Travel Information
Compare train, flight, and bus for Greenville, SC to Pittsburgh, PA
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Pittsburgh, PA among Omio's users. If you are prioritising price take the train with prices starting from $184. For those with little time consider booking a flight which can get you there in 5h 40m. The ticket price range depends on the travel mode: a train costs an average of $184, and a flight costs an average of $311.
Distance: 407 miles (656 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
$239 Average price | $343 Average price | $184 Average price Cheapest |
16h 35m Average total duration 16h 5m Onboard + 30m Additional time* | 8h 40m Average total duration Fastest 5h 40m Onboard + 3h 0m Additional time* | 21h 47m Average total duration 21h 17m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Greenville, SC to Pittsburgh, PA by train, flight, or bus
Compare train, flight, and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Greenville, SC to Pittsburgh, PA buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, flight and bus to ensure you get the best deal for traveling from Greenville, SC to Pittsburgh, PA.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train, flight and bus to find the ideal travel option from Greenville, SC to Pittsburgh, PA.
Journey information
Overview: Bus from Greenville, SC to Pittsburgh, PA
Buses from Greenville, SC to Pittsburgh, PA run on average 3 times per day, taking around 16h 5m. Cheap bus tickets for this journey start at $239 (€194) but you can travel from only $184 (€149) by train.
The earliest bus runs at 01:30, the last at 23:10. The fastest bus covers the 407 miles (656 km) distance in 19h 50m.
Distance 407 miles (656 km) |
Average bus duration 16h 5m |
Cheapest ticket price $239 (€194) |
Buses per day 3 |
Fastest bus 19h 50m |
First bus 01:30 |
Last bus 23:10 |
Bus providers: FlixBus from Greenville, SC to Pittsburgh, PAYou can travel by bus between Greenville, SC to Pittsburgh, PA with FlixBus for as low as $184 (€149). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Greenville, SC to Pittsburgh, PA
Find answers to the most common questions about traveling from Greenville, SC to Pittsburgh, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Pittsburgh, PA, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- The Andy Warhol Museum, a comprehensive collection dedicated to the life and works of the iconic pop artist
- Phipps Conservatory and Botanical Gardens, a historic greenhouse with diverse plant exhibits and sustainable architecture
- Carnegie Museum of Natural History, featuring extensive dinosaur displays and global cultural artifacts
- Point State Park, a scenic urban park at the confluence of three rivers with historical significance
- Mount Washington, offering panoramic views of Pittsburgh's skyline from its renowned overlooks.
- Heinz History Center, an affiliate of the Smithsonian Institution showcasing Western Pennsylvania's history and heritage
- Take a ride on the Duquesne Incline for a historic cable car experience and stunning city views
- Explore the Strip District, known for its vibrant markets, eateries, and unique shops
- Visit the National Aviary, home to a diverse collection of birds from around the world
- Enjoy a Pittsburgh Pirates game at PNC Park, renowned for its beautiful views of the city skyline.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Greenville, SC to Pittsburgh, PA
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Pittsburgh, PA
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