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A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
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Journey information
Overview: Bus from Indianapolis, IN to Greenville, SC
USAUSA
Buses from Indianapolis, IN to Greenville, SC run on average 6 times per day, taking around 14h 1m. Cheap bus tickets for this journey start at $70 if you book in advance.
The earliest bus runs at 03:15, the last at 23:30. The fastest bus covers the 397 miles (640 km) distance in 11h 50m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 397 miles (640 km) |
Average bus duration 14h 1m |
Cheapest ticket price $70 |
Buses per day 6 |
Fastest bus 11h 50m |
First bus 3:15 AM |
Last bus 11:30 PM |
Cheapest Month Sep |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your Indianapolis, IN to Greenville, SC trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Indianapolis, IN to Greenville, SC.
Cheap bus tickets from Indianapolis, IN to Greenville, SC can start from as little as $70 when you book in advance. The average bus ticket price for Indianapolis, IN to Greenville, SC is $98 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from Indianapolis, IN to Greenville, SC leaves at 3:15 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Indianapolis, IN to Greenville, SC leaves at 11:30 PM.
There are 6 buses a day from Indianapolis, IN to Greenville, SC which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
Indianapolis, IN to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 03:40AM | Arrival Time 09:30PM | Duration 17h50 | Departure days Sun | Cheapest price $93 |
Operator Greyhound | Departure Time 11:15AM | Arrival Time 03:15AM | Duration 16h00 | Departure days Sun | Cheapest price $93 |
Operator Greyhound | Departure Time 04:05PM | Arrival Time 07:00AM | Duration 14h55 | Departure days Sun | Cheapest price $93 |
Operator FlixBus | Departure Time 06:35PM | Arrival Time 10:40AM | Duration 16h05 | Departure days Sun | Cheapest price $93 |
Operator Greyhound | Departure Time 08:05PM | Arrival Time 02:35PM | Duration 18h30 | Departure days Sun | Cheapest price $93 |
Operator Greyhound | Departure Time 08:10PM | Arrival Time 04:10PM | Duration 20h00 | Departure days Sun | Cheapest price $93 |
Operator FlixBus | Departure Time 11:25PM | Arrival Time 04:10PM | Duration 16h45 | Departure days Sun | Cheapest price $93 |
Live departures
Indianapolis, IN to Greenville, SC bus times
The table below shows live departures for Indianapolis, IN to Greenville, SC buses for today, Sunday, November 1. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 + FlixBus | 3:40 AM Indianapolis, Illinois St (Greyhound Bus Station) | 17h50 | 9:30 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| · | 11:15 AM Indianapolis, Illinois St (Greyhound Bus Station) | 16h00 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| · | 4:05 PM Indianapolis, Illinois St (Greyhound Bus Station) | 14h55 | 7:00 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| FlixBus+ | 6:35 PM Indianapolis, E Washington St / N Delaware St (City/County Building), IN | 16h05 | 10:40 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| · · | 8:05 PM Indianapolis, Illinois St (Greyhound Bus Station) | 18h30 | 2:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| +FlixBus | 8:10 PM Indianapolis, Illinois St (Greyhound Bus Station) | 20h00 | 4:10 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Indianapolis, IN to Greenville, SC buses with Omio?
Greyhound as well as FlixBus offer buses services from Indianapolis, IN to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Indianapolis, IN to Greenville, SC.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Indianapolis, IN to Greenville, SC.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and train to ensure you get the best deal for traveling from Indianapolis, IN to Greenville, SC.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Indianapolis, IN to Greenville, SC.
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Indianapolis, IN to Greenville, SC.
Bus providers: Greyhound, FlixBus from Indianapolis, IN to Greenville, SCYou can travel by bus between Indianapolis, IN to Greenville, SC with Greyhound, FlixBus for as low as $70. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
11h 55m
Cheapest FlixBus Price
$70
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
11h 50m
Cheapest Greyhound Price
$70
Greyhound frequency
4 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Companies, tickets, and onboard amenities between Indianapolis, IN and Greenville, SC
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from Indianapolis, IN to Greenville, SC, you can count on Greyhound, FlixBus for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Indianapolis, IN and Greenville, SC and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from Indianapolis, IN to Greenville, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Indianapolis, IN to Greenville, SC for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Indianapolis, IN to Greenville, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from Indianapolis, IN to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Indianapolis, IN to Greenville, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Indianapolis, IN to Greenville, SC:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Indianapolis, IN to Greenville, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Indianapolis, IN to Greenville, SC with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Indianapolis, IN to Greenville, SC with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Indianapolis, IN to Greenville, SC with the following bus company: Greyhound, FlixBus.
Complete guide to Greenville, SC
Things to do in Greenville, SC
Discover the best of Greenville, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville, SC trip today.
