- Must visit
San Diego Museum of Art
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
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The cheapest and fastest buses from Greenville, SC to San Diego, CA
Showing times, prices and bookable tickets for Sep 19
Cheapest price on Sep 19
$159
Average ticket price on Sep 19
$159
Fastest journey on Sep 19
2 d 10 h 30 m
Average journey duration on Sep 19
2 d 10 h 30 m
Buses on Sep 19
1
Distance
3206 km
Cheap tickets
The best way to find a cheap bus ticket from Greenville, SC to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to San Diego, CA will cost around $159 if you buy it on the day, but the cheapest tickets can be found for only $159.
Fast buses
On Sat, Sep 19, we found 1 buses from Greenville, SC to San Diego, CA, including 1 direct services.
On Sat, Sep 19 the direct buses cover the 3206 km distance in an average of 2 d 10 h 30 m but if you time it right, some buses will get you there in just 2 d 10 h 30 m .
On Sat, Sep 19 the slowest buses will take 2 d 10 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
6:45 PM58h30Greenville, SC5:15 AMSan Diego, CA$1591One-way0 transfers
- 6:45 PM58h30Greenville, SC5:15 AMSan Diego, CA$1591One-way0 transfers
Travel Information
Compare bus and flight for Greenville, SC to San Diego, CA
Omio recommends booking the bus as it is the most popular option from Greenville, SC to San Diego, CA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $329 For those with little time, consider booking a flight, which has an average total journey time of 9h 21m. Average ticket prices depend on the travel mode: a bus costs an average of $329, while a flight costs an average of $683.
Distance: 1992 miles (3206 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$329 Average price Cheapest | $683 Average price | $468 Average price (fuel + tolls) |
57h 5m Average total duration 56h 35m Onboard + 30m Additional time* | 9h 21m Average total duration Fastest 7h 21m Onboard + 2h 0m Additional time* | 32h 54m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Greenville, SC to San Diego, CA is a bus with an average price of $329 (€269).
This is compared to other travel options from Greenville, SC to San Diego, CA:
A bus is $237 (€194) less than a flight for this route with tickets for a flight from Greenville, SC to San Diego, CA costing on average $566 (€463).
The fastest way to travel from Greenville, SC to San Diego, CA is by flight with an average journey time of 7h 6m.
Other travel options to San Diego, CA take longer:
Bus takes on average 56h 35m.
It's helpful to compare your options as there are 2 ways to travel between Greenville, SC and San Diego, CA including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Greenville, SC to San Diego, CA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $329 (€269) compared to roughly $468 (€383) in fuel and tolls — a saving of about $139 (€114). The journey takes 56h 35m versus 32h 54m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Greenville, SC to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:45PM | Arrival Time 05:15AM | Duration 58h30 | Departure days Mon, Thu, Sat | Cheapest price $159 |
Operator Greyhound | Departure Time 07:45PM | Arrival Time 02:20AM | Duration 54h35 | Departure days Thu | Cheapest price $326 |
Compare prices and tickets Greenville, SC to San Diego, CA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Greenville, SC to San Diego, CA buses with Omio?
Greyhound operates all buses services from Greenville, SC to San Diego, CA.
Omio is an official ticket reseller for all your travel options from Greenville, SC to San Diego, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Greenville, SC to San Diego, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Greenville, SC to San Diego, CA.
Journey information
Overview: Bus from Greenville, SC to San Diego, CA
USAUSA
Buses from Greenville, SC to San Diego, CA run on average 7 times per day, taking around 56h 35m. Cheap bus tickets for this journey start at $197 (€161) if you book in advance.
The earliest bus runs at 06:45, the last at 22:00. The fastest bus covers the 1992 miles (3206 km) distance in 49h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1992 miles (3206 km) |
Average bus duration 56h 35m |
Cheapest ticket price $197 (€161) |
Buses per day 7 |
Fastest bus 49h 10m |
First bus 6:45 AM |
Last bus 10:00 PM |
Cheapest Month Jun |
Cheapest Day Sun |
High Season Oct - Dec |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Greenville, SC to San Diego, CAYou can travel by bus between Greenville, SC to San Diego, CA with Greyhound for as low as $197 (€161). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
49h 10m
Cheapest Greyhound Price
$302 (€248)
Greyhound frequency
8 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to San Diego, CA
Things to do in San Diego, CA
Discover the best of San Diego, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego, CA trip today.
