- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
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The cheapest and fastest buses from Greenville, SC to Indianapolis, IN
Showing times and prices for Jul 22
Cheapest price
$90
Average price
$92
Fastest journey
15 h 35 m
Average duration
17 h 40 m
Buses per day
6
Distance
640 km
Cheap tickets
The best way to find a cheap bus ticket from Greenville, SC to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Indianapolis, IN will cost around $92 if you buy it on the day, but the cheapest tickets can be found for only $90.
Fast buses
It's difficult to get from Greenville, SC to Indianapolis, IN without transferring at least once.
· 8:20 PM15h50Greenville, Woodruff Rd ("Raceway" gas station), SC12:10 PMIndianapolis, Illinois St (Greyhound Bus Station)$901One-way1 transfer- · 2:45 PM18h45Greenville, Woodruff Rd ("Raceway" gas station), SC9:30 AMIndianapolis, Illinois St (Greyhound Bus Station)$901One-way1 transfer
FlixBus+1:20 PM15h35Greenville, Woodruff Rd ("Raceway" gas station), SC4:55 AMIndianapolis, Illinois St (Greyhound Bus Station)$901One-way1 transfer- FlixBus+2:45 PM17h15Greenville, Woodruff Rd ("Raceway" gas station), SC8:00 AMIndianapolis, E Washington St / N Delaware St (City/County Building), IN$911One-way1 transfer
- FlixBus · FlixBus+9:35 PM24h10Greenville, Woodruff Rd ("Raceway" gas station), SC9:45 PMIndianapolis, E Washington St / N Delaware St (City/County Building), IN$911One-way2 transfers
- FlixBus+1:20 PM15h35Greenville, Woodruff Rd ("Raceway" gas station), SC4:55 AMIndianapolis, Illinois St (Greyhound Bus Station)$901One-way1 transfer
- · 8:20 PM15h50Greenville, Woodruff Rd ("Raceway" gas station), SC12:10 PMIndianapolis, Illinois St (Greyhound Bus Station)$901One-way1 transfer
- FlixBus+2:45 PM17h15Greenville, Woodruff Rd ("Raceway" gas station), SC8:00 AMIndianapolis, E Washington St / N Delaware St (City/County Building), IN$911One-way1 transfer
- · 2:45 PM18h45Greenville, Woodruff Rd ("Raceway" gas station), SC9:30 AMIndianapolis, Illinois St (Greyhound Bus Station)$901One-way1 transfer
- FlixBus+ · 9:35 PM20h55Greenville, Woodruff Rd ("Raceway" gas station), SC6:30 PMIndianapolis, Illinois St (Greyhound Bus Station)$971One-way2 transfers
Travel Information
Compare bus, train, and flight for Greenville, SC to Indianapolis, IN
Omio recommends booking the train as it is the most popular option from Greenville, SC to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from $90. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a bus costs an average of $90, and a train costs an average of $136.
Distance: 397 miles (640 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$90 Average price Cheapest | $136 Average price | $136 Average price | $82 Average price (fuel + tolls) |
15h 55m Average total duration 15h 25m Onboard + 30m Additional time* | 28h 2m Average total duration 27h 32m Onboard + 30m Additional time* | 10h 22m Average total duration Fastest 7h 22m Onboard + 3h 0m Additional time* | 8h 12m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Greenville, SC to Indianapolis, IN is a bus with an average price of $90 (€90).
This is compared to other travel options from Greenville, SC to Indianapolis, IN:
A bus is $46 (€46) less than a flight for this route with tickets for a flight from Greenville, SC to Indianapolis, IN costing on average $136 (€136).
A bus is $47 (€47) less than a train for this route with tickets for a train from Greenville, SC to Indianapolis, IN costing on average $136 (€136).
The fastest way to travel from Greenville, SC to Indianapolis, IN is by flight with an average journey time of 7h 22m.
Other travel options to Indianapolis, IN take longer:
Bus takes on average 15h 25m.
Train takes on average 27h 32m.
It's helpful to compare your options as there are 3 ways to travel between Greenville, SC and Indianapolis, IN including taking a bus, train, and flight.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Greenville, SC to Indianapolis, IN Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:20PM | Arrival Time 04:55AM | Duration 15h35 | Departure days Everyday | Cheapest price $72 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 09:30AM | Duration 18h45 | Departure days Everyday | Cheapest price $72 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 08:00AM | Duration 17h15 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $72 |
Operator FlixBus | Departure Time 08:20PM | Arrival Time 11:15PM | Duration 26h55 | Departure days Thu | Cheapest price $73 |
Operator Greyhound | Departure Time 08:20PM | Arrival Time 12:10PM | Duration 15h50 | Departure days Everyday | Cheapest price $72 |
Operator Greyhound | Departure Time 09:35PM | Arrival Time 06:30PM | Duration 20h55 | Departure days Everyday | Cheapest price $74 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 09:45PM | Duration 24h10 | Departure days Everyday | Cheapest price $75 |
Live departures
Greenville, SC to Indianapolis, IN bus times
The table below shows live departures for Greenville, SC to Indianapolis, IN buses for today, Tuesday, July 21. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · | 8:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 15h50 | 12:10 PM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
| FlixBus · FlixBus+ | 9:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 24h10 | 9:45 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 2 transfers | |
| FlixBus+ · | 9:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 20h55 | 6:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 2 transfers | |
| Wednesday, July 22 | |||||
| FlixBus+ | 1:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 15h35 | 4:55 AM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
| · | 2:45 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 18h45 | 9:30 AM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
| +FlixBus | 2:45 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 17h15 | 8:00 AM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Greenville, SC to Indianapolis, IN by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Greenville, SC to Indianapolis, IN
USAUSA
Buses from Greenville, SC to Indianapolis, IN run on average 6 times per day, taking around 15h 25m. Cheap bus tickets for this journey start at $90 (€90) if you book in advance.
