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Compare prices and tickets St. Louis, MO to Des Moines, IA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Train from St. Louis, MO to Des Moines, IA
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $170 (€138)
Distance 273 miles (440 km) |
Key Takeaways
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $170 (€138)
FAQs: Trains from St. Louis, MO to Des Moines, IA
Find answers to the most common questions about traveling from St. Louis, MO to Des Moines, IA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

Typically, spending 2 to 3 days in Des Moines, IA, allows visitors to explore major attractions such as the State Capitol, the Des Moines Art Center, and the Pappajohn Sculpture Park, while also enjoying local dining and entertainment.
The cheapest way to get from St. Louis, MO to Des Moines, IA is by bus, with a cost of around $170 (€138).
The train journey from St. Louis, MO to Des Moines, IA offers a mix of urban and rural scenery, including views of rolling farmlands, small towns, and sections of the Mississippi River, providing a pleasant, although not particularly dramatic, visual experience.
Unfortunately, there is no night train available from St. Louis, MO to Des Moines, IA.
The distance by train from St. Louis, MO to Des Moines, IA is 273 miles (440 km).
No, you cannot take the train from St. Louis, MO to Des Moines, IA.
Most popular train connections from St. Louis, MO
More options for your journey from St. Louis, MO to Des Moines, IA
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