- Must visit
The Children's Museum of Indianapolis
The world's largest children's museum, known for immersive science, history, and culture exhibits for all ages.
Flights from Greenville, SC to Indianapolis, IN depart on average 5 times per day, taking around 7h 22m. Cheap flight tickets for this journey start at $169 (€136) but you can travel from only $111 (€90) by bus.
The earliest flight runs at 05:10, the last at 20:21. The fastest flight covers the 397 miles (640 km) distance in 7h 22m. June is the cheapest month to fly.
Distance 397 miles (640 km) |
Average flight duration 7h 22m |
Cheapest ticket price $169 (€136) |
Flights per day 5 |
Fastest flight 7h 22m |
First flight 5:10 AM |
Last flight 8:21 PM |
Cheapest Month Jun |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Jul - Sep |
Omio recommends booking the train as it is the most popular option from Greenville, SC to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from $111. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a bus costs an average of $111, and a train costs an average of $169.
Distance: 397 miles (640 km)
| Flight | Most popular Train | Bus | Driving |
|---|---|---|---|
$169 Average price | $169 Average price | $111 Average price Cheapest | $101 Average price (fuel + tolls) |
10h 22m Average total duration Fastest 7h 22m Onboard + 3h 0m Additional time* | 28h 2m Average total duration 27h 32m Onboard + 30m Additional time* | 15h 55m Average total duration 15h 25m Onboard + 30m Additional time* | 8h 12m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Greenville, SC to Indianapolis, IN:
A bus is $58 (€46) less than a flight for this route with tickets for a flight from Greenville, SC to Indianapolis, IN costing on average $169 (€136).
A bus is $58 (€47) less than a train for this route with tickets for a train from Greenville, SC to Indianapolis, IN costing on average $169 (€136).
Other travel options to Indianapolis, IN take longer:
Bus takes on average 15h 25m.
Train takes on average 27h 32m.
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Indianapolis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis trip today.
The world's largest children's museum, known for immersive science, history, and culture exhibits for all ages.
A major art campus featuring the Indianapolis Museum of Art, gardens, and rotating exhibitions in a scenic setting.
A must for racing fans, with historic cars, Indianapolis 500 artifacts, and motorsport heritage.
Downtown's central circle and gathering place, lined with historic buildings and anchored by the city's iconic monument.
Major urban park linking museums, trails, green space, and canal-side walks in the heart of the city.
Trendy cultural district known for independent shops, theaters, murals, and strong day-to-night energy.
A Hoosier classic: a breaded and fried pork cutlet served on a bun, often much larger than the bread. It is one of Central Indiana's most iconic comfort foods.
Indianapolis is famous for steakhouse-style shrimp cocktail topped with very spicy cocktail sauce, especially associated with old-school downtown dining.
Often called Hoosier pie, this simple custard-like pie made with cream, sugar, and flour is one of Indiana's signature desserts.
Historic downtown steakhouse best known for dry-aged steaks and its legendary spicy shrimp cocktail. Classic, upscale, and one of Indianapolis's most famous dining rooms.
Well-regarded New American restaurant in Fletcher Place, known for seasonal menus, thoughtful cocktails, and a stylish neighborhood setting.
Historic no-frills tavern famous for old-school burgers and a classic local atmosphere. A beloved casual stop with deep Indianapolis roots.
Moderate by U.S. city standards. Hotels vary by events, while casual dining, coffee, and transport are generally manageable.
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis 10-15%, hotel staff USD 2-5, and round up for casual services.
Find answers to the most common questions about traveling from Greenville, SC to Indianapolis, IN by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

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