St. Louis, MO to San Diego, CA bus with Greyhound

Sun, Sep 06
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The cheapest and fastest buses from St. Louis, MO to San Diego, CA

Showing times, prices and bookable tickets for Sep 06

Cheapest price on Sep 06

$206

Average ticket price on Sep 06

$215

Fastest journey on Sep 06

1 d 18 h 25 m

Average journey duration on Sep 06

1 d 19 h 56 m

Buses on Sep 06

13

Distance

2512 km

Cheap tickets

The best way to find a cheap bus ticket from St. Louis, MO to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from St. Louis, MO to San Diego, CA will cost around $215 if you buy it on the day, but the cheapest tickets can be found for only $206.

Fast buses

It's difficult to get from St. Louis, MO to San Diego, CA without transferring at least once.

  • Greyhound · · ·
    9:10 AM52h35
    St. Louis, Lambert International Airport
    11:45 AMSan Diego, Congress Street (Old Town Park), CA
    $2061One-way
    3 transfers
  • Greyhound · · +FlixBusFlixBus
    9:10 AM52h25
    St. Louis, Lambert International Airport
    11:35 AMSan Diego, Congress Street (Old Town Park), CA
    $2071One-way
    3 transfers
  • Greyhound · · +FlixBusFlixBus
    9:10 AM52h45
    St. Louis, Lambert International Airport
    11:55 AMSan Diego, West Harbor Drive (The Headquarters at Seaport District), CA
    $2071One-way
    3 transfers
  • FlixBusFlixBus+Greyhound · ·
    4:00 PM51h45
    St. Louis, S 15th St (Civic center)
    5:45 PMSan Diego, Congress Street (Old Town Park), CA
    $2071One-way
    3 transfers
  • Greyhound · · ·
    8:40 AM53h05
    St. Louis, S 15th St (Civic center)
    11:45 AMSan Diego, Congress Street (Old Town Park), CA
    $2081One-way
    3 transfers

Travel Information

Compare train, bus, and flight for St. Louis, MO to San Diego, CA

Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Diego, CA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $229 For those with little time, consider booking a flight, which has an average total journey time of 9h 22m. Average ticket prices depend on the travel mode: a bus costs an average of $229, while a train costs an average of $304.

Distance: 1560 miles (2512 km)

Compare bus with

Bus
Most popular
Train
Flight
Driving

$229

Average price

Cheapest

$304

Average price

$246

Average price

$389

Average price

(fuel + tolls)

39h 10m

Average total duration

38h 40m

Onboard

+

30m

Additional time*

61h 24m

Average total duration

60h 54m

Onboard

+

30m

Additional time*

9h 22m

Average total duration

Fastest

7h 22m

Onboard

+

2h 0m

Additional time*

26h 33m

Average total duration

(door-to-door)

Greyhound

Most popular bus company

Amtrak

Most popular train company

American Airlines

Most popular airline

Your own car or car rental

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from St. Louis, MO to San Diego, CA is a bus with an average price of $229.

This is compared to other travel options from St. Louis, MO to San Diego, CA:

A bus is $17 less than a flight for this route with tickets for a flight from St. Louis, MO to San Diego, CA costing on average $246.

A bus is $75 less than a train for this route with tickets for a train from St. Louis, MO to San Diego, CA costing on average $304.

The fastest way to travel from St. Louis, MO to San Diego, CA is by flight with an average journey time of 7h 22m.

Other travel options to San Diego, CA take longer:

Bus takes on average 38h 40m.

Train takes on average 60h 54m.

It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around $229 compared to roughly $389 in fuel and tolls — a saving of about $160. The journey takes 38h 40m versus 26h 33m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

St. Louis, MO to San Diego, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
01:20AM
Arrival Time
06:20PM
Duration
43h00
Departure days
Everyday
Cheapest price
$197
Operator
Greyhound
Departure Time
08:40AM
Arrival Time
11:45AM
Duration
53h05
Departure days
Everyday
Cheapest price
$195
Operator
Greyhound
Departure Time
09:10AM
Arrival Time
11:35AM
Duration
52h25
Departure days
Everyday
Cheapest price
$176
Operator
Greyhound
Departure Time
04:00PM
Arrival Time
05:45PM
Duration
51h45
Departure days
Everyday
Cheapest price
$190
Operator
Greyhound
Departure Time
05:15PM
Arrival Time
11:35AM
Duration
44h20
Departure days
Everyday
Cheapest price
$181

