- Must visit
San Diego Museum of Art
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
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The cheapest and fastest buses from St. Louis, MO to San Diego, CA
Showing times and prices for Jul 22
Cheapest price
$135
Average price
$199
Fastest journey
2 d 10 m
Average duration
2 d 3 h 2 m
Buses per day
3
Distance
2512 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to San Diego, CA will cost around $199 if you buy it on the day, but the cheapest tickets can be found for only $135.
Fast buses
Of the 3 buses that leave St. Louis, MO for San Diego, CA on Wed, Jul 22, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jul 22 the direct buses cover the 2512 km distance in an average of 2 d 3 h 2 m but if you time it right, some buses will get you there in just 2 d 10 m .
On Wed, Jul 22 the slowest buses will take 2 d 4 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:10 PM52h35St. Louis, MO6:45 PMSan Diego, CA$1351One-way0 transfers- 9:00 PM52h20St. Louis, MO1:20 AMSan Diego, CA$1801One-way0 transfers
- 10:30 PM48h10St. Louis, MO10:40 PMSan Diego, CA$2831One-way0 transfers
- 10:30 PM48h10St. Louis, MO10:40 PMSan Diego, CA$2831One-way0 transfers
- 9:00 PM52h20St. Louis, MO1:20 AMSan Diego, CA$1801One-way0 transfers
- 2:10 PM52h35St. Louis, MO6:45 PMSan Diego, CA$1351One-way0 transfers
Travel Information
Compare train, bus, and flight for St. Louis, MO to San Diego, CA
Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Diego, CA among Omio's users. If you are prioritising price take the flight with prices starting from $145. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a flight costs an average of $145, and a train costs an average of $214.
Distance: 1560 miles (2512 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$273 Average price | $276 Average price | $260 Average price Cheapest | $378 Average price (fuel + tolls) |
39h 10m Average total duration 38h 40m Onboard + 30m Additional time* | 61h 41m Average total duration 61h 11m Onboard + 30m Additional time* | 10h 22m Average total duration Fastest 7h 22m Onboard + 3h 0m Additional time* | 26h 33m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to San Diego, CA is a flight with an average price of $260 (€214).
This is compared to other travel options from St. Louis, MO to San Diego, CA:
A flight is $13 (€11) less than a bus for this route with tickets for a bus from St. Louis, MO to San Diego, CA costing on average $273 (€225).
A flight is $16 (€13) less than a train for this route with tickets for a train from St. Louis, MO to San Diego, CA costing on average $276 (€227).
The fastest way to travel from St. Louis, MO to San Diego, CA is by flight with an average journey time of 7h 22m.
Other travel options to San Diego, CA take longer:
Bus takes on average 38h 40m.
Train takes on average 61h 11m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
St. Louis, MO to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:20AM | Arrival Time 05:15AM | Duration 46h55 | Departure days Fri | Cheapest price $185 |
Operator Greyhound | Departure Time 07:20AM | Arrival Time 02:20AM | Duration 43h00 | Departure days Sun | Cheapest price $235 |
Operator Greyhound | Departure Time 01:40PM | Arrival Time 05:35PM | Duration 51h55 | Departure days Thu | Cheapest price $280 |
Operator Greyhound | Departure Time 02:10PM | Arrival Time 06:45PM | Duration 52h35 | Departure days Wed, Sat | Cheapest price $135 |
Operator Greyhound | Departure Time 03:10PM | Arrival Time 08:20PM | Duration 53h10 | Departure days Mon, Fri | Cheapest price $231 |
Operator Greyhound | Departure Time 09:00PM | Arrival Time 01:20AM | Duration 52h20 | Departure days Wed | Cheapest price $180 |
Operator Greyhound | Departure Time 09:30PM | Arrival Time 05:15AM | Duration 55h45 | Departure days Mon, Tue, Thu, Fri, Sat | Cheapest price $257 |
Operator Greyhound | Departure Time 10:30PM | Arrival Time 10:40PM | Duration 48h10 | Departure days Wed, Fri, Sat | Cheapest price $278 |
Live departures
St. Louis, MO to San Diego, CA bus times
The table below shows live departures for St. Louis, MO to San Diego, CA buses for today, Tuesday, July 21. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 9:30 PM St. Louis, MO | 49h55 | 11:25 PM San Diego, CA | 0 transfersDirect | |
| Wednesday, July 22 | |||||
| 2:10 PM St. Louis, MO | 52h35 | 6:45 PM San Diego, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to San Diego, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book St. Louis, MO to San Diego, CA buses with Omio?
Greyhound operates all buses services from St. Louis, MO to San Diego, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to San Diego, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to San Diego, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to San Diego, CA.
Journey information
Overview: Bus from St. Louis, MO to San Diego, CA
USAUSA
Buses from St. Louis, MO to San Diego, CA run on average 10 times per day, taking around 38h 40m. Cheap bus tickets for this journey start at $135 (€111) if you book in advance.
