- Must visit
San Diego Museum of Art
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
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The cheapest and fastest buses from St. Louis, MO to San Diego, CA
Showing times, prices and bookable tickets for Oct 21
Cheapest price on Oct 21
$164
Average ticket price on Oct 21
$170
Fastest journey on Oct 21
1 d 18 h 25 m
Average journey duration on Oct 21
1 d 19 h 56 m
Buses on Oct 21
12
Distance
2512 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to San Diego, CA will cost around $170 if you buy it on the day, but the cheapest tickets can be found for only $164.
Fast buses
It's difficult to get from St. Louis, MO to San Diego, CA without transferring at least once.
· · +
FlixBus5:15 PM44h40St. Louis, S 15th St (Civic center)11:55 AMSan Diego, West Harbor Drive (The Headquarters at Seaport District), CA$1641One-way3 transfers- · · +FlixBus5:15 PM44h20St. Louis, S 15th St (Civic center)11:35 AMSan Diego, Congress Street (Old Town Park), CA$1641One-way3 transfers
- · · · 8:40 AM53h05St. Louis, S 15th St (Civic center)11:45 AMSan Diego, Congress Street (Old Town Park), CA$1661One-way3 transfers
- · · · 9:10 AM52h35St. Louis, Lambert International Airport11:45 AMSan Diego, Congress Street (Old Town Park), CA$1661One-way3 transfers
- +FlixBus1:20 AM46h55St. Louis, S 15th St (Civic center)10:15 PMSan Diego, West Harbor Drive (The Headquarters at Seaport District), CA$1671One-way1 transfer
- · 1:20 AM42h25St. Louis, S 15th St (Civic center)5:45 PMSan Diego, Congress Street (Old Town Park), CA$1701One-way1 transfer
- · 1:20 AM43h00St. Louis, S 15th St (Civic center)6:20 PMSan Diego, San Ysidro Transit Center$1751One-way1 transfer
- · · +FlixBus5:15 PM44h20St. Louis, S 15th St (Civic center)11:35 AMSan Diego, Congress Street (Old Town Park), CA$1641One-way3 transfers
- · · +FlixBus5:15 PM44h40St. Louis, S 15th St (Civic center)11:55 AMSan Diego, West Harbor Drive (The Headquarters at Seaport District), CA$1641One-way3 transfers
- · · +FlixBus5:15 PM45h15St. Louis, S 15th St (Civic center)12:30 PMSan Diego, San Ysidro Transit Center$1721One-way3 transfers
Journey information
Overview: Bus from St. Louis, MO to San Diego, CA
USAUSA
Buses from St. Louis, MO to San Diego, CA run on average 14 times per day, taking around 40h 59m. Cheap bus tickets for this journey start at $130 (€109) if you book in advance.
The earliest bus runs at 01:20, the last at 23:30. The fastest bus covers the 1560 miles (2512 km) distance in 38h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1560 miles (2512 km) |
Average bus duration 40h 59m |
Cheapest ticket price $130 (€109) |
Buses per day 14 |
Fastest bus 38h 40m |
First bus 1:20 AM |
Last bus 11:30 PM |
Cheapest Month Jan |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jul - Sep |
Best time to book 6 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
St. Louis, MO to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:20AM | Arrival Time 06:20PM | Duration 43h00 | Departure days Everyday | Cheapest price $158 |
Operator Greyhound | Departure Time 08:40AM | Arrival Time 11:45AM | Duration 53h05 | Departure days Everyday | Cheapest price $137 |
Operator Greyhound | Departure Time 09:10AM | Arrival Time 11:55AM | Duration 52h45 | Departure days Everyday | Cheapest price $135 |
Operator Greyhound | Departure Time 04:00PM | Arrival Time 05:45PM | Duration 51h45 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $151 |
Operator Greyhound | Departure Time 05:15PM | Arrival Time 12:30PM | Duration 45h15 | Departure days Everyday | Cheapest price $137 |
Live departures
St. Louis, MO to San Diego, CA bus times
The table below shows live departures for St. Louis, MO to San Diego, CA buses for today, Tuesday, October 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · | 1:20 AM St. Louis, S 15th St (Civic center) | 43h00 | 6:20 PM San Diego, San Ysidro Transit Center | 1 transfer | |
| · | 1:20 AM St. Louis, S 15th St (Civic center) | 42h25 | 5:45 PM San Diego, Congress Street (Old Town Park), CA | 1 transfer | |
| +FlixBus | 1:20 AM St. Louis, S 15th St (Civic center) | 46h55 | 10:15 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 1 transfer | |
| · · · | 8:40 AM St. Louis, S 15th St (Civic center) | 53h05 | 11:45 AM San Diego, Congress Street (Old Town Park), CA | 3 transfers | |
| · · · | 8:40 AM St. Louis, S 15th St (Civic center) | 53h40 | 12:20 PM San Diego, San Ysidro Transit Center | 3 transfers | |
| · · +FlixBus | 9:10 AM St. Louis, Lambert International Airport | 52h45 | 11:55 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 3 transfers | |
| · · +FlixBus | 9:10 AM St. Louis, Lambert International Airport | 52h25 | 11:35 AM San Diego, Congress Street (Old Town Park), CA | 3 transfers | |
| · · · | 9:10 AM St. Louis, Lambert International Airport | 52h35 | 11:45 AM San Diego, Congress Street (Old Town Park), CA | 3 transfers | |
| · · · | 9:10 AM St. Louis, Lambert International Airport | 53h10 | 12:20 PM San Diego, San Ysidro Transit Center | 3 transfers | |
| · · +FlixBus | 5:15 PM St. Louis, S 15th St (Civic center) | 45h15 | 12:30 PM San Diego, San Ysidro Transit Center | 3 transfers | |
| · · +FlixBus | 5:15 PM St. Louis, S 15th St (Civic center) | 44h20 | 11:35 AM San Diego, Congress Street (Old Town Park), CA | 3 transfers | |
| · · +FlixBus | 5:15 PM St. Louis, S 15th St (Civic center) | 44h40 | 11:55 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book St. Louis, MO to San Diego, CA buses with Omio?
