- Must visit
Philadelphia Museum of Art
World-class art museum famous for major collections and the Rocky Steps. A top cultural stop with strong city views.
The best way to find a cheap bus ticket from Greenville, SC to Philadelphia, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Philadelphia, PA will cost around $181 if you buy it on the day, but the cheapest tickets can be found for only $155.
On Thu, Nov 05, we found 2 buses from Greenville, SC to Philadelphia, PA, including 2 direct services.
On Thu, Nov 05 the direct buses cover the 854 km distance in an average of 15 h 28 m but if you time it right, some buses will get you there in just 13 h 45 m .
On Thu, Nov 05 the slowest buses will take 17 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Greenville, SC to Philadelphia, PA run on average 4 times per day, taking around 14h 5m. Cheap bus tickets for this journey start at $71 if you book in advance.
The earliest bus runs at 01:50, the last at 23:15. The fastest bus covers the 530 miles (854 km) distance in 12h 45m.
Distance 530 miles (854 km) |
Average bus duration 14h 5m |
Cheapest ticket price $71 |
Buses per day 4 |
Fastest bus 12h 45m |
First bus 1:50 AM |
Last bus 11:15 PM |
Cheapest Month Mar |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 14 days |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Greenville, SC to Philadelphia, PA.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:00AM | Arrival Time 03:45PM | Duration 13h45 | Departure days Wed, Thu | Cheapest price $136 |
Operator Greyhound | Departure Time 07:10AM | Arrival Time 10:30PM | Duration 15h20 | Departure days Mon, Thu, Fri, Sun | Cheapest price $79 |
Operator Greyhound | Departure Time 11:00AM | Arrival Time 03:05AM | Duration 16h05 | Departure days Mon | Cheapest price $77 |
Operator Greyhound | Departure Time 11:10AM | Arrival Time 04:20AM | Duration 17h10 | Departure days Tue, Wed | Cheapest price $100 |
Operator Greyhound | Departure Time 12:10PM | Arrival Time 05:20AM | Duration 17h10 | Departure days Tue | Cheapest price $212 |
Operator FlixBus | Departure Time 12:55PM | Arrival Time 03:05AM | Duration 14h10 | Departure days Thu, Fri, Sun | Cheapest price $84 |
Operator FlixBus | Departure Time 04:15PM | Arrival Time 06:45AM | Duration 14h30 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 08:15PM | Arrival Time 06:30PM | Duration 22h15 | Departure days Sat | Cheapest price $89 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 11:45AM | Duration 14h10 | Departure days Mon, Thu, Fri, Sun | Cheapest price $79 |
The table below shows live departures for Greenville, SC to Philadelphia, PA buses for tomorrow, Wednesday, November 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:00 AM Greenville, SC | 13h45 | 3:45 PM Philadelphia, PA | 0 transfersDirect | |
![]() | 11:10 AM Greenville, SC | 17h10 | 4:20 AM Philadelphia, PA | 0 transfersDirect | |
This is the last bus of the day. | |||||
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Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Philadelphia, PA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Philadelphia, PA trip today.
World-class art museum famous for major collections and the Rocky Steps. A top cultural stop with strong city views.
Hands-on science museum for all ages, known for interactive exhibits and the giant walk-through heart near the Parkway.
Celebrated collection of Impressionist, Post-Impressionist, and modern works in an intimate gallery setting on the Parkway.
Historic district packed with foundational sites, cobblestone streets, and museums. The best base for first-time visitors.
Beloved park atop a hill with skyline views, trails, and the Rocky Steps approach. Great for walking and photography.
Walkable district of rowhouses, boutiques, and small parks. A classic local neighborhood for architecture and relaxed city strolling.
A long roll packed with thin-sliced beef and melted cheese, often with fried onions. It is Philadelphia's signature street and comfort food.
A soft pretzel with a distinct figure-eight twist and chewy texture. Sold by street vendors and bakeries, it is a classic Philadelphia snack.
A roast pork sandwich with garlicky pork, sharp provolone, and broccoli rabe. Many locals consider it the city's best traditional sandwich.
Acclaimed fine dining restaurant by Chef Marc Vetri, known for refined Italian tasting menus and one of Philadelphia's top culinary experiences.
Historic roast pork and cheesesteak shop in South Philadelphia, known for hearty sandwiches and a no-frills local atmosphere.
Beloved local chain specializing in water ice and frozen custard. It is a go-to stop for a classic Philadelphia summer dessert.
Moderate for a major US city. Hotels can be pricey in Center City, but dining and transit are often cheaper than New York or Washington.
Tip 18-20% in restaurants, 15-20% for taxis, and $1-2 per drink or cafe order if service is provided.
Official public transport app
Philadelphia Bus Terminal -> Philadelphia City Hall, Philadelphia, PA
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Philadelphia, PA.
Find answers to the most common questions about traveling from Greenville, SC to Philadelphia, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Philadelphia, PA, this guide helps you travel smarter and with confidence.

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