Greenville Center for Creative Arts
A contemporary art center showing regional and international artists through rotating exhibitions in a modern downtown gallery space.
Metropolitan Arts Council Gallery
A local gallery and arts space featuring exhibitions, classes, and community-focused programming in Greenville's Village area.
- Must visit
Falls Park on the Reedy
A signature downtown park with waterfalls, gardens, river trails, and lawns. It is Greenville's most popular public space for walking and views.
- Must visit
Main Street
Greenville's central street lined with shops, public art, and historic buildings. It is ideal for strolling between downtown attractions.
- Recommended
Prisma Health Swamp Rabbit Trail
A swamp rabbit-themed riverside greenway popular for walking and cycling, linking downtown Greenville with parks and nearby districts.
- Gluten-free
South Carolina Mustard-Style Barbecue
South Carolina barbecue is slow-smoked pork, often chopped or pulled, and classically served with the state’s distinctive mustard-based sauce.
- Gluten-free
Shrimp And Grits
Shrimp and grits pairs creamy stone-ground grits with shrimp, often enriched with bacon or sausage. It is a Lowcountry staple found across Greenville.
- Vegetarian
Fried Green Tomatoes
Fried green tomatoes are tart unripe tomatoes breaded and fried. They are a beloved Southern side and common on Upstate menus.
Henry's Smokehouse
Casual Greenville barbecue spot serving smoked meats, classic sides, and a relaxed neighborhood atmosphere.
Hall's Chophouse Greenville
Upscale downtown steakhouse and oyster bar with dry-aged beef, seafood, and an elegant supper-club feel.
Soby's
Refined Southern restaurant known for seasonal plates, thoughtful cocktails, and a polished downtown setting.
United States dollar ($)
Moderate for a U.S. city. Hotels and dining are usually cheaper than major metros, but car travel and limited transit can add to visitor costs.
Average meal costs
- Budget
- $10-15 for fast food or a casual meal.
- Mid-range
- $20-35 per person for a restaurant meal.
- Fine dining
- $60+ per person for upscale dining.
- Coffee
- $3-5 for coffee or a cappuccino.
Tipping culture
Tip 18-20% at restaurants, more for excellent service. Taxis usually get 10-15%. Cafes often have tip jars; $1-2 is common for drinks.
Plan your visit to Greenville, SC
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Greenville, SC.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from Indianapolis, IN to Greenville, SC
Find answers to the most common questions about traveling from Indianapolis, IN to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 2 ways to travel between Indianapolis, IN and Greenville, SC including taking a bus and train.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
popular bus stations
Popular bus stations from Indianapolis, IN to Greenville, SC
Most Indianapolis, IN to Greenville, SC buses use the Indianapolis, Illinois St (Greyhound Bus Station) to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Indianapolis, IN and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Indianapolis
Arrival bus stations in Greenville
Which Indianapolis, IN station do buses to Greenville, SC leave from?
Buses from Indianapolis, IN to Greenville, SC leave from Indianapolis, Illinois St (Greyhound Bus Station). The station is 0 miles (1 km) from Indianapolis, IN city centre at 350 S Illinois St, Indianapolis, IN 46225, USA.
Indianapolis, Illinois St (Greyhound Bus Station)350 S Illinois St, Indianapolis, IN 46225, USA
City-centre transport
Getting to Indianapolis, Illinois St (Greyhound Bus Station) from Indianapolis city centre
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Indianapolis, Illinois St (Greyhound Bus Station) bus station facilities and services
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Fast food outlets are available.
Wi-Fi and ATMs
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Tickets and information
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Parking, taxis and toilets
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
Which Greenville, SC station do buses from Indianapolis, IN arrive at?
Buses from Indianapolis, IN to Greenville, SC arrive at Greenville, Woodruff Rd ("Raceway" gas station). Greenville, Woodruff Rd ("Raceway" gas station) is 4 miles (8 km) from Greenville, SC city centre.
Greenville, Woodruff Rd ("Raceway" gas station)Woodruff Rd, Greenville, SC, USA
City-centre transport
Getting to Greenville, Woodruff Rd ("Raceway" gas station) from Greenville city centre
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
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Greenville, Woodruff Rd ("Raceway" gas station) bus station facilities and services
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Limited dining options available in adjacent areas.
Wi-Fi and ATMs
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Tickets and information
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Parking, taxis and toilets
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Bus stations for Indianapolis, IN to Greenville, SC
Check bus stations information for Indianapolis, IN and Greenville, SC, including where buses depart and arrive on this route.
Passengers board the bus most frequently from Indianapolis, Illinois St (Greyhound Bus Station), which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Greenville, Woodruff Rd ("Raceway" gas station), located 8 away from the city centre.
Most popular bus connections from Indianapolis, IN
More options for your journey from Indianapolis, IN to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Indianapolis, IN
Most popular bus connections to Greenville, SC
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