- Recommended
Greenville County Museum of Art
A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Detroit, MI to Greenville, SC
Showing times, prices and bookable tickets for Sep 20
Cheapest price on Sep 20
$93
Average ticket price on Sep 20
$94
Fastest journey on Sep 20
18 h 40 m
Average journey duration on Sep 20
23 h 20 m
Buses on Sep 20
5
Distance
834 km
Cheap tickets
The best way to find a cheap bus ticket from Detroit, MI to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Detroit, MI to Greenville, SC will cost around $94 if you buy it on the day, but the cheapest tickets can be found for only $93.
Fast buses
It's difficult to get from Detroit, MI to Greenville, SC without transferring at least once.
· 7:55 PM18h40Detroit, Greyhound Terminal2:35 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$931One-way1 transfer- · +
FlixBus1:50 PM22h45Detroit, Greyhound Terminal12:35 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$931One-way2 transfers - · · 11:15 PM28h00Detroit, Greyhound Terminal3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$951One-way2 transfers
- FlixBus · FlixBus+7:25 AM27h15Detroit, Greyhound Terminal10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$951One-way2 transfers
- · 7:15 AM20h00Detroit, Greyhound Terminal3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$951One-way1 transfer
- · 7:55 PM18h40Detroit, Greyhound Terminal2:35 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$931One-way1 transfer
- · 7:15 AM20h00Detroit, Greyhound Terminal3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$951One-way1 transfer
- · +FlixBus1:50 PM22h45Detroit, Greyhound Terminal12:35 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$931One-way2 transfers
- FlixBus · FlixBus+7:25 AM27h15Detroit, Greyhound Terminal10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$951One-way2 transfers
- · · 11:15 PM28h00Detroit, Greyhound Terminal3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$951One-way2 transfers
Travel Information
Compare bus and train for Detroit, MI to Greenville, SC
Omio recommends booking the bus as it is the most popular option from Detroit, MI to Greenville, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $128 For those with little time, consider booking a bus, which has an average total journey time of 20h 19m. Average ticket prices depend on the travel mode: a bus costs an average of $128, while a train costs an average of $445.
Distance: 518 miles (834 km)
Compare bus with
Most popular Bus | Train | Driving |
|---|---|---|
$128 Average price Cheapest | $445 Average price | $134 Average price (fuel + tolls) |
20h 19m Average total duration Fastest 19h 49m Onboard + 30m Additional time* | 34h 41m Average total duration 34h 11m Onboard + 30m Additional time* | 10h 13m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Detroit, MI to Greenville, SC is a bus with an average price of $128 (€105).
This is compared to other travel options from Detroit, MI to Greenville, SC:
A bus is $316 (€259) less than a train for this route with tickets for a train from Detroit, MI to Greenville, SC costing on average $445 (€364).
A bus is $529 (€433) less than a flight for this route with tickets for a flight from Detroit, MI to Greenville, SC costing on average $658 (€538).
The fastest way to travel from Detroit, MI to Greenville, SC is by flight with an average journey time of 4h 25m.
Other travel options to Greenville, SC take longer:
Bus takes on average 19h 49m.
Train takes on average 34h 11m.
It's helpful to compare your options as there are 2 ways to travel between Detroit, MI and Greenville, SC including taking a bus and train.
We recommend using the bus as it is the most popular way to get from Detroit, MI to Greenville, SC among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $128 (€105) compared to roughly $134 (€109) in fuel and tolls — a saving of about $5 (€4). The journey takes 19h 49m versus 10h 13m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Detroit, MI to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 07:15AM | Arrival Time 03:15AM | Duration 20h00 | Departure days Everyday | Cheapest price $81 |
Operator FlixBus | Departure Time 07:25AM | Arrival Time 10:40AM | Duration 27h15 | Departure days Tue, Fri, Sun | Cheapest price $91 |
Operator Greyhound | Departure Time 01:50PM | Arrival Time 12:35PM | Duration 22h45 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price $82 |
Operator Greyhound | Departure Time 07:55PM | Arrival Time 02:35PM | Duration 18h40 | Departure days Everyday | Cheapest price $82 |
Operator FlixBus | Departure Time 11:15PM | Arrival Time 10:40AM | Duration 35h25 | Departure days Mon, Sat | Cheapest price $84 |
Operator Greyhound | Departure Time 11:15PM | Arrival Time 03:15AM | Duration 28h00 | Departure days Tue, Wed, Thu, Fri, Sun | Cheapest price $89 |
Live departures
Detroit, MI to Greenville, SC bus times
The table below shows live departures for Detroit, MI to Greenville, SC buses for today, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · | 7:55 PM Detroit, Greyhound Terminal | 18h40 | 2:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| · · +FlixBus | 11:15 PM Detroit, Greyhound Terminal | 35h25 | 10:40 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 4 transfers | |
| Sunday, September 20 | |||||
| · | 7:15 AM Detroit, Greyhound Terminal | 20h00 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| FlixBus · FlixBus+ | 7:25 AM Detroit, Greyhound Terminal | 27h15 | 10:40 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| · +FlixBus | 1:50 PM Detroit, Greyhound Terminal | 22h45 | 12:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
Find all the dates and times for this journey
Compare prices and tickets Detroit, MI to Greenville, SC by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sun
Sep 20
Sep 20
Mon
Sep 21
Sep 21
Tue
Sep 22
Sep 22
Wed
Sep 23
Sep 23
Thu
Sep 24
Sep 24
Fri
Sep 25
Sep 25
Sat
Sep 26
Sep 26
Why should you book Detroit, MI to Greenville, SC buses with Omio?
Greyhound operates all buses services from Detroit, MI to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Detroit, MI to Greenville, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and train to ensure you get the best deal for traveling from Detroit, MI to Greenville, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Detroit, MI to Greenville, SC.
