Journey information
Overview: Bus from Detroit, MI to Greenville, SC
Take a bus from Detroit, MI to Greenville, SC and enjoy the approximately 518 miles (834 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 02:23, the last at 22:15.
Distance 518 miles (834 km) |
Average bus duration 19h 25m |
Buses per day 3 |
First bus 02:23 |
Last bus 22:15 |
Bus providers: Greyhound from Detroit, MI to Greenville, SCYou can travel by bus between Detroit, MI to Greenville, SC with Greyhound. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Detroit, MI to Greenville, SC
Find answers to the most common questions about traveling from Detroit, MI to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Detroit, MI to Greenville, SC, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Detroit, MI to Greenville, SC
Most popular bus connections from Detroit, MI
More options for your journey from Detroit, MI to Greenville, SC
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