The cheapest and fastest buses from St. Louis, MO to San Francisco, CA
Cheapest price
$200
Average price
$200
Fastest journey
2 d 1 h 50 m
Average duration
2 d 1 h 50 m
Buses per day
1
Distance
2803 km
The best way to find a cheap bus ticket from St. Louis, MO to San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to San Francisco, CA will cost around $200 if you buy it on the day, but the cheapest tickets can be found for only $200.
Of the 1 buses that leave St. Louis, MO for San Francisco, CA on Thu, Dec 11, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Dec 11 the direct buses cover the 2803 km distance in an average of 2 d 1 h 50 m but if you time it right, some buses will get you there in just 2 d 1 h 50 m .
On Thu, Dec 11 the slowest buses will take 2 d 1 h 50 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for St. Louis, MO to San Francisco, CA
Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from €130. For those with little time consider booking a flight which can get you there in 11h 50m. The ticket price range depends on the travel mode: a bus costs an average of €130, and a train costs an average of €183.
Distance: 1741 miles (2803 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€163 Average price Cheapest | €277 Average price | €201 Average price |
49h 25m Average total duration 48h 55m Onboard + 30m Additional time* | 59h 0m Average total duration 58h 30m Onboard + 30m Additional time* | 14h 50m Average total duration Fastest 11h 50m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
St. Louis, MO to San Francisco, CA bus times
The table below shows live departures for St. Louis, MO to San Francisco, CA buses for tomorrow, Thursday, December 11. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:25 PM St. Louis, MO | 49h50 | 2:15 PM San Francisco, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Dec 17
Journey information
Overview: Bus from St. Louis, MO to San Francisco, CA
Buses from St. Louis, MO to San Francisco, CA run on average 10 times per day, taking around 48h 55m. Cheap bus tickets for this journey start at $162 (€130) if you book in advance.
The earliest bus runs at 04:55, the last at 23:25. The fastest bus covers the 1741 miles (2803 km) distance in 45h 55m.
Distance 1741 miles (2803 km) |
Average bus duration 48h 55m |
Cheapest ticket price $162 (€130) |
Buses per day 10 |
Fastest bus 45h 55m |
First bus 04:55 |
Last bus 23:25 |
Bus providers: Greyhound from St. Louis, MO to San Francisco, CAYou can travel by bus between St. Louis, MO to San Francisco, CA with Greyhound for as low as $162 (€130). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from St. Louis, MO to San Francisco, CA
Find answers to the most common questions about traveling from St. Louis, MO to San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Golden Gate Bridge, an iconic suspension bridge offering panoramic views of the San Francisco Bay
- Alcatraz Island, a historic site featuring the infamous former prison and informative audio tours
- Fisherman's Wharf, a bustling waterfront area known for seafood, shops, and sea lions
- Golden Gate Park, a large urban park with gardens, museums, and recreational activities
- Chinatown, the oldest and one of the largest Chinatowns in North America, offering vibrant culture and cuisine.
- Ride a cable car through the steep streets of San Francisco for a classic city experience
- Explore the vibrant murals and street art in the Mission District
- Visit the Exploratorium, an interactive science museum perfect for all ages
- Take a scenic walk along the Embarcadero, offering views of the Bay Bridge and access to the Ferry Building Marketplace
- Enjoy a wine tasting tour in nearby Napa Valley, a short drive from the city.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from St. Louis, MO to San Francisco, CA, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from St. Louis, MO to San Francisco, CA
Most popular bus connections from St. Louis, MO
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