- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
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The cheapest and fastest buses from San Francisco, CA to Indianapolis, IN
Showing times, prices and bookable tickets for Sep 09
Cheapest price on Sep 09
€137
Average ticket price on Sep 09
€148
Fastest journey on Sep 09
2 d 3 h 20 m
Average journey duration on Sep 09
2 d 7 h 58 m
Buses on Sep 09
8
Distance
3130 km
Cheap tickets
The best way to find a cheap bus ticket from San Francisco, CA to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Francisco, CA to Indianapolis, IN will cost around €148 if you buy it on the day, but the cheapest tickets can be found for only €137.
Fast buses
It's difficult to get from San Francisco, CA to Indianapolis, IN without transferring at least 2 times.
· · · 1:10 PM51h20San Francisco, Transit Center Bay 297:30 PMIndianapolis, Illinois St (Greyhound Bus Station)€1371One-way3 transfers
FlixBus+ · 1:00 AM58h30San Francisco, Townsend Street / 5th Street, CA2:30 PMIndianapolis, Illinois St (Greyhound Bus Station)€1371One-way2 transfers- FlixBus+ · · 8:55 AM55h35San Francisco, Townsend Street / 5th Street, CA7:30 PMIndianapolis, Illinois St (Greyhound Bus Station)€1381One-way4 transfers
- · · +FlixBus1:10 PM55h05San Francisco, Transit Center Bay 2911:15 PMIndianapolis, IN€1481One-way3 transfers
- FlixBus+ · · 8:55 AM59h20San Francisco, Townsend Street / 5th Street, CA11:15 PMIndianapolis, IN€1491One-way4 transfers
- · · · 1:10 PM51h20San Francisco, Transit Center Bay 297:30 PMIndianapolis, Illinois St (Greyhound Bus Station)€1371One-way3 transfers
- · · +FlixBus1:10 PM55h05San Francisco, Transit Center Bay 2911:15 PMIndianapolis, IN€1481One-way3 transfers
- FlixBus+ · · 8:55 AM55h35San Francisco, Townsend Street / 5th Street, CA7:30 PMIndianapolis, Illinois St (Greyhound Bus Station)€1381One-way4 transfers
- FlixBus+ · 1:00 AM58h30San Francisco, Townsend Street / 5th Street, CA2:30 PMIndianapolis, Illinois St (Greyhound Bus Station)€1371One-way2 transfers
- FlixBus+ · · 8:55 AM59h20San Francisco, Townsend Street / 5th Street, CA11:15 PMIndianapolis, IN€1491One-way4 transfers
Travel Information
Compare bus, train, and flight for San Francisco, CA to Indianapolis, IN
Omio recommends booking the train as it is the most popular option from San Francisco, CA to Indianapolis, IN among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €273 For those with little time, consider booking a flight, which has an average total journey time of 8h 27m. Average ticket prices depend on the travel mode: a bus costs an average of €273, while a train costs an average of €929.
Distance: 1944 miles (3130 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
€273 Average price Cheapest | €929 Average price | €689 Average price | €377 Average price (fuel + tolls) |
54h 58m Average total duration 54h 28m Onboard + 30m Additional time* | 57h 38m Average total duration 57h 8m Onboard + 30m Additional time* | 8h 27m Average total duration Fastest 6h 27m Onboard + 2h 0m Additional time* | 32h 50m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from San Francisco, CA to Indianapolis, IN is a bus with an average price of €273.
This is compared to other travel options from San Francisco, CA to Indianapolis, IN:
A bus is €416 less than a flight for this route with tickets for a flight from San Francisco, CA to Indianapolis, IN costing on average €689.
A bus is €656 less than a train for this route with tickets for a train from San Francisco, CA to Indianapolis, IN costing on average €929.
The fastest way to travel from San Francisco, CA to Indianapolis, IN is by flight with an average journey time of 6h 27m.
Other travel options to Indianapolis, IN take longer:
Bus takes on average 54h 28m.
Train takes on average 57h 8m.
It's helpful to compare your options as there are 3 ways to travel between San Francisco, CA and Indianapolis, IN including taking a bus, train, and flight.
