- Must visit
USS Midway Museum
Museum aboard the historic aircraft carrier USS Midway with restored aircraft, flight deck exhibits, and audio tours on San Diego Bay.
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Travel Information
Compare bus and flight for Des Moines, IA to San Diego, CA
Omio recommends booking the flight as it is the most popular option from Des Moines, IA to San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from $237. For those with little time consider booking a flight which can get you there in 4h 38m. The ticket price range depends on the travel mode: a bus costs an average of $237, and a flight costs an average of $539.
Distance: 1428 miles (2299 km)
Compare bus with
| Bus | Most popular Flight | Driving |
|---|---|---|
$250 Average price Cheapest | $568 Average price | $355 Average price (fuel + tolls) |
46h 32m Average total duration 46h 2m Onboard + 30m Additional time* | 7h 38m Average total duration Fastest 4h 38m Onboard + 3h 0m Additional time* | 25h 6m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Des Moines, IA to San Diego, CA is a bus with an average price of $250 (€204).
This is compared to other travel options from Des Moines, IA to San Diego, CA:
A bus is $318 (€260) less than a flight for this route with tickets for a flight from Des Moines, IA to San Diego, CA costing on average $568 (€463).
The fastest way to travel from Des Moines, IA to San Diego, CA is by flight with an average journey time of 4h 38m.
Other travel options to San Diego, CA take longer:
Bus takes on average 46h 2m.
It's helpful to compare your options as there are 2 ways to travel between Des Moines, IA and San Diego, CA including taking a bus and flight.
We recommend using the flight as it is the most popular way to get from Des Moines, IA to San Diego, CA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Des Moines, IA to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:35AM | Arrival Time 12:10AM | Duration 47h35 | Departure days Mon, Fri | Cheapest price $237 |
Operator Greyhound | Departure Time 01:15AM | Arrival Time 10:40PM | Duration 45h25 | Departure days Fri | Cheapest price $246 |
Operator Greyhound USA | Departure Time 07:15PM | Arrival Time 10:15PM | Duration 51h00 | Departure days Mon, Tue, Wed | Cheapest price $484 |
Compare prices and tickets Des Moines, IA to San Diego, CA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Des Moines, IA to San Diego, CA buses with Omio?
Greyhound operates all buses services from Des Moines, IA to San Diego, CA.
Omio is an official ticket reseller for all your travel options from Des Moines, IA to San Diego, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Des Moines, IA to San Diego, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Des Moines, IA to San Diego, CA.
Journey information
Overview: Bus from Des Moines, IA to San Diego, CA
USAUSA
Buses from Des Moines, IA to San Diego, CA run on average 5 times per day, taking around 46h 2m. Cheap bus tickets for this journey start at $237 (€193) if you book in advance.
The earliest bus runs at 06:45, the last at 19:35. The fastest bus covers the 1428 miles (2299 km) distance in 45h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1428 miles (2299 km) |
Average bus duration 46h 2m |
Cheapest ticket price $237 (€193) |
Buses per day 5 |
Fastest bus 45h 5m |
First bus 6:45 AM |
Last bus 7:35 PM |
Cheapest Month Mar |
Cheapest Day Tue |
High Season Jan - Mar |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Des Moines, IA to San Diego, CAYou can travel by bus between Des Moines, IA to San Diego, CA with Greyhound for as low as $237 (€193). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
45h 5m
Cheapest Price
$237 (€193)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to San Diego
Things to do in San Diego
Discover the best of San Diego — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego trip today.
- Recommended
San Diego Museum of Art
Balboa Park art museum known for Spanish old masters, South Asian works, and rotating exhibitions in a landmark building.
- Recommended
Museum of Contemporary Art San Diego
Leading contemporary art museum with major postwar and current works, especially strong in Southern California and Pacific Rim artists.
- Must visit
Balboa Park
Vast cultural park with gardens, museums, Spanish Colonial Revival architecture, walking paths, and some of San Diego's best photo spots.
- Must visit
La Jolla Cove
Scenic cove known for sea lions, clear water, coastal cliffs, and highly shareable sunset and ocean-view walks.
- Must visit
Coronado Beach
Wide sandy beach beside the Hotel del Coronado, popular for walking, photography, and classic Southern California scenery.
- Gluten-free
Fish Tacos
Beer-battered or grilled local fish in tortillas, usually topped with cabbage, crema, and salsa. A signature coastal San Diego staple with strong Baja influence.
California Burrito
A San Diego original burrito filled with carne asada, fries, cheese, and salsa. It is one of the city’s most iconic late-night and casual foods.
