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Journey information
Overview: Bus from Des Moines, IA to San Diego, CA
Take a bus from Des Moines, IA to San Diego, CA and enjoy the approximately 1428 miles (2299 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 05:30, the last at 19:35.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1428 miles (2299 km) |
Buses per day 5 |
First bus 05:30 |
Last bus 19:35 |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
FAQs: Bus from Des Moines, IA to San Diego, CA
Find answers to the most common questions about traveling from Des Moines, IA to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.

Cheap bus tickets from Des Moines, IA to San Diego, CA can start from as little as $262 (€214) when you book in advance. The average bus ticket price for Des Moines, IA to San Diego, CA is $263 (€215); however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
On average the Des Moines, IA to San Diego, CA bus time is 62 h 15 min covering the 1425 mile (2298 km) long route, but the journey time can vary depending on specific dates or if traveling on weekends and holidays.
The first bus from Des Moines, IA to San Diego, CA leaves at 5: 30AM. Plan your trip with the Journey Planner from Omio.
The last bus from Des Moines, IA to San Diego, CA leaves at 7: 35PM.
The cheapest month to travel from Des Moines, IA to San Diego, CA by bus is November.
It's helpful to compare your options as there are 2 ways to travel between Des Moines, IA and San Diego, CA including taking a bus or flight.
No, the bus from Des Moines, IA to San Diego, CA has no accessibility options.
No, there are no bathrooms on board the bus from Des Moines, IA to San Diego, CA.
Some of the most interesting sights to explore in San Diego, CA are:
- Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
- USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
- La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
- Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
- Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best things to do in San Diego, CA include:
- Explore the vibrant art scene at the Museum of Contemporary Art San Diego
- Enjoy a harbor cruise for stunning views of the skyline and naval ships
- Hike the scenic trails at Torrey Pines State Natural Reserve
- Visit the Birch Aquarium to learn about marine life and ocean conservation
- Experience the thrill of a whale watching tour off the coast.
No, bikes are not allowed on board the bus from Des Moines, IA to San Diego, CA.
To find the cheapest bus tickets for your trip from Des Moines, IA to San Diego, CA, follow these tips:
Start your search now and compare ticket prices to find the best deal!
Yes, there is food available to purchase on board the bus from Des Moines, IA to San Diego, CA.
No, luggage for the bus from Des Moines, IA to San Diego, CA needs to be booked in addition.
No, there are no additional luggage options for the bus from Des Moines, IA to San Diego, CA.
Unfortunately, pets are not allowed on the bus from Des Moines, IA to San Diego, CA.
No, there are no USB plugs on board the bus from Des Moines, IA to San Diego, CA.
No, there is no WiFi on board the bus from Des Moines, IA to San Diego, CA.
Most popular bus connections from Des Moines, IA
More options for your journey from Des Moines, IA to San Diego, CA
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