- Must visit
Greenville County Museum of Art
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Indianapolis, IN to Greenville, SC
Showing times and prices for Jun 19
Cheapest price
$136
Average price
$140
Fastest journey
14 h 55 m
Average duration
15 h 56 m
Buses per day
6
Distance
640 km
Cheap tickets
The best way to find a cheap bus ticket from Indianapolis, IN to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Indianapolis, IN to Greenville, SC will cost around $140 if you buy it on the day, but the cheapest tickets can be found for only $136.
Fast buses
It's difficult to get from Indianapolis, IN to Greenville, SC without transferring at least once.
FlixBus · FlixBus11:30 PM16h40Indianapolis, E Washington St / N Delaware St (City/County Building), IN4:10 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1361One-way1 transfer
· 4:05 PM14h55Indianapolis, Illinois St (Greyhound Bus Station)7:00 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1361One-way1 transfer- FlixBus+6:25 PM16h15Indianapolis, E Washington St / N Delaware St (City/County Building), IN10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1361One-way1 transfer
- +FlixBus8:10 PM15h50Indianapolis, Illinois St (Greyhound Bus Station)12:00 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1361One-way1 transfer
- · 11:15 AM16h00Indianapolis, Illinois St (Greyhound Bus Station)3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1491One-way1 transfer
- · 4:05 PM14h55Indianapolis, Illinois St (Greyhound Bus Station)7:00 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1361One-way1 transfer
- +FlixBus8:10 PM15h50Indianapolis, Illinois St (Greyhound Bus Station)12:00 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1361One-way1 transfer
- · 11:15 AM16h00Indianapolis, Illinois St (Greyhound Bus Station)3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1491One-way1 transfer
- FlixBus+6:25 PM16h15Indianapolis, E Washington St / N Delaware St (City/County Building), IN10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1361One-way1 transfer
- FlixBus · FlixBus11:30 PM16h40Indianapolis, E Washington St / N Delaware St (City/County Building), IN4:10 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1361One-way1 transfer
Indianapolis, IN to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 04:40AM | Arrival Time 09:30PM | Duration 16h50 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $112 |
Operator Greyhound | Departure Time 11:15AM | Arrival Time 03:15AM | Duration 16h00 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $108 |
Operator Greyhound | Departure Time 04:05PM | Arrival Time 07:00AM | Duration 14h55 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $107 |
Operator Greyhound | Departure Time 04:20PM | Arrival Time 02:35PM | Duration 22h15 | Departure days Wed | Cheapest price $119 |
Operator FlixBus | Departure Time 06:25PM | Arrival Time 10:40AM | Duration 16h15 | Departure days Mon, Tue, Thu, Fri, Sat | Cheapest price $107 |
Operator Greyhound | Departure Time 07:55PM | Arrival Time 02:35PM | Duration 18h40 | Departure days Mon, Tue | Cheapest price $108 |
Operator Greyhound | Departure Time 08:10PM | Arrival Time 12:00PM | Duration 15h50 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $107 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 04:10PM | Duration 16h40 | Departure days Mon, Tue, Wed, Fri, Sat | Cheapest price $107 |
Live departures
Indianapolis, IN to Greenville, SC bus times
The table below shows live departures for Indianapolis, IN to Greenville, SC buses for today, Thursday, June 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| +FlixBus | 4:40 AM Indianapolis, Illinois St (Greyhound Bus Station) | 16h50 | 9:30 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| · | 11:15 AM Indianapolis, Illinois St (Greyhound Bus Station) | 16h00 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| · | 4:05 PM Indianapolis, Illinois St (Greyhound Bus Station) | 14h55 | 7:00 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| FlixBus+ | 6:25 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 16h15 | 10:40 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| +FlixBus | 8:10 PM Indianapolis, Illinois St (Greyhound Bus Station) | 15h50 | 12:00 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer |
Find all the dates and times for this journey
Journey information
Overview: Bus from Indianapolis, IN to Greenville, SC
USAUSA
Take a bus from Indianapolis, IN to Greenville, SC and enjoy the approximately 397 miles (640 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 03:15, the last at 23:30.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 397 miles (640 km) |
Buses per day 12 |
First bus 3:15 AM |
Last bus 11:30 PM |
Cheapest Month May |
Cheapest Day Mon |
High Season Apr - Jun |
Low Season Apr - Jun |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to Greenville
Things to do in Greenville
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
- Recommended
Upcountry History Museum
Regional history museum with permanent and rotating exhibits on the people and stories of Upstate South Carolina. A strong choice for understanding Greenville’s local context.