Greyhound operates all buses services from St. Louis, MO to San Diego, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to San Diego, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to San Diego, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to San Diego, CA.
Bus providers: Greyhound from St. Louis, MO to San Diego, CAYou can travel by bus between St. Louis, MO to San Diego, CA with Greyhound for as low as $130 (€109). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
38h 40m
Cheapest Greyhound Price
$130 (€109)
Greyhound frequency
14 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to San Diego, CA
Things to do in San Diego, CA
Discover the best of San Diego, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego, CA trip today.
- Must visit
Museum of Contemporary Art San Diego
Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.
- Must visit
USS Midway Museum
Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.
- Must visit
Balboa Park
Balboa Park is San Diego's grand cultural park, packed with gardens, architecture, museums, and walkable plazas worth lingering in.
- Must visit
Gaslamp Quarter
Historic Gaslamp Quarter offers Victorian-era streets, nightlife energy, and preserved downtown architecture for an atmospheric walk.
- Must visit
La Jolla Cove
Dramatic seaside cliffs and walking paths in La Jolla, famous for waves, sea lions, and sweeping Pacific views.
Fish Taco
A San Diego staple: grilled fish in a soft tortilla with cabbage, crema, and salsa. Popularized by Baja influence and coastal seafood culture.
California Burrito
French fries, carne asada, cheese, guacamole, and crema wrapped in a flour tortilla. A late-night local favorite born in San Diego taquerias.
- Gluten-free
Sea Urchin (Uni)
Fresh local sea urchin served raw, prized for its rich, buttery taste. It reflects San Diego's access to Pacific seafood and sushi culture.
Sushi Ota
Celebrated sushi restaurant specializing in omakase and pristine seafood, including uni. Intimate, polished, and highly respected by locals.
Mitch's Seafood
Iconic casual seafood counter known for fish tacos, smoked fish, and harbor views. A classic stop for San Diego's Baja-inspired seafood style.
Juniper and Ivy
Refined fine-dining restaurant showcasing local seafood and seasonal California ingredients. Elegant room with one of the city's strongest reputations.
US Dollar ($)
San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $25-45 per person for a mid-range meal.
- Fine dining
- $75+ per person for upscale dining.
- Coffee
- $4-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.
FAQs: Bus from St. Louis, MO to San Diego, CA
Find answers to the most common questions about traveling from St. Louis, MO to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to San Diego, CA can start from as little as $130 (€109) when you book in advance. The average bus ticket price for St. Louis, MO to San Diego, CA is $206 (€172) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to San Diego, CA is 38h 40m to travel the 1560 miles (2512 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to San Diego, CA leaves at 1:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to San Diego, CA leaves at 11:30 PM.
There are 14 buses a day from St. Louis, MO to San Diego, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to San Diego, CA, you can count on Greyhound for the best way to get you to San Diego, CA. You can also check all possible bus companies who offer a service between St. Louis, MO and San Diego, CA and compare the amenities they offer before buying a bus ticket.
