Jacksonville, FL to Des Moines, IA bus with FlixBus

Sat, Aug 29
+ Add return
FlixBus
Greyhound
Alsa
BlaBlaCar Bus
Rede Expressos
2,000+ travel companies
FlixBus
Greyhound
Alsa
BlaBlaCar Bus
Rede Expressos
2,000+ travel companies
QR-Code
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
rate4.9
42K ratings
Google Play
rate4.6
136K reviews

Travel Information

Compare bus and flight for Jacksonville, FL to Des Moines, IA

Omio recommends booking the bus as it is the most popular option from Jacksonville, FL to Des Moines, IA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of Kč3422 For those with little time, consider booking a flight, which has an average total journey time of 6h 10m. Average ticket prices depend on the travel mode: a bus costs an average of Kč3422, while a flight costs an average of Kč3806.

Distance: 1024 miles (1648 km)

Compare bus with

Most popular
Bus
Flight
Driving

Kč3422

Average price

Cheapest

Kč3806

Average price

Kč5151

Average price

(fuel + tolls)

29h 3m

Average total duration

28h 33m

Onboard

+

30m

Additional time*

6h 10m

Average total duration

Fastest

4h 10m

Onboard

+

2h 0m

Additional time*

18h 30m

Average total duration

(door-to-door)

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Jacksonville, FL to Des Moines, IA is a bus with an average price of Kč3422.

This is compared to other travel options from Jacksonville, FL to Des Moines, IA:

A bus is Kč384 less than a flight for this route with tickets for a flight from Jacksonville, FL to Des Moines, IA costing on average Kč3806.

The fastest way to travel from Jacksonville, FL to Des Moines, IA is by flight with an average journey time of 4h 10m.

Other travel options to Des Moines, IA take longer:

Bus takes on average 28h 33m.

It's helpful to compare your options as there are 2 ways to travel between Jacksonville, FL and Des Moines, IA including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Jacksonville, FL to Des Moines, IA among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.

You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.

Direct coaches are operated by {directProviders}.

Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.

Jacksonville, FL to Des Moines, IA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
FlixBus
Departure Time
01:25AM
Arrival Time
07:35PM
Duration
42h10
Departure days
Fri
Cheapest price
5425
Operator
Greyhound USA
Departure Time
09:30AM
Arrival Time
06:35PM
Duration
33h05
Departure days
Mon, Wed, Fri, Sun
Cheapest price
6558
Operator
Greyhound
Departure Time
10:00AM
Arrival Time
10:05PM
Duration
37h05
Departure days
Tue
Cheapest price
3009
Operator
FlixBus
Departure Time
05:25PM
Arrival Time
02:35PM
Duration
46h10
Departure days
Tue
Cheapest price
3032
Operator
FlixBus
Departure Time
08:30PM
Arrival Time
04:45AM
Duration
32h15
Departure days
Thu
Cheapest price
3814
Operator
Flixbus USA
Departure Time
09:25PM
Arrival Time
02:35PM
Duration
41h10
Departure days
Mon, Wed, Sun
Cheapest price
5915

Compare prices and tickets Jacksonville, FL to Des Moines, IA by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sat
Aug 29
Sun
Aug 30
Mon
Aug 31
Tue
Sep 01
Wed
Sep 02
Thu
Sep 03
Fri
Sep 04

Why should you book Jacksonville, FL to Des Moines, IA buses with Omio?

FlixBus as well as Greyhound offer buses services from Jacksonville, FL to Des Moines, IA.
Omio is an official ticket reseller for all your travel options from Jacksonville, FL to Des Moines, IA.

Why book with Omio vs FlixBus?

  • Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Jacksonville, FL to Des Moines, IA.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Jacksonville, FL to Des Moines, IA.

Why book with Omio over Wanderu or Trainline?

  • Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Jacksonville, FL to Des Moines, IA.
  • Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Jacksonville, FL to Des Moines, IA.

Journey information

Overview: Bus from Jacksonville, FL to Des Moines, IA

USAUSA
USAUSA
Icon of bus

Buses from Jacksonville, FL to Des Moines, IA run on average 2 times per day, taking around 28h 33m. Cheap bus tickets for this journey start at Kč2675 but you can travel from only Kč965 by flight.

