The cheapest and fastest buses from Greenville, SC to Chicago, IL
Cheapest price
$163
Average price
$163
Fastest journey
20 h 35 m
Average duration
20 h 35 m
Buses per day
1
Distance
903 km
The best way to find a cheap bus ticket from Greenville, SC to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Chicago, IL will cost around $163 if you buy it on the day, but the cheapest tickets can be found for only $163.
Of the 1 buses that leave Greenville, SC for Chicago, IL on Tue, Mar 24, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Mar 24 the direct buses cover the 903 km distance in an average of 20 h 35 m but if you time it right, some buses will get you there in just 20 h 35 m .
On Tue, Mar 24 the slowest buses will take 20 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for Greenville, SC to Chicago, IL
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from $124. For those with little time consider booking a flight which can get you there in 2h 48m. The ticket price range depends on the travel mode: a bus costs an average of $124, and a flight costs an average of $220.
Distance: 561 miles (903 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
$188 Average price Cheapest | $321 Average price | $264 Average price |
19h 10m Average total duration 18h 40m Onboard + 30m Additional time* | 5h 48m Average total duration Fastest 2h 48m Onboard + 3h 0m Additional time* | 33h 42m Average total duration 33h 12m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Greenville, SC to Chicago, IL bus times
The table below shows live departures for Greenville, SC to Chicago, IL buses for tomorrow, Sunday, March 22. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:40 AM Greenville, SC | 20h35 | 9:15 PM Chicago, IL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Greenville, SC to Chicago, IL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Mar 28
Mar 29
Why should you book Greenville, SC to Chicago, IL buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Chicago, IL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Greenville, SC to Chicago, IL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Chicago, IL.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Greenville, SC to Chicago, IL.
Journey information
Overview: Bus from Greenville, SC to Chicago, IL
Buses from Greenville, SC to Chicago, IL run on average 6 times per day, taking around 18h 40m. Cheap bus tickets for this journey start at $124 (€101) if you book in advance.
The earliest bus runs at 05:25, the last at 23:50. The fastest bus covers the 561 miles (903 km) distance in 19h 40m.
Distance 561 miles (903 km) |
Average bus duration 18h 40m |
Cheapest ticket price $124 (€101) |
Buses per day 6 |
Fastest bus 19h 40m |
First bus 05:25 |
Last bus 23:50 |
Cheapest month Aug |
Cheapest day Mon |
High season Apr - Jun |
Low season Oct - Dec |
Bus providers: Greyhound, FlixBus from Greenville, SC to Chicago, ILYou can travel by bus between Greenville, SC to Chicago, IL with Greyhound, FlixBus for as low as $124 (€101). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Greenville, SC to Chicago, IL
Find answers to the most common questions about traveling from Greenville, SC to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Greenville, SC to Chicago, IL
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Chicago, IL
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