- Must visit
Des Moines Art Center
Leading contemporary and modern art museum with notable architecture and a respected permanent collection; a top cultural stop in the city.
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The cheapest and fastest buses from Jacksonville, FL to Des Moines, IA
Showing times and prices for May 19
Cheapest price
$319
Average price
$319
Fastest journey
1 d 10 h 25 m
Average duration
1 d 10 h 25 m
Buses per day
1
Distance
1648 km
Cheap tickets
The best way to find a cheap bus ticket from Jacksonville, FL to Des Moines, IA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Jacksonville, FL to Des Moines, IA will cost around $319 if you buy it on the day, but the cheapest tickets can be found for only $319.
Fast buses
Of the 1 buses that leave Jacksonville, FL for Des Moines, IA on Tue, May 19, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, May 19 the direct buses cover the 1648 km distance in an average of 1 d 10 h 25 m but if you time it right, some buses will get you there in just 1 d 10 h 25 m .
On Tue, May 19 the slowest buses will take 1 d 10 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
1:30 PM34h25Jacksonville, FL11:55 PMDes Moines, IA$3191One-way0 transfers
- 1:30 PM34h25Jacksonville, FL11:55 PMDes Moines, IA$3191One-way0 transfers
Travel Information
Compare bus and flight for Jacksonville, FL to Des Moines, IA
Omio recommends booking the bus as it is the most popular option from Jacksonville, FL to Des Moines, IA among Omio's users. If you are prioritising price take the bus with prices starting from $184. For those with little time consider booking a flight which can get you there in 3h 55m. The ticket price range depends on the travel mode: a bus costs an average of $184, and a flight costs an average of $534.
Distance: 1024 miles (1648 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$255 Average price Cheapest | $554 Average price | $245 Average price (fuel + tolls) |
29h 3m Average total duration 28h 33m Onboard + 30m Additional time* | 6h 55m Average total duration Fastest 3h 55m Onboard + 3h 0m Additional time* | 18h 30m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Jacksonville, FL to Des Moines, IA is a bus with an average price of $255 (€206).
This is compared to other travel options from Jacksonville, FL to Des Moines, IA:
A bus is $299 (€242) less than a flight for this route with tickets for a flight from Jacksonville, FL to Des Moines, IA costing on average $554 (€448).
The fastest way to travel from Jacksonville, FL to Des Moines, IA is by flight with an average journey time of 3h 55m.
Other travel options to Des Moines, IA take longer:
Bus takes on average 28h 33m.
It's helpful to compare your options as there are 2 ways to travel between Jacksonville, FL and Des Moines, IA including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Jacksonville, FL to Des Moines, IA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Jacksonville, FL to Des Moines, IA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:25AM | Arrival Time 07:35PM | Duration 42h10 | Departure days Fri | Cheapest price $261 |
Operator Greyhound USA | Departure Time 09:30AM | Arrival Time 06:35PM | Duration 33h05 | Departure days Mon, Wed, Fri, Sun | Cheapest price $316 |
Operator FlixBus | Departure Time 01:30PM | Arrival Time 11:55PM | Duration 34h25 | Departure days Tue | Cheapest price $319 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 04:45AM | Duration 32h15 | Departure days Thu | Cheapest price $184 |
Operator Flixbus USA | Departure Time 09:25PM | Arrival Time 02:35PM | Duration 41h10 | Departure days Mon, Wed, Sun | Cheapest price $285 |
Live departures
Jacksonville, FL to Des Moines, IA bus times
The table below shows live departures for Jacksonville, FL to Des Moines, IA buses for today, Monday, May 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 9:30 AM Jacksonville, FL | 33h05 | 6:35 PM Des Moines, IA | 2 transfers | |
| 9:25 PM Jacksonville, FL | 41h10 | 2:35 PM Des Moines, IA | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Jacksonville, FL to Des Moines, IA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Tue
May 19
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Why should you book Jacksonville, FL to Des Moines, IA buses with Omio?
FlixBus as well as Greyhound offer buses services from Jacksonville, FL to Des Moines, IA.
Omio is an official ticket reseller for all your travel options from Jacksonville, FL to Des Moines, IA.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Jacksonville, FL to Des Moines, IA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Jacksonville, FL to Des Moines, IA.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Jacksonville, FL to Des Moines, IA.
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Jacksonville, FL to Des Moines, IA.
Journey information
Overview: Bus from Jacksonville, FL to Des Moines, IA
USAUSA
Buses from Jacksonville, FL to Des Moines, IA run on average 2 times per day, taking around 28h 33m. Cheap bus tickets for this journey start at $184 (€148) if you book in advance.
