4.9
4.6The cheapest and fastest buses from St. Louis, MO to Des Moines, IA
Cheapest price
$64
Average price
$80
Fastest journey
8 h 25 m
Average duration
11 h 45 m
Buses per day
2
Distance
440 km
The best way to find a cheap bus ticket from St. Louis, MO to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Des Moines, IA will cost around $80 if you buy it on the day, but the cheapest tickets can be found for only $64.
Of the 2 buses that leave St. Louis, MO for Des Moines, IA on Wed, Jul 15, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jul 15 the direct buses cover the 440 km distance in an average of 11 h 45 m but if you time it right, some buses will get you there in just 8 h 25 m .
On Wed, Jul 15 the slowest buses will take 15 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
3:20 PM8h25St. Louis, S 15th St (Civic center)11:45 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$641One-way0 transfers
FlixBus+11:30 PM15h05St. Louis, S 15th St (Civic center)2:35 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$961One-way1 transfer
- 3:20 PM8h25St. Louis, S 15th St (Civic center)11:45 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$641One-way0 transfers
- FlixBus+11:30 PM15h05St. Louis, S 15th St (Civic center)2:35 PMDes Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA$961One-way1 transfer
Travel Information
Compare bus and flight for St. Louis, MO to Des Moines, IA
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Des Moines, IA among Omio's users. If you are prioritising price take the bus with prices starting from $70. For those with little time consider booking a flight which can get you there in 3h 22m. The ticket price range depends on the travel mode: a bus costs an average of $70, and a flight costs an average of $163.
Distance: 273 miles (440 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$109 Average price Cheapest | $347 Average price | $67 Average price (fuel + tolls) |
9h 32m Average total duration 9h 2m Onboard + 30m Additional time* | 6h 22m Average total duration Fastest 3h 22m Onboard + 3h 0m Additional time* | 5h 26m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from St. Louis, MO to Des Moines, IA:
A bus is $238 (€196) less than a flight for this route with tickets for a flight from St. Louis, MO to Des Moines, IA costing on average $347 (€286).
Other travel options to Des Moines, IA take longer:
Bus takes on average 9h 2m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
St. Louis, MO to Des Moines, IA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Infobus | Departure Time 09:00AM | Arrival Time 06:10PM | Duration 9h10 | Departure days Mon, Thu | Cheapest price $138 |
Operator Greyhound | Departure Time 03:20PM | Arrival Time 11:45PM | Duration 8h25 | Departure days Everyday | Cheapest price $52 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 02:35PM | Duration 15h05 | Departure days Everyday | Cheapest price $75 |
Live departures
St. Louis, MO to Des Moines, IA bus times
The table below shows live departures for St. Louis, MO to Des Moines, IA buses for today, Tuesday, July 14. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 3:20 PM St. Louis, S 15th St (Civic center) | 8h25 | 11:45 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 0 transfersDirect | |
| FlixBus+ | 11:30 PM St. Louis, S 15th St (Civic center) | 15h05 | 2:35 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Des Moines, IA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jul 15
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Jul 17
Jul 18
Jul 19
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Jul 21
Why should you book St. Louis, MO to Des Moines, IA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Des Moines, IA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from St. Louis, MO to Des Moines, IA.
Journey information
Overview: Bus from St. Louis, MO to Des Moines, IA
USAUSA
Buses from St. Louis, MO to Des Moines, IA run on average 1 times per day, taking around 9h 2m. Cheap bus tickets for this journey start at $70 (€57) if you book in advance.
The earliest bus runs at 05:30, the last at 23:30. The fastest bus covers the 273 miles (440 km) distance in 8h 25m.
Distance 273 miles (440 km) |
Average bus duration 9h 2m |
Cheapest ticket price $70 (€57) |
Buses per day 1 |
Fastest bus 8h 25m |
First bus 5:30 AM |
Last bus 11:30 PM |
Cheapest Month Aug |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Bus providers: Greyhound from St. Louis, MO to Des Moines, IAYou can travel by bus between St. Louis, MO to Des Moines, IA with Greyhound for as low as $70 (€57). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from St. Louis, MO to Des Moines, IA
Find answers to the most common questions about traveling from St. Louis, MO to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from St. Louis, MO to Des Moines, IA
Most St. Louis, MO to Des Moines, IA buses use the St. Louis, S 15th St (Civic center) to station pair. Use this guide to compare St. Louis, MO and Des Moines, IA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Des Moines, IA
Here are some other resources that might have the information you need
Most popular buses to and from Des Moines, IA and St. Louis, MO
Most popular bus connections to Des Moines, IA
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