- Must visit
USS Midway Museum
A historic aircraft carrier museum on the waterfront with restored aircraft, flight deck exhibits, and naval history displays. One of San Diego’s signature attractions.
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The cheapest and fastest buses from St. Louis, MO to San Diego, CA
Showing times and prices for Jun 07
Cheapest price
$237
Average price
$237
Fastest journey
1 d 19 h
Average duration
1 d 19 h
Buses per day
1
Distance
2512 km
Cheap tickets
The best way to find a cheap bus ticket from St. Louis, MO to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from St. Louis, MO to San Diego, CA will cost around $237 if you buy it on the day, but the cheapest tickets can be found for only $237.
Fast buses
Of the 1 buses that leave St. Louis, MO for San Diego, CA on Sun, Jun 07, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 07 the direct buses cover the 2512 km distance in an average of 1 d 19 h but if you time it right, some buses will get you there in just 1 d 19 h .
On Sun, Jun 07 the slowest buses will take 1 d 19 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
7:20 AM43h00St. Louis, MO2:20 AMSan Diego, CA$2371One-way0 transfers
- 7:20 AM43h00St. Louis, MO2:20 AMSan Diego, CA$2371One-way0 transfers
Travel Information
Compare train, bus, and flight for St. Louis, MO to San Diego, CA
Omio recommends booking the train as it is the most popular option from St. Louis, MO to San Diego, CA among Omio's users. If you are prioritising price take the flight with prices starting from $147. For those with little time consider booking a flight which can get you there in 7h 22m. The ticket price range depends on the travel mode: a flight costs an average of $147, and a train costs an average of $216.
Distance: 1560 miles (2512 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$276 Average price | $279 Average price | $262 Average price Cheapest | $381 Average price (fuel + tolls) |
39h 10m Average total duration 38h 40m Onboard + 30m Additional time* | 61h 41m Average total duration 61h 11m Onboard + 30m Additional time* | 10h 22m Average total duration Fastest 7h 22m Onboard + 3h 0m Additional time* | 26h 33m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from St. Louis, MO to San Diego, CA is a flight with an average price of $262 (€214).
This is compared to other travel options from St. Louis, MO to San Diego, CA:
A flight is $13 (€11) less than a bus for this route with tickets for a bus from St. Louis, MO to San Diego, CA costing on average $276 (€225).
A flight is $17 (€13) less than a train for this route with tickets for a train from St. Louis, MO to San Diego, CA costing on average $279 (€227).
The fastest way to travel from St. Louis, MO to San Diego, CA is by flight with an average journey time of 7h 22m.
Other travel options to San Diego, CA take longer:
Bus takes on average 38h 40m.
Train takes on average 61h 11m.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
St. Louis, MO to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:20AM | Arrival Time 05:15AM | Duration 46h55 | Departure days Fri | Cheapest price $187 |
Operator Greyhound | Departure Time 07:20AM | Arrival Time 02:20AM | Duration 43h00 | Departure days Sun | Cheapest price $237 |
Operator Greyhound | Departure Time 01:40PM | Arrival Time 05:35PM | Duration 51h55 | Departure days Thu | Cheapest price $282 |
Operator Greyhound | Departure Time 02:10PM | Arrival Time 06:45PM | Duration 52h35 | Departure days Wed, Sat | Cheapest price $136 |
Operator Greyhound | Departure Time 03:10PM | Arrival Time 08:20PM | Duration 53h10 | Departure days Mon, Fri | Cheapest price $233 |
Operator Greyhound | Departure Time 09:00PM | Arrival Time 01:20AM | Duration 52h20 | Departure days Wed | Cheapest price $181 |
Operator Greyhound | Departure Time 09:30PM | Arrival Time 11:25PM | Duration 49h55 | Departure days Mon, Tue, Thu, Fri, Sat | Cheapest price $259 |
Operator Greyhound | Departure Time 10:30PM | Arrival Time 10:40PM | Duration 48h10 | Departure days Wed, Fri, Sat | Cheapest price $280 |
Live departures
St. Louis, MO to San Diego, CA bus times
The table below shows live departures for St. Louis, MO to San Diego, CA buses for today, Saturday, June 6. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 2:10 PM St. Louis, MO | 52h35 | 6:45 PM San Diego, CA | 0 transfersDirect | |
| 9:30 PM St. Louis, MO | 49h55 | 11:25 PM San Diego, CA | 0 transfersDirect | |
| 10:30 PM St. Louis, MO | 48h10 | 10:40 PM San Diego, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets St. Louis, MO to San Diego, CA by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Jun 07
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Why should you book St. Louis, MO to San Diego, CA buses with Omio?
Greyhound operates all buses services from St. Louis, MO to San Diego, CA.
Omio is an official ticket reseller for all your travel options from St. Louis, MO to San Diego, CA.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from St. Louis, MO to San Diego, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from St. Louis, MO to San Diego, CA.
Journey information
Overview: Bus from St. Louis, MO to San Diego, CA
USAUSA
Buses from St. Louis, MO to San Diego, CA run on average 10 times per day, taking around 38h 40m. Cheap bus tickets for this journey start at $136 (€111) if you book in advance.
The earliest bus runs at 01:20, the last at 23:30. The fastest bus covers the 1560 miles (2512 km) distance in 43h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1560 miles (2512 km) |
Average bus duration 38h 40m |
Cheapest ticket price $136 (€111) |
Buses per day 10 |
Fastest bus 43h 0m |
First bus 1:20 AM |
Last bus 11:30 PM |
Cheapest Month Aug |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jul - Sep |
Best time to book 6 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from St. Louis, MO to San Diego, CAYou can travel by bus between St. Louis, MO to San Diego, CA with Greyhound for as low as $136 (€111). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
43h 0m
Cheapest Price
$136 (€111)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to San Diego
Things to do in San Diego
Discover the best of San Diego — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego trip today.
