The cheapest and fastest buses from Tampa, FL to Greenville, SC
Cheapest price
$115
Average price
$143
Fastest journey
14 h 20 m
Average duration
14 h 58 m
Buses per day
2
Distance
768 km
The best way to find a cheap bus ticket from Tampa, FL to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Tampa, FL to Greenville, SC will cost around $143 if you buy it on the day, but the cheapest tickets can be found for only $115.
Of the 2 buses that leave Tampa, FL for Greenville, SC on Fri, Feb 06, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Feb 06 the direct buses cover the 768 km distance in an average of 14 h 58 m but if you time it right, some buses will get you there in just 14 h 20 m .
On Fri, Feb 06 the slowest buses will take 15 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare bus, train, and flight for Tampa, FL to Greenville, SC
Omio recommends booking the train as it is the most popular option from Tampa, FL to Greenville, SC among Omio's users. If you are prioritising price take the flight with prices starting from €44. For those with little time consider booking a flight which can get you there in 1h 29m. The ticket price range depends on the travel mode: a flight costs an average of €44, and a train costs an average of €113.
Distance: 477 miles (768 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€139 Average price | €187 Average price | €105 Average price Cheapest |
20h 31m Average total duration 20h 1m Onboard + 30m Additional time* | 22h 37m Average total duration 22h 7m Onboard + 30m Additional time* | 4h 29m Average total duration Fastest 1h 29m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Tampa, FL to Greenville, SC bus times
The table below shows live departures for Tampa, FL to Greenville, SC buses for today, Thursday, February 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:10 PM Tampa, FL | 14h20 | 11:30 AM Greenville, SC | 0 transfersDirect | |
| Friday, February 6 | |||||
![]() | 10:20 AM Tampa, FL | 15h35 | 1:55 AM Greenville, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Tampa, FL to Greenville, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 06
Feb 07
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Feb 09
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Feb 11
Feb 12
Journey information
Overview: Bus from Tampa, FL to Greenville, SC
Buses from Tampa, FL to Greenville, SC run on average 6 times per day, taking around 20h 1m. Cheap bus tickets for this journey start at $113 (€90) but you can travel from only $55 (€44) by flight.
The earliest bus runs at 02:23, the last at 22:35. The fastest bus covers the 477 miles (768 km) distance in 14h 40m.
Distance 477 miles (768 km) |
Average bus duration 20h 1m |
Cheapest ticket price $113 (€90) |
Buses per day 6 |
Fastest bus 14h 40m |
First bus 02:23 |
Last bus 22:35 |
FAQs: Bus from Tampa, FL to Greenville, SC
Find answers to the most common questions about traveling from Tampa, FL to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

popular bus stations
Popular bus stations from Tampa, FL to Greenville, SC
Most popular bus connections from Tampa, FL
More options for your journey from Tampa, FL to Greenville, SC
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