- Must visit
Museum of Contemporary Art San Diego
Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.
- Must visit
USS Midway Museum
Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.
- Must visit
Balboa Park
Balboa Park is San Diego's grand cultural park, packed with gardens, architecture, museums, and walkable plazas worth lingering in.
- Must visit
Gaslamp Quarter
Historic Gaslamp Quarter offers Victorian-era streets, nightlife energy, and preserved downtown architecture for an atmospheric walk.
- Must visit
La Jolla Cove
Dramatic seaside cliffs and walking paths in La Jolla, famous for waves, sea lions, and sweeping Pacific views.
Fish Taco
A San Diego staple: grilled fish in a soft tortilla with cabbage, crema, and salsa. Popularized by Baja influence and coastal seafood culture.
California Burrito
French fries, carne asada, cheese, guacamole, and crema wrapped in a flour tortilla. A late-night local favorite born in San Diego taquerias.
- Gluten-free
Sea Urchin (Uni)
Fresh local sea urchin served raw, prized for its rich, buttery taste. It reflects San Diego's access to Pacific seafood and sushi culture.
Sushi Ota
Celebrated sushi restaurant specializing in omakase and pristine seafood, including uni. Intimate, polished, and highly respected by locals.
Mitch's Seafood
Iconic casual seafood counter known for fish tacos, smoked fish, and harbor views. A classic stop for San Diego's Baja-inspired seafood style.
Juniper and Ivy
Refined fine-dining restaurant showcasing local seafood and seasonal California ingredients. Elegant room with one of the city's strongest reputations.
US Dollar ($)
San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $25-45 per person for a mid-range meal.
- Fine dining
- $75+ per person for upscale dining.
- Coffee
- $4-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.
FAQs: Bus from Greenville, SC to San Diego, CA
Find answers to the most common questions about traveling from Greenville, SC to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Greenville, SC to San Diego, CA can start from as little as $302 (€248) when you book in advance. The average bus ticket price for Greenville, SC to San Diego, CA is $482 (€394) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Greenville, SC to San Diego, CA is 49h 10m to travel the 1992 miles (3206 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Greenville, SC to San Diego, CA leaves at 6:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Greenville, SC to San Diego, CA leaves at 10:00 PM.
There are 8 buses a day from Greenville, SC to San Diego, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Greenville, SC to San Diego, CA, you can count on Greyhound for the best way to get you to San Diego, CA. You can also check all possible bus companies who offer a service between Greenville, SC and San Diego, CA and compare the amenities they offer before buying a bus ticket.
When departing from Greenville, SC , you have various bus station options to start your journey from including Greenville, Woodruff Rd ("Raceway" gas station), SC . When arriving in San Diego, CA , you can end your journey in bus stations like San Diego, Congress Street (Old Town Park), CA, San Diego, San Ysidro Transit Center, San Diego, West Harbor Drive (The Headquarters at Seaport District), CA, San Diego, Rail Ct / E San Ysidro Blvd (McDonald`s), CA .Passengers board the bus most frequently from Greenville, Woodruff Rd ("Raceway" gas station), SC, which is located around 4 miles (8 km) away from the city centre, and they get off the bus at San Diego, Congress Street (Old Town Park), CA, located 5 away from the city centre.
A trip to San Diego, CA from Greenville, SC is worth doing but not as a day trip with a journey time of 49h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Greenville, SC to San Diego, CA is June.
It's helpful to compare your options as there are 2 ways to travel between Greenville, SC and San Diego, CA including taking a bus and flight.
Yes, there are bathrooms on board the bus from Greenville, SC to San Diego, CA for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from Greenville, SC to San Diego, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Some of the most interesting sights to explore in San Diego, CA are:
- Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
- USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
- La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
- Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
- Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best things to do in San Diego, CA include:
- Explore the vibrant art scene at the Museum of Contemporary Art San Diego
- enjoy a harbor cruise for stunning views of the skyline and naval ships
- hike the scenic trails at Torrey Pines State Natural Reserve
- visit the Birch Aquarium to learn about marine life and ocean conservation
- experience the thrill of a whale watching tour off the coast.
Whether you can cancel your bus ticket from Greenville, SC to San Diego, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Greenville, SC to San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from Greenville, SC to San Diego, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Greenville, SC to San Diego, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Greenville, SC to San Diego, CA.
