The cheapest and fastest buses from Greenville, SC to Chicago, IL
Cheapest price
$132
Average price
$132
Fastest journey
21 h 45 m
Average duration
21 h 45 m
Buses per day
1
Distance
903 km
The best way to find a cheap bus ticket from Greenville, SC to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Chicago, IL will cost around $132 if you buy it on the day, but the cheapest tickets can be found for only $132.
Of the 1 buses that leave Greenville, SC for Chicago, IL on Sat, Nov 08, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Nov 08 the direct buses cover the 903 km distance in an average of 21 h 45 m but if you time it right, some buses will get you there in just 21 h 45 m .
On Sat, Nov 08 the slowest buses will take 21 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for Greenville, SC to Chicago, IL
Omio recommends booking the train as it is the most popular option from Greenville, SC to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from €76. For those with little time consider booking a flight which can get you there in 5h 57m. The ticket price range depends on the travel mode: a bus costs an average of €76, and a train costs an average of €176.
Distance: 561 miles (903 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€123 Average price Cheapest | €302 Average price | €242 Average price |
21h 30m Average total duration 21h 0m Onboard + 30m Additional time* | 32h 17m Average total duration 31h 47m Onboard + 30m Additional time* | 8h 57m Average total duration Fastest 5h 57m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Greenville, SC to Chicago, IL bus times
The table below shows live departures for Greenville, SC to Chicago, IL buses for today, Friday, November 7. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:45 PM Greenville, SC | 21h45 | 4:30 PM Chicago, IL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Greenville, SC to Chicago, IL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 08
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Nov 14
Journey information
Overview: Bus from Greenville, SC to Chicago, IL
Distance 561 miles (903 km) |
Average bus duration 21h 0m |
Cheapest ticket price $94 (€76) |
Buses per day 6 |
Fastest bus 20h 30m |
First bus 05:45 |
Last bus 23:50 |
Key Takeaways
Train Ticket Prices
- Budget Options: Train tickets from Greenville, SC to Chicago, IL start from as low as $94 (€76) if booked well in advance.
- Standard Fares: Typically, trains cost $151 (€123) depending on the train type and class.
FAQs: Bus from Greenville, SC to Chicago, IL
Find answers to the most common questions about traveling from Greenville, SC to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. Rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U. S. Offering free admission.
To find the cheapest bus tickets for your trip from Greenville, SC to Chicago, IL, follow these tips:
Start your search now and compare ticket prices to find the best deal!
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Popular bus stations from Greenville, SC to Chicago, IL
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