- Gluten-free
Carne Asada Fries
French fries topped with carne asada, cheese, guacamole, sour cream, and salsa. This indulgent dish is strongly associated with San Diego taco shop culture.
Mitch's Seafood
Popular waterfront seafood restaurant serving fresh local catch, fish tacos, and sandwiches in a relaxed harbor setting near the fishing fleet.
Las Cuatro Milpas
Historic, no-frills Mexican restaurant famous for house-made tortillas, rolled tacos, and comforting traditional plates. A beloved local institution with a classic atmosphere.
Hodad's
Iconic casual spot in Ocean Beach known for oversized burgers, fries, and a lively beach-town vibe. A long-standing San Diego favorite.
United States Dollar
Prices are high by U.S. standards, especially for hotels, dining, and parking near the coast and downtown.
Average meal costs
- Budget
- USD 10-18 for tacos, fast food, or casual takeout.
- Mid-range
- USD 20-40 per person at a standard sit-down restaurant.
- Fine dining
- USD 75+ per person before drinks and tax.
- Coffee
- USD 4-7 for a latte or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 20%+ for great service. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and valet.
FAQs: Bus from Des Moines, IA to San Diego, CA
Find answers to the most common questions about traveling from Des Moines, IA to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Des Moines, IA to San Diego, CA can start from as little as $237 (€193) when you book in advance. The average bus ticket price for Des Moines, IA to San Diego, CA is $250 (€204) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Des Moines, IA to San Diego, CA is 45h 5m to travel the 1428 miles (2299 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Des Moines, IA to San Diego, CA leaves at 6:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Des Moines, IA to San Diego, CA leaves at 7:35 PM.
There are 5 buses a day from Des Moines, IA to San Diego, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Des Moines, IA to San Diego, CA, you can count on Greyhound for the best way to get you to San Diego, CA. You can also check all possible bus companies who offer a service between Des Moines, IA and San Diego, CA and compare the amenities they offer before buying a bus ticket.
A trip to San Diego, CA from Des Moines, IA is worth doing but not as a day trip with a journey time of 45h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Des Moines, IA to San Diego, CA is March.
It's helpful to compare your options as there are 2 ways to travel between Des Moines, IA and San Diego, CA including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Des Moines, IA to San Diego, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Des Moines, IA to San Diego, CA for bus company Greyhound.
Some of the most interesting sights to explore in San Diego, CA are:
- Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
- USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
- La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
- Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
- Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best things to do in San Diego, CA include:
- Explore the vibrant art scene at the Museum of Contemporary Art San Diego
- enjoy a harbor cruise for stunning views of the skyline and naval ships
- hike the scenic trails at Torrey Pines State Natural Reserve
- visit the Birch Aquarium to learn about marine life and ocean conservation
- experience the thrill of a whale watching tour off the coast.
Whether you can cancel your bus ticket from Des Moines, IA to San Diego, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Des Moines, IA to San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from Des Moines, IA to San Diego, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Des Moines, IA to San Diego, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Des Moines, IA to San Diego, CA.
You can reserve your seat on the bus from Des Moines, IA to San Diego, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Des Moines, IA to San Diego, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Des Moines, IA to San Diego, CA with the following bus company: Greyhound.
Since neither Des Moines, IA nor San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from Des Moines, IA to San Diego, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Des Moines, IA to San Diego, CA
Most Des Moines, IA to San Diego, CA buses use the to San Diego, Congress Street (Old Town Park) station pair, with some services arriving at San Diego, San Ysidro Transit Center. Use this guide to compare Des Moines, IA and San Diego, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Des Moines
Arrival bus stations in San Diego
San Diego, Congress Street (Old Town Park)
City-centre transport
Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre
BusFlixBus 2017 · 20m · $1
83 · 26m · $6
TramGreen, Blue, Event · 16m · every ~18 min
Blue · 21m · every ~9 min
San Diego, West Harbor Drive (The Headquarters at Seaport District)
San Diego, San Ysidro Transit Center
City-centre transport
Getting to San Diego, San Ysidro Transit Center from San Diego city centre
BusFlixBus 2017 · 25m · $2
910 · 41m · $6
TramBlue · 41m · $17 · every ~14 min
Blue · 43m · $17 · every ~14 min
Most popular bus connections from Des Moines, IA
More options for your journey from Des Moines, IA to San Diego, CA
Here are some other resources that might have the information you need
Most popular buses to and from San Diego, CA and Des Moines, IA
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