- Recommended
San Diego Museum of Art
Balboa Park’s major fine arts museum, known for Spanish old masters, European paintings, and rotating international exhibitions.
- Recommended
Museum of Contemporary Art San Diego
A leading contemporary art museum with major installations, ocean views at La Jolla, and a strong program of modern and experimental art.
- Must visit
Balboa Park
San Diego’s flagship cultural park, home to major museums, gardens, historic architecture, and wide promenades. Essential for first-time visitors.
- Must visit
La Jolla Cove
A picturesque coastal area known for sea lions, cliffs, turquoise water, and some of the city’s most photographed ocean views.
- Must visit
Old Town San Diego State Historic Park
A walkable historic district celebrating early California history, with preserved buildings, museums, and lively public spaces.
- Gluten-free
Fish Tacos
Beer-battered or grilled local fish in corn tortillas, usually topped with cabbage, crema, and salsa. A defining San Diego staple shaped by Baja California influence.
California Burrito
A San Diego original burrito filled with carne asada, fries, cheese, and salsa. It is one of the city’s most famous late-night and taqueria foods.
- Gluten-free
Carne Asada Fries
French fries topped with carne asada, cheese, guacamole, sour cream, and salsa. This indulgent border-style dish is strongly associated with San Diego taco shops.
Mitch's Seafood
Well-known waterfront seafood restaurant in Point Loma serving fresh local catch, fish sandwiches, and harbor views.
Las Cuatro Milpas
Historic Barrio Logan favorite known for handmade tortillas, tacos, rice, beans, and a classic old-school atmosphere.
Oscar's Mexican Seafood
Popular casual spot celebrated for Baja-style fish tacos, ceviche, and fresh seafood in a relaxed beach-city setting.
United States Dollar
Prices are high by U.S. standards, especially for hotels and dining near the coast. Budget options exist inland and via casual eateries.
Average meal costs
- Budget
- USD 10-18 for tacos, fast food, or casual takeout.
- Mid-range
- USD 25-45 per person at a mid-range restaurant.
- Fine dining
- USD 75+ per person before drinks and tip.
- Coffee
- USD 4-7 for a regular coffee or latte.
Tipping culture
Tip 18-20% at restaurants; 20%+ for great service. Bars: USD 1-2 per drink. Taxis/rideshares: 10-15%. Hotel staff: USD 2-5. Little or no tip for counter service.
FAQs: Bus from St. Louis, MO to San Diego, CA
Find answers to the most common questions about traveling from St. Louis, MO to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from St. Louis, MO to San Diego, CA can start from as little as $136 (€111) when you book in advance. The average bus ticket price for St. Louis, MO to San Diego, CA is $276 (€225) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from St. Louis, MO to San Diego, CA is 43h 0m to travel the 1560 miles (2512 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from St. Louis, MO to San Diego, CA leaves at 1:20 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from St. Louis, MO to San Diego, CA leaves at 11:30 PM.
There are 10 buses a day from St. Louis, MO to San Diego, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from St. Louis, MO to San Diego, CA, you can count on Greyhound for the best way to get you to San Diego, CA. You can also check all possible bus companies who offer a service between St. Louis, MO and San Diego, CA and compare the amenities they offer before buying a bus ticket.
A trip to San Diego, CA from St. Louis, MO is worth doing but not as a day trip with a journey time of 43h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from St. Louis, MO to San Diego, CA is August.
It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and San Diego, CA including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from St. Louis, MO to San Diego, CA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from St. Louis, MO to San Diego, CA for bus company Greyhound.
Some of the most interesting sights to explore in San Diego, CA are:
- Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
- USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
- La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
- Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
- Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best things to do in San Diego, CA include:
- Explore the vibrant art scene at the Museum of Contemporary Art San Diego
- enjoy a harbor cruise for stunning views of the skyline and naval ships
- hike the scenic trails at Torrey Pines State Natural Reserve
- visit the Birch Aquarium to learn about marine life and ocean conservation
- experience the thrill of a whale watching tour off the coast.
Whether you can cancel your bus ticket from St. Louis, MO to San Diego, CA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from St. Louis, MO to San Diego, CA.
Yes, the following luggage options are included when booking a bus ticket from St. Louis, MO to San Diego, CA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from St. Louis, MO to San Diego, CA:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from St. Louis, MO to San Diego, CA.
You can reserve your seat on the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from St. Louis, MO to San Diego, CA with the following bus company: Greyhound.
Since neither St. Louis, MO nor San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from St. Louis, MO to San Diego, CA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from St. Louis, MO to San Diego, CA
St. Louis
San Diego
The major bus station for departures in St. Louis is St. Louis, S 15th St (Civic center). Find all the information you need to know about services, amenities and connections at St. Louis, S 15th St (Civic center) for your trip from St. Louis to San Diego.
St. Louis, S 15th St (Civic center)
information
St. Louis, Lambert International Airport
information
The major bus station for arrivals in San Diego is San Diego, Congress Street (Old Town Park). Find all the information you need to know about services, amenities and connections at San Diego, Congress Street (Old Town Park) for your trip to San Diego from St. Louis.
San Diego, Congress Street (Old Town Park)
information
San Diego, West Harbor Drive (The Headquarters at Seaport District)
information
San Diego, San Ysidro Transit Center
information
Most popular bus connections from St. Louis, MO
More options for your journey from St. Louis, MO to San Diego, CA
Here are some other resources that might have the information you need
Most popular buses to and from San Diego, CA and St. Louis, MO
Most popular bus connections to San Diego, CA
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