Live departures

St. Louis, MO to San Diego, CA bus times

The table below shows live departures for St. Louis, MO to San Diego, CA buses for today, Saturday, September 5. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Greyhound · 1:20 AM St. Louis, S 15th St (Civic center)
43h00
6:20 PM San Diego, San Ysidro Transit Center1 transfer
Greyhound+FlixBusFlixBus1:20 AM St. Louis, S 15th St (Civic center)
46h55
10:15 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA1 transfer
Greyhound · 1:20 AM St. Louis, S 15th St (Civic center)
42h25
5:45 PM San Diego, Congress Street (Old Town Park), CA1 transfer
Greyhound · · · 8:40 AM St. Louis, S 15th St (Civic center)
53h05
11:45 AM San Diego, Congress Street (Old Town Park), CA3 transfers
Greyhound · · · 8:40 AM St. Louis, S 15th St (Civic center)
53h40
12:20 PM San Diego, San Ysidro Transit Center3 transfers
Greyhound · · +FlixBusFlixBus9:10 AM St. Louis, Lambert International Airport
52h25
11:35 AM San Diego, Congress Street (Old Town Park), CA3 transfers
Greyhound · · · 9:10 AM St. Louis, Lambert International Airport
52h35
11:45 AM San Diego, Congress Street (Old Town Park), CA3 transfers
Greyhound · · · 9:10 AM St. Louis, Lambert International Airport
53h10
12:20 PM San Diego, San Ysidro Transit Center3 transfers
Greyhound · · +FlixBusFlixBus9:10 AM St. Louis, Lambert International Airport
52h45
11:55 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA3 transfers
FlixBusFlixBus+Greyhound · · 4:00 PM St. Louis, S 15th St (Civic center)
51h45
5:45 PM San Diego, Congress Street (Old Town Park), CA3 transfers
Greyhound · · +FlixBusFlixBus5:15 PM St. Louis, S 15th St (Civic center)
44h20
11:35 AM San Diego, Congress Street (Old Town Park), CA3 transfers
Greyhound · · +FlixBusFlixBus5:15 PM St. Louis, S 15th St (Civic center)
45h15
12:30 PM San Diego, San Ysidro Transit Center3 transfers
Greyhound · · +FlixBusFlixBus5:15 PM St. Louis, S 15th St (Civic center)
44h40
11:55 AM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA3 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets St. Louis, MO to San Diego, CA by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Why should you book St. Louis, MO to San Diego, CA buses with Omio?

Greyhound operates all buses services from St. Louis, MO to San Diego, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to San Diego, CA.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to San Diego, CA.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to San Diego, CA.

Journey information

Overview: Bus from St. Louis, MO to San Diego, CA

USAUSA
USAUSA
Icon of bus

Buses from St. Louis, MO to San Diego, CA run on average 10 times per day, taking around 38h 40m. Cheap bus tickets for this journey start at $134 if you book in advance.

The earliest bus runs at 01:20, the last at 23:30. The fastest bus covers the 1560 miles (2512 km) distance in 49h 10m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
1560 miles (2512 km)
Average bus duration
38h 40m
Cheapest ticket price
$134
Buses per day
10
Fastest bus
49h 10m
First bus
1:20 AM
Last bus
11:30 PM
Cheapest Month
Aug
Cheapest Day
Tue
High Season
Oct - Dec
Low Season
Jul - Sep
Best time to book
6 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound from St. Louis, MO to San Diego, CAYou can travel by bus between St. Louis, MO to San Diego, CA with Greyhound for as low as $134. When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
49h 10m
Cheapest Greyhound Price
$134
Greyhound frequency
10 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

Complete guide to San Diego, CA

Things to do in San Diego, CA

Discover the best of San Diego, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego, CA trip today.

  • Must visit

San Diego Museum of Art

Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.

  • Must visit

Museum of Contemporary Art San Diego

Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.

  • Must visit

USS Midway Museum

Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.

US Dollar ($)

San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.

Average meal costs

Budget
$10-18 for fast food or casual takeout.
Mid-range
$25-45 per person for a mid-range meal.
Fine dining
$75+ per person for upscale dining.
Coffee
$4-6 for coffee or cappuccino.

