St. Louis, MO to San Diego, CA bus with Greyhound

Wed, Apr 22
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2,000+ travel companies
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The cheapest and fastest buses from St. Louis, MO to San Diego, CA

Showing times and prices for Apr 22

Cheapest price

$221

Average price

$221

Fastest journey

1 d 23 h 40 m

Average duration

1 d 23 h 40 m

Buses per day

1

Distance

2512 km

Cheap tickets

The best way to find a cheap bus ticket from St. Louis, MO to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from St. Louis, MO to San Diego, CA will cost around $221 if you buy it on the day, but the cheapest tickets can be found for only $221.

Fast buses

Of the 1 buses that leave St. Louis, MO for San Diego, CA on Wed, Apr 22, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

On Wed, Apr 22 the direct buses cover the 2512 km distance in an average of 1 d 23 h 40 m but if you time it right, some buses will get you there in just 1 d 23 h 40 m .

On Wed, Apr 22 the slowest buses will take 1 d 23 h 40 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • Greyhound
    10:30 PM47h40
    St. Louis, MO
    10:10 PMSan Diego, CA
    $2211One-way
    0 transfers

Travel Information

Compare bus, train, and flight for St. Louis, MO to San Diego, CA

Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from $155. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a bus costs an average of $155, and a train costs an average of $221.

Distance: 1560 miles (2512 km)

Compare bus with

Bus
Most popular
Train
Flight

$310

Average price

Cheapest

$686

Average price

$343

Average price

50h 1m

Average total duration

49h 31m

Onboard

+

30m

Additional time*

60h 54m

Average total duration

60h 24m

Onboard

+

30m

Additional time*

10h 22m

Average total duration

Fastest

7h 22m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Direct Options

Compare prices and tickets St. Louis, MO to San Diego, CA by bus, train, or flight

Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Wed
Apr 22
Thu
Apr 23
Fri
Apr 24
Sat
Apr 25
Sun
Apr 26
Mon
Apr 27
Tue
Apr 28

Why should you book St. Louis, MO to San Diego, CA buses with Omio?

Greyhound operates all buses services from St. Louis, MO to San Diego, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to San Diego, CA.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from St. Louis, MO to San Diego, CA.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from St. Louis, MO to San Diego, CA.

Journey information

Overview: Bus from St. Louis, MO to San Diego, CA

USAUSA
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Buses from St. Louis, MO to San Diego, CA run on average 12 times per day, taking around 49h 31m. Cheap bus tickets for this journey start at $155 (€124) if you book in advance.

The earliest bus runs at 01:20, the last at 23:30. The fastest bus covers the 1560 miles (2512 km) distance in 43h 0m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
1560 miles (2512 km)
Average bus duration
49h 31m
Cheapest ticket price
$155 (€124)
Buses per day
12
Fastest bus
43h 0m
First bus
1:20 AM
Last bus
11:30 PM
Cheapest Month
Aug
Cheapest Day
Fri
High Season
Oct - Dec
Low Season
Jul - Sep
Best time to book
6 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound from St. Louis, MO to San Diego, CAYou can travel by bus between St. Louis, MO to San Diego, CA with Greyhound for as low as $155 (€124). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
43h 0m
Cheapest Price
$155 (€124)
Greyhound frequency
12 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from St. Louis, MO to San Diego, CA

Find answers to the most common questions about traveling from St. Louis, MO to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from St. Louis, MO to San Diego, CA can start from as little as $155 (€124) when you book in advance. The average bus ticket price for St. Louis, MO to San Diego, CA is $310 (€248) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to San Diego, CA is 43h 0m to travel the 1560 miles (2512 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to San Diego, CA leaves at 1:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to San Diego, CA leaves at 11:30 PM.
There are 12 buses a day from St. Louis, MO to San Diego, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to San Diego, CA, you can count on Greyhound for the best way to get you to San Diego, CA. You can also check all possible bus companies who offer a service between St. Louis, MO and San Diego, CA and compare the amenities they offer before buying a bus ticket.
A trip to San Diego, CA from St. Louis, MO is worth doing but not as a day trip with a journey time of 43h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to San Diego, CA is August.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a bus, train, and flight.
Yes, there are bathrooms on board the bus from St. Louis, MO to San Diego, CA for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to San Diego, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Some of the most interesting sights to explore in San Diego, CA are:
  • Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
  • USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
  • La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
  • Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
  • Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best things to do in San Diego, CA include:
  • Explore the vibrant art scene at the Museum of Contemporary Art San Diego
  • enjoy a harbor cruise for stunning views of the skyline and naval ships
  • hike the scenic trails at Torrey Pines State Natural Reserve
  • visit the Birch Aquarium to learn about marine life and ocean conservation
  • experience the thrill of a whale watching tour off the coast.
Whether you can cancel your bus ticket from St. Louis, MO to San Diego, CA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to San Diego, CA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to San Diego, CA:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to San Diego, CA.
You can reserve your seat on the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Since neither St. Louis, MO nor San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from St. Louis, MO to San Diego, CA

St. Louis
San Diego
The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to San Diego.
St. Louis, S 15th St (Civic center)
information
St. Louis, Lambert International Airport
information
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