- Must visit
The Charles Hosmer Morse Museum of American Art
Celebrated museum in nearby Winter Park famous for the world’s most comprehensive collection of works by Louis Comfort Tiffany.
Omio recommends booking the train as it is the most popular option from Greenville, SC to Orlando, FL among Omio's users. If you are prioritising price take the bus with prices starting from $77. For those with little time consider booking a flight which can get you there in 2h 38m. The ticket price range depends on the travel mode: a bus costs an average of $77, and a train costs an average of $133.
Distance: 440 miles (709 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$123 Average price Cheapest | $218 Average price | $217 Average price | $102 Average price (fuel + tolls) |
15h 40m Average total duration 15h 10m Onboard + 30m Additional time* | 28h 54m Average total duration 28h 24m Onboard + 30m Additional time* | 5h 38m Average total duration Fastest 2h 38m Onboard + 3h 0m Additional time* | 7h 36m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Greenville, SC to Orlando, FL:
A bus is $93 (€76) less than a flight for this route with tickets for a flight from Greenville, SC to Orlando, FL costing on average $217 (€177).
A bus is $95 (€77) less than a train for this route with tickets for a train from Greenville, SC to Orlando, FL costing on average $218 (€177).
Other travel options to Orlando, FL take longer:
Bus takes on average 15h 10m.
Train takes on average 28h 24m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 08:20PM | Duration 18h20 | Departure days Thu, Sun | Cheapest price $124 |
Operator FlixBus | Departure Time 11:10AM | Arrival Time 01:15AM | Duration 14h05 | Departure days Wed, Thu | Cheapest price $99 |
Operator FlixBus | Departure Time 03:15PM | Arrival Time 03:59AM | Duration 12h44 | Departure days Tue, Thu, Sat | Cheapest price $94 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 04:59AM | Duration 12h44 | Departure days Tue, Wed, Thu | Cheapest price $90 |
Operator FlixBus | Departure Time 05:20PM | Arrival Time 04:35AM | Duration 11h15 | Departure days Fri | Cheapest price $77 |
The table below shows live departures for Greenville, SC to Orlando, FL buses for today, Saturday, June 6. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:00 AM Greenville, SC | 18h20 | 8:20 PM Orlando, FL | 0 transfersDirect | |
![]() | 3:15 PM Greenville, SC | 12h44 | 3:59 AM Orlando, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Greenville, SC to Orlando, FL run on average 6 times per day, taking around 15h 10m. Cheap bus tickets for this journey start at $77 (€63) if you book in advance.
The earliest bus runs at 04:00, the last at 23:40. The fastest bus covers the 440 miles (709 km) distance in 11h 15m.
Distance 440 miles (709 km) |
Average bus duration 15h 10m |
Cheapest ticket price $77 (€63) |
Buses per day 6 |
Fastest bus 11h 15m |
First bus 4:00 AM |
Last bus 11:40 PM |
Cheapest Month Sep |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of Orlando — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Orlando trip today.
Celebrated museum in nearby Winter Park famous for the world’s most comprehensive collection of works by Louis Comfort Tiffany.
Established art museum in Loch Haven Park with American art, African art, and rotating exhibitions; a leading cultural stop in the city.
Well-regarded history museum in a restored courthouse covering Central Florida history, tourism, citrus, aviation, and local communities.
Downtown Orlando’s most famous urban park, popular for skyline views, the lake loop, swan boats, events, and easy walking.
Orlando’s best-known tourist corridor, lined with attractions, entertainment complexes, and highly photographed nightlife spots.
Charming, walkable main street area just north of Orlando, loved for its brick streets, boutique atmosphere, and polished local feel.
A pressed sandwich with roast pork, ham, Swiss cheese, pickles, and mustard on Cuban bread. It is a Central Florida staple shaped by the region’s Cuban influences.
Fried alligator tail pieces, usually served with a dipping sauce. This is a classic Florida novelty dish tied to the state’s wetlands and Southern cooking traditions.
A sandwich made with local grouper, often grilled, blackened, or fried. It is one of the most recognizable seafood dishes in Central Florida.
Orlando’s flagship fine-dining destination at Walt Disney World, known for tasting menus, polished service, and special-occasion dining.
Beloved neighborhood bakery and diner famous for Southern comfort food, biscuits, and outstanding pies and cakes.
A well-known Winter Park gastropub near Orlando, celebrated for refined American cooking, strong charcuterie, and a lively upscale-casual atmosphere.
Moderate overall. Theme parks and resort areas are pricey, but casual dining and chain hotels can be reasonable outside peak seasons.
Tip 18-20% at restaurants if service is not included. Tip bartenders USD 1-2 per drink, taxis and rideshares 10-15%, hotel staff USD 1-5, and round up for cafes if desired.
Find answers to the most common questions about traveling from Greenville, SC to Orlando, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Orlando, FL, this guide helps you travel smarter and with confidence.

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