St. Louis, MO to San Francisco, CA bus with Greyhound

Mon, Sep 14
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The cheapest and fastest buses from St. Louis, MO to San Francisco, CA

Showing times, prices and bookable tickets for Sep 14

Cheapest price on Sep 14

$237

Average ticket price on Sep 14

$254

Fastest journey on Sep 14

1 d 21 h 20 m

Average journey duration on Sep 14

2 d 18 m

Buses on Sep 14

6

Distance

2803 km

Cheap tickets

The best way to find a cheap bus ticket from St. Louis, MO to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from St. Louis, MO to San Francisco, CA will cost around $254 if you buy it on the day, but the cheapest tickets can be found for only $237.

Fast buses

It's difficult to get from St. Louis, MO to San Francisco, CA without transferring at least 2 times.

  • Greyhound · ·
    5:15 PM45h20
    St. Louis, S 15th St (Civic center)
    12:35 PMSan Francisco, Transit Center Bay 29
    $2371One-way
    2 transfers
  • Greyhound · · +FlixBusFlixBus
    5:15 PM50h40
    St. Louis, S 15th St (Civic center)
    5:55 PMSan Francisco, Townsend Street / 5th Street, CA
    $2471One-way
    3 transfers
  • Greyhound · +FlixBusFlixBus
    9:10 AM49h35
    St. Louis, Lambert International Airport
    8:45 AMSan Francisco, Townsend Street / 5th Street, CA
    $2571One-way
    2 transfers
  • Greyhound · +FlixBusFlixBus
    8:40 AM50h05
    St. Louis, S 15th St (Civic center)
    8:45 AMSan Francisco, Townsend Street / 5th Street, CA
    $2571One-way
    2 transfers
  • Greyhound · ·
    8:40 AM48h30
    St. Louis, S 15th St (Civic center)
    7:10 AMSan Francisco, Transit Center Bay 29
    $2631One-way
    2 transfers

Travel Information

Compare bus, train, and flight for St. Louis, MO to San Francisco, CA

Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Francisco, CA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $315 For those with little time, consider booking a flight, which has an average total journey time of 8h 33m. Average ticket prices depend on the travel mode: a bus costs an average of $315, while a train costs an average of $688.

Distance: 1741 miles (2803 km)

Compare bus with

Bus
Most popular
Train
Flight
Driving

$315

Average price

Cheapest

$688

Average price

$572

Average price

$425

Average price

(fuel + tolls)

46h 39m

Average total duration

46h 9m

Onboard

+

30m

Additional time*

62h 55m

Average total duration

62h 25m

Onboard

+

30m

Additional time*

8h 33m

Average total duration

Fastest

6h 33m

Onboard

+

2h 0m

Additional time*

30h 13m

Average total duration

(door-to-door)

Greyhound

Most popular bus company

Amtrak

Most popular train company

American Airlines

Most popular airline

Your own car or car rental

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from St. Louis, MO to San Francisco, CA is a bus with an average price of $315 (€255).

This is compared to other travel options from St. Louis, MO to San Francisco, CA:

A bus is $257 (€208) less than a flight for this route with tickets for a flight from St. Louis, MO to San Francisco, CA costing on average $572 (€463).

A bus is $373 (€302) less than a train for this route with tickets for a train from St. Louis, MO to San Francisco, CA costing on average $688 (€557).

The fastest way to travel from St. Louis, MO to San Francisco, CA is by flight with an average journey time of 6h 33m.

Other travel options to San Francisco, CA take longer:

Bus takes on average 46h 9m.

Train takes on average 62h 25m.

