- Must visit
The Children's Museum of Indianapolis
The world's largest children's museum, known for immersive science, history, and culture exhibits for all ages.
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Travel Information
Compare bus, train, and flight for Greenville, SC to Indianapolis, IN
Omio recommends booking the train as it is the most popular option from Greenville, SC to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from $110. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a bus costs an average of $110, and a train costs an average of $167.
Distance: 397 miles (640 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$110 Average price Cheapest | $167 Average price | $167 Average price | $100 Average price (fuel + tolls) |
15h 55m Average total duration 15h 25m Onboard + 30m Additional time* | 28h 2m Average total duration 27h 32m Onboard + 30m Additional time* | 10h 22m Average total duration Fastest 7h 22m Onboard + 3h 0m Additional time* | 8h 12m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Greenville, SC to Indianapolis, IN is a bus with an average price of $110 (€90).
This is compared to other travel options from Greenville, SC to Indianapolis, IN:
A bus is $57 (€46) less than a flight for this route with tickets for a flight from Greenville, SC to Indianapolis, IN costing on average $167 (€136).
A bus is $57 (€47) less than a train for this route with tickets for a train from Greenville, SC to Indianapolis, IN costing on average $167 (€136).
The fastest way to travel from Greenville, SC to Indianapolis, IN is by flight with an average journey time of 7h 22m.
Other travel options to Indianapolis, IN take longer:
Bus takes on average 15h 25m.
Train takes on average 27h 32m.
It's helpful to compare your options as there are 3 ways to travel between Greenville, SC and Indianapolis, IN including taking a bus, train, and flight.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Greenville, SC to Indianapolis, IN Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:20PM | Arrival Time 08:45AM | Duration 15h25 | Departure days Wed | Cheapest price $110 |
Compare prices and tickets Greenville, SC to Indianapolis, IN by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Greenville, SC to Indianapolis, IN
USAUSA
Buses from Greenville, SC to Indianapolis, IN run on average 6 times per day, taking around 15h 25m. Cheap bus tickets for this journey start at $110 (€90) if you book in advance.
The earliest bus runs at 02:40, the last at 23:30. The fastest bus covers the 397 miles (640 km) distance in 15h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 397 miles (640 km) |
Average bus duration 15h 25m |
Cheapest ticket price $110 (€90) |
Buses per day 6 |
Fastest bus 15h 25m |
First bus 2:40 AM |
Last bus 11:30 PM |
Cheapest Month Jun |
Cheapest Day Mon |
High Season Apr - Jun |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to Indianapolis
Things to do in Indianapolis
Discover the best of Indianapolis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis trip today.
- Must visit
Newfields
A major art campus featuring the Indianapolis Museum of Art, gardens, and rotating exhibitions in a scenic setting.
- Must visit
Indianapolis Motor Speedway Museum
A must for racing fans, with historic cars, Indianapolis 500 artifacts, and motorsport heritage.
- Must visit
Monument Circle
Downtown's central circle and gathering place, lined with historic buildings and anchored by the city's iconic monument.
- Must visit
White River State Park
Major urban park linking museums, trails, green space, and canal-side walks in the heart of the city.
- Must visit
Massachusetts Avenue
Trendy cultural district known for independent shops, theaters, murals, and strong day-to-night energy.
Pork Tenderloin Sandwich
A Hoosier classic: a breaded and fried pork cutlet served on a bun, often much larger than the bread. It is one of Central Indiana's most iconic comfort foods.
- Gluten-free
Shrimp Cocktail
Indianapolis is famous for steakhouse-style shrimp cocktail topped with very spicy cocktail sauce, especially associated with old-school downtown dining.
- Vegetarian
Sugar Cream Pie
Often called Hoosier pie, this simple custard-like pie made with cream, sugar, and flour is one of Indiana's signature desserts.
St. Elmo Steak House
Historic downtown steakhouse best known for dry-aged steaks and its legendary spicy shrimp cocktail. Classic, upscale, and one of Indianapolis's most famous dining rooms.
Bluebeard
Well-regarded New American restaurant in Fletcher Place, known for seasonal menus, thoughtful cocktails, and a stylish neighborhood setting.
Workingman's Friend
Historic no-frills tavern famous for old-school burgers and a classic local atmosphere. A beloved casual stop with deep Indianapolis roots.
