The cheapest and fastest buses from Greenville, SC to Chicago, IL
Cheapest price
$186
Average price
$186
Fastest journey
21 h 45 m
Average duration
21 h 45 m
Buses per day
1
Distance
903 km
The best way to find a cheap bus ticket from Greenville, SC to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Chicago, IL will cost around $186 if you buy it on the day, but the cheapest tickets can be found for only $186.
Of the 1 buses that leave Greenville, SC for Chicago, IL on Fri, Feb 06, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Feb 06 the direct buses cover the 903 km distance in an average of 21 h 45 m but if you time it right, some buses will get you there in just 21 h 45 m .
On Fri, Feb 06 the slowest buses will take 21 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for Greenville, SC to Chicago, IL
Omio recommends booking the bus as it is the most popular option from Greenville, SC to Chicago, IL among Omio's users. If you are prioritising price take the bus with prices starting from €101. For those with little time consider booking a flight which can get you there in 4h 4m. The ticket price range depends on the travel mode: a bus costs an average of €101, and a flight costs an average of €268.
Distance: 561 miles (903 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
€117 Average price Cheapest | €359 Average price | €195 Average price |
19h 10m Average total duration 18h 40m Onboard + 30m Additional time* | 7h 4m Average total duration Fastest 4h 4m Onboard + 3h 0m Additional time* | 32h 30m Average total duration 32h 0m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Greenville, SC to Chicago, IL by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 06
Feb 07
Feb 08
Feb 09
Feb 10
Feb 11
Feb 12
Journey information
Overview: Bus from Greenville, SC to Chicago, IL
Buses from Greenville, SC to Chicago, IL run on average 6 times per day, taking around 18h 40m. Cheap bus tickets for this journey start at $127 (€101) if you book in advance.
The earliest bus runs at 05:25, the last at 23:50. The fastest bus covers the 561 miles (903 km) distance in 20h 35m.
Distance 561 miles (903 km) |
Average bus duration 18h 40m |
Cheapest ticket price $127 (€101) |
Buses per day 6 |
Fastest bus 20h 35m |
First bus 05:25 |
Last bus 23:50 |
FAQs: Bus from Greenville, SC to Chicago, IL
Find answers to the most common questions about traveling from Greenville, SC to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
popular bus stations
Popular bus stations from Greenville, SC to Chicago, IL
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Chicago, IL
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