Detroit, MI to Greenville, SC bus with Greyhound

Sun, Mar 22
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Greyhound
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2,000+ travel companies
Greyhound
FlixBus
Alsa
Costa Verde
BlaBlaCar Bus
2,000+ travel companies
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Why should you book Detroit, MI to Greenville, SC buses with Omio?

Greyhound operates all buses services from Detroit, MI to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Detroit, MI to Greenville, SC.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.

Journey information

Overview: Bus from Detroit, MI to Greenville, SC

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Take a bus from Detroit, MI to Greenville, SC and enjoy the approximately 518 miles (834 km) long journey. Find schedules and pricing options for a convenient and affordable trip.

The earliest bus runs at 02:23, the last at 23:15.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
518 miles (834 km)
Average bus duration
19h 25m
Buses per day
4
First bus
02:23
Last bus
23:15
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound from Detroit, MI to Greenville, SCYou can travel by bus between Detroit, MI to Greenville, SC with Greyhound. When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from Detroit, MI to Greenville, SC

Find answers to the most common questions about traveling from Detroit, MI to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

FAQs
The earliest bus from Detroit, MI to Greenville, SC leaves at 2:23 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Detroit, MI to Greenville, SC leaves at 11:15 PM.
There are 4 buses a day from Detroit, MI to Greenville, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Detroit, MI to Greenville, SC, you can count on Greyhound for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Detroit, MI and Greenville, SC and compare the amenities they offer before buying a bus ticket.
The cheapest month for a bus from Detroit, MI to Greenville, SC is September.
Yes, you can take a between Detroit, MI and Greenville, SC.
Yes, the following accessibility options are available when taking the bus from Detroit, MI to Greenville, SC:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Detroit, MI to Greenville, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Detroit, MI to Greenville, SC depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Detroit, MI to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Detroit, MI to Greenville, SC:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Detroit, MI to Greenville, SC:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Detroit, MI to Greenville, SC.
You can reserve your seat on the bus from Detroit, MI to Greenville, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Detroit, MI to Greenville, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Detroit, MI to Greenville, SC with the following bus company: Greyhound.

popular bus stations

Popular bus stations from Detroit, MI to Greenville, SC

Detroit
Greenville
The major bus station for departures in Detroit is Detroit, Greyhound Terminal. Find all the information you need to know about services, amenities and connections at Detroit, Greyhound Terminal for your trip from Detroit to Greenville.
Detroit, Greyhound Terminal
information

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