- Recommended
Sigal Music Museum
Specialized museum displaying rare historic instruments from around the world. A distinctive local favorite for music, design, and cultural history.
- Must visit
Main Street
Greenville’s central downtown street lined with shops, public art, plazas, and event spaces. It is the main place to walk and experience the city atmosphere.
- Must visit
Falls Park on the Reedy
Downtown park built around waterfalls, gardens, and river overlooks. It is Greenville’s signature public space and a top stop for first-time visitors.
- Must visit
Swamp Rabbit Trail
Popular multi-use greenway for walking and cycling, linking Greenville with nearby communities. Widely loved by locals and visitors for active sightseeing.
- Gluten-free
South Carolina Barbecue
Slow-smoked pork, often chopped or pulled, served with the state's signature mustard-based sauce. It is a defining Upstate and South Carolina tradition.
- Vegetarian
Fried Green Tomatoes
Slices of unripe tomato coated and fried until crisp, often served with remoulade or pimento cheese. A classic Southern starter common in Greenville restaurants.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, gravy, or bacon. This Lowcountry favorite is widely loved in Greenville as part of broader South Carolina cuisine.
The Anchorage
Well-regarded neighborhood restaurant focused on seasonal Southern-influenced American cooking with a polished but relaxed atmosphere.
Soby's
A long-running downtown Greenville favorite serving refined Southern cuisine in a lively, upscale setting. Known for shrimp and grits, brunch, and strong wine selections.
Smoke On The Water
Popular casual spot for barbecue, ribs, and Southern comfort food near Falls Park. Lively atmosphere and a good place to try local smoked meats.
United States Dollar
Moderate by U.S. standards: casual dining is affordable, while upscale downtown hotels and restaurants cost more.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual restaurant.
- Fine dining
- USD 50-100+ per person at upscale restaurants.
- Coffee
- USD 3-6 for a coffee drink.
Tipping culture
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff a few dollars, and round up for coffee only if desired.
FAQs: Bus from Indianapolis, IN to Greenville, SC
Find answers to the most common questions about traveling from Indianapolis, IN to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
The earliest bus from Indianapolis, IN to Greenville, SC leaves at 3:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Indianapolis, IN to Greenville, SC leaves at 11:30 PM.
The cheapest month for a bus from Indianapolis, IN to Greenville, SC is May.
Yes, you can take a between Indianapolis, IN and Greenville, SC.
No, there are no bathrooms on board the bus from Indianapolis, IN to Greenville, SC.
No, the bus from Indianapolis, IN to Greenville, SC has no accessibility options.
No, bikes are not allowed on board the bus from Indianapolis, IN to Greenville, SC.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Indianapolis, IN to Greenville, SC.
No, luggage for the bus from Indianapolis, IN to Greenville, SC needs to be booked in addition.
No, there are no additional luggage options for the bus from Indianapolis, IN to Greenville, SC.
Unfortunately, pets are not allowed on the bus from Indianapolis, IN to Greenville, SC.
No, there are no USB plugs on board the bus from Indianapolis, IN to Greenville, SC.
No, there is no WiFi on board the bus from Indianapolis, IN to Greenville, SC.
Since neither Indianapolis, IN nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Indianapolis, IN to Greenville, SC
Indianapolis
Greenville
The major bus station for departures in Indianapolis is Indianapolis, Illinois St (Greyhound Bus Station). Find all the information you need to know about services, amenities and connections at Indianapolis, Illinois St (Greyhound Bus Station) for your trip from Indianapolis to Greenville.
Indianapolis, Illinois St (Greyhound Bus Station)
information
Indianapolis, E Washington St / N Delaware St (City/County Building)
information
The major bus station for arrivals in Greenville is Greenville, Woodruff Rd ("Raceway" gas station). Find all the information you need to know about services, amenities and connections at Greenville, Woodruff Rd ("Raceway" gas station) for your trip to Greenville from Indianapolis.
Greenville, Woodruff Rd ("Raceway" gas station)
information
Most popular bus connections from Indianapolis, IN
More options for your journey from Indianapolis, IN to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Indianapolis, IN
Most popular bus connections to Greenville, SC
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
