- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
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The cheapest and fastest buses from Greenville, SC to Chicago, IL
Showing times and prices for Aug 06
Cheapest price
$111
Average price
$128
Fastest journey
19 h 40 m
Average duration
21 h 5 m
Buses per day
6
Distance
903 km
Cheap tickets
The best way to find a cheap bus ticket from Greenville, SC to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Greenville, SC to Chicago, IL will cost around $128 if you buy it on the day, but the cheapest tickets can be found for only $111.
Fast buses
It's difficult to get from Greenville, SC to Chicago, IL without transferring at least once.
· 8:20 PM19h55Greenville, Woodruff Rd ("Raceway" gas station), SC3:15 PMChicago, Greyhound Bus Station$1111One-way1 transfer- +
FlixBus2:45 PM21h45Greenville, Woodruff Rd ("Raceway" gas station), SC11:30 AMChicago, Greyhound Bus Station$1151One-way1 transfer - FlixBus+1:20 PM19h40Greenville, Woodruff Rd ("Raceway" gas station), SC8:00 AMChicago, Union Station (Amtrak), IL$1221One-way1 transfer
- FlixBus+1:20 PM20h05Greenville, Woodruff Rd ("Raceway" gas station), SC8:25 AMChicago, Greyhound Bus Station$1221One-way1 transfer
- · 2:45 PM24h00Greenville, Woodruff Rd ("Raceway" gas station), SC1:45 PMChicago, Union Station (Amtrak), IL$1461One-way1 transfer
- FlixBus+1:20 PM19h40Greenville, Woodruff Rd ("Raceway" gas station), SC8:00 AMChicago, Union Station (Amtrak), IL$1221One-way1 transfer
- · 8:20 PM19h55Greenville, Woodruff Rd ("Raceway" gas station), SC3:15 PMChicago, Greyhound Bus Station$1111One-way1 transfer
- FlixBus+1:20 PM20h05Greenville, Woodruff Rd ("Raceway" gas station), SC8:25 AMChicago, Greyhound Bus Station$1221One-way1 transfer
- +FlixBus2:45 PM21h45Greenville, Woodruff Rd ("Raceway" gas station), SC11:30 AMChicago, Greyhound Bus Station$1151One-way1 transfer
- · 2:45 PM24h00Greenville, Woodruff Rd ("Raceway" gas station), SC1:45 PMChicago, Union Station (Amtrak), IL$1461One-way1 transfer
Journey information
Overview: Bus from Greenville, SC to Chicago, IL
USAUSA
Buses from Greenville, SC to Chicago, IL run on average 7 times per day, taking around 18h 40m. Cheap bus tickets for this journey start at $128 if you book in advance.
The earliest bus runs at 05:25, the last at 23:50. The fastest bus covers the 561 miles (903 km) distance in 19h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 561 miles (903 km) |
Average bus duration 18h 40m |
Cheapest ticket price $128 |
Buses per day 7 |
Fastest bus 19h 40m |
First bus 5:25 AM |
Last bus 11:50 PM |
Cheapest Month Aug |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Greenville, SC to Chicago, IL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:20PM | Arrival Time 08:00AM | Duration 19h40 | Departure days Everyday | Cheapest price $119 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 01:45PM | Duration 24h00 | Departure days Everyday | Cheapest price $117 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 11:30AM | Duration 21h45 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $106 |
Operator Greyhound | Departure Time 08:20PM | Arrival Time 03:15PM | Duration 19h55 | Departure days Everyday | Cheapest price $105 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 08:00AM | Duration 35h25 | Departure days Everyday | Cheapest price $107 |
Live departures
Greenville, SC to Chicago, IL bus times
The table below shows live departures for Greenville, SC to Chicago, IL buses for today, Wednesday, August 5. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus+ | 1:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 20h05 | 8:25 AM Chicago, Greyhound Bus Station | 1 transfer | |
| FlixBus+ | 1:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 19h40 | 8:00 AM Chicago, Union Station (Amtrak), IL | 1 transfer | |
| · | 2:45 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 24h00 | 1:45 PM Chicago, Union Station (Amtrak), IL | 1 transfer | |
| FlixBus+ | 2:45 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 21h45 | 11:30 AM Chicago, Greyhound Bus Station | 1 transfer | |
| · | 8:20 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 19h55 | 3:15 PM Chicago, Greyhound Bus Station | 1 transfer | |
| FlixBus · FlixBus+ | 9:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 27h35 | 12:10 AM Chicago, Greyhound Bus Station | 2 transfers | |
| FlixBus+ · · | 9:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 35h25 | 8:00 AM Chicago, Union Station (Amtrak), IL | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Greenville, SC to Chicago, IL buses with Omio?
Greyhound as well as FlixBus offer buses services from Greenville, SC to Chicago, IL.
Omio is an official ticket reseller for all your travel options from Greenville, SC to Chicago, IL.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Chicago, IL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Greenville, SC to Chicago, IL.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Greenville, SC to Chicago, IL.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Greenville, SC to Chicago, IL.