The earliest bus runs at 01:20, the last at 23:30. The fastest bus covers the 1560 miles (2512 km) distance in 43h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1560 miles (2512 km) |
Average bus duration 38h 40m |
Cheapest ticket price $135 (€111) |
Buses per day 10 |
Fastest bus 43h 0m |
First bus 1:20 AM |
Last bus 11:30 PM |
Cheapest Month Aug |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jul - Sep |
Best time to book 6 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from St. Louis, MO to San Diego, CAYou can travel by bus between St. Louis, MO to San Diego, CA with Greyhound for as low as $135 (€111). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
43h 0m
Cheapest Price
$135 (€111)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to San Diego
Things to do in San Diego
Discover the best of San Diego — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego trip today.
- Must visit
Museum of Contemporary Art San Diego
Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.
- Must visit
USS Midway Museum
Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.
- Must visit
Balboa Park
Balboa Park is San Diego's grand cultural park, packed with gardens, architecture, museums, and walkable plazas worth lingering in.
- Must visit
Gaslamp Quarter
Historic Gaslamp Quarter offers Victorian-era streets, nightlife energy, and preserved downtown architecture for an atmospheric walk.
- Must visit
La Jolla Cove
Dramatic seaside cliffs and walking paths in La Jolla, famous for waves, sea lions, and sweeping Pacific views.
Fish Taco
A San Diego staple: grilled fish in a soft tortilla with cabbage, crema, and salsa. Popularized by Baja influence and coastal seafood culture.
California Burrito
French fries, carne asada, cheese, guacamole, and crema wrapped in a flour tortilla. A late-night local favorite born in San Diego taquerias.
- Gluten-free
Sea Urchin (Uni)
Fresh local sea urchin served raw, prized for its rich, buttery taste. It reflects San Diego's access to Pacific seafood and sushi culture.
Sushi Ota
Celebrated sushi restaurant specializing in omakase and pristine seafood, including uni. Intimate, polished, and highly respected by locals.
Mitch's Seafood
Iconic casual seafood counter known for fish tacos, smoked fish, and harbor views. A classic stop for San Diego's Baja-inspired seafood style.
Juniper and Ivy
Refined fine-dining restaurant showcasing local seafood and seasonal California ingredients. Elegant room with one of the city's strongest reputations.
US Dollar ($)
San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $25-45 per person for a mid-range meal.
- Fine dining
- $75+ per person for upscale dining.
- Coffee
- $4-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.
FAQs: Bus from St. Louis, MO to San Diego, CA
Find answers to the most common questions about traveling from St. Louis, MO to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to San Diego, CA can start from as little as $135 (€111) when you book in advance. The average bus ticket price for St. Louis, MO to San Diego, CA is $273 (€225) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to San Diego, CA is 43h 0m to travel the 1560 miles (2512 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to San Diego, CA leaves at 1:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to San Diego, CA leaves at 11:30 PM.
There are 10 buses a day from St. Louis, MO to San Diego, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to San Diego, CA, you can count on Greyhound for the best way to get you to San Diego, CA. You can also check all possible bus companies who offer a service between St. Louis, MO and San Diego, CA and compare the amenities they offer before buying a bus ticket.
A trip to San Diego, CA from St. Louis, MO is worth doing but not as a day trip with a journey time of 43h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to San Diego, CA is August.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to San Diego, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to San Diego, CA for bus company Greyhound.
Some of the most interesting sights to explore in San Diego, CA are:
- Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
- USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
- La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
- Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
- Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best things to do in San Diego, CA include:
- Explore the vibrant art scene at the Museum of Contemporary Art San Diego
- enjoy a harbor cruise for stunning views of the skyline and naval ships
- hike the scenic trails at Torrey Pines State Natural Reserve
- visit the Birch Aquarium to learn about marine life and ocean conservation
- experience the thrill of a whale watching tour off the coast.
Whether you can cancel your bus ticket from St. Louis, MO to San Diego, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to San Diego, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to San Diego, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to San Diego, CA.
You can reserve your seat on the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Since neither St. Louis, MO nor San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to San Diego, CA
Most St. Louis, MO to San Diego, CA buses use the St. Louis, S 15th St (Civic center) to San Diego, Congress Street (Old Town Park) station pair, with some services arriving at San Diego, West Harbor Drive (The Headquarters at Seaport District). Use this guide to compare St. Louis, MO and San Diego, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in St. Louis
Arrival bus stations in San Diego
St. Louis, S 15th St (Civic center)
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, Lambert International Airport
City-centre transport
Getting to St. Louis, Lambert International Airport from St. Louis city centre
TrainMlr · 31m · $4 · every ~7 min
Bus4 · 1h 3m · $30 · every ~4 min
San Diego, Congress Street (Old Town Park)
City-centre transport
Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre
BusFlixBus 2017 · 20m · $1
83 · 26m · $6
TramGreen, Blue, Event · 16m · every ~18 min
Blue · 21m · every ~9 min
San Diego, West Harbor Drive (The Headquarters at Seaport District)
San Diego, San Ysidro Transit Center
City-centre transport
Getting to San Diego, San Ysidro Transit Center from San Diego city centre
BusFlixBus 2017 · 25m · $2
910 · 41m · $6
TramBlue · 41m · $17 · every ~14 min
Blue · 43m · $17 · every ~14 min
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to San Diego, CA
Here are some other resources that might have the information you need
Most popular buses to and from San Diego, CA and St. Louis, MO
Most popular bus connections to San Diego, CA
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