The earliest bus runs at 02:40, the last at 23:30. The fastest bus covers the 397 miles (640 km) distance in 15h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 397 miles (640 km) |
Average bus duration 15h 25m |
Cheapest ticket price $90 (€90) |
Buses per day 6 |
Fastest bus 15h 25m |
First bus 2:40 AM |
Last bus 11:30 PM |
Cheapest Month Jun |
Cheapest Day Mon |
High Season Apr - Jun |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to Indianapolis, IN
Things to do in Indianapolis, IN
Discover the best of Indianapolis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis trip today.
- Must visit
Indianapolis Museum of Art at Newfields
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
- Recommended
Benjamin Harrison Presidential Site
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
- Must visit
Central Canal
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
- Must visit
Monument Circle
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
- Must visit
Indianapolis Cultural Trail
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Pork Tenderloin Sandwich
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
- Vegetarian
Sugar Cream Pie
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
- Gluten-free
St. Elmo-Style Shrimp Cocktail
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Vida
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
St. Elmo Steak House
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Harry & Izzy's
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
United States Dollar ($)
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Average meal costs
- Budget
- $10-$18 for fast food or a casual meal.
- Mid-range
- $20-$40 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-$6 for coffee or a cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
FAQs: Bus from Greenville, SC to Indianapolis, IN
Find answers to the most common questions about traveling from Greenville, SC to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Greenville, SC to Indianapolis, IN can start from as little as $90 (€90) when you book in advance. The average bus ticket price for Greenville, SC to Indianapolis, IN is $90 (€90) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Greenville, SC to Indianapolis, IN is 15h 25m to travel the 397 miles (640 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Greenville, SC to Indianapolis, IN leaves at 2:40 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Greenville, SC to Indianapolis, IN leaves at 11:30 PM.
A trip to Indianapolis, IN from Greenville, SC is worth doing but not as a day trip with a journey time of 15h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Greenville, SC to Indianapolis, IN is June.
It's helpful to compare your options as there are 3 ways to travel between Greenville, SC and Indianapolis, IN including taking a bus, train, and flight.
No, the bus from Greenville, SC to Indianapolis, IN has no accessibility options.
No, there are no bathrooms on board the bus from Greenville, SC to Indianapolis, IN.
Some of the most interesting sights to explore in Indianapolis, IN are:
- Indianapolis Motor Speedway, a historic racing circuit known for hosting the Indianapolis 500
- The Children's Museum of Indianapolis, the world's largest children's museum featuring interactive exhibits
- Indianapolis Zoo, a popular attraction with diverse animal exhibits and a botanical garden
- Indiana State Museum, showcasing the state's history, art, and science through various exhibits
- White River State Park, a sprawling urban park offering trails, gardens, and cultural attractions.
The best things to do in Indianapolis, IN include:
- Indianapolis Museum of Art at Newfields, a vast art museum with extensive collections and beautiful gardens
- Attend a race at the Indianapolis Motor Speedway, home of the iconic Indy 500
- Explore the interactive exhibits and educational programs at The Children's Museum of Indianapolis
- Visit the dolphin pavilion and animal habitats at the Indianapolis Zoo
- Enjoy a walk along the canal and cultural attractions at White River State Park.
No, bikes are not allowed on board the bus from Greenville, SC to Indianapolis, IN.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Greenville, SC to Indianapolis, IN.
No, luggage for the bus from Greenville, SC to Indianapolis, IN needs to be booked in addition.
No, there are no additional luggage options for the bus from Greenville, SC to Indianapolis, IN.
Unfortunately, pets are not allowed on the bus from Greenville, SC to Indianapolis, IN.
No, there are no USB plugs on board the bus from Greenville, SC to Indianapolis, IN.
No, there is no WiFi on board the bus from Greenville, SC to Indianapolis, IN.
Since neither Greenville, SC nor Indianapolis, IN are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Indianapolis, travelers should be cautious of pickpocketing and vehicle break-ins, especially in busy areas like downtown and near major event venues. Common scams include overcharging by unofficial taxi or rideshare drivers and distraction tactics used to steal belongings. It's advised to use authorized transportation services, avoid poorly lit or unfamiliar areas at night, and keep valuables secure.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Greenville, SC to Indianapolis, IN
Most Greenville, SC to Indianapolis, IN buses use the Greenville, Woodruff Rd ("Raceway" gas station) to Indianapolis, Illinois St (Greyhound Bus Station) station pair, with some services arriving at Indianapolis, E Washington St / N Delaware St (City/County Building). Use this guide to compare Greenville, SC and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Greenville
Arrival bus stations in Indianapolis
Greenville, Woodruff Rd ("Raceway" gas station)
Indianapolis, Illinois St (Greyhound Bus Station)
Indianapolis, E Washington St / N Delaware St (City/County Building)
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Indianapolis, IN
Here are some other resources that might have the information you need
Most popular buses to and from Indianapolis, IN and Greenville, SC
Most popular bus connections to Indianapolis, IN
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