, Wed, Thu, Fri, Sat | Cheapest price $163 |
Operator FlixBus | Departure Time 02:25PM | Arrival Time 12:25AM | Duration 34h00 | Departure days Wed | Cheapest price $155 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 09:50AM | Duration 43h05 | Departure days Thu | Cheapest price $294 |
Operator FlixBus | Departure Time 03:20PM | Arrival Time 04:59AM | Duration 37h39 | Departure days Sat, Sun | Cheapest price $262 |
Operator Greyhound | Departure Time 03:45PM | Arrival Time 10:50AM | Duration 43h05 | Departure days Fri | Cheapest price $423 |
The table below shows live departures for Des Moines, IA to Orlando, FL buses for tomorrow, Sunday, August 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:20 PM Des Moines, IA | 37h39 | 4:59 AM Orlando, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of Orlando, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Orlando, FL trip today.
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
Major local history museum in a restored 1927 courthouse, covering Central Florida's past through engaging permanent and special exhibits.
Smithsonian-affiliated art museum with American, African, and ancient works, plus strong rotating exhibitions in Winter Park.
Orlando's signature urban park with lake views, swan boats, skyline scenes, and frequent festivals in the city center.
Upscale main street area famous for boutiques, brick streets, and a polished small-town atmosphere in nearby Winter Park.
Lively entertainment district with nightlife, murals, and historic architecture around downtown's Church Street corridor.
A Central Florida favorite of smoked or fried local catfish, often served with hushpuppies and grits. It reflects the region's freshwater fishing and Southern roots.
Fresh Atlantic or Gulf shrimp, commonly peel-and-eat, grilled, or fried. It is a staple across Florida and prized in Orlando seafood spots for its regional freshness.
Cuban coffee sweetened during brewing for a bold, syrupy shot. Popular in Central Florida's Latin communities, it is a daily ritual and local caffeine classic.
Popular Cuban cafe serving strong cafecito, Cuban sandwiches, and pastries in a busy, no-frills neighborhood setting.
Historic casual seafood house known for Florida gator tail, frog legs, and laid-back Old Florida charm near downtown Orlando.
Refined restaurant in Winter Park highlighting Florida seafood and seasonal Southern ingredients in an elegant but relaxed space.
Moderate for a major US tourist city. Theme parks and hotels raise trip costs, while casual dining and ride-hailing are widely available at typical US urban prices.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis or ride-hailing, and small change or up to 10% at cafes if table service is provided.
Find answers to the most common questions about traveling from Des Moines, IA to Orlando, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Orlando, FL, this guide helps you travel smarter and with confidence.

Most Des Moines, IA to Orlando, FL buses use the to Orlando, N John Young Pkwy (Greyhound Bus Station) station pair, with some services arriving at Orlando, The Florida Mall. Use this guide to compare Des Moines, IA and Orlando, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need