The cheapest and fastest buses from San Diego, CA to Indianapolis, IN
Cheapest price
$485
Average price
$485
Fastest journey
2 d 3 h 5 m
Average duration
2 d 3 h 5 m
Buses per day
1
Distance
2873 km
The best way to find a cheap bus ticket from San Diego, CA to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Diego, CA to Indianapolis, IN will cost around $485 if you buy it on the day, but the cheapest tickets can be found for only $485.
Of the 1 buses that leave San Diego, CA for Indianapolis, IN on Wed, Mar 04, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Mar 04 the direct buses cover the 2873 km distance in an average of 2 d 3 h 5 m but if you time it right, some buses will get you there in just 2 d 3 h 5 m .
On Wed, Mar 04 the slowest buses will take 2 d 3 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare train, bus, and flight for San Diego, CA to Indianapolis, IN
Omio recommends booking the bus as it is the most popular option from San Diego, CA to Indianapolis, IN among Omio's users. If you are prioritising price take the flight with prices starting from $96. For those with little time consider booking a flight which can get you there in 5h 48m. The ticket price range depends on the travel mode: a flight costs an average of $96, and a train costs an average of $215.
Distance: 1785 miles (2873 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
$325 Average price | $247 Average price Cheapest | $462 Average price |
45h 7m Average total duration 44h 37m Onboard + 30m Additional time* | 8h 48m Average total duration Fastest 5h 48m Onboard + 3h 0m Additional time* | 56h 49m Average total duration 56h 19m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
San Diego, CA to Indianapolis, IN bus times
The table below shows live departures for San Diego, CA to Indianapolis, IN buses for today, Tuesday, March 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:50 PM San Diego, CA | 71h40 | 7:30 PM Indianapolis, IN | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Diego, CA to Indianapolis, IN by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 04
Mar 05
Mar 06
Mar 07
Mar 08
Mar 09
Mar 10
Why should you book San Diego, CA to Indianapolis, IN buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from San Diego, CA to Indianapolis, IN.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from San Diego, CA to Indianapolis, IN.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from San Diego, CA to Indianapolis, IN.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from San Diego, CA to Indianapolis, IN.
Journey information
Overview: Bus from San Diego, CA to Indianapolis, IN
Buses from San Diego, CA to Indianapolis, IN run on average 16 times per day, taking around 44h 37m. Cheap bus tickets for this journey start at $152 (€123) but you can travel from only $96 (€77) by flight.
The earliest bus runs at 03:15, the last at 23:55. The fastest bus covers the 1785 miles (2873 km) distance in 50h 5m.
Distance 1785 miles (2873 km) |
Average bus duration 44h 37m |
Cheapest ticket price $152 (€123) |
Buses per day 16 |
Fastest bus 50h 5m |
First bus 03:15 |
Last bus 23:55 |
Bus providers: Greyhound, FlixBus from San Diego, CA to Indianapolis, INYou can travel by bus between San Diego, CA to Indianapolis, IN with Greyhound, FlixBus for as low as $96 (€77). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from San Diego, CA to Indianapolis, IN
Find answers to the most common questions about traveling from San Diego, CA to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Indianapolis Motor Speedway, a historic racing circuit known for hosting the Indianapolis 500
- The Children's Museum of Indianapolis, the world's largest children's museum featuring interactive exhibits
- Indianapolis Zoo, a popular attraction with diverse animal exhibits and a botanical garden
- Indiana State Museum, showcasing the state's history, art, and science through various exhibits
- White River State Park, a sprawling urban park offering trails, gardens, and cultural attractions.
- Indianapolis Museum of Art at Newfields, a vast art museum with extensive collections and beautiful gardens
- Attend a race at the Indianapolis Motor Speedway, home of the iconic Indy 500
- Explore the interactive exhibits and educational programs at The Children's Museum of Indianapolis
- Visit the dolphin pavilion and animal habitats at the Indianapolis Zoo
- Enjoy a walk along the canal and cultural attractions at White River State Park.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from San Diego, CA to Indianapolis, IN
More options for your journey from San Diego, CA to Indianapolis, IN
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