It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Francisco, CA including taking a bus, train, and flight.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Francisco, CA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around $315 (€255) compared to roughly $425 (€344) in fuel and tolls — a saving of about $110 (€89). The journey takes 46h 9m versus 30h 13m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

St. Louis, MO to San Francisco, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
08:40AM
Arrival Time
08:45AM
Duration
50h05
Departure days
Everyday
Cheapest price
$181
Operator
Greyhound
Departure Time
09:10AM
Arrival Time
08:45AM
Duration
49h35
Departure days
Everyday
Cheapest price
$181
Operator
Greyhound
Departure Time
05:15PM
Arrival Time
12:35PM
Duration
45h20
Departure days
Everyday
Cheapest price
$172

Live departures

St. Louis, MO to San Francisco, CA bus times

The table below shows live departures for St. Louis, MO to San Francisco, CA buses for today, Sunday, September 13. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Greyhound · +FlixBusFlixBus8:40 AM St. Louis, S 15th St (Civic center)
50h05
8:45 AM San Francisco, Townsend Street / 5th Street, CA2 transfers
Greyhound · · 8:40 AM St. Louis, S 15th St (Civic center)
48h30
7:10 AM San Francisco, Transit Center Bay 292 transfers
Greyhound · · 9:10 AM St. Louis, Lambert International Airport
48h00
7:10 AM San Francisco, Transit Center Bay 292 transfers
Greyhound · +FlixBusFlixBus9:10 AM St. Louis, Lambert International Airport
49h35
8:45 AM San Francisco, Townsend Street / 5th Street, CA2 transfers
Greyhound · · +FlixBusFlixBus5:15 PM St. Louis, S 15th St (Civic center)
50h40
5:55 PM San Francisco, Townsend Street / 5th Street, CA3 transfers
Greyhound · · 5:15 PM St. Louis, S 15th St (Civic center)
45h20
12:35 PM San Francisco, Transit Center Bay 292 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets St. Louis, MO to San Francisco, CA by bus, train, or flight

Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Why should you book St. Louis, MO to San Francisco, CA buses with Omio?

Greyhound operates all buses services from St. Louis, MO to San Francisco, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to San Francisco, CA.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from St. Louis, MO to San Francisco, CA.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from St. Louis, MO to San Francisco, CA.

Journey information

Overview: Bus from St. Louis, MO to San Francisco, CA

USAUSA
USAUSA
Icon of bus

Buses from St. Louis, MO to San Francisco, CA run on average 5 times per day, taking around 46h 9m. Cheap bus tickets for this journey start at $169 (€137) but you can travel from only $169 (€136) by flight.

The earliest bus runs at 01:20, the last at 23:25. The fastest bus covers the 1741 miles (2803 km) distance in 44h 10m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $169 (€136)
Distance
1741 miles (2803 km)
Average bus duration
46h 9m
Cheapest ticket price
$169 (€137)
Buses per day
5
Fastest bus
44h 10m
First bus
1:20 AM
Last bus
11:25 PM
Cheapest Month
Oct
Cheapest Day
Mon
High Season
Jan - Mar
Low Season
Oct - Dec
Best time to book
28 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $169 (€136)

Bus providers: Greyhound from St. Louis, MO to San Francisco, CAYou can travel by bus between St. Louis, MO to San Francisco, CA with Greyhound for as low as $169 (€137). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
44h 10m
Cheapest Greyhound Price
$169 (€137)
Greyhound frequency
5 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

Complete guide to San Francisco, CA

Things to do in San Francisco, CA

Discover the best of San Francisco, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Francisco, CA trip today.

  • Must visit

California Academy of Sciences

Renowned science museum with rainforest dome, aquarium, and planetarium. Interactive exhibits make it a standout for all ages.

  • Must visit

de Young Museum

Major fine arts museum in Golden Gate Park with American art, textiles, and a panoramic tower. A classic cultural highlight.

  • Must visit

San Francisco Museum of Modern Art

Leading modern and contemporary art museum with landmark architecture and strong global collections. Essential for art-focused visitors.

US Dollar ($)

Very high hotel, dining, and transport costs make San Francisco pricier than most US cities and many major tourist destinations.

Average meal costs

Budget
$12-20 for fast food or casual takeout.
Mid-range
$25-45 per person for a restaurant meal.
Fine dining
$90+ per person for upscale dining.
Coffee
$4-7 for coffee or cappuccino.

Tipping culture

Tip 18-20% at restaurants, 15-20% for taxis, and round up or tip $1 at cafes for good service.

