San Francisco, CA to Indianapolis, IN bus with Greyhound

Tue, Dec 09
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Greyhound
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
1,000+ travel companies
Greyhound
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
1,000+ travel companies
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Compare prices and tickets San Francisco, CA to Indianapolis, IN by bus, train, or flight

Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Journey information

Overview: Bus from San Francisco, CA to Indianapolis, IN

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Buses from San Francisco, CA to Indianapolis, IN run on average 12 times per day, taking around 57h 30m. Cheap bus tickets for this journey start at $927 (€748) if you book in advance.

The earliest bus runs at 03:15, the last at 23:55. The fastest bus covers the 1944 miles (3130 km) distance in 67h 35m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
1944 miles (3130 km)
Average bus duration
57h 30m
Cheapest ticket price
$927 (€748)
Buses per day
12
Fastest bus
67h 35m
First bus
03:15
Last bus
23:55
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound, FlixBus from San Francisco, CA to Indianapolis, INYou can travel by bus between San Francisco, CA to Indianapolis, IN with Greyhound, FlixBus for as low as $927 (€748). When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
67h 35m
Cheapest Price
$920 (€742)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
71h 45m
Cheapest Price
$224 (€180)
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from San Francisco, CA to Indianapolis, IN

Find answers to the most common questions about traveling from San Francisco, CA to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from San Francisco, CA to Indianapolis, IN can start from as little as $250 (€202) when you book in advance. The average bus ticket price for San Francisco, CA to Indianapolis, IN is $340 (€274); however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Francisco, CA to Indianapolis, IN is 62 h 15 min   to travel the 1940 mile (3129 km) long trip, with around there are 11 buses per day. Journey times can vary on weekends and holidays.
The first bus from San Francisco, CA to Indianapolis, IN leaves at 3: 30AM. Plan your trip with the Journey Planner   from Omio.
The last bus from San Francisco, CA to Indianapolis, IN leaves at 11: 55PM.
There are 11 buses a day from San Francisco, CA to Indianapolis, IN which require at least one change with Greyhound or FlixBus. Schedules can vary on holidays or weekends with fewer buses.
For the best San Francisco, CA to Indianapolis, IN bus to book, you can travel safely and comfortably with Greyhound or FlixBus. However, it's always good to check all possible bus providers with services from San Francisco, CA to Indianapolis, IN to compare what amenities they may offer.
The cheapest month for a bus from San Francisco, CA to Indianapolis, IN is November.
You have options as you can travel between San Francisco, CA and Indianapolis, IN 3 different ways: bus, train or flight.
Yes, the following accessibility options are available when taking the bus from San Francisco, CA to Indianapolis, IN:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Francisco, CA to Indianapolis, IN for bus companies Greyhound and FlixBus.
Some of the most interesting sights to explore in Indianapolis, IN are:
  • Indianapolis Motor Speedway, a historic racing circuit known for hosting the Indianapolis 500
  • The Children's Museum of Indianapolis, the world's largest children's museum featuring interactive exhibits
  • Indianapolis Zoo, a popular attraction with diverse animal exhibits and a botanical garden
  • Indiana State Museum, showcasing the state's history, art, and science through various exhibits
  • White River State Park, a sprawling urban park offering trails, gardens, and cultural attractions.
The best things to do in Indianapolis, IN include:
  • Indianapolis Museum of Art at Newfields, a vast art museum with extensive collections and beautiful gardens
  • Attend a race at the Indianapolis Motor Speedway, home of the iconic Indy 500
  • Explore the interactive exhibits and educational programs at The Children's Museum of Indianapolis
  • Visit the dolphin pavilion and animal habitats at the Indianapolis Zoo
  • Enjoy a walk along the canal and cultural attractions at White River State Park.
Yes, bikes are allowed on board the bus with bus companies Greyhound and FlixBus.
Whether you can cancel your bus ticket from San Francisco, CA to Indianapolis, IN depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.

To find the cheapest bus tickets for your trip from San Francisco, CA to Indianapolis, IN, follow these tips:

  • Book in advance: Tickets are often cheaper when booked early.
  • Be flexible with dates and times: Traveling during off-peak hours or on weekdays can help you save money.
  • Use our search filters: Sort results by price to quickly identify the most affordable options.
  • Look for special deals or discounts: Check for promotions or discounts available on our website and app.
  • Start your search now and compare ticket prices to find the best deal!

    Yes, there is food available to purchase on board the bus from San Francisco, CA to Indianapolis, IN.
    Yes, the following luggage options are included when booking a bus ticket from San Francisco, CA to Indianapolis, IN:
    • Greyhound
      • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
    • FlixBus
      • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
    Yes, the following additional luggage options are available when booking a bus ticket from San Francisco, CA to Indianapolis, IN:
    • Greyhound
      • $15 per additional bag.
    • FlixBus
      • Additional luggage can be purchased for a fee.
    Yes, you can bring your pet on the bus from San Francisco, CA to Indianapolis, IN. The following conditions apply:
    • FlixBus
      • Small pets in carriers allowed
      • Guide dogs travel for free.
    You can reserve your seat on the bus from San Francisco, CA to Indianapolis, IN with the following bus companies: Greyhound and FlixBus
    Yes, there are USB plugs on board the bus from San Francisco, CA to Indianapolis, IN with the following bus companies: Greyhound and FlixBus.
    Yes, there is Wifi on board the bus from San Francisco, CA to Indianapolis, IN with the following bus companies: Greyhound and FlixBus.

    popular bus stations

    Popular bus stations from San Francisco, CA to Indianapolis, IN

    San Francisco
    Indianapolis
    The major bus station for departures in San Francisco is San Francisco, Townsend Street / 5th Street. Find all the information you need to know about services, amenities and connections at San Francisco, Townsend Street / 5th Street for your trip from San Francisco to Indianapolis.
    San Francisco, Townsend Street / 5th Street
    San Francisco, Transit Center Bay 29
    information

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