- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Cheapest price
$71
Average price
$118
Fastest journey
12 h 20 m
Average duration
13 h 15 m
Buses per day
8
Distance
791 km
The best way to find a cheap bus ticket from Harrisburg, PA to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Indianapolis, IN will cost around $118 if you buy it on the day, but the cheapest tickets can be found for only $71.
Of the 8 buses that leave Harrisburg, PA for Indianapolis, IN on Wed, Jul 22, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jul 22 the direct buses cover the 791 km distance in an average of 13 h 15 m but if you time it right, some buses will get you there in just 12 h 20 m .
On Wed, Jul 22 the slowest buses will take 13 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
FlixBus
FlixBus

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FlixBus
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FlixBusOmio recommends booking the bus as it is the most popular option from Harrisburg, PA to Indianapolis, IN among Omio's users. If you are prioritising price take the bus with prices starting from $68. For those with little time consider booking a flight which can get you there in 4h 57m. The ticket price range depends on the travel mode: a bus costs an average of $68, and a flight costs an average of $190.
Distance: 491 miles (791 km)
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$100 Average price Cheapest | $293 Average price | $397 Average price | $109 Average price (fuel + tolls) |
12h 15m Average total duration 11h 45m Onboard + 30m Additional time* | 21h 0m Average total duration 20h 30m Onboard + 30m Additional time* | 7h 57m Average total duration Fastest 4h 57m Onboard + 3h 0m Additional time* | 8h 27m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Harrisburg, PA to Indianapolis, IN:
A bus is $192 (€158) less than a train for this route with tickets for a train from Harrisburg, PA to Indianapolis, IN costing on average $293 (€241).
A bus is $297 (€244) less than a flight for this route with tickets for a flight from Harrisburg, PA to Indianapolis, IN costing on average $397 (€327).
Other travel options to Indianapolis, IN take longer:
Bus takes on average 11h 45m.
Train takes on average 20h 30m.
Tickets start at around $100 (€83) compared to roughly $109 (€90) in fuel and tolls — a saving of about $9 (€7). The journey takes 11h 45m versus 8h 27m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Greyhound, FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:15AM | Arrival Time 04:00PM | Duration 13h45 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $71 |
Operator Greyhound | Departure Time 02:15AM | Arrival Time 06:30PM | Duration 16h15 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $120 |
Operator Greyhound | Departure Time 02:30AM | Arrival Time 06:10PM | Duration 15h40 | Departure days Sat | Cheapest price $100 |
Operator FlixBus | Departure Time 02:30AM | Arrival Time 04:00PM | Duration 13h30 | Departure days Sat | Cheapest price $92 |
Operator Greyhound | Departure Time 02:35PM | Arrival Time 04:00AM | Duration 13h25 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $84 |
Operator FlixBus | Departure Time 02:40PM | Arrival Time 03:00AM | Duration 12h20 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $71 |
Operator Greyhound | Departure Time 02:50PM | Arrival Time 04:10AM | Duration 13h20 | Departure days Sat | Cheapest price $84 |
Operator Greyhound | Departure Time 07:50PM | Arrival Time 09:20AM | Duration 13h30 | Departure days Everyday | Cheapest price $83 |
Operator Greyhound | Departure Time 08:05PM | Arrival Time 09:20AM | Duration 13h15 | Departure days Everyday | Cheapest price $97 |
Operator Greyhound | Departure Time 11:20PM | Arrival Time 06:10PM | Duration 18h50 | Departure days Sat | Cheapest price $97 |
Operator Greyhound | Departure Time 11:40PM | Arrival Time 06:30PM | Duration 18h50 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $122 |
The table below shows live departures for Harrisburg, PA to Indianapolis, IN buses for today, Tuesday, July 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:35 PM Harrisburg, Market St (Bus Station), PA | 13h25 | 4:00 AM Indianapolis, Illinois St (Greyhound Bus Station) | 0 transfersDirect | |
![]() | 7:50 PM Harrisburg, Market St (Bus Station), PA | 13h30 | 9:20 AM Indianapolis, Illinois St (Greyhound Bus Station) | 0 transfersDirect | |
· + FlixBus | 8:05 PM Harrisburg, Market St (Bus Station), PA | 17h10 | 1:15 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 2 transfers | |
· | 8:05 PM Harrisburg, Market St (Bus Station), PA | 13h15 | 9:20 AM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
· | 11:40 PM Harrisburg, Market St (Bus Station), PA | 18h50 | 6:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
FlixBus | 2:15 AM Harrisburg, Market St (Bus Station), PA | 13h45 | 4:00 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 0 transfersDirect | |
· | 2:15 AM Harrisburg, Market St (Bus Station), PA | 16h15 | 6:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Harrisburg, PA to Indianapolis, IN run on average 7 times per day, taking around 11h 45m. Cheap bus tickets for this journey start at $68 (€56) if you book in advance.
There are 3 buses per day. The earliest bus runs at 00:15, the last at 21:10. The fastest bus covers the 491 miles (791 km) distance in 13h 30m.
Distance 491 miles (791 km) |
Average bus duration 11h 45m |
Cheapest ticket price $68 (€56) |
Buses per day 7 |
Direct buses 3 |
Fastest bus 13h 30m |
First bus 12:15 AM |
Last bus 9:10 PM |
Cheapest Month Aug |
Cheapest Day Sat |
High Season Jan - Mar |
Low Season Oct - Dec |
Best time to book 28 days |
Discover the best of Indianapolis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis trip today.
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
Find answers to the most common questions about traveling from Harrisburg, PA to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

Most Harrisburg, PA to Indianapolis, IN buses use the Harrisburg, Market St (Bus Station) to Indianapolis, Illinois St (Greyhound Bus Station) station pair, with some services arriving at Indianapolis, E Washington St / N Delaware St (City/County Building). Use this guide to compare Harrisburg, PA and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need