- Must visit
Des Moines Art Center
Leading art museum with strong American, contemporary, and decorative arts collections, plus a sculpture park just outside downtown.
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The cheapest and fastest buses from St. Louis, MO to Des Moines, IA
Showing times, prices and bookable tickets for Oct 13
Cheapest price on Oct 13
$63
Average ticket price on Oct 13
$88
Fastest journey on Oct 13
8 h 30 m
Average journey duration on Oct 13
10 h 37 m
Buses on Oct 13
3
Distance
440 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Des Moines, IA will cost around $88 if you buy it on the day, but the cheapest tickets can be found for only $63.
Fast buses
On Tue, Oct 13, we found 3 buses from St. Louis, MO to Des Moines, IA, including 1 direct services.
On Tue, Oct 13 the direct buses cover the 440 km distance in an average of 10 h 37 m but if you time it right, some buses will get you there in just 8 h 30 m .
On Tue, Oct 13 the slowest buses will take 12 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:35 PM8h30St. Louis, S 15th St (Civic center)11:05 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$631One-way0 transfers
FlixBus+10:00 AM12h05St. Louis, S 15th St (Civic center)10:05 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$1011One-way1 transfer- · 12:30 PM11h15St. Louis, S 15th St (Civic center)11:45 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$1011One-way1 transfer
- 2:35 PM8h30St. Louis, S 15th St (Civic center)11:05 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$631One-way0 transfers
- · 12:30 PM11h15St. Louis, S 15th St (Civic center)11:45 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$1011One-way1 transfer
- FlixBus+10:00 AM12h05St. Louis, S 15th St (Civic center)10:05 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$1011One-way1 transfer
Journey information
Overview: Bus from St. Louis, MO to Des Moines, IA
USAUSA
Buses from St. Louis, MO to Des Moines, IA run on average 2 times per day, taking around 10h 51m. Cheap bus tickets for this journey start at $49 if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:30, the last at 23:30. The fastest bus covers the 273 miles (440 km) distance in 1h 55m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 273 miles (440 km) |
Average bus duration 10h 51m |
Cheapest ticket price $49 |
Buses per day 2 |
Direct buses 1 |
Fastest bus 1h 55m |
First bus 5:30 AM |
Last bus 11:30 PM |
Cheapest Month Aug |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 1 day |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
St. Louis, MO to Des Moines, IA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:00AM | Arrival Time 10:05PM | Duration 20h05 | Departure days Wed | Cheapest price $93 |
Operator Greyhound | Departure Time 10:00AM | Arrival Time 10:05PM | Duration 12h05 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $86 |
Operator Greyhound | Departure Time 12:30PM | Arrival Time 11:45PM | Duration 11h15 | Departure days Tue, Wed, Sat | Cheapest price $91 |
Operator Greyhound | Departure Time 02:35PM | Arrival Time 11:05PM | Duration 8h30 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $55 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 02:35PM | Duration 15h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $81 |
Live departures
St. Louis, MO to Des Moines, IA bus times
The table below shows live departures for St. Louis, MO to Des Moines, IA buses for today, Monday, October 12. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 2:35 PM St. Louis, S 15th St (Civic center) | 8h30 | 11:05 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 0 transfersDirect | |
| FlixBus+ | 11:30 PM St. Louis, S 15th St (Civic center) | 15h05 | 2:35 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 1 transfer | |
| Tuesday, October 13 | |||||
| FlixBus+ | 10:00 AM St. Louis, S 15th St (Civic center) | 12h05 | 10:05 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book St. Louis, MO to Des Moines, IA buses with Omio?
Greyhound as well as Infobus offer buses services from St. Louis, MO to Des Moines, IA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to Des Moines, IA.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of Infobus to find the best option for your trip from St. Louis, MO to Des Moines, IA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Des Moines, IA.
Why book with Omio over Wanderu, Busbud or Checkmybus?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from St. Louis, MO to Des Moines, IA.
