Travel Information
Compare bus and flight for St. Louis, MO to Des Moines, IA
Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Des Moines, IA among Omio's users. If you are prioritising price take the bus with prices starting from €75. For those with little time consider booking a flight which can get you there in 3h 22m. The ticket price range depends on the travel mode: a bus costs an average of €75, and a flight costs an average of €70.
Distance: 273 miles (440 km)
Compare flight with
Most popular Flight | Bus |
|---|---|
€227 Average price | €114 Average price Cheapest |
6h 22m Average total duration Fastest 3h 22m Onboard + 3h 0m Additional time* | 15h 30m Average total duration 15h 0m Onboard + 30m Additional time* |
![]() Most popular airline | ![]() Most popular bus company |
Direct Options | Direct Options |
Compare prices and tickets St. Louis, MO to Des Moines, IA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Train from St. Louis, MO to Des Moines, IA
Take a train from St. Louis, MO to Des Moines, IA and enjoy the approximately 273 miles (440 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
Distance 273 miles (440 km) |
FAQs: Trains from St. Louis, MO to Des Moines, IA
Find answers to the most common questions about traveling from St. Louis, MO to Des Moines, IA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

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