- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Cheapest price on Sep 06
$106
Average ticket price on Sep 06
$107
Fastest journey on Sep 06
15 h 35 m
Average journey duration on Sep 06
17 h 40 m
Buses on Sep 06
6
Distance
640 km
The best way to find a cheap bus ticket from Greenville, SC to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Indianapolis, IN will cost around $107 if you buy it on the day, but the cheapest tickets can be found for only $106.
It's difficult to get from Greenville, SC to Indianapolis, IN without transferring at least once.
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· Omio recommends booking the train as it is the most popular option from Greenville, SC to Indianapolis, IN among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $118 For those with little time, consider booking a bus, which has an average total journey time of 16h 17m. Average ticket prices depend on the travel mode: a bus costs an average of $118, while a train costs an average of $217.
Distance: 397 miles (640 km)
| Bus | Most popular Train | Driving |
|---|---|---|
$118 Average price Cheapest | $217 Average price | $102 Average price (fuel + tolls) |
16h 17m Average total duration Fastest 15h 47m Onboard + 30m Additional time* | 24h 24m Average total duration 23h 54m Onboard + 30m Additional time* | 8h 12m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Greenville, SC to Indianapolis, IN:
A bus is $99 (€80) less than a train for this route with tickets for a train from Greenville, SC to Indianapolis, IN costing on average $217 (€175).
A bus is $486 (€393) less than a flight for this route with tickets for a flight from Greenville, SC to Indianapolis, IN costing on average $604 (€488).
Other travel options to Indianapolis, IN take longer:
Bus takes on average 15h 47m.
Train takes on average 23h 54m.
Tickets start at around $118 (€95) compared to roughly $102 (€83) in fuel and tolls — a saving of about $-15.42 (€-12.46). The journey takes 15h 47m versus 8h 12m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:20PM | Arrival Time 04:55AM | Duration 15h35 | Departure days Everyday | Cheapest price $83 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 09:30AM | Duration 18h45 | Departure days Everyday | Cheapest price $83 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 08:00AM | Duration 17h15 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $85 |
Operator FlixBus | Departure Time 08:20PM | Arrival Time 11:15PM | Duration 26h55 | Departure days Thu | Cheapest price $90 |
Operator Greyhound | Departure Time 08:20PM | Arrival Time 12:10PM | Duration 15h50 | Departure days Everyday | Cheapest price $82 |
Operator Greyhound | Departure Time 09:35PM | Arrival Time 06:10PM | Duration 20h35 | Departure days Everyday | Cheapest price $83 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 09:45PM | Duration 24h10 | Departure days Everyday | Cheapest price $84 |
The table below shows live departures for Greenville, SC to Indianapolis, IN buses for today, Saturday, September 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+![]() | 1:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 15h35 | 4:55 AM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
FlixBus+![]() | 2:45 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 17h15 | 8:00 AM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 1 transfer | |
· | 2:45 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 18h45 | 9:30 AM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
· | 8:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 15h50 | 12:10 PM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Greenville, SC to Indianapolis, IN run on average 6 times per day, taking around 15h 47m. Cheap bus tickets for this journey start at $86 (€69) if you book in advance.
The earliest bus runs at 02:40, the last at 23:30. The fastest bus covers the 397 miles (640 km) distance in 14h 20m.
Distance 397 miles (640 km) |
Average bus duration 15h 47m |
Cheapest ticket price $86 (€69) |
Buses per day 6 |
Fastest bus 14h 20m |
First bus 2:40 AM |
Last bus 11:30 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Apr - Jun |
Discover the best of Indianapolis, IN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis, IN trip today.
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
Find answers to the most common questions about traveling from Greenville, SC to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

Most Greenville, SC to Indianapolis, IN buses use the Greenville, Woodruff Rd ("Raceway" gas station) to Indianapolis, Illinois St (Greyhound Bus Station) station pair. Use this guide to compare Greenville, SC and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Limited dining options available in adjacent areas.
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Fast food outlets are available.
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
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