Journey information
Overview: Bus from Detroit, MI to Greenville, SC
USAUSA
Buses from Detroit, MI to Greenville, SC run on average 4 times per day, taking around 19h 49m. Cheap bus tickets for this journey start at $89 (€72) if you book in advance.
The earliest bus runs at 02:23, the last at 23:45. The fastest bus covers the 518 miles (834 km) distance in 17h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 518 miles (834 km) |
Average bus duration 19h 49m |
Cheapest ticket price $89 (€72) |
Buses per day 4 |
Fastest bus 17h 25m |
First bus 2:23 AM |
Last bus 11:45 PM |
Cheapest Month Jun |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Oct - Dec |
Best time to book 35 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Detroit, MI to Greenville, SCYou can travel by bus between Detroit, MI to Greenville, SC with Greyhound, FlixBus for as low as $89 (€72). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
23h 5m
Cheapest FlixBus Price
$93 (€76)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
17h 25m
Cheapest Greyhound Price
$89 (€72)
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Greenville, SC
Things to do in Greenville, SC
Discover the best of Greenville, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville, SC trip today.
Greenville Center for Creative Arts
A contemporary art center showing regional and international artists through rotating exhibitions in a modern downtown gallery space.
Metropolitan Arts Council Gallery
A local gallery and arts space featuring exhibitions, classes, and community-focused programming in Greenville's Village area.
- Must visit
Falls Park on the Reedy
A signature downtown park with waterfalls, gardens, river trails, and lawns. It is Greenville's most popular public space for walking and views.
- Must visit
Main Street
Greenville's central street lined with shops, public art, and historic buildings. It is ideal for strolling between downtown attractions.
- Recommended
Prisma Health Swamp Rabbit Trail
A swamp rabbit-themed riverside greenway popular for walking and cycling, linking downtown Greenville with parks and nearby districts.
FAQs: Bus from Detroit, MI to Greenville, SC
Find answers to the most common questions about traveling from Detroit, MI to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Detroit, MI to Greenville, SC can start from as little as $89 (€72) when you book in advance. The average bus ticket price for Detroit, MI to Greenville, SC is $128 (€105) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Detroit, MI to Greenville, SC is 17h 25m to travel the 518 miles (834 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Detroit, MI to Greenville, SC leaves at 2:23 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Detroit, MI to Greenville, SC leaves at 11:45 PM.
There are 4 buses a day from Detroit, MI to Greenville, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Detroit, MI to Greenville, SC, you can count on Greyhound for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Detroit, MI and Greenville, SC and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Detroit, Greyhound Terminal, which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Greenville, Woodruff Rd ("Raceway" gas station), SC, located 8 away from the city centre.
A trip to Greenville, SC from Detroit, MI is worth doing but not as a day trip with a journey time of 17h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Detroit, MI to Greenville, SC is June.
It's helpful to compare your options as there are 2 ways to travel between Detroit, MI and Greenville, SC including taking a bus and train.
Yes, the following accessibility options are available when taking the bus from Detroit, MI to Greenville, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Detroit, MI to Greenville, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Detroit, MI to Greenville, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Detroit, MI to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Detroit, MI to Greenville, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Detroit, MI to Greenville, SC:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Detroit, MI to Greenville, SC.
You can reserve your seat on the bus from Detroit, MI to Greenville, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Detroit, MI to Greenville, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Detroit, MI to Greenville, SC with the following bus company: Greyhound.
Since neither Detroit, MI nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Detroit, MI to Greenville, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Detroit, MI to Greenville, SC
Most Detroit, MI to Greenville, SC buses use the Detroit, Greyhound Terminal to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Detroit, MI and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Detroit
Arrival bus stations in Greenville
Which Detroit, MI station do buses to Greenville, SC leave from?
Buses from Detroit, MI to Greenville, SC leave from Detroit, Greyhound Terminal. The station is 0 miles (1 km) from Detroit, MI city centre at Detroit, 1001 Howard St, Detroit, MI 48226, USA.
Detroit, Greyhound TerminalDetroit, 1001 Howard St, Detroit, MI 48226, USA
City-centre transport
Getting to Detroit, Greyhound Terminal from Detroit city centre
Detroit, Greyhound Terminal is 1 km from Detroit city centre. Public transport options include:
TRUE
Detroit, Greyhound Terminal bus station facilities and services
Detroit, Greyhound Terminal has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Fast food and coffee shops available.
Wi-Fi and ATMs
Free Wi-Fi available in waiting areas. ATMs are aTM located near the main entrance.
Tickets and information
Ticket office support is available at Detroit, Greyhound Terminal.
Parking, taxis and toilets
Available at Detroit, Greyhound Terminal: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Detroit, Greyhound Terminal: Wheelchair accessible facilities available.
Which Greenville, SC station do buses from Detroit, MI arrive at?
Buses from Detroit, MI to Greenville, SC arrive at Greenville, Woodruff Rd ("Raceway" gas station). Greenville, Woodruff Rd ("Raceway" gas station) is 4 miles (8 km) from Greenville, SC city centre.
Greenville, Woodruff Rd ("Raceway" gas station)Woodruff Rd, Greenville, SC, USA
City-centre transport
Getting to Greenville, Woodruff Rd ("Raceway" gas station) from Greenville city centre
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
TRUE
Greenville, Woodruff Rd ("Raceway" gas station) bus station facilities and services
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Limited dining options available in adjacent areas.
Wi-Fi and ATMs
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Tickets and information
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Parking, taxis and toilets
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
More options for your journey from Detroit, MI to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Detroit, MI
Most popular bus connections to Greenville, SC
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