Bus providers: Greyhound, Infobus from St. Louis, MO to Des Moines, IAYou can travel by bus between St. Louis, MO to Des Moines, IA with Greyhound, Infobus for as low as $49. When you search for schedules and tickets, Omio will show you the best journey
Infobus
About
Infobus is an international IT company that operates as an online service for finding and purchasing bus, train, and plane tickets, rather than being a bus company itself. Established in 2002, Infobus acts as an intermediary between passengers and various transport carriers, particularly helping smaller bus companies offer online booking services. They utilize their own "BusSystem" to manage routes and ticket sales globally. Infobus covers over 30 countries and 300 cities, offering a wide range of routes and daily departures. While amenities can vary by carrier, Infobus aims to provide affordable and convenient travel with features like online booking, 24/7 support, and prompt notifications.
Luggage & cancellation policy
Average Infobus Duration
1h 55m
Cheapest Infobus Price
$128
Infobus frequency
1 a day
Luggage included
One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
Additional luggage
10€ per additional bag.
Cancellation Policy
You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Transport for wheelchairs and mobility aids.
Bikes
Bikes are allowed; may require prior reservation and an additional fee.
Pets
Small pets allowed in carriers; larger pets may require a separate ticket.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
8h 25m
Cheapest Greyhound Price
$49
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Des Moines, IA
Things to do in Des Moines, IA
Discover the best of Des Moines, IA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Des Moines, IA trip today.
- Recommended
State Historical Museum of Iowa
Compact state museum covering Iowa history, culture, and artifacts. A practical stop for visitors wanting context before exploring the city.
- Recommended
Science Center of Iowa
Science museum with interactive exhibits, a planetarium, and hands-on displays suited to families and curious adults alike.
- Must visit
John and Mary Pappajohn Sculpture Park
A 4.4-acre downtown sculpture park with major contemporary works, open lawns, and easy walking access to nearby restaurants and museums.
- Recommended
East Village
Historic neighborhood east of the river with indie shops, murals, nightlife, and restored buildings. Ideal for an easy local walk.
- Recommended
Gray's Lake Park
Large urban park with wooded trails, picnic areas, a lake, and river views. A favorite local green escape close to downtown.
Pork Tenderloin Sandwich
Iowa pork tenderloin sandwich features a thin, breaded pork cutlet fried and served on a bun. It is a classic Iowa diner specialty known for its oversized cutlet.
Loose Meat Sandwich
Loose meat sandwich is seasoned ground beef served warm on a bun without being formed into a patty. It is a longtime Iowa lunch-counter staple.
- Vegetarian
- Vegan
- Gluten-free
Iowa Sweet Corn
Sweet corn is a signature Iowa summer food, prized for its sweetness and freshness. It is commonly boiled or grilled at fairs, cookouts, and family meals.
Des Moines Downtown Farmers' Market
Historic market hall with multiple local food vendors, ideal for sampling regional snacks, coffee, craft beer, and casual meals.
Smitty's Tenderloin Shop
Casual local favorite for the classic Iowa breaded pork tenderloin sandwich, plus burgers and comfort food in a laid-back setting.
Smokey D's BBQ
Long-running smokehouse known for Iowa-style barbecue, ribs, brisket, and hearty sides in a relaxed neighborhood atmosphere.
US Dollar ($)
Moderate for US city breaks; hotels and dining are usually cheaper than larger US metros, while car use can add transport costs.
Average meal costs
- Budget
- $10-15 for fast food or a casual meal.
- Mid-range
- $20-35 per person for a restaurant meal.
- Fine dining
- $50+ per person for upscale dining.
- Coffee
- $3-6 for coffee or a cappuccino.
Tipping culture
Tip 15-20% at restaurants, $1-2 per drink at bars, round up or add 10-15% for taxis, and tip a little at cafes only if table service is provided.
FAQs: Bus from St. Louis, MO to Des Moines, IA
Find answers to the most common questions about traveling from St. Louis, MO to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to Des Moines, IA can start from as little as $49 when you book in advance. The average bus ticket price for St. Louis, MO to Des Moines, IA is $94 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to Des Moines, IA is 1h 55m to travel the 273 miles (440 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to Des Moines, IA leaves at 5:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to Des Moines, IA leaves at 11:30 PM.
Yes, there are 1 direct buses a day from St. Louis, MO to Des Moines, IA with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from St. Louis, MO to Des Moines, IA, you can count on Greyhound, Infobus for the best way to get you to Des Moines, IA. You can also check all possible bus companies who offer a service between St. Louis, MO and Des Moines, IA and compare the amenities they offer before buying a bus ticket.