We recommend using the train as it is the most popular way to get from San Francisco, CA to Indianapolis, IN among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around €273 compared to roughly €377 in fuel and tolls — a saving of about €104. The journey takes 54h 28m versus 32h 50m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
San Francisco, CA to Indianapolis, IN Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:00AM | Arrival Time 02:30PM | Duration 58h30 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price €121 |
Operator Greyhound | Departure Time 08:55AM | Arrival Time 07:30PM | Duration 55h35 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price €122 |
Operator Greyhound | Departure Time 01:10PM | Arrival Time 11:15PM | Duration 55h05 | Departure days Everyday | Cheapest price €121 |
Operator Greyhound | Departure Time 06:05PM | Arrival Time 02:30PM | Duration 65h25 | Departure days Mon, Tue, Wed, Sun | Cheapest price €131 |
Operator Greyhound | Departure Time 10:30PM | Arrival Time 02:30PM | Duration 61h00 | Departure days Everyday | Cheapest price €141 |
Live departures
San Francisco, CA to Indianapolis, IN bus times
The table below shows live departures for San Francisco, CA to Indianapolis, IN buses for today, Tuesday, September 8. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus+ · | 1:00 AM San Francisco, Townsend Street / 5th Street, CA | 58h30 | 2:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 2 transfers | |
| FlixBus+ · · | 8:55 AM San Francisco, Townsend Street / 5th Street, CA | 55h35 | 7:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 4 transfers | |
| FlixBus+ · · | 8:55 AM San Francisco, Townsend Street / 5th Street, CA | 60h10 | 12:05 AM Indianapolis, IN | 4 transfers | |
| · · · | 1:10 PM San Francisco, Transit Center Bay 29 | 51h20 | 7:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 3 transfers | |
| · · +FlixBus | 1:10 PM San Francisco, Transit Center Bay 29 | 55h55 | 12:05 AM Indianapolis, IN | 3 transfers | |
| FlixBus+ · · | 6:05 PM San Francisco, Townsend Street / 5th Street, CA | 65h25 | 2:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 4 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Francisco, CA to Indianapolis, IN by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book San Francisco, CA to Indianapolis, IN buses with Omio?
FlixBus operates all buses services from San Francisco, CA to Indianapolis, IN.
Omio is an official ticket reseller for all your travel options from San Francisco, CA to Indianapolis, IN.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from San Francisco, CA to Indianapolis, IN.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from San Francisco, CA to Indianapolis, IN.
Journey information
Overview: Bus from San Francisco, CA to Indianapolis, IN
USAUSA
Buses from San Francisco, CA to Indianapolis, IN run on average 6 times per day, taking around 54h 28m. Cheap bus tickets for this journey start at €170 but you can travel from only €150 by flight.
The earliest bus runs at 03:15, the last at 23:55. The fastest bus covers the 1944 miles (3130 km) distance in 48h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from €150
Distance 1944 miles (3130 km) |
Average bus duration 54h 28m |
Cheapest ticket price €170 |
Buses per day 6 |
Fastest bus 48h 0m |
First bus 3:15 AM |
Last bus 11:55 PM |
Cheapest Month Jan |
Cheapest Day Fri |
High Season Jul - Sep |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from €150
Bus providers: Greyhound from San Francisco, CA to Indianapolis, INYou can travel by bus between San Francisco, CA to Indianapolis, IN with Greyhound for as low as €170. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
48h 0m
Cheapest Greyhound Price
€170
Greyhound frequency
6 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Indianapolis, IN
Things to do in Indianapolis, IN
Discover the best of Indianapolis, IN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis, IN trip today.
- Must visit
Indianapolis Museum of Art at Newfields
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
- Recommended
Benjamin Harrison Presidential Site
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
- Must visit
Central Canal
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
- Must visit
Monument Circle
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
- Must visit
Indianapolis Cultural Trail
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Pork Tenderloin Sandwich
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
- Vegetarian
Sugar Cream Pie
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
- Gluten-free
St. Elmo-Style Shrimp Cocktail
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Vida
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
St. Elmo Steak House
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Harry & Izzy's
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
United States Dollar ($)
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Average meal costs
- Budget
- $10-$18 for fast food or a casual meal.
- Mid-range
- $20-$40 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-$6 for coffee or a cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
FAQs: Bus from San Francisco, CA to Indianapolis, IN
Find answers to the most common questions about traveling from San Francisco, CA to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.
Cheap bus tickets from San Francisco, CA to Indianapolis, IN can start from as little as €170 when you book in advance. The average bus ticket price for San Francisco, CA to Indianapolis, IN is €273 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Francisco, CA to Indianapolis, IN is 48h 0m to travel the 1944 miles (3130 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Francisco, CA to Indianapolis, IN leaves at 3:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Francisco, CA to Indianapolis, IN leaves at 11:55 PM.
There are 6 buses a day from San Francisco, CA to Indianapolis, IN which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from San Francisco, CA to Indianapolis, IN, you can count on FlixBus for the best way to get you to Indianapolis, IN. You can also check all possible bus companies who offer a service between San Francisco, CA and Indianapolis, IN and compare the amenities they offer before buying a bus ticket.
When departing from San Francisco, CA , you have various bus station options to start your journey from including San Francisco, Transit Center Bay 29, San Francisco, Townsend Street / 5th Street, CA . When arriving in Indianapolis, IN , you can end your journey in bus stations like Indianapolis, Illinois St (Greyhound Bus Station) .Passengers board the bus most frequently from San Francisco, Transit Center Bay 29, which is located around 1 miles (2 km) away from the city centre, and they get off the bus at Indianapolis, Illinois St (Greyhound Bus Station), located 0 away from the city centre.
A trip to Indianapolis, IN from San Francisco, CA is worth doing but not as a day trip with a journey time of 48h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from San Francisco, CA to Indianapolis, IN is January.
It's helpful to compare your options as there are 3 ways to travel between San Francisco, CA and Indianapolis, IN including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from San Francisco, CA to Indianapolis, IN:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Francisco, CA to Indianapolis, IN for bus company FlixBus.
