4.9
4.6The cheapest and fastest buses from St. Louis, MO to Des Moines, IA
Cheapest price on Aug 30
$163
Average ticket price on Aug 30
$163
Fastest journey on Aug 30
15 h 5 m
Average journey duration on Aug 30
15 h 5 m
Buses on Aug 30
1
Distance
440 km
The best way to find a cheap bus ticket from St. Louis, MO to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Des Moines, IA will cost around $163 if you buy it on the day, but the cheapest tickets can be found for only $163.
On Sun, Aug 30, we found 1 buses from St. Louis, MO to Des Moines, IA, including 1 direct services.
On Sun, Aug 30 the direct buses cover the 440 km distance in an average of 15 h 5 m but if you time it right, some buses will get you there in just 15 h 5 m .
On Sun, Aug 30 the slowest buses will take 15 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
5:30 AM15h05St. Louis, MO8:35 PMDes Moines, IA$1631One-way0 transfers
- 5:30 AM15h05St. Louis, MO8:35 PMDes Moines, IA$1631One-way0 transfers
Travel Information
Compare bus and flight for St. Louis, MO to Des Moines, IA
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Des Moines, IA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $66 For those with little time, consider booking a flight, which has an average total journey time of 5h 22m. Average ticket prices depend on the travel mode: a bus costs an average of $66, while a flight costs an average of $282.
Distance: 273 miles (440 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$66 Average price Cheapest | $282 Average price | $70 Average price (fuel + tolls) |
9h 19m Average total duration 8h 49m Onboard + 30m Additional time* | 5h 22m Average total duration Fastest 3h 22m Onboard + 2h 0m Additional time* | 5h 26m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from St. Louis, MO to Des Moines, IA:
A bus is $216 (€174) less than a flight for this route with tickets for a flight from St. Louis, MO to Des Moines, IA costing on average $282 (€227).
Other travel options to Des Moines, IA take longer:
Bus takes on average 8h 49m.
Tickets start at around $66 (€53) compared to roughly $70 (€56) in fuel and tolls — a saving of about $4 (€3). The journey takes 8h 49m versus 5h 26m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Greyhound.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
St. Louis, MO to Des Moines, IA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:30AM | Arrival Time 08:35PM | Duration 15h05 | Departure days Sun | Cheapest price $163 |
Operator Greyhound | Departure Time 10:00AM | Arrival Time 10:05PM | Duration 12h05 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $84 |
Operator Greyhound | Departure Time 02:35PM | Arrival Time 11:05PM | Duration 8h30 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $56 |
Operator Greyhound | Departure Time 11:30PM | Arrival Time 02:35PM | Duration 15h05 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $86 |
Live departures
St. Louis, MO to Des Moines, IA bus times
The table below shows live departures for St. Louis, MO to Des Moines, IA buses for today, Friday, August 28. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 FlixBus+ | 10:00 AM St. Louis, S 15th St (Civic center) | 12h05 | 10:05 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 1 transfer | |
| 2:35 PM St. Louis, S 15th St (Civic center) | 8h30 | 11:05 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 0 transfersDirect | |
| FlixBus+ | 11:30 PM St. Louis, S 15th St (Civic center) | 15h05 | 2:35 PM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 1 transfer | |
| Saturday, August 29 | |||||
| 5:30 AM St. Louis, MO | 15h05 | 8:35 PM Des Moines, IA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Des Moines, IA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Aug 29
Aug 30
Aug 31
Sep 01
Sep 02
Sep 03
Sep 04
Sep 05
Sep 06
Sep 07
Sep 08
Sep 09
Sep 10
Sep 11
Why should you book St. Louis, MO to Des Moines, IA buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of Infobus to find the best option for your trip from St. Louis, MO to Des Moines, IA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Des Moines, IA.
Why book with Omio over Wanderu, Busbud or Checkmybus?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from St. Louis, MO to Des Moines, IA.
Journey information
Overview: Bus from St. Louis, MO to Des Moines, IA
USAUSA
Buses from St. Louis, MO to Des Moines, IA run on average 2 times per day, taking around 8h 49m. Cheap bus tickets for this journey start at $51 (€41) if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:30, the last at 23:30. The fastest bus covers the 273 miles (440 km) distance in 8h 25m.
Distance 273 miles (440 km) |
Average bus duration 8h 49m |
Cheapest ticket price $51 (€41) |
Buses per day 2 |
Direct buses 1 |
Fastest bus 8h 25m |
First bus 5:30 AM |
Last bus 11:30 PM |
Cheapest Month Aug |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 1 day |
Bus providers: Greyhound, Infobus from St. Louis, MO to Des Moines, IAYou can travel by bus between St. Louis, MO to Des Moines, IA with Greyhound, Infobus for as low as $51 (€41). When you search for schedules and tickets, Omio will show you the best journey
Infobus
Greyhound
FAQs: Bus from St. Louis, MO to Des Moines, IA
Find answers to the most common questions about traveling from St. Louis, MO to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.
- Infobus
- Assistance
- Priority seating
- Transport for wheelchairs and mobility aids.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Infobus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Infobus
- One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Infobus
- 10€ per additional bag.
- Greyhound
- $15 per additional bag.
- Infobus
- Small pets allowed in carriers
- larger pets may require a separate ticket.
popular bus stations
Popular bus stations from St. Louis, MO to Des Moines, IA
Most St. Louis, MO to Des Moines, IA buses use the St. Louis, S 15th St (Civic center) to Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) station pair, with some services arriving at Des Moines, Grand Ave & 10th St. Use this guide to compare St. Louis, MO and Des Moines, IA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which St. Louis, MO station do buses to Des Moines, IA leave from?
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Getting to St. Louis from St. Louis city centre
St. Louis bus station facilities and services
St. Louis has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: There are food vendors in the station.
Wi-Fi and ATMs
Free wifi is available in the waiting area. ATMs are aTM available near the entrance.
Tickets and information
Ticket office support is available at St. Louis.
Parking, taxis and toilets
Available at St. Louis: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis: The station is accessible to wheelchairs.
Which Des Moines, IA station do buses from St. Louis, MO arrive at?
Getting to Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) from Des Moines city centre
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) is 3 km from Des Moines city centre. Public transport options include:
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) bus station facilities and services
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). ATMs are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Tickets and information
Ticket office support is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Parking, taxis and toilets
Available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Wheelchair accessible buses available.
Getting to Des Moines, Grand Ave & 10th St from Des Moines city centre
Des Moines, Grand Ave & 10th St is 2 km from Des Moines city centre. Public transport options include:
Des Moines, Grand Ave & 10th St bus station facilities and services
Des Moines, Grand Ave & 10th St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Des Moines, Grand Ave & 10th St. ATMs are available at Des Moines, Grand Ave & 10th St.
Tickets and information
Ticket office support is available at Des Moines, Grand Ave & 10th St.
Parking, taxis and toilets
Available at Des Moines, Grand Ave & 10th St: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Des Moines, Grand Ave & 10th St: Accessible for passengers with limited mobility.
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Des Moines, IA
Here are some other resources that might have the information you need
Most popular buses to and from Des Moines, IA and St. Louis, MO
Most popular bus connections to Des Moines, IA
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
