- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Flights from Greenville, SC to Indianapolis, IN depart on average 5 times per day, taking around 7h 22m. Cheap flight tickets for this journey start at $136 (€136) but you can travel from only $90 (€90) by bus.
The earliest flight runs at 05:10, the last at 20:21. The fastest flight covers the 397 miles (640 km) distance in 7h 22m. June is the cheapest month to fly.
Distance 397 miles (640 km) |
Average flight duration 7h 22m |
Cheapest ticket price $136 (€136) |
Flights per day 5 |
Fastest flight 7h 22m |
First flight 5:10 AM |
Last flight 8:21 PM |
Cheapest Month Jun |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Jul - Sep |
Omio recommends booking the train as it is the most popular option from Greenville, SC to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from $90. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a bus costs an average of $90, and a train costs an average of $136.
Distance: 397 miles (640 km)
| Flight | Most popular Train | Bus | Driving |
|---|---|---|---|
$136 Average price | $136 Average price | $90 Average price Cheapest | $82 Average price (fuel + tolls) |
10h 22m Average total duration Fastest 7h 22m Onboard + 3h 0m Additional time* | 28h 2m Average total duration 27h 32m Onboard + 30m Additional time* | 15h 55m Average total duration 15h 25m Onboard + 30m Additional time* | 8h 12m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Greenville, SC to Indianapolis, IN:
A bus is $46 (€46) less than a flight for this route with tickets for a flight from Greenville, SC to Indianapolis, IN costing on average $136 (€136).
A bus is $47 (€47) less than a train for this route with tickets for a train from Greenville, SC to Indianapolis, IN costing on average $136 (€136).
Other travel options to Indianapolis, IN take longer:
Bus takes on average 15h 25m.
Train takes on average 27h 32m.
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Indianapolis, IN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis, IN trip today.
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
Find answers to the most common questions about traveling from Greenville, SC to Indianapolis, IN by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

Most Greenville, SC to Indianapolis, IN flights use the Greenville-Spartanburg International Airport to Indianapolis International Airport airport pair. Use this guide to compare Greenville, SC and Indianapolis, IN airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Indianapolis International Airport is 8 km from Indianapolis city centre. Public transport options include:
Indianapolis International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food options include: Restaurants in Civic Plaza, including fast food and sit-down options like Chick-fil-A and Harry & Izzy's
Free Wi-Fi available throughout the airport. ATMs are located near baggage claim and ticketingas.
Lost and found is available at the station.
Available at Indianapolis International Airport: Parking, Taxis, WC.
Available at Indianapolis International Airport: Car Rental.
Accessibility facilities are available at Indianapolis International Airport.
Nearby hotels include Hotels nearby, such as the Crowne Plaza Indiapolis Airport..
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