Some of the most interesting sights to explore in Indianapolis, IN are:
- Indianapolis Motor Speedway, a historic racing circuit known for hosting the Indianapolis 500
- The Children's Museum of Indianapolis, the world's largest children's museum featuring interactive exhibits
- Indianapolis Zoo, a popular attraction with diverse animal exhibits and a botanical garden
- Indiana State Museum, showcasing the state's history, art, and science through various exhibits
- White River State Park, a sprawling urban park offering trails, gardens, and cultural attractions.
The best things to do in Indianapolis, IN include:
- Indianapolis Museum of Art at Newfields, a vast art museum with extensive collections and beautiful gardens
- Attend a race at the Indianapolis Motor Speedway, home of the iconic Indy 500
- Explore the interactive exhibits and educational programs at The Children's Museum of Indianapolis
- Visit the dolphin pavilion and animal habitats at the Indianapolis Zoo
- Enjoy a walk along the canal and cultural attractions at White River State Park.
Whether you can cancel your bus ticket from San Francisco, CA to Indianapolis, IN depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Francisco, CA to Indianapolis, IN.
Yes, the following luggage options are included when booking a bus ticket from San Francisco, CA to Indianapolis, IN:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from San Francisco, CA to Indianapolis, IN:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from San Francisco, CA to Indianapolis, IN. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from San Francisco, CA to Indianapolis, IN with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from San Francisco, CA to Indianapolis, IN with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from San Francisco, CA to Indianapolis, IN with the following bus company: FlixBus.
Since neither San Francisco, CA nor Indianapolis, IN are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from San Francisco, CA to Indianapolis, IN among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Indianapolis, travelers should be cautious of pickpocketing and vehicle break-ins, especially in busy areas like downtown and near major event venues. Common scams include overcharging by unofficial taxi or rideshare drivers and distraction tactics used to steal belongings. It's advised to use authorized transportation services, avoid poorly lit or unfamiliar areas at night, and keep valuables secure.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from San Francisco, CA to Indianapolis, IN
Most San Francisco, CA to Indianapolis, IN buses use the San Francisco, Transit Center Bay 29 to Indianapolis, Illinois St (Greyhound Bus Station) station pair. Use this guide to compare San Francisco, CA and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in San Francisco
Arrival bus stations in Indianapolis
Which San Francisco, CA station do buses to Indianapolis, IN leave from?
Buses from San Francisco, CA to Indianapolis, IN leave from San Francisco, Transit Center Bay 29. The station is 1 miles (3 km) from San Francisco, CA city centre at Transit Center Bay 29, San Francisco, CA 94105, USA.
San Francisco, Transit Center Bay 29Transit Center Bay 29, San Francisco, CA 94105, USA
City-centre transport
Getting to San Francisco, Transit Center Bay 29 from San Francisco city centre
San Francisco, Transit Center Bay 29 is 2 km from San Francisco city centre. Public transport options include:
Bus397 · 8m · €2
14, 14R · 13m · €2 · every ~30 min
101, 120 · 14m · €5 · every ~9 min
7 · 21m · €2 · every ~10 min
SubwayYellow-N, Green-N, Red-N, Blue-N · 10m · €2 · every ~27 min
San Francisco, Transit Center Bay 29 bus station facilities and services
San Francisco, Transit Center Bay 29 has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at San Francisco, Transit Center Bay 29. ATMs are available at San Francisco, Transit Center Bay 29.
Tickets and information
Ticket office support is available at San Francisco, Transit Center Bay 29.
Parking, taxis and toilets
Available at San Francisco, Transit Center Bay 29: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Francisco, Transit Center Bay 29: Wheelchair accessible areas present.
San Francisco, Townsend Street / 5th StreetSan Francisco Bus Station,401 Townsend St,94107
City-centre transport
Getting to San Francisco, Townsend Street / 5th Street from San Francisco city centre
BusEast, West · 20m · every ~4 min
Nbus, Nowl · 24m · €2 · every ~2 min
TramN · 23m · €2 · every ~11 min
Which Indianapolis, IN station do buses from San Francisco, CA arrive at?
Buses from San Francisco, CA to Indianapolis, IN most often arrive at Indianapolis, Illinois St (Greyhound Bus Station). Some services arrive at {secondaryArrivalStation}, so check your ticket before travel to confirm your Indianapolis, IN arrival station.
Indianapolis, Illinois St (Greyhound Bus Station)350 S Illinois St, Indianapolis, IN 46225, USA
City-centre transport
Getting to Indianapolis, Illinois St (Greyhound Bus Station) from Indianapolis city centre
TRUE
Indianapolis, Illinois St (Greyhound Bus Station) bus station facilities and services
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Fast food outlets are available.
Wi-Fi and ATMs
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Tickets and information
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Parking, taxis and toilets
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
Most popular bus connections from San Francisco, CA
More options for your journey from San Francisco, CA to Indianapolis, IN
Here are some other resources that might have the information you need
Most popular buses to and from Indianapolis, IN and San Francisco, CA
Most popular bus connections to Indianapolis, IN
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