You can reserve your seat on the bus from Greenville, SC to San Diego, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Greenville, SC to San Diego, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Greenville, SC to San Diego, CA with the following bus company: Greyhound.
Since neither Greenville, SC nor San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Greenville, SC to San Diego, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Greenville, SC to San Diego, CA
Most Greenville, SC to San Diego, CA buses use the Greenville, Woodruff Rd ("Raceway" gas station) to San Diego, Congress Street (Old Town Park) station pair, with some services arriving at San Diego, West Harbor Drive (The Headquarters at Seaport District). Use this guide to compare Greenville, SC and San Diego, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Greenville
Arrival bus stations in San Diego
Which Greenville, SC station do buses to San Diego, CA leave from?
Buses from Greenville, SC to San Diego, CA leave from Greenville, Woodruff Rd ("Raceway" gas station). The station is 4 miles (8 km) from Greenville, SC city centre at Woodruff Rd, Greenville, SC, USA.
Greenville, Woodruff Rd ("Raceway" gas station)Woodruff Rd, Greenville, SC, USA
City-centre transport
Getting to Greenville, Woodruff Rd ("Raceway" gas station) from Greenville city centre
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
TRUE
Greenville, Woodruff Rd ("Raceway" gas station) bus station facilities and services
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Limited dining options available in adjacent areas.
Wi-Fi and ATMs
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Tickets and information
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Parking, taxis and toilets
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Which San Diego, CA station do buses from Greenville, SC arrive at?
Buses from Greenville, SC to San Diego, CA most often arrive at San Diego, Congress Street (Old Town Park). Some services arrive at San Diego, San Ysidro Transit Center, so check your ticket before travel to confirm your San Diego, CA arrival station.
San Diego, Congress Street (Old Town Park)Congress St, San Diego, CA 92110, USA
City-centre transport
Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre
San Diego, Congress Street (Old Town Park) is 5 km from San Diego city centre. Public transport options include:
BusFlixBus 2017 · 20m · $1
83 · 26m · $6
TramGreen, Blue, Event · 16m · every ~18 min
Blue · 21m · every ~9 min
San Diego, Congress Street (Old Town Park) bus station facilities and services
San Diego, Congress Street (Old Town Park) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several dining options nearby.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, Congress Street (Old Town Park). ATMs are available at San Diego, Congress Street (Old Town Park).
Tickets and information
Ticket office support is available at San Diego, Congress Street (Old Town Park).
Parking, taxis and toilets
Available at San Diego, Congress Street (Old Town Park): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, Congress Street (Old Town Park): Wheelchair accessible routes available.
San Diego, San Ysidro Transit CenterSan Ysidro Station, San Diego, CA 92173, USA
City-centre transport
Getting to San Diego, San Ysidro Transit Center from San Diego city centre
San Diego, San Ysidro Transit Center is 22 km from San Diego city centre. Public transport options include:
BusFlixBus 2017 · 25m · $2
910 · 41m · $6
TramBlue · 41m · $17 · every ~14 min
Blue · 43m · $17 · every ~14 min
San Diego, San Ysidro Transit Center bus station facilities and services
San Diego, San Ysidro Transit Center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several fast food eateries located nearby.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, San Ysidro Transit Center. ATMs are available near the entrance.
Tickets and information
Ticket office support is available at San Diego, San Ysidro Transit Center.
Parking, taxis and toilets
Available at San Diego, San Ysidro Transit Center: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, San Ysidro Transit Center: Wheelchair accessible with ramps.
San Diego, West Harbor Drive (The Headquarters at Seaport District)W Harbor Dr, San Diego, CA, USA
City-centre transport
Getting to San Diego, West Harbor Drive (The Headquarters at Seaport District) from San Diego city centre
San Diego, West Harbor Drive (The Headquarters at Seaport District) is 1 km from San Diego city centre. Public transport options include:
TRUE
San Diego, West Harbor Drive (The Headquarters at Seaport District) bus station facilities and services
San Diego, West Harbor Drive (The Headquarters at Seaport District) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several dining options are in the area.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, West Harbor Drive (The Headquarters at Seaport District). ATMs are available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Tickets and information
Ticket office support is available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Parking, taxis and toilets
Available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Accessible for persons with disabilities.
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to San Diego, CA
Here are some other resources that might have the information you need
Most popular buses to and from San Diego, CA and Greenville, SC
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