Jacksonville, FL to Des Moines, IA bus with FlixBus

Wed, Jul 15
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The cheapest and fastest buses from Jacksonville, FL to Des Moines, IA

Showing times and prices for Jul 15

Cheapest price

$279

Average price

$294

Fastest journey

1 d 9 h 5 m

Average duration

1 d 13 h 8 m

Buses per day

2

Distance

1648 km

Cheap tickets

The best way to find a cheap bus ticket from Jacksonville, FL to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Jacksonville, FL to Des Moines, IA will cost around $294 if you buy it on the day, but the cheapest tickets can be found for only $279.

Fast buses

It's difficult to get from Jacksonville, FL to Des Moines, IA without transferring at least 2 times.

  • Flixbus USA
    9:25 PM41h10
    Jacksonville, FL
    2:35 PMDes Moines, IA
    $2791One-way
    2 transfers
  • Greyhound USA
    9:30 AM33h05
    Jacksonville, FL
    6:35 PMDes Moines, IA
    $3091One-way
    2 transfers

Travel Information

Compare bus and flight for Jacksonville, FL to Des Moines, IA

Omio recommends booking the bus as it is the most popular option from Jacksonville, FL to Des Moines, IA among Omio's users. If you are prioritising price take the bus with prices starting from $180. For those with little time consider booking a flight which can get you there in 3h 55m. The ticket price range depends on the travel mode: a bus costs an average of $180, and a flight costs an average of $523.

Distance: 1024 miles (1648 km)

Compare bus with

Most popular
Bus
Flight
Driving

$250

Average price

Cheapest

$543

Average price

$240

Average price

(fuel + tolls)

29h 3m

Average total duration

28h 33m

Onboard

+

30m

Additional time*

6h 55m

Average total duration

Fastest

3h 55m

Onboard

+

3h 0m

Additional time*

18h 30m

Average total duration

(door-to-door)

FlixBus

Most popular bus company

United

Most popular airline

Your own car or car rental

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Jacksonville, FL to Des Moines, IA is a bus with an average price of $250 (€206).

This is compared to other travel options from Jacksonville, FL to Des Moines, IA:

A bus is $293 (€242) less than a flight for this route with tickets for a flight from Jacksonville, FL to Des Moines, IA costing on average $543 (€448).

The fastest way to travel from Jacksonville, FL to Des Moines, IA is by flight with an average journey time of 3h 55m.

Other travel options to Des Moines, IA take longer:

Bus takes on average 28h 33m.

It's helpful to compare your options as there are 2 ways to travel between Jacksonville, FL and Des Moines, IA including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Jacksonville, FL to Des Moines, IA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.

You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.

Direct coaches are operated by {directProviders}.

Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.

Jacksonville, FL to Des Moines, IA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
FlixBus
Departure Time
01:25AM
Arrival Time
07:35PM
Duration
42h10
Departure days
Fri
Cheapest price
$256
Operator
Greyhound USA
Departure Time
09:30AM
Arrival Time
06:35PM
Duration
33h05
Departure days
Mon, Wed, Fri, Sun
Cheapest price
$309
Operator
FlixBus
Departure Time
01:30PM
Arrival Time
11:55PM
Duration
34h25
Departure days
Tue
Cheapest price
$313
Operator
FlixBus
Departure Time
08:30PM
Arrival Time
04:45AM
Duration
32h15
Departure days
Thu
Cheapest price
$180
Operator
Flixbus USA
Departure Time
09:25PM
Arrival Time
02:35PM
Duration
41h10
Departure days
Mon, Wed, Sun
Cheapest price
$279

Live departures

Jacksonville, FL to Des Moines, IA bus times

The table below shows live departures for Jacksonville, FL to Des Moines, IA buses for today, Tuesday, July 14. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
FlixBus1:30 PM Jacksonville, FL
34h25
11:55 PM Des Moines, IA0 transfersDirect
Wednesday, July 15
Greyhound USA9:30 AM Jacksonville, FL
33h05
6:35 PM Des Moines, IA2 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Jacksonville, FL to Des Moines, IA by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Wed
Jul 15
Thu
Jul 16
Fri
Jul 17
Sat
Jul 18
Sun
Jul 19
Mon
Jul 20
Tue
Jul 21

Why should you book Jacksonville, FL to Des Moines, IA buses with Omio?

FlixBus as well as Greyhound offer buses services from Jacksonville, FL to Des Moines, IA.
Omio is an official ticket reseller for all your travel options from Jacksonville, FL to Des Moines, IA.

