- Must visit
Des Moines Art Center
Major modern and contemporary art museum with notable architecture and a strong permanent collection. A top cultural stop in the city.
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The cheapest and fastest buses from San Diego, CA to Des Moines, IA
Showing times and prices for May 28
Cheapest price
$238
Average price
$238
Fastest journey
1 d 17 h 45 m
Average duration
1 d 17 h 45 m
Buses per day
1
Distance
2299 km
Cheap tickets
The best way to find a cheap bus ticket from San Diego, CA to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Diego, CA to Des Moines, IA will cost around $238 if you buy it on the day, but the cheapest tickets can be found for only $238.
Fast buses
Of the 1 buses that leave San Diego, CA for Des Moines, IA on Thu, May 28, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, May 28 the direct buses cover the 2299 km distance in an average of 1 d 17 h 45 m but if you time it right, some buses will get you there in just 1 d 17 h 45 m .
On Thu, May 28 the slowest buses will take 1 d 17 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
8:10 PM41h45San Diego, CA1:55 PMDes Moines, IA$2381One-way0 transfers
- 8:10 PM41h45San Diego, CA1:55 PMDes Moines, IA$2381One-way0 transfers
Travel Information
Compare bus and flight for San Diego, CA to Des Moines, IA
Omio recommends booking the flight as it is the most popular option from San Diego, CA to Des Moines, IA among Omio's users. If you are prioritising price take the bus with prices starting from $238. For those with little time consider booking a flight which can get you there in 3h 49m. The ticket price range depends on the travel mode: a bus costs an average of $238, and a flight costs an average of $607.
Distance: 1428 miles (2299 km)
Compare bus with
| Bus | Most popular Flight | Driving |
|---|---|---|
$238 Average price Cheapest | $607 Average price | $359 Average price (fuel + tolls) |
62h 0m Average total duration 61h 30m Onboard + 30m Additional time* | 6h 49m Average total duration Fastest 3h 49m Onboard + 3h 0m Additional time* | 25h 7m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from San Diego, CA to Des Moines, IA is a bus with an average price of $238 (€192).
This is compared to other travel options from San Diego, CA to Des Moines, IA:
A bus is $369 (€298) less than a flight for this route with tickets for a flight from San Diego, CA to Des Moines, IA costing on average $607 (€490).
The fastest way to travel from San Diego, CA to Des Moines, IA is by flight with an average journey time of 3h 49m.
Other travel options to Des Moines, IA take longer:
Bus takes on average 61h 30m.
It's helpful to compare your options as there are 2 ways to travel between San Diego, CA and Des Moines, IA including taking a bus and flight.
We recommend using the flight as it is the most popular way to get from San Diego, CA to Des Moines, IA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
San Diego, CA to Des Moines, IA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 07:05AM | Arrival Time 08:55AM | Duration 47h50 | Departure days Sun | Cheapest price $175 |
Operator Greyhound | Departure Time 09:25AM | Arrival Time 08:55AM | Duration 45h30 | Departure days Sun | Cheapest price $175 |
Operator Greyhound | Departure Time 12:40PM | Arrival Time 08:55AM | Duration 42h15 | Departure days Sun | Cheapest price $233 |
Operator Greyhound | Departure Time 01:10PM | Arrival Time 08:55AM | Duration 41h45 | Departure days Sun | Cheapest price $174 |
Operator Greyhound Mexico | Departure Time 07:25PM | Arrival Time 08:55AM | Duration 61h30 | Departure days Tue, Wed, Fri | Cheapest price $491 |
Operator Greyhound | Departure Time 08:10PM | Arrival Time 01:55PM | Duration 41h45 | Departure days Thu | Cheapest price $238 |
Live departures
San Diego, CA to Des Moines, IA bus times
The table below shows live departures for San Diego, CA to Des Moines, IA buses for today, Wednesday, May 27. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 7:25 PM San Diego, CA | 61h30 | 8:55 AM Des Moines, IA | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Diego, CA to Des Moines, IA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Thu
May 28
May 28
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May 29
May 29
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May 30
May 30
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May 31
Mon
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Why should you book San Diego, CA to Des Moines, IA buses with Omio?
Greyhound operates all buses services from San Diego, CA to Des Moines, IA.
Omio is an official ticket reseller for all your travel options from San Diego, CA to Des Moines, IA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from San Diego, CA to Des Moines, IA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from San Diego, CA to Des Moines, IA.
Journey information
Overview: Bus from San Diego, CA to Des Moines, IA
USAUSA
Buses from San Diego, CA to Des Moines, IA run on average 4 times per day, taking around 61h 30m. Cheap bus tickets for this journey start at $238 (€192) if you book in advance.