The earliest bus runs at 04:55, the last at 21:25. The fastest bus covers the 1024 miles (1648 km) distance in 32h 15m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from Kč965
Distance
1024 miles (1648 km)
Average bus duration
28h 33m
Cheapest ticket price
Kč2675
Buses per day
2
Fastest bus
32h 15m
First bus
4:55 AM
Last bus
9:25 PM
Cheapest Month
Jul
Cheapest Day
Sun
High Season
Apr - Jun
Low Season
Jul - Sep
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from Kč965

Bus providers: FlixBus, Greyhound from Jacksonville, FL to Des Moines, IAYou can travel by bus between Jacksonville, FL to Des Moines, IA with FlixBus, Greyhound for as low as Kč965. When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
32h 15m
Cheapest FlixBus Price
Kč2675
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
33h 5m
Cheapest Greyhound Price
Kč6558
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from Jacksonville, FL to Des Moines, IA

Find answers to the most common questions about traveling from Jacksonville, FL to Des Moines, IA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Jacksonville, FL to Des Moines, IA can start from as little as Kč2675 when you book in advance. The average bus ticket price for Jacksonville, FL to Des Moines, IA is Kč3422 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Jacksonville, FL to Des Moines, IA is 32h 15m to travel the 1024 miles (1648 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Jacksonville, FL to Des Moines, IA leaves at 4:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Jacksonville, FL to Des Moines, IA leaves at 9:25 PM.
There are 2 buses a day from Jacksonville, FL to Des Moines, IA which require at least one change with FlixBus, Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Jacksonville, FL to Des Moines, IA, you can count on FlixBus, Greyhound for the best way to get you to Des Moines, IA. You can also check all possible bus companies who offer a service between Jacksonville, FL and Des Moines, IA and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St, which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.), IA, located 3 away from the city centre.
A trip to Des Moines, IA from Jacksonville, FL is worth doing but not as a day trip with a journey time of 32h 15m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Jacksonville, FL to Des Moines, IA is July.
It's helpful to compare your options as there are 2 ways to travel between Jacksonville, FL and Des Moines, IA including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Jacksonville, FL to Des Moines, IA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Jacksonville, FL to Des Moines, IA for bus company FlixBus, Greyhound.
Whether you can cancel your bus ticket from Jacksonville, FL to Des Moines, IA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus, Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Jacksonville, FL to Des Moines, IA.
Yes, the following luggage options are included when booking a bus ticket from Jacksonville, FL to Des Moines, IA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Jacksonville, FL to Des Moines, IA:
  • Greyhound
    • $15 per additional bag.
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Jacksonville, FL to Des Moines, IA. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound
Yes, there are USB plugs on board the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound.
Yes, there is Wifi on board the bus from Jacksonville, FL to Des Moines, IA with the following bus company: FlixBus, Greyhound.
Since neither Jacksonville, FL nor Des Moines, IA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Jacksonville, FL to Des Moines, IA among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Des Moines, IA, travelers should be cautious of pickpocketing and occasional vehicle break-ins, especially in crowded areas and parking lots. Common scams include fake ticket sellers for local events and unofficial ride services. Staying alert in busy downtown spots and using authorized transportation options helps ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Jacksonville, FL to Des Moines, IA

Most Jacksonville, FL to Des Moines, IA buses use the Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St to Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) station pair. Use this guide to compare Jacksonville, FL and Des Moines, IA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in Jacksonville
Arrival bus stations in Des Moines

Which Jacksonville, FL station do buses to Des Moines, IA leave from?

Buses from Jacksonville, FL to Des Moines, IA leave from Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. The station is 1 miles (2 km) from Jacksonville, FL city centre at 1111 W Forsyth St, Jacksonville, FL 32204, USA.
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St1111 W Forsyth St, Jacksonville, FL 32204, USAWifiParkingATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St from Jacksonville city centre

Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 km from Jacksonville city centre. Public transport options include:

Bus1, 11, 18, 205, 3, Nassau, St. Johns, Clay · 12m · Kč77 · every ~18 min
1, 19, 3 · 17m · Kč77 · every ~17 min
SubwaySky · 10m · every ~4 min

Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St bus station facilities and services

Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Wi-Fi and ATMs

Wi-Fi is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. ATMs are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.

Tickets and information

Ticket office support is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.

Parking, taxis and toilets

Available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Wheelchair accessible entrances.

More options for your journey from Jacksonville, FL to Des Moines, IA

Here are some other resources that might have the information you need

Most popular buses to and from Des Moines, IA and Jacksonville, FL

HomeBusesBuses in USABus tickets to Des Moines, IAJacksonville, FL to Des Moines, IA bus

The Omio App Makes Travel Planning Easy

We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.

ios-badge
android-badge
Hand With Phone