Bus providers: Greyhound, FlixBus from Greenville, SC to Chicago, ILYou can travel by bus between Greenville, SC to Chicago, IL with Greyhound, FlixBus for as low as $128. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
21h 45m
Cheapest Price
$128
FlixBus frequency
3 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
19h 40m
Cheapest Price
$152
Greyhound frequency
4 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Chicago, IL
Things to do in Chicago, IL
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
- Must visit
Field Museum
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
- Must visit
Museum of Science and Industry
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
- Must visit
Millennium Park
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
- Must visit
Magnificent Mile
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
- Must visit
Chicago Riverwalk
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-Dish Pizza
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
Chicago-Style Hot Dog
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian Beef Sandwich
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Johnnie's Beef
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Superdawg Drive-In
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
Alinea
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
US dollar ($)
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $75+ per person for upscale restaurants.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
FAQs: Bus from Greenville, SC to Chicago, IL
Find answers to the most common questions about traveling from Greenville, SC to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Greenville, SC to Chicago, IL can start from as little as $128 when you book in advance. The average bus ticket price for Greenville, SC to Chicago, IL is $193 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Greenville, SC to Chicago, IL is 19h 40m to travel the 561 miles (903 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Greenville, SC to Chicago, IL leaves at 5:25 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Greenville, SC to Chicago, IL leaves at 11:50 PM.
There are 7 buses a day from Greenville, SC to Chicago, IL which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Greenville, SC to Chicago, IL, you can count on Greyhound, FlixBus for the best way to get you to Chicago, IL. You can also check all possible bus companies who offer a service between Greenville, SC and Chicago, IL and compare the amenities they offer before buying a bus ticket.
When departing from Greenville, SC , you have various bus station options to start your journey from including Greenville, Woodruff Rd ("Raceway" gas station), SC . When arriving in Chicago, IL , you can end your journey in bus stations like Chicago, Greyhound Bus Station, Chicago, Union Station (Amtrak), IL, Chicago, 95th Red Line Station .Passengers board the bus most frequently from Greenville, Woodruff Rd ("Raceway" gas station), SC, which is located around 4 miles (8 km) away from the city centre, and they get off the bus at Chicago, Greyhound Bus Station, located 2 away from the city centre.
It's helpful to compare your options as there are 3 ways to travel between Greenville, SC and Chicago, IL including taking a bus, train, and flight.
Yes, there are bathrooms on board the bus from Greenville, SC to Chicago, IL for bus company Greyhound, FlixBus.
Yes, the following accessibility options are available when taking the bus from Greenville, SC to Chicago, IL:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Greenville, SC to Chicago, IL depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Greenville, SC to Chicago, IL.
Yes, the following luggage options are included when booking a bus ticket from Greenville, SC to Chicago, IL:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Greenville, SC to Chicago, IL:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Greenville, SC to Chicago, IL. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Greenville, SC to Chicago, IL with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Greenville, SC to Chicago, IL with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Greenville, SC to Chicago, IL with the following bus company: Greyhound, FlixBus.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Greenville, SC to Chicago, IL
Most Greenville, SC to Chicago, IL buses use the Greenville, Woodruff Rd ("Raceway" gas station) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Greenville, SC and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Greenville
Arrival bus stations in Chicago
Which Greenville, SC station do buses to Chicago, IL leave from?
Buses from Greenville, SC to Chicago, IL leave from Greenville, Woodruff Rd ("Raceway" gas station). The station is 4 miles (8 km) from Greenville, SC city centre at Woodruff Rd, Greenville, SC, USA.
Greenville, Woodruff Rd ("Raceway" gas station)Woodruff Rd, Greenville, SC, USA
City-centre transport
Getting to Greenville, Woodruff Rd ("Raceway" gas station) from Greenville city centre
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
TRUE
Greenville, Woodruff Rd ("Raceway" gas station) bus station facilities and services
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Limited dining options available in adjacent areas.
Wi-Fi and ATMs
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Tickets and information
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Parking, taxis and toilets
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Which Chicago, IL station do buses from Greenville, SC arrive at?
Buses from Greenville, SC to Chicago, IL most often arrive at Chicago, Greyhound Bus Station. Some services arrive at Chicago, Union Station (Amtrak), so check your ticket before travel to confirm your Chicago, IL arrival station.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USA
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Bus7 · 8m · $4 · every ~6 min
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak)Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USA
City-centre transport
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Bus28, 151 · 7m · $4 · every ~13 min
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Chicago, 95th Red Line Station95th Red Line Station, Chicago, IL 60620, USA
City-centre transport
Getting to Chicago, 95th Red Line Station from Chicago city centre
Chicago, 95th Red Line Station is 14 km from Chicago city centre. Public transport options include:
BusGreyhound US0100 · 20m · $2
29 · 47m · $4 · every ~11 min
29 · 48m · $4 · every ~11 min
SubwayRed Line · 24m · $6 · every ~23 min
Red Line · 25m · $6 · every ~23 min
Chicago, 95th Red Line Station bus station facilities and services
Chicago, 95th Red Line Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Chicago, 95th Red Line Station. ATMs are available at Chicago, 95th Red Line Station.
Tickets and information
Ticket office support is available at Chicago, 95th Red Line Station.
Parking, taxis and toilets
Available at Chicago, 95th Red Line Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, 95th Red Line Station: Wheelchair accessible entrances available.
Most popular bus connections from Greenville, SC
More options for your journey from Greenville, SC to Chicago, IL
Here are some other resources that might have the information you need
Most popular buses to and from Chicago, IL and Greenville, SC
Most popular bus connections to Chicago, IL
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