- Must visit
San Diego Museum of Art
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
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Journey information
Overview: Bus from Greenville, SC to San Diego, CA
USAUSA
Buses from Greenville, SC to San Diego, CA run on average 7 times per day, taking around 56h 27m. Cheap bus tickets for this journey start at €147 if you book in advance.
The earliest bus runs at 06:45, the last at 22:00. The fastest bus covers the 1992 miles (3206 km) distance in 49h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1992 miles (3206 km) |
Average bus duration 56h 27m |
Cheapest ticket price €147 |
Buses per day 7 |
Fastest bus 49h 10m |
First bus 6:45 AM |
Last bus 10:00 PM |
Cheapest Month Jun |
Cheapest Day Sun |
High Season Oct - Dec |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your Greenville, SC to San Diego, CA trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Greenville, SC to San Diego, CA.
Cheap bus tickets from Greenville, SC to San Diego, CA can start from as little as €147 when you book in advance. The average bus ticket price for Greenville, SC to San Diego, CA is €251 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from Greenville, SC to San Diego, CA leaves at 6:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Greenville, SC to San Diego, CA leaves at 10:00 PM.
There are 7 buses a day from Greenville, SC to San Diego, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
Greenville, SC to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:45PM | Arrival Time 05:15AM | Duration 58h30 | Departure days Mon, Thu, Sat | Cheapest price €130 |
Operator Greyhound | Departure Time 07:45PM | Arrival Time 02:20AM | Duration 54h35 | Departure days Thu | Cheapest price €267 |
Live departures
Greenville, SC to San Diego, CA bus times
The table below shows live departures for Greenville, SC to San Diego, CA buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 6:45 PM Greenville, SC | 59h00 | 5:45 AM San Diego, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Greenville, SC to San Diego, CA buses with Omio?
Greyhound operates all buses services from Greenville, SC to San Diego, CA.
Omio is an official ticket reseller for all your travel options from Greenville, SC to San Diego, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Greenville, SC to San Diego, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Greenville, SC to San Diego, CA.
Bus providers: Greyhound from Greenville, SC to San Diego, CAYou can travel by bus between Greenville, SC to San Diego, CA with Greyhound for as low as €147. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
49h 10m
Cheapest Greyhound Price
€147
Greyhound frequency
7 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Companies, tickets, and onboard amenities between Greenville, SC and San Diego, CA
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from Greenville, SC to San Diego, CA, you can count on Greyhound for the best way to get you to San Diego, CA. You can also check all possible bus companies who offer a service between Greenville, SC and San Diego, CA and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from Greenville, SC to San Diego, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Greenville, SC to San Diego, CA for bus company Greyhound.
Whether you can cancel your bus ticket from Greenville, SC to San Diego, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from Greenville, SC to San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from Greenville, SC to San Diego, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Greenville, SC to San Diego, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Greenville, SC to San Diego, CA.
You can reserve your seat on the bus from Greenville, SC to San Diego, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Greenville, SC to San Diego, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Greenville, SC to San Diego, CA with the following bus company: Greyhound.
Complete guide to San Diego, CA
Things to do in San Diego, CA
Discover the best of San Diego, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego, CA trip today.
- Must visit
Museum of Contemporary Art San Diego
Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.
- Must visit
USS Midway Museum
Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.
- Must visit
Balboa Park
Balboa Park is San Diego's grand cultural park, packed with gardens, architecture, museums, and walkable plazas worth lingering in.
- Must visit
Gaslamp Quarter
Historic Gaslamp Quarter offers Victorian-era streets, nightlife energy, and preserved downtown architecture for an atmospheric walk.
- Must visit
La Jolla Cove
Dramatic seaside cliffs and walking paths in La Jolla, famous for waves, sea lions, and sweeping Pacific views.
Fish Taco
A San Diego staple: grilled fish in a soft tortilla with cabbage, crema, and salsa. Popularized by Baja influence and coastal seafood culture.
California Burrito
French fries, carne asada, cheese, guacamole, and crema wrapped in a flour tortilla. A late-night local favorite born in San Diego taquerias.
- Gluten-free
Sea Urchin (Uni)
Fresh local sea urchin served raw, prized for its rich, buttery taste. It reflects San Diego's access to Pacific seafood and sushi culture.
Sushi Ota
Celebrated sushi restaurant specializing in omakase and pristine seafood, including uni. Intimate, polished, and highly respected by locals.
Mitch's Seafood
Iconic casual seafood counter known for fish tacos, smoked fish, and harbor views. A classic stop for San Diego's Baja-inspired seafood style.
Juniper and Ivy
Refined fine-dining restaurant showcasing local seafood and seasonal California ingredients. Elegant room with one of the city's strongest reputations.
US Dollar ($)
San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $25-45 per person for a mid-range meal.
- Fine dining
- $75+ per person for upscale dining.
- Coffee
- $4-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.
Plan your visit to San Diego, CA
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in San Diego, CA.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from Greenville, SC to San Diego, CA
Find answers to the most common questions about traveling from Greenville, SC to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 2 ways to travel between Greenville, SC and San Diego, CA including taking a bus and flight.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to San Diego, CA
Here are some other resources that might have the information you need
Most popular buses to and from San Diego, CA and Greenville, SC
Most popular bus connections to San Diego, CA
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