Tipping culture

Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.

FAQs: Bus from St. Louis, MO to San Diego, CA

Find answers to the most common questions about traveling from St. Louis, MO to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from St. Louis, MO to San Diego, CA can start from as little as $134 when you book in advance. The average bus ticket price for St. Louis, MO to San Diego, CA is $229 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to San Diego, CA is 49h 10m to travel the 1560 miles (2512 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to San Diego, CA leaves at 1:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to San Diego, CA leaves at 11:30 PM.
There are 10 buses a day from St. Louis, MO to San Diego, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to San Diego, CA, you can count on Greyhound for the best way to get you to San Diego, CA. You can also check all possible bus companies who offer a service between St. Louis, MO and San Diego, CA and compare the amenities they offer before buying a bus ticket.
When departing from St. Louis, MO , you have various bus station options to start your journey from including St. Louis, S 15th St (Civic center), St. Louis, Lambert International Airport . When arriving in San Diego, CA , you can end your journey in bus stations like San Diego, Congress Street (Old Town Park), CA, San Diego, West Harbor Drive (The Headquarters at Seaport District), CA, San Diego, San Ysidro Transit Center, La Jolla, UCSD Health La Jolla Station, CA, San Diego, Rail Ct / E San Ysidro Blvd (McDonald`s), CA .Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around away from the city centre, and they get off the bus at San Diego, Congress Street (Old Town Park), CA, located 5 away from the city centre.
A trip to San Diego, CA from St. Louis, MO is worth doing but not as a day trip with a journey time of 49h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to San Diego, CA is August.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to San Diego, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to San Diego, CA for bus company Greyhound.
Some of the most interesting sights to explore in San Diego, CA are:
  • Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
  • USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
  • La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
  • Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
  • Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best things to do in San Diego, CA include:
  • Explore the vibrant art scene at the Museum of Contemporary Art San Diego
  • enjoy a harbor cruise for stunning views of the skyline and naval ships
  • hike the scenic trails at Torrey Pines State Natural Reserve
  • visit the Birch Aquarium to learn about marine life and ocean conservation
  • experience the thrill of a whale watching tour off the coast.
Whether you can cancel your bus ticket from St. Louis, MO to San Diego, CA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to San Diego, CA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to San Diego, CA:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to San Diego, CA.
You can reserve your seat on the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Since neither St. Louis, MO nor San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from St. Louis, MO to San Diego, CA

Most St. Louis, MO to San Diego, CA buses use the St. Louis, S 15th St (Civic center) to San Diego, Congress Street (Old Town Park) station pair, with some services arriving at San Diego, West Harbor Drive (The Headquarters at Seaport District). Use this guide to compare St. Louis, MO and San Diego, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in St. Louis
Arrival bus stations in San Diego

Which St. Louis, MO station do buses to San Diego, CA leave from?

Buses from St. Louis, MO to San Diego, CA leave from St. Louis, S 15th St (Civic center). The station is 0 miles (1 km) from St. Louis, MO city centre at S 15th St, St. Louis, MO, USA.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USAWifiParkingATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre

TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min

St. Louis, S 15th St (Civic center) bus station facilities and services

St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Wi-Fi and ATMs

Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).

Tickets and information

Ticket office support is available at St. Louis, S 15th St (Civic center).

Parking, taxis and toilets

Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.

St. Louis, Lambert International AirportSt. Louis Lambert International Airport (STL), 10701 Lambert International Blvd, St. Louis, MO 63145, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to St. Louis, Lambert International Airport from St. Louis city centre

St. Louis, Lambert International Airport is 19 km from St. Louis city centre. Public transport options include:

TrainMlr · 31m · $4 · every ~7 min
Bus4 · 1h 3m · $31 · every ~4 min

St. Louis, Lambert International Airport bus station facilities and services

St. Louis, Lambert International Airport has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Multiple dining options available in terminals.

Wi-Fi and ATMs

Free Wi-Fi available throughout the airport. ATMs are aTMs available in terminal areas.

Tickets and information

Ticket office support is available at St. Louis, Lambert International Airport.

Parking, taxis and toilets

Available at St. Louis, Lambert International Airport: Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at St. Louis, Lambert International Airport: Wheelchair accessible facilities available.

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