- Must visit
Des Moines Art Center
Leading art museum with strong American, contemporary, and decorative arts collections, plus a sculpture park just outside downtown.
The best way to find a cheap bus ticket from Denver, CO to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Denver, CO to Des Moines, IA will cost around $77 if you buy it on the day, but the cheapest tickets can be found for only $77.
On Tue, Nov 03, we found 1 buses from Denver, CO to Des Moines, IA, including 1 direct services.
On Tue, Nov 03 the direct buses cover the 981 km distance in an average of 13 h but if you time it right, some buses will get you there in just 13 h .
On Tue, Nov 03 the slowest buses will take 13 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Denver, CO to Des Moines, IA run on average 1 times per day, taking around 12h 43m. Cheap bus tickets for this journey start at $59 if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:30, the last at 20:10. The fastest bus covers the 609 miles (981 km) distance in 11h 45m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Denver, CO to Des Moines, IA.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:55PM | Arrival Time 08:55AM | Duration 13h00 | Departure days Everyday | Cheapest price $76 |
The table below shows live departures for Denver, CO to Des Moines, IA buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:55 PM Denver, Union Station | 13h00 | 8:55 AM Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Denver, CO to Des Moines, IA with Greyhound and Infobus. Overnight buses available on this route with Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Des Moines, IA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Des Moines, IA trip today.
Leading art museum with strong American, contemporary, and decorative arts collections, plus a sculpture park just outside downtown.
Compact state museum covering Iowa history, culture, and artifacts. A practical stop for visitors wanting context before exploring the city.
Science museum with interactive exhibits, a planetarium, and hands-on displays suited to families and curious adults alike.
A 4.4-acre downtown sculpture park with major contemporary works, open lawns, and easy walking access to nearby restaurants and museums.
Historic neighborhood east of the river with indie shops, murals, nightlife, and restored buildings. Ideal for an easy local walk.
Large urban park with wooded trails, picnic areas, a lake, and river views. A favorite local green escape close to downtown.
Iowa pork tenderloin sandwich features a thin, breaded pork cutlet fried and served on a bun. It is a classic Iowa diner specialty known for its oversized cutlet.
Loose meat sandwich is seasoned ground beef served warm on a bun without being formed into a patty. It is a longtime Iowa lunch-counter staple.
Sweet corn is a signature Iowa summer food, prized for its sweetness and freshness. It is commonly boiled or grilled at fairs, cookouts, and family meals.
Historic market hall with multiple local food vendors, ideal for sampling regional snacks, coffee, craft beer, and casual meals.
Casual local favorite for the classic Iowa breaded pork tenderloin sandwich, plus burgers and comfort food in a laid-back setting.
Long-running smokehouse known for Iowa-style barbecue, ribs, brisket, and hearty sides in a relaxed neighborhood atmosphere.
Moderate for US city breaks; hotels and dining are usually cheaper than larger US metros, while car use can add transport costs.
Tip 15-20% at restaurants, $1-2 per drink at bars, round up or add 10-15% for taxis, and tip a little at cafes only if table service is provided.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Des Moines, IA.
Find answers to the most common questions about traveling from Denver, CO to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

Most Denver, CO to Des Moines, IA buses use the Denver, Union Station to Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) station pair, with some services arriving at Des Moines, Grand Ave & 10th St. Use this guide to compare Denver, CO and Des Moines, IA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Denver has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Denver. ATMs are available at Denver.
Ticket office support is available at Denver.
Available at Denver: Parking, Taxis, WC.
Accessibility facilities are available at Denver: The station is wheelchair accessible.
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) is 3 km from Des Moines city centre. Public transport options include:
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). ATMs are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Ticket office support is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Parking, Taxis, WC.
Accessibility facilities are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Wheelchair accessible buses available.
Des Moines, Grand Ave & 10th St is 2 km from Des Moines city centre. Public transport options include:
Des Moines, Grand Ave & 10th St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Des Moines, Grand Ave & 10th St. ATMs are available at Des Moines, Grand Ave & 10th St.
Ticket office support is available at Des Moines, Grand Ave & 10th St.
Available at Des Moines, Grand Ave & 10th St: Parking, Taxis, WC.
Accessibility facilities are available at Des Moines, Grand Ave & 10th St: Accessible for passengers with limited mobility.