St. Louis, MO to Des Moines, IA train

Fri, Feb 06
+ Add return
Deutsche Bahn
Regionale
iryo
Ouigo
Italo
1,000+ travel companies
Deutsche Bahn
Regionale
iryo
Ouigo
Italo
1,000+ travel companies
QR-Code
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
rate4.9
42K ratings
Google Play
rate4.6
136K reviews

Travel Information

Compare bus and flight for St. Louis, MO to Des Moines, IA

Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Des Moines, IA among Omio's users. If you are prioritising price take the bus with prices starting from €75. For those with little time consider booking a flight which can get you there in 3h 22m. The ticket price range depends on the travel mode: a bus costs an average of €75, and a flight costs an average of €70.

Distance: 273 miles (440 km)

Compare flight with

Most popular
Flight
Bus

€227

Average price

€114

Average price

Cheapest

6h 22m

Average total duration

Fastest

3h 22m

Onboard

+

3h 0m

Additional time*

15h 30m

Average total duration

15h 0m

Onboard

+

30m

Additional time*

Republic Airlines

Most popular airline

Greyhound

Most popular bus company

Direct Options

Direct Options

Compare prices and tickets St. Louis, MO to Des Moines, IA by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Fri
Feb 06
Sat
Feb 07
Sun
Feb 08
Mon
Feb 09
Tue
Feb 10
Wed
Feb 11
Thu
Feb 12

Journey information

Overview: Train from St. Louis, MO to Des Moines, IA

USAUSA
USAUSA
Icon of train

Take a train from St. Louis, MO to Des Moines, IA and enjoy the approximately 273 miles (440 km) long journey. Find schedules and pricing options for a convenient and affordable trip.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $87 (€70)
Distance
273 miles (440 km)
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $87 (€70)

FAQs: Trains from St. Louis, MO to Des Moines, IA

Find answers to the most common questions about traveling from St. Louis, MO to Des Moines, IA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

FAQs
The distance by train from St. Louis, MO to Des Moines, IA is 273 miles (440 km).
Unfortunately, there is no night train available from St. Louis, MO to Des Moines, IA.
The cheapest way to get from St. Louis, MO to Des Moines, IA is by flight, with a cost of around $87 (€70).
The train journey from St. Louis, MO to Des Moines, IA offers a mix of urban and rural scenery, including views of rolling farmlands, small towns, and sections of the Mississippi River, providing a pleasant, although not particularly dramatic, visual experience.
Typically, spending 2 to 3 days in Des Moines, IA, allows visitors to explore major attractions such as the State Capitol, the Des Moines Art Center, and the Pappajohn Sculpture Park, while also enjoying local dining and entertainment.
No, you cannot take the train from St. Louis, MO to Des Moines, IA.

Most popular train connections to Des Moines, IA

HomeTrainsTrains in USATrain Times to Des Moines, IASt. Louis, MO to Des Moines, IA train

The Omio App Makes Travel Planning Easy

We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.

ios-badge
android-badge
Hand With Phone