- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Cheapest price on Aug 29
zł148
Average ticket price on Aug 29
zł171
Fastest journey on Aug 29
4 h 25 m
Average journey duration on Aug 29
5 h 21 m
Buses on Aug 29
4
Distance
370 km
The best way to find a cheap bus ticket from St. Louis, MO to Indianapolis, IN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Indianapolis, IN will cost around zł171 if you buy it on the day, but the cheapest tickets can be found for only zł148.
On Sat, Aug 29, we found 4 buses from St. Louis, MO to Indianapolis, IN, including 3 direct services.
On Sat, Aug 29 the direct buses cover the 370 km distance in an average of 5 h 21 m but if you time it right, some buses will get you there in just 4 h 25 m .
On Sat, Aug 29 the slowest buses will take 7 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.



FlixBus+



FlixBus+
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Indianapolis, IN among Omio's users. If you are prioritising price, take the bus, with an average ticket price of zł205 For those with little time, consider booking a bus, which has an average total journey time of 5h 7m. Average ticket prices depend on the travel mode: a bus costs an average of zł205, while a flight costs an average of zł2438.
Distance: 229 miles (370 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
zł205 Average price Cheapest | zł2438 Average price | zł1132 Average price | zł187 Average price (fuel + tolls) |
5h 7m Average total duration Fastest 4h 37m Onboard + 30m Additional time* | 6h 2m Average total duration 4h 2m Onboard + 2h 0m Additional time* | 11h 2m Average total duration 10h 32m Onboard + 30m Additional time* | 3h 39m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from St. Louis, MO to Indianapolis, IN:
A bus is zł927 less than a train for this route with tickets for a train from St. Louis, MO to Indianapolis, IN costing on average zł1132.
A bus is zł2233 less than a flight for this route with tickets for a flight from St. Louis, MO to Indianapolis, IN costing on average zł2438.
Other travel options to Indianapolis, IN take longer:
Bus takes on average 4h 37m.
Train takes on average 10h 32m.
You'll arrive about -1h -58m sooner (4h 37m by bus vs 3h 39m by car) and save roughly zł-17.78 compared to fuel and tolls (zł205 vs zł187). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by Greyhound.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 07:30AM | Duration 4h30 | Departure days Everyday | Cheapest price zł120 |
Operator Amtrak | Departure Time 06:35AM | Arrival Time 07:50PM | Duration 12h15 | Departure days Wed | Cheapest price zł329 |
Operator Greyhound | Departure Time 08:45AM | Arrival Time 02:30PM | Duration 4h45 | Departure days Everyday | Cheapest price zł120 |
Operator FlixBus | Departure Time 10:00AM | Arrival Time 06:45PM | Duration 7h45 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price zł243 |
Operator Greyhound | Departure Time 01:55PM | Arrival Time 07:20PM | Duration 4h25 | Departure days Thu | Cheapest price zł148 |
Operator Greyhound | Departure Time 02:05PM | Arrival Time 07:30PM | Duration 4h25 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price zł122 |
The table below shows live departures for St. Louis, MO to Indianapolis, IN buses for today, Friday, August 28. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+![]() | 10:00 AM St. Louis, S 15th St (Civic center) | 7h45 | 6:45 PM Indianapolis, Illinois St (Greyhound Bus Station) | 1 transfer | |
![]() | 2:05 PM St. Louis, S 15th St (Civic center) | 4h25 | 7:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 0 transfersDirect | |
| Saturday, August 29 | |||||
![]() | 2:00 AM St. Louis, S 15th St (Civic center) | 4h30 | 7:30 AM Indianapolis, Illinois St (Greyhound Bus Station) | 0 transfersDirect | |
![]() | 8:45 AM St. Louis, S 15th St (Civic center) | 4h45 | 2:30 PM Indianapolis, Illinois St (Greyhound Bus Station) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from St. Louis, MO to Indianapolis, IN run on average 3 times per day, taking around 4h 37m. Cheap bus tickets for this journey start at zł118 if you book in advance.
There are 3 buses per day. The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 229 miles (370 km) distance in 4h 25m.
Distance 229 miles (370 km) |
Average bus duration 4h 37m |
Cheapest ticket price zł118 |
Buses per day 3 |
Direct buses 3 |
Fastest bus 4h 25m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Nov |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Mon |
Least Busy Day Tue |
Best time to book 35 days |
Discover the best of Indianapolis, IN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis, IN trip today.
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
Find answers to the most common questions about traveling from St. Louis, MO to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

Most St. Louis, MO to Indianapolis, IN buses use the St. Louis, S 15th St (Civic center) to Indianapolis, Illinois St (Greyhound Bus Station) station pair, with some services arriving at Indianapolis, E Washington St / N Delaware St (City/County Building). Use this guide to compare St. Louis, MO and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Fast food outlets are available.
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
Indianapolis, E Washington St / N Delaware St (City/County Building) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Indianapolis, E Washington St / N Delaware St (City/County Building). ATMs are available at Indianapolis, E Washington St / N Delaware St (City/County Building).
Ticket office support is available at Indianapolis, E Washington St / N Delaware St (City/County Building).
Available at Indianapolis, E Washington St / N Delaware St (City/County Building): Parking, Taxis, WC.
Accessibility facilities are available at Indianapolis, E Washington St / N Delaware St (City/County Building): Wheelchair accessible buses available.
Here are some other resources that might have the information you need