When departing from St. Louis, MO , you have various bus station options to start your journey from including St. Louis, S 15th St (Civic center), St. Louis, MO . When arriving in Des Moines, IA , you can end your journey in bus stations like Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA, Des Moines, Grand Ave & 10th St .Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around away from the city centre, and they get off the bus at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA, located 3 away from the city centre.
It's helpful to compare your options as there are 2 ways to travel between St. Louis, MO and Des Moines, IA including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to Des Moines, IA:
- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to Des Moines, IA for bus company Greyhound, Infobus.
Whether you can cancel your bus ticket from St. Louis, MO to Des Moines, IA depends on the bus companies:
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound, Infobus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to Des Moines, IA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to Des Moines, IA:
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to Des Moines, IA:
- Infobus
- 10€ per additional bag.
- Greyhound
- $15 per additional bag.
Yes, you can bring your pet on the bus from St. Louis, MO to Des Moines, IA. The following conditions apply:
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
You can reserve your seat on the bus from St. Louis, MO to Des Moines, IA with the following bus company: Greyhound, Infobus
Yes, there are USB plugs on board the bus from St. Louis, MO to Des Moines, IA with the following bus company: Greyhound, Infobus.
Yes, there is Wifi on board the bus from St. Louis, MO to Des Moines, IA with the following bus company: Greyhound, Infobus.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Des Moines, IA, travelers should be cautious of pickpocketing and occasional vehicle break-ins, especially in crowded areas and parking lots. Common scams include fake ticket sellers for local events and unofficial ride services. Staying alert in busy downtown spots and using authorized transportation options helps ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to Des Moines, IA
Most St. Louis, MO to Des Moines, IA buses use the St. Louis, S 15th St (Civic center) to Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) station pair, with some services arriving at Des Moines, Grand Ave & 10th St. Use this guide to compare St. Louis, MO and Des Moines, IA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in Des Moines
Which St. Louis, MO station do buses to Des Moines, IA leave from?
Buses from St. Louis, MO to Des Moines, IA leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
St. LouisSt. Louis, MO, USA
City-centre transport
Getting to St. Louis from St. Louis city centre
TRUE
St. Louis bus station facilities and services
St. Louis has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: There are food vendors in the station.
Wi-Fi and ATMs
Free wifi is available in the waiting area. ATMs are aTM available near the entrance.
Tickets and information
Ticket office support is available at St. Louis.
Parking, taxis and toilets
Available at St. Louis: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis: The station is accessible to wheelchairs.
Which Des Moines, IA station do buses from St. Louis, MO arrive at?
Buses from St. Louis, MO to Des Moines, IA most often arrive at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). Some services arrive at Des Moines, Grand Ave & 10th St, so check your ticket before travel to confirm your Des Moines, IA arrival station.
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.)1625 E Euclid Ave, Des Moines, IA 50313, USA
City-centre transport
Getting to Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) from Des Moines city centre
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) is 3 km from Des Moines city centre. Public transport options include:
TRUE
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) bus station facilities and services
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). ATMs are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Tickets and information
Ticket office support is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Parking, taxis and toilets
Available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Wheelchair accessible buses available.
Des Moines, Grand Ave & 10th St10th St & Grand Ave, Des Moines, IA 50309, USA
City-centre transport
Getting to Des Moines, Grand Ave & 10th St from Des Moines city centre
Des Moines, Grand Ave & 10th St is 2 km from Des Moines city centre. Public transport options include:
TRUE
Des Moines, Grand Ave & 10th St bus station facilities and services
Des Moines, Grand Ave & 10th St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Des Moines, Grand Ave & 10th St. ATMs are available at Des Moines, Grand Ave & 10th St.
Tickets and information
Ticket office support is available at Des Moines, Grand Ave & 10th St.
Parking, taxis and toilets
Available at Des Moines, Grand Ave & 10th St: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Des Moines, Grand Ave & 10th St: Accessible for passengers with limited mobility.
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Des Moines, IA
Here are some other resources that might have the information you need
Most popular buses to and from Des Moines, IA and St. Louis, MO
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