- Must visit
Tampa Museum of Art
Major art museum on the Riverwalk with Greek and Roman antiquities, modern art, and a strong photography collection.
The best way to find a cheap bus ticket from Greenville, SC to Tampa, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Tampa, FL will cost around €163 if you buy it on the day, but the cheapest tickets can be found for only €132.
On Thu, Nov 05, we found 4 buses from Greenville, SC to Tampa, FL, including 4 direct services.
On Thu, Nov 05 the direct buses cover the 768 km distance in an average of 1 d 26 m but if you time it right, some buses will get you there in just 18 h 45 m .
On Thu, Nov 05 the slowest buses will take 1 d 11 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Greenville, SC to Tampa, FL run on average 6 times per day, taking around 13h 30m. Cheap bus tickets for this journey start at €55 if you book in advance.
The earliest bus runs at 06:20, the last at 22:35. The fastest bus covers the 477 miles (768 km) distance in 10h 45m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Greenville, SC to Tampa, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:00AM | Arrival Time 01:25PM | Duration 35h25 | Departure days Thu | Cheapest price €132 |
Operator FlixBus | Departure Time 03:00AM | Arrival Time 03:25AM | Duration 24h25 | Departure days Thu | Cheapest price €146 |
Operator FlixBus | Departure Time 01:20PM | Arrival Time 06:00AM | Duration 16h40 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price €71 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 07:10AM | Duration 16h25 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price €71 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 11:00AM | Duration 18h45 | Departure days Wed | Cheapest price €204 |
Operator FlixBus | Departure Time 06:45PM | Arrival Time 01:55PM | Duration 19h10 | Departure days Wed | Cheapest price €171 |
Operator FlixBus | Departure Time 08:20PM | Arrival Time 12:45PM | Duration 16h25 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price €72 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 10:25PM | Duration 24h50 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price €72 |
The table below shows live departures for Greenville, SC to Tampa, FL buses for today, Tuesday, November 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 1:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 16h40 | 6:00 AM Tampa, Marion Transit Center | 2 transfers | |
+ FlixBus | 2:45 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 16h25 | 7:10 AM Tampa, Marion Transit Center | 1 transfer | |
+ FlixBus | 2:45 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 15h55 | 6:40 AM Tampa, USF Holly Drive (Central Plant), FL | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Greenville, SC to Tampa, FL with FlixBus and Greyhound. Overnight buses available on this route with FlixBus and Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Tampa, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Tampa, FL trip today.
Major art museum on the Riverwalk with Greek and Roman antiquities, modern art, and a strong photography collection.
Engaging family-friendly museum exploring Tampa Bay history through exhibits on pirates, cigars, industry, and local communities.
Fascinating history museum inside the former Tampa Bay Hotel, showcasing Gilded Age rooms, décor, and Florida tourism heritage.
Scenic waterfront promenade linking parks, museums, and downtown landmarks; ideal for walking, biking, and skyline views.
Tampa's most historic district, known for brick streets, cigar heritage, nightlife, and a distinctive Cuban and immigrant legacy.
Popular bayside path and green space on Davis Islands with sweeping water views, downtown panoramas, and sunset appeal.
A Cuban sandwich layered with roast pork, ham, salami, Swiss cheese, pickles, and mustard on pressed Cuban bread. Tampa's version is a defining local classic.
Deviled crab is a Tampa staple: seasoned blue crab mixed with Cuban bread crumbs, shaped into a shell-like croquette, then breaded and fried.
A chilled espresso drink sweetened and shaken until frothy. Popular in Tampa's Cuban communities, it is a local coffee ritual and social pick-me-up.
Beloved Tampa institution known for deviled crab, Cuban sandwiches, and casual old-Tampa counter service.
Upscale modern Spanish restaurant in historic Ybor, known for refined tapas, cocktails, and a polished dining room.
Historic Ybor City restaurant famed for the original Tampa Cuban sandwich and old-school Spanish-Cuban atmosphere.
Moderate for U.S. beach cities: hotels can be high in peak season, but dining and local transport are usually manageable for most visitors.
Tip 15-20% at restaurants, 18-22% for great service. Taxis usually 10-15%. For cafes, small change or $1 per drink is common but optional.
Official public transport app
Tampa International Airport -> Downtown Tampa, Tampa, FL
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Tampa, FL.
Find answers to the most common questions about traveling from Greenville, SC to Tampa, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Tampa, FL, this guide helps you travel smarter and with confidence.