The earliest bus runs at 05:30, the last at 19:35. The fastest bus covers the 1428 miles (2299 km) distance in 41h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1428 miles (2299 km) |
Average bus duration 61h 30m |
Cheapest ticket price $238 (€192) |
Buses per day 4 |
Fastest bus 41h 45m |
First bus 5:30 AM |
Last bus 7:35 PM |
Cheapest Month Aug |
Cheapest Day Mon |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from San Diego, CA to Des Moines, IAYou can travel by bus between San Diego, CA to Des Moines, IA with Greyhound for as low as $238 (€192). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
41h 45m
Cheapest Price
$238 (€192)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Des Moines
Things to do in Des Moines
Discover the best of Des Moines — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Des Moines trip today.
- Recommended
State Historical Museum of Iowa
Museum covering Iowa history through artifacts, exhibits, and state-focused interpretation. Good for understanding the region beyond downtown sights.
- Recommended
Salisbury House & Gardens
Historic house museum with art, books, and decorative collections in an estate setting. Popular for its distinctive architecture and interiors.
- Must visit
Pappajohn Sculpture Park
Large downtown sculpture park with major works in an open urban setting. One of the city's most photogenic and social-media-friendly stops.
- Must visit
East Village
Walkable district east of the river known for local shops, murals, and lively street atmosphere near the Capitol.
- Recommended
Greater Des Moines Botanical Garden
Riverfront garden with indoor conservatory spaces and landscaped grounds. Popular for photos, seasonal displays, and a relaxing stroll.
Pork Tenderloin Sandwich
An Iowa classic featuring a pork cutlet pounded thin, breaded, fried, and served on a bun. It is one of the most iconic comfort foods in Central Iowa.
- Vegetarian
- Vegan
- Gluten-free
Sweet Corn
Iowa sweet corn is prized in summer for its tenderness and natural sweetness. It is a simple local staple strongly tied to the state’s farming identity.
Loose Meat Sandwich
A seasoned ground beef sandwich served loose on a bun rather than formed into a patty. It is a long-standing regional Midwestern favorite found across Iowa.
801 Chophouse Des Moines
An established upscale steakhouse known for prime steaks, seafood, and polished service in a classic fine-dining setting.
The Iowa Taproom
A popular venue highlighting Iowa beer, local ingredients, and regional comfort food in a spacious and welcoming setting.
Centro
A well-known downtown restaurant serving Italian fare, wood-fired pizzas, and pasta in a lively, stylish atmosphere.
United States Dollar
Moderate by U.S. standards. Hotels and dining are usually cheaper than in major coastal cities, while everyday costs stay manageable for most visitors.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 20-35 per person at a casual sit-down restaurant.
- Fine dining
- USD 50-100+ per person at upscale restaurants.
- Coffee
- USD 3-6 for a regular coffee or latte.
Tipping culture
Tip 18-20% in restaurants. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff USD 2-5. Tipping is expected for table service, but not usually for counter service.
FAQs: Bus from San Diego, CA to Des Moines, IA
Find answers to the most common questions about traveling from San Diego, CA to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from San Diego, CA to Des Moines, IA can start from as little as $238 (€192) when you book in advance. The average bus ticket price for San Diego, CA to Des Moines, IA is $238 (€192) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Diego, CA to Des Moines, IA is 41h 45m to travel the 1428 miles (2299 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Diego, CA to Des Moines, IA leaves at 5:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Diego, CA to Des Moines, IA leaves at 7:35 PM.
There are 4 buses a day from San Diego, CA to Des Moines, IA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from San Diego, CA to Des Moines, IA, you can count on Greyhound for the best way to get you to Des Moines, IA. You can also check all possible bus companies who offer a service between San Diego, CA and Des Moines, IA and compare the amenities they offer before buying a bus ticket.
A trip to Des Moines, IA from San Diego, CA is worth doing but not as a day trip with a journey time of 41h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from San Diego, CA to Des Moines, IA is August.
It's helpful to compare your options as there are 2 ways to travel between San Diego, CA and Des Moines, IA including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from San Diego, CA to Des Moines, IA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from San Diego, CA to Des Moines, IA for bus company Greyhound.
Whether you can cancel your bus ticket from San Diego, CA to Des Moines, IA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Diego, CA to Des Moines, IA.
Yes, the following luggage options are included when booking a bus ticket from San Diego, CA to Des Moines, IA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from San Diego, CA to Des Moines, IA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from San Diego, CA to Des Moines, IA.
You can reserve your seat on the bus from San Diego, CA to Des Moines, IA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from San Diego, CA to Des Moines, IA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from San Diego, CA to Des Moines, IA with the following bus company: Greyhound.
Since neither San Diego, CA nor Des Moines, IA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from San Diego, CA to Des Moines, IA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Des Moines, IA, travelers should be cautious of pickpocketing and occasional vehicle break-ins, especially in crowded areas and parking lots. Common scams include fake ticket sellers for local events and unofficial ride services. Staying alert in busy downtown spots and using authorized transportation options helps ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from San Diego, CA to Des Moines, IA
San Diego
Des Moines
San Diego, Congress Street (Old Town Park)
information
San Diego, San Ysidro Transit Center
information
San Diego, West Harbor Drive (The Headquarters at Seaport District)
information
More options for your journey from San Diego, CA to Des Moines, IA
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Most popular buses to and from Des Moines, IA and San Diego, CA
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