United States Dollar
Moderate by U.S. city standards. Hotels vary by events, while casual dining, coffee, and transport are generally manageable.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 20-35 per person at a mid-range restaurant.
- Fine dining
- USD 60+ per person before drinks and tax.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis 10-15%, hotel staff USD 2-5, and round up for casual services.
FAQs: Bus from Greenville, SC to Indianapolis, IN
Find answers to the most common questions about traveling from Greenville, SC to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Greenville, SC to Indianapolis, IN can start from as little as $110 (€90) when you book in advance. The average bus ticket price for Greenville, SC to Indianapolis, IN is $110 (€90) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Greenville, SC to Indianapolis, IN is 15h 25m to travel the 397 miles (640 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Greenville, SC to Indianapolis, IN leaves at 2:40 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Greenville, SC to Indianapolis, IN leaves at 11:30 PM.
A trip to Indianapolis, IN from Greenville, SC is worth doing but not as a day trip with a journey time of 15h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Greenville, SC to Indianapolis, IN is June.
It's helpful to compare your options as there are 3 ways to travel between Greenville, SC and Indianapolis, IN including taking a bus, train, and flight.
No, the bus from Greenville, SC to Indianapolis, IN has no accessibility options.
No, there are no bathrooms on board the bus from Greenville, SC to Indianapolis, IN.
Some of the most interesting sights to explore in Indianapolis, IN are:
- Indianapolis Motor Speedway, a historic racing circuit known for hosting the Indianapolis 500
- The Children's Museum of Indianapolis, the world's largest children's museum featuring interactive exhibits
- Indianapolis Zoo, a popular attraction with diverse animal exhibits and a botanical garden
- Indiana State Museum, showcasing the state's history, art, and science through various exhibits
- White River State Park, a sprawling urban park offering trails, gardens, and cultural attractions.
The best things to do in Indianapolis, IN include:
- Indianapolis Museum of Art at Newfields, a vast art museum with extensive collections and beautiful gardens
- Attend a race at the Indianapolis Motor Speedway, home of the iconic Indy 500
- Explore the interactive exhibits and educational programs at The Children's Museum of Indianapolis
- Visit the dolphin pavilion and animal habitats at the Indianapolis Zoo
- Enjoy a walk along the canal and cultural attractions at White River State Park.
No, bikes are not allowed on board the bus from Greenville, SC to Indianapolis, IN.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Greenville, SC to Indianapolis, IN.
No, luggage for the bus from Greenville, SC to Indianapolis, IN needs to be booked in addition.
No, there are no additional luggage options for the bus from Greenville, SC to Indianapolis, IN.
Unfortunately, pets are not allowed on the bus from Greenville, SC to Indianapolis, IN.
No, there are no USB plugs on board the bus from Greenville, SC to Indianapolis, IN.
No, there is no WiFi on board the bus from Greenville, SC to Indianapolis, IN.
Since neither Greenville, SC nor Indianapolis, IN are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Indianapolis, travelers should be cautious of pickpocketing and vehicle break-ins, especially in busy areas like downtown and near major event venues. Common scams include overcharging by unofficial taxi or rideshare drivers and distraction tactics used to steal belongings. It's advised to use authorized transportation services, avoid poorly lit or unfamiliar areas at night, and keep valuables secure.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Greenville, SC to Indianapolis, IN
Greenville
Indianapolis
The major bus station for departures in Greenville is Greenville, Woodruff Rd ("Raceway" gas station). Find all the information you need to know about services, amenities and connections at Greenville, Woodruff Rd ("Raceway" gas station) for your trip from Greenville to Indianapolis.
Greenville, Woodruff Rd ("Raceway" gas station)
information
The major bus station for arrivals in Indianapolis is Indianapolis, Illinois St (Greyhound Bus Station). Find all the information you need to know about services, amenities and connections at Indianapolis, Illinois St (Greyhound Bus Station) for your trip to Indianapolis from Greenville.
Indianapolis, Illinois St (Greyhound Bus Station)
information
Indianapolis, E Washington St / N Delaware St (City/County Building)
information
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Indianapolis, IN
Here are some other resources that might have the information you need
Most popular buses to and from Indianapolis, IN and Greenville, SC
Most popular bus connections to Indianapolis, IN
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