The cheapest and fastest buses from St. Louis, MO to Philadelphia, PA
Cheapest price
$104
Average price
$164
Fastest journey
22 h 5 m
Average duration
1 d 9 m
Buses per day
4
Distance
1301 km
The best way to find a cheap bus ticket from St. Louis, MO to Philadelphia, PA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to Philadelphia, PA will cost around $164 if you buy it on the day, but the cheapest tickets can be found for only $104.
Of the 4 buses that leave St. Louis, MO for Philadelphia, PA on Sun, Mar 08, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Mar 08 the direct buses cover the 1301 km distance in an average of 1 d 9 m but if you time it right, some buses will get you there in just 22 h 5 m .
On Sun, Mar 08 the slowest buses will take 1 d 5 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Travel Information
Compare train, bus, and flight for St. Louis, MO to Philadelphia, PA
Omio recommends booking the bus as it is the most popular option from St. Louis, MO to Philadelphia, PA among Omio's users. If you are prioritising price take the bus with prices starting from $98. For those with little time consider booking a flight which can get you there in 2h 9m. The ticket price range depends on the travel mode: a bus costs an average of $98, and a flight costs an average of $178.
Distance: 808 miles (1301 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
$141 Average price Cheapest | $379 Average price | $393 Average price |
22h 38m Average total duration 22h 8m Onboard + 30m Additional time* | 24h 1m Average total duration 23h 31m Onboard + 30m Additional time* | 5h 9m Average total duration Fastest 2h 9m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Live departures
St. Louis, MO to Philadelphia, PA bus times
The table below shows live departures for St. Louis, MO to Philadelphia, PA buses for today, Saturday, March 7. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:00 AM St. Louis, MO | 22h50 | 6:50 AM Philadelphia, PA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to Philadelphia, PA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 08
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Mar 13
Mar 14
Why should you book St. Louis, MO to Philadelphia, PA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to Philadelphia, PA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to Philadelphia, PA.
Journey information
Overview: Bus from St. Louis, MO to Philadelphia, PA
Buses from St. Louis, MO to Philadelphia, PA run on average 7 times per day, taking around 22h 8m. Cheap bus tickets for this journey start at $98 (€79) if you book in advance.
There are 2 buses per day. The earliest bus runs at 01:40, the last at 23:30. The fastest bus covers the 808 miles (1301 km) distance in 22h 5m.
Distance 808 miles (1301 km) |
Average bus duration 22h 8m |
Cheapest ticket price $98 (€79) |
Buses per day 7 |
Direct buses 2 |
Fastest bus 22h 5m |
First bus 01:40 |
Last bus 23:30 |
Cheapest month Jun |
Cheapest day Tue |
High season Oct - Dec |
Low season Jan - Mar |
Busiest day Sun |
Least busy day Sun |
Best day to book ahead 7 days |
Bus providers: Greyhound from St. Louis, MO to Philadelphia, PAYou can travel by bus between St. Louis, MO to Philadelphia, PA with Greyhound for as low as $98 (€79). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from St. Louis, MO to Philadelphia, PA
Find answers to the most common questions about traveling from St. Louis, MO to Philadelphia, PA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Philadelphia, PA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Liberty Bell, an iconic symbol of American independence housed in Liberty Bell Center
- Independence Hall, the birthplace of the United States where the Declaration of Independence and Constitution were signed
- Philadelphia Museum of Art, renowned for its vast collection of art and famous Rocky Steps
- Reading Terminal Market, a historic public market offering diverse food vendors and local specialties
- Eastern State Penitentiary, a former prison now a museum known for its grand architecture and historical significance.
- Liberty Bell, an iconic symbol of American independence located in the Liberty Bell Center
- Independence Hall, the historic site where the Declaration of Independence and the U.S. Constitution were debated and adopted
- Philadelphia Museum of Art, renowned for its vast collection of art and the famous Rocky Steps
- Reading Terminal Market, a bustling indoor market offering diverse food options and local specialties
- Philadelphia Zoo, America's first zoo featuring a wide variety of animals and interactive exhibits.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from St. Louis, MO to Philadelphia, PA
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to Philadelphia, PA
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