- Must visit
Greenville County Museum of Art
Major art museum known for its Southern art collection and works by Andrew Wyeth and Jasper Johns. One of the city’s top cultural attractions.
Flights from Tampa, FL to Greenville, SC depart on average 17 times per day, taking around 1h 29m. Cheap flight tickets for this journey start at $107 (€88) if you book in advance.
There are 1 flights per day. The earliest flight runs at 05:00, the last at 22:04. The fastest flight covers the 477 miles (768 km) distance in 1h 30m. January is the cheapest month to fly.
Distance 477 miles (768 km) |
Average flight duration 1h 29m |
Cheapest ticket price $107 (€88) |
Flights per day 17 |
Direct flights 1 |
Fastest flight 1h 30m |
First flight 5:00 AM |
Last flight 10:04 PM |
Cheapest Month Jan |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Apr - Jun |
Busiest Day Sat |
Least Busy Day Sat |
Best time to book 77 days |
Omio recommends booking the train as it is the most popular option from Tampa, FL to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $130. For those with little time consider booking a flight which can get you there in 1h 29m. The ticket price range depends on the travel mode: a bus costs an average of $130, and a train costs an average of $212.
Distance: 477 miles (768 km)
| Flight | Most popular Train | Bus | Driving |
|---|---|---|---|
$215 Average price | $278 Average price | $167 Average price Cheapest | $114 Average price (fuel + tolls) |
4h 29m Average total duration Fastest 1h 29m Onboard + 3h 0m Additional time* | 23h 54m Average total duration 23h 24m Onboard + 30m Additional time* | 18h 37m Average total duration 18h 7m Onboard + 30m Additional time* | 8h 35m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Tampa, FL to Greenville, SC:
A bus is $48 (€39) less than a flight for this route with tickets for a flight from Tampa, FL to Greenville, SC costing on average $215 (€175).
A bus is $110 (€90) less than a train for this route with tickets for a train from Tampa, FL to Greenville, SC costing on average $278 (€226).
Other travel options to Greenville, SC take longer:
Bus takes on average 18h 7m.
Train takes on average 23h 24m.
The table below shows live departures for Tampa, FL to Greenville, SC flights for today, Saturday, June 6. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:55 PM Tampa, FL | 3h45 | 9:40 PM Greenville, SC | 0 transfersDirect | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
Major art museum known for its Southern art collection and works by Andrew Wyeth and Jasper Johns. One of the city’s top cultural attractions.
Regional history museum with rotating exhibitions on the Upstate’s people, industry, and culture. A strong choice for understanding Greenville beyond downtown.
Specialized museum displaying historic string, keyboard, and wind instruments from around the world. A lesser-known but distinctive Greenville stop.
The core downtown street lined with shops, public art, plazas, and event spaces. It is Greenville’s main walking corridor and a top first stop.
Multi-use greenway linking Greenville with nearby communities. Highly popular for walking and cycling, and one of the city’s most loved outdoor assets.
Lively downtown district near Falls Park known for baseball, galleries, restored buildings, and a strong local atmosphere. Popular for strolling and photos.
Slow-smoked pork, often chopped or pulled, served with the state's famous mustard-based 'Carolina Gold' sauce. It is a defining Upstate and statewide tradition.
Unripe green tomatoes sliced, breaded, and fried until crisp. A classic Southern starter found on many Greenville-area menus.
Creamy stone-ground grits topped with shrimp, often with bacon, gravy, or a rich butter sauce. A beloved Lowcountry and broader South Carolina favorite.
Acclaimed neighborhood restaurant focused on seasonal Southern-influenced cooking, thoughtful plates, and a more polished dining experience.
A long-running downtown favorite serving refined Southern cuisine, including shrimp and grits and seasonal regional dishes, in a lively historic setting.
Stylish downtown restaurant known for handmade pasta, oysters, and city views. It is one of Greenville's best-known upscale dining rooms.
Costs are moderate by U.S. standards. Dining is reasonable, while hotels rise during events and peak weekends.
Tip 18-20% in restaurants; 20%+ for excellent service. Tip bartenders USD 1-2 per drink, taxis 10-15%, hotel staff USD 2-5, and round up for coffee if desired.
Find answers to the most common questions about traveling from Tampa, FL to Greenville, SC by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

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