Why book with Omio vs FlixBus?

  • Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Jacksonville, FL to Des Moines, IA.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Jacksonville, FL to Des Moines, IA.

Why book with Omio over Wanderu or Trainline?

  • Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Jacksonville, FL to Des Moines, IA.
  • Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Jacksonville, FL to Des Moines, IA.

Journey information

Overview: Bus from Jacksonville, FL to Des Moines, IA

USAUSA
USAUSA
Icon of bus

Buses from Jacksonville, FL to Des Moines, IA run on average 2 times per day, taking around 28h 33m. Cheap bus tickets for this journey start at $180 (€148) if you book in advance.

The earliest bus runs at 04:55, the last at 21:25. The fastest bus covers the 1024 miles (1648 km) distance in 32h 15m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
1024 miles (1648 km)
Average bus duration
28h 33m
Cheapest ticket price
$180 (€148)
Buses per day
2
Fastest bus
32h 15m
First bus
4:55 AM
Last bus
9:25 PM
Cheapest Month
Jun
Cheapest Day
Thu
High Season
Apr - Jun
Low Season
Jul - Sep
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: FlixBus, Greyhound from Jacksonville, FL to Des Moines, IAYou can travel by bus between Jacksonville, FL to Des Moines, IA with FlixBus, Greyhound for as low as $180 (€148). When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
32h 15m
Cheapest Price
$180 (€148)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Learn more about FlixBus

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
33h 5m
Cheapest Price
$309 (€255)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Learn more about Greyhound

FAQs: Bus from Jacksonville, FL to Des Moines, IA

Find answers to the most common questions about traveling from Jacksonville, FL to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Jacksonville, FL to Des Moines, IA can start from as little as $180 (€148) when you book in advance. The average bus ticket price for Jacksonville, FL to Des Moines, IA is $250 (€206) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Jacksonville, FL to Des Moines, IA is 32h 15m to travel the 1024 miles (1648 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Jacksonville, FL to Des Moines, IA leaves at 4:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Jacksonville, FL to Des Moines, IA leaves at 9:25 PM.
There are 2 buses a day from Jacksonville, FL to Des Moines, IA which require at least one change with FlixBus, Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Jacksonville, FL to Des Moines, IA, you can count on FlixBus, Greyhound for the best way to get you to Des Moines, IA. You can also check all possible bus companies who offer a service between Jacksonville, FL and Des Moines, IA and compare the amenities they offer before buying a bus ticket.
A trip to Des Moines, IA from Jacksonville, FL is worth doing but not as a day trip with a journey time of 32h 15m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Jacksonville, FL to Des Moines, IA is June.
It's helpful to compare your options as there are 2 ways to travel between Jacksonville, FL and Des Moines, IA including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Jacksonville, FL to Des Moines, IA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Jacksonville, FL to Des Moines, IA for bus company FlixBus, Greyhound.
Whether you can cancel your bus ticket from Jacksonville, FL to Des Moines, IA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus, Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Jacksonville, FL to Des Moines, IA.
Yes, the following luggage options are included when booking a bus ticket from Jacksonville, FL to Des Moines, IA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Jacksonville, FL to Des Moines, IA:
  • Greyhound
    • $15 per additional bag.
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Jacksonville, FL to Des Moines, IA. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound
Yes, there are USB plugs on board the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound.
Yes, there is Wifi on board the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound.
Since neither Jacksonville, FL nor Des Moines, IA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Jacksonville, FL to Des Moines, IA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Des Moines, IA, travelers should be cautious of pickpocketing and occasional vehicle break-ins, especially in crowded areas and parking lots. Common scams include fake ticket sellers for local events and unofficial ride services. Staying alert in busy downtown spots and using authorized transportation options helps ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Jacksonville, FL to Des Moines, IA

Most Jacksonville, FL to Des Moines, IA buses use the Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St to station pair. Use this guide to compare Jacksonville, FL and Des Moines, IA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in Jacksonville
Arrival bus stations in Des Moines
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St
City-centre transport

Getting to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St from Jacksonville city centre

Bus1, 11, 18, 205, 3, Nassau, St. Johns, Clay · 12m · $4 · every ~18 min
1, 19, 3 · 17m · $4 · every ~17 min
SubwaySky · 10m · every ~4 min

More options for your journey from Jacksonville, FL to Des Moines, IA

Here are some other resources that might have the information you need

Trains from Jacksonville, FL to Des Moines, IA
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Tickets and more information for coaches to Des Moines, IA

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