FAQs: Bus from St. Louis, MO to San Francisco, CA

Find answers to the most common questions about traveling from St. Louis, MO to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from St. Louis, MO to San Francisco, CA can start from as little as $169 (€137) when you book in advance. The average bus ticket price for St. Louis, MO to San Francisco, CA is $315 (€255) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to San Francisco, CA is 44h 10m to travel the 1741 miles (2803 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to San Francisco, CA leaves at 1:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to San Francisco, CA leaves at 11:25 PM.
There are 5 buses a day from St. Louis, MO to San Francisco, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to San Francisco, CA, you can count on Greyhound for the best way to get you to San Francisco, CA. You can also check all possible bus companies who offer a service between St. Louis, MO and San Francisco, CA and compare the amenities they offer before buying a bus ticket.
When departing from St. Louis, MO , you have various bus station options to start your journey from including St. Louis, S 15th St (Civic center), St. Louis, Lambert International Airport . When arriving in San Francisco, CA , you can end your journey in bus stations like San Francisco, Transit Center Bay 29, San Francisco, Townsend Street / 5th Street, CA .Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around away from the city centre, and they get off the bus at San Francisco, Transit Center Bay 29, located 2 away from the city centre.
A trip to San Francisco, CA from St. Louis, MO is worth doing but not as a day trip with a journey time of 44h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to San Francisco, CA is October.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Francisco, CA including taking a bus, train, and flight.
Yes, there are bathrooms on board the bus from St. Louis, MO to San Francisco, CA for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to San Francisco, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Some of the most interesting sights to explore in San Francisco, CA are:
  • Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
  • Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
  • Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
  • Golden Gate Park, a large urban park with gardens, museums, and recreational activities
  • Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
The best things to do in San Francisco, CA include:
  • Ride a cable car through the steep streets of San Francisco for a classic city experience
  • Explore the vibrant murals and street art in the Mission District
  • Visit the Exploratorium, an interactive science museum perfect for all ages
  • Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
  • Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
Whether you can cancel your bus ticket from St. Louis, MO to San Francisco, CA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to San Francisco, CA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to San Francisco, CA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to San Francisco, CA:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to San Francisco, CA.
You can reserve your seat on the bus from St. Louis, MO to San Francisco, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to San Francisco, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to San Francisco, CA with the following bus company: Greyhound.
Since neither St. Louis, MO nor San Francisco, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Francisco, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Francisco, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like Fisherman's Wharf and Union Square. Common scams include distraction techniques used by groups to steal wallets and fake charity solicitations. It's advisable to avoid poorly lit or isolated areas at night and be wary of unofficial taxi services to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from St. Louis, MO to San Francisco, CA

Most St. Louis, MO to San Francisco, CA buses use the St. Louis, S 15th St (Civic center) to San Francisco, Transit Center Bay 29 station pair, with some services arriving at San Francisco, Townsend Street / 5th Street. Use this guide to compare St. Louis, MO and San Francisco, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in St. Louis
Arrival bus stations in San Francisco

Which St. Louis, MO station do buses to San Francisco, CA leave from?

Buses from St. Louis, MO to San Francisco, CA leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USAWifiParkingATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre

TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min

St. Louis, S 15th St (Civic center) bus station facilities and services

St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Wi-Fi and ATMs

Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).

Tickets and information

Ticket office support is available at St. Louis, S 15th St (Civic center).

Parking, taxis and toilets

Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.

St. Louis, Lambert International AirportSt. Louis Lambert International Airport (STL), 10701 Lambert International Blvd, St. Louis, MO 63145, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to St. Louis, Lambert International Airport from St. Louis city centre

St. Louis, Lambert International Airport is 19 km from St. Louis city centre. Public transport options include:

TrainMlr · 31m · $4 · every ~7 min
Bus4 · 1h 3m · $31 · every ~4 min

St. Louis, Lambert International Airport bus station facilities and services

St. Louis, Lambert International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Multiple dining options available in terminals.

Wi-Fi and ATMs

Free Wi-Fi available throughout the airport. ATMs are aTMs available in terminal areas.

Tickets and information

Ticket office support is available at St. Louis, Lambert International Airport.

Parking, taxis and toilets

Available at St. Louis, Lambert International Airport: Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at St. Louis, Lambert International Airport: Wheelchair accessible facilities available.

More options for your journey from St. Louis, MO to San Francisco, CA

Here are some other resources that might have the information you need

Most popular buses to and from San Francisco, CA and St. Louis, MO

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