When departing from St. Louis, MO , you have various bus station options to start your journey from including St. Louis, S 15th St (Civic center), St. Louis, Lambert International Airport . When arriving in San Diego, CA , you can end your journey in bus stations like San Diego, Congress Street (Old Town Park), CA, San Diego, San Ysidro Transit Center, San Diego, West Harbor Drive (The Headquarters at Seaport District), CA, San Diego, Rail Ct / E San Ysidro Blvd (McDonald`s), CA .Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around away from the city centre, and they get off the bus at San Diego, Congress Street (Old Town Park), CA, located 5 away from the city centre.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
Yes, there are bathrooms on board the bus from St. Louis, MO to San Diego, CA for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to San Diego, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from St. Louis, MO to San Diego, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to San Diego, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to San Diego, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to San Diego, CA.
You can reserve your seat on the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to San Diego, CA
Most St. Louis, MO to San Diego, CA buses use the St. Louis, S 15th St (Civic center) to San Diego, Congress Street (Old Town Park) station pair, with some services arriving at San Diego, San Ysidro Transit Center. Use this guide to compare St. Louis, MO and San Diego, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in San Diego
Which St. Louis, MO station do buses to San Diego, CA leave from?
Buses from St. Louis, MO to San Diego, CA leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $2 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
St. Louis, Lambert International AirportSt. Louis Lambert International Airport (STL), 10701 Lambert International Blvd, St. Louis, MO 63145, USA
City-centre transport
Getting to St. Louis, Lambert International Airport from St. Louis city centre
St. Louis, Lambert International Airport is 19 km from St. Louis city centre. Public transport options include:
TrainMlr · 31m · $4 · every ~7 min
Bus4 · 1h 3m · $30 · every ~4 min
St. Louis, Lambert International Airport bus station facilities and services
St. Louis, Lambert International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options available in terminals.
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are aTMs available in terminal areas.
Tickets and information
Ticket office support is available at St. Louis, Lambert International Airport.
Parking, taxis and toilets
Available at St. Louis, Lambert International Airport: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, Lambert International Airport: Wheelchair accessible facilities available.
Which San Diego, CA station do buses from St. Louis, MO arrive at?
Buses from St. Louis, MO to San Diego, CA most often arrive at San Diego, Congress Street (Old Town Park). Some services arrive at San Diego, San Ysidro Transit Center, so check your ticket before travel to confirm your San Diego, CA arrival station.
San Diego, Congress Street (Old Town Park)Congress St, San Diego, CA 92110, USA
City-centre transport
Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre
San Diego, Congress Street (Old Town Park) is 5 km from San Diego city centre. Public transport options include:
BusFlixBus 2017 · 20m · $2
83 · 26m · $6
TramGreen, Blue, Event · 16m · every ~18 min
Blue · 21m · every ~9 min
San Diego, Congress Street (Old Town Park) bus station facilities and services
San Diego, Congress Street (Old Town Park) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several dining options nearby.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, Congress Street (Old Town Park). ATMs are available at San Diego, Congress Street (Old Town Park).
Tickets and information
Ticket office support is available at San Diego, Congress Street (Old Town Park).
Parking, taxis and toilets
Available at San Diego, Congress Street (Old Town Park): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, Congress Street (Old Town Park): Wheelchair accessible routes available.
San Diego, San Ysidro Transit CenterSan Ysidro Station, San Diego, CA 92173, USA
City-centre transport
Getting to San Diego, San Ysidro Transit Center from San Diego city centre
San Diego, San Ysidro Transit Center is 22 km from San Diego city centre. Public transport options include:
BusFlixBus 2017 · 25m · $3
910 · 41m · $6
TramBlue · 41m · $17 · every ~14 min
Blue · 43m · $17 · every ~14 min
San Diego, San Ysidro Transit Center bus station facilities and services
San Diego, San Ysidro Transit Center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several fast food eateries located nearby.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, San Ysidro Transit Center. ATMs are available near the entrance.
Tickets and information
Ticket office support is available at San Diego, San Ysidro Transit Center.
Parking, taxis and toilets
Available at San Diego, San Ysidro Transit Center: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, San Ysidro Transit Center: Wheelchair accessible with ramps.
San Diego, West Harbor Drive (The Headquarters at Seaport District)W Harbor Dr, San Diego, CA, USA
City-centre transport
Getting to San Diego, West Harbor Drive (The Headquarters at Seaport District) from San Diego city centre
San Diego, West Harbor Drive (The Headquarters at Seaport District) is 1 km from San Diego city centre. Public transport options include:
TRUE
San Diego, West Harbor Drive (The Headquarters at Seaport District) bus station facilities and services
San Diego, West Harbor Drive (The Headquarters at Seaport District) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several dining options are in the area.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, West Harbor Drive (The Headquarters at Seaport District). ATMs are available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Tickets and information
Ticket office support is available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Parking, taxis and toilets
Available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Accessible for persons with disabilities.
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to San Diego, CA
Here are some other resources that might have the information you need
Most popular buses to and from San Diego, CA and St. Louis, MO
Most popular bus connections to San Diego, CA
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