The cheapest and fastest buses from Des Moines, IA to Phoenix, AZ
Cheapest price
$644
Average price
$644
Fastest journey
1 d 12 h 5 m
Average duration
1 d 12 h 5 m
Buses per day
1
Distance
1858 km
The best way to find a cheap bus ticket from Des Moines, IA to Phoenix, AZ is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Des Moines, IA to Phoenix, AZ will cost around $644 if you buy it on the day, but the cheapest tickets can be found for only $644.
It's difficult to get from Des Moines, IA to Phoenix, AZ without transferring at least 2 times.


Travel Information
Compare bus and flight for Des Moines, IA to Phoenix, AZ
Omio recommends booking the bus as it is the most popular option from Des Moines, IA to Phoenix, AZ among Omio's users. If you are prioritising price take the flight with prices starting from €180. For those with little time consider booking a flight which can get you there in 5h 28m. The ticket price range depends on the travel mode: a flight costs an average of €180, and a bus costs an average of €356.
Distance: 1154 miles (1858 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
€360 Average price | €297 Average price Cheapest |
50h 53m Average total duration 50h 23m Onboard + 30m Additional time* | 8h 28m Average total duration Fastest 5h 28m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Live departures
Des Moines, IA to Phoenix, AZ bus times
The table below shows live departures for Des Moines, IA to Phoenix, AZ buses for today, Tuesday, November 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:30 PM Des Moines, IA | 36h05 | 6:35 AM Phoenix, AZ | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Des Moines, IA to Phoenix, AZ by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Des Moines, IA to Phoenix, AZ
Buses from Des Moines, IA to Phoenix, AZ run on average 2 times per day, taking around 50h 23m. Cheap bus tickets for this journey start at $439 (€356) but you can travel from only $222 (€180) by flight.
The earliest bus runs at 05:30, the last at 23:05. The fastest bus covers the 1154 miles (1858 km) distance in 50h 5m.
Distance 1154 miles (1858 km) |
Average bus duration 50h 23m |
Cheapest ticket price $439 (€356) |
Buses per day 2 |
Fastest bus 50h 5m |
First bus 05:30 |
Last bus 23:05 |
Bus providers: Jefferson Lines from Des Moines, IA to Phoenix, AZYou can travel by bus between Des Moines, IA to Phoenix, AZ with Jefferson Lines for as low as $222 (€180). When you search for schedules and tickets, Omio will show you the best journey
Jefferson Lines
FAQs: Bus from Des Moines, IA to Phoenix, AZ
Find answers to the most common questions about traveling from Des Moines, IA to Phoenix, AZ by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Phoenix, AZ, this guide helps you travel smarter and with confidence.

- Desert Botanical Garden, a 140-acre garden showcasing a vast collection of arid-land plants and desert landscapes
- Heard Museum, a renowned museum dedicated to the advancement of American Indian art and culture
- Phoenix Art Museum, the largest art museum in the southwestern United States featuring diverse collections and exhibitions
- Camelback Mountain, a popular hiking destination offering panoramic views of the city and surrounding desert
- Papago Park, a scenic park known for its distinctive geological formations and recreational opportunities.
- Musical Instrument Museum, a unique museum showcasing instruments from around the world
- South Mountain Park and Preserve, offering extensive trails and breathtaking views of the desert landscape
- Roosevelt Row, a vibrant arts district known for its galleries, murals, and local eateries
- Phoenix Zoo, a family-friendly attraction with a wide variety of animals and interactive exhibits
- Taliesin West, the winter home and architectural school of Frank Lloyd Wright, offering tours of its stunning design.
To find the cheapest bus tickets for your trip from Des Moines, IA to Phoenix, AZ, follow these tips:
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Popular bus stations from Des Moines, IA to Phoenix, AZ
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