The earliest bus runs at 04:55, the last at 21:25. The fastest bus covers the 1024 miles (1648 km) distance in 32h 15m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 1024 miles (1648 km) |
Average bus duration 28h 33m |
Cheapest ticket price $184 (€148) |
Buses per day 2 |
Fastest bus 32h 15m |
First bus 4:55 AM |
Last bus 9:25 PM |
Cheapest Month Jun |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus, Greyhound from Jacksonville, FL to Des Moines, IAYou can travel by bus between Jacksonville, FL to Des Moines, IA with FlixBus, Greyhound for as low as $184 (€148). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
32h 15m
Cheapest Price
$184 (€148)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
33h 5m
Cheapest Price
$316 (€255)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Des Moines
Things to do in Des Moines
Discover the best of Des Moines — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Des Moines trip today.
- Recommended
State Historical Museum of Iowa
Museum covering Iowa history through statewide exhibits, artifacts, and rotating displays inside the State Historical Building.
- Recommended
Salisbury House & Gardens
Historic house museum with art, rare books, and grand interiors inspired by English manor architecture; well known for tours and events.
- Must visit
East Village
Lively historic district east of the river known for independent shops, murals, restored storefronts, and easy access to the Capitol.
- Must visit
Principal Riverwalk
Downtown riverfront walking route with bridges, public art, events spaces, and some of the city’s best skyline perspectives.
- Recommended
Gray's Lake Park
Popular urban park with a large lake, illuminated pedestrian bridge, and scenic path favored for walks and sunset views.
Pork Tenderloin Sandwich
An Iowa classic featuring a breaded, fried pork tenderloin cutlet served on a bun, often comically larger than the bread. It is one of the state’s most iconic comfort foods.
- Vegetarian
- Gluten-free
Sweet Corn
Iowa sweet corn is a summer staple, prized for its freshness and sweetness. Locals eat it boiled or grilled with butter at fairs, backyard cookouts, and seasonal farm stands.
Loose Meat Sandwich
A seasoned ground beef sandwich served loose on a bun rather than formed into a patty. It is a longtime Midwestern lunch counter favorite found across Iowa.
Aposto at the Scala House
A respected fine-dining spot in a historic house, serving Italian-influenced cuisine with a romantic atmosphere and strong local reputation.
801 Chophouse Des Moines
An established upscale steakhouse known for prime steaks, seafood, and polished service in an elegant downtown setting.
Alba Restaurant
A well-known contemporary American restaurant in the East Village, popular for refined seasonal dishes and a stylish but approachable atmosphere.
United States Dollar
Generally affordable by major U.S. city standards. Hotels and dining are usually moderate, with good budget options.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 20-35 per person at a casual sit-down restaurant.
- Fine dining
- USD 60+ per person at upscale restaurants.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% at restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, and hotel staff a few USD.
FAQs: Bus from Jacksonville, FL to Des Moines, IA
Find answers to the most common questions about traveling from Jacksonville, FL to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Jacksonville, FL to Des Moines, IA can start from as little as $184 (€148) when you book in advance. The average bus ticket price for Jacksonville, FL to Des Moines, IA is $255 (€206) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Jacksonville, FL to Des Moines, IA is 32h 15m to travel the 1024 miles (1648 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Jacksonville, FL to Des Moines, IA leaves at 4:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Jacksonville, FL to Des Moines, IA leaves at 9:25 PM.
There are 2 buses a day from Jacksonville, FL to Des Moines, IA which require at least one change with FlixBus, Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Jacksonville, FL to Des Moines, IA, you can count on FlixBus, Greyhound for the best way to get you to Des Moines, IA. You can also check all possible bus companies who offer a service between Jacksonville, FL and Des Moines, IA and compare the amenities they offer before buying a bus ticket.
A trip to Des Moines, IA from Jacksonville, FL is worth doing but not as a day trip with a journey time of 32h 15m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Jacksonville, FL to Des Moines, IA is June.
It's helpful to compare your options as there are 2 ways to travel between Jacksonville, FL and Des Moines, IA including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Jacksonville, FL to Des Moines, IA:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Jacksonville, FL to Des Moines, IA for bus company FlixBus, Greyhound.
Whether you can cancel your bus ticket from Jacksonville, FL to Des Moines, IA depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus, Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Jacksonville, FL to Des Moines, IA.
Yes, the following luggage options are included when booking a bus ticket from Jacksonville, FL to Des Moines, IA:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Jacksonville, FL to Des Moines, IA:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Jacksonville, FL to Des Moines, IA. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound
Yes, there are USB plugs on board the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound.
Yes, there is Wifi on board the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound.
Since neither Jacksonville, FL nor Des Moines, IA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Jacksonville, FL to Des Moines, IA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Des Moines, IA, travelers should be cautious of pickpocketing and occasional vehicle break-ins, especially in crowded areas and parking lots. Common scams include fake ticket sellers for local events and unofficial ride services. Staying alert in busy downtown spots and using authorized transportation options helps ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Jacksonville, FL to Des Moines, IA
Jacksonville
Des Moines
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St
information
Most popular bus connections from Jacksonville, FL
More options for your journey from Jacksonville, FL to Des Moines, IA
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Most popular buses to and from Des Moines, IA and Jacksonville, FL
Most popular bus connections to Des Moines, IA
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