Columbus, OH to Greenville, SC bus with Greyhound

Fri, Dec 19
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Greyhound
FlixBus
Alsa
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Rede Expressos
1,000+ travel companies
Greyhound
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
1,000+ travel companies
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Travel Information

Compare bus and flight for Columbus, OH to Greenville, SC

Omio recommends booking the bus as it is the most popular option from Columbus, OH to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from €59. For those with little time consider booking a flight which can get you there in 6h 2m. The ticket price range depends on the travel mode: a bus costs an average of €59, and a flight costs an average of €222.

Distance: 354 miles (571 km)

Compare bus with

Most popular
Bus
Flight

€70

Average price

Cheapest

€227

Average price

13h 35m

Average total duration

13h 5m

Onboard

+

30m

Additional time*

9h 2m

Average total duration

Fastest

6h 2m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Compare prices and tickets Columbus, OH to Greenville, SC by bus or flight

Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Journey information

Overview: Bus from Columbus, OH to Greenville, SC

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Icon of bus

Buses from Columbus, OH to Greenville, SC run on average 5 times per day, taking around 13h 5m. Cheap bus tickets for this journey start at $74 (€59) if you book in advance.

The earliest bus runs at 12:55, the last at 22:15. The fastest bus covers the 354 miles (571 km) distance in 21h 30m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
354 miles (571 km)
Average bus duration
13h 5m
Cheapest ticket price
$74 (€59)
Buses per day
5
Fastest bus
21h 30m
First bus
12:55
Last bus
22:15
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound from Columbus, OH to Greenville, SCYou can travel by bus between Columbus, OH to Greenville, SC with Greyhound for as low as $74 (€59). When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
13h 50m
Cheapest Price
$85 (€68)
Greyhound frequency
5 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Learn more about Greyhound

FAQs: Bus from Columbus, OH to Greenville, SC

Find answers to the most common questions about traveling from Columbus, OH to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Columbus, OH to Greenville, SC can start from as little as $100 (€80) when you book in advance. The average bus ticket price for Columbus, OH to Greenville, SC is $139 (€111); however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
On average the Columbus, OH to Greenville, SC bus travel time is 14 h 55 min   for the 353 mile (570 km) long route, but the duration can vary if you travel on weekends and holidays.
The first bus from Columbus, OH to Greenville, SC leaves at 12: 15AM. Plan your trip with the Journey Planner   from Omio.
The last bus from Columbus, OH to Greenville, SC leaves at 10: 45PM.
The cheapest month to travel from Columbus, OH to Greenville, SC by bus is November.
You have options as you can travel from Columbus, OH to Greenville, SC 2 different ways: bus or flight.
No, the bus from Columbus, OH to Greenville, SC has no accessibility options.
No, there are no bathrooms on board the bus from Columbus, OH to Greenville, SC.
No, bikes are not allowed on board the bus from Columbus, OH to Greenville, SC.

To find the cheapest bus tickets for your trip from Columbus, OH to Greenville, SC, follow these tips:

  • Book in advance: Tickets are often cheaper when booked early.
  • Be flexible with dates and times: Traveling during off-peak hours or on weekdays can help you save money.
  • Use our search filters: Sort results by price to quickly identify the most affordable options.
  • Look for special deals or discounts: Check for promotions or discounts available on our website and app.

    • Start your search now and compare ticket prices to find the best deal!

    Yes, there is food available to purchase on board the bus from Columbus, OH to Greenville, SC.
    No, luggage for the bus from Columbus, OH to Greenville, SC needs to be booked in addition.
    No, there are no additional luggage options for the bus from Columbus, OH to Greenville, SC.
    Unfortunately, pets are not allowed on the bus from Columbus, OH to Greenville, SC.
    No, there are no USB plugs on board the bus from Columbus, OH to Greenville, SC.
    No, there is no WiFi on board the bus from Columbus, OH to Greenville, SC.

    popular bus stations

    Popular bus stations from Columbus, OH to Greenville, SC

    Columbus
    Greenville
    The major bus station for departures in Columbus is Columbus, E Town St (Bus Station). Find all the information you need to know about services, amenities and connections at Columbus, E Town St (Bus Station) for your trip from Columbus to Greenville.
    Columbus, E Town St (Bus Station)
    information
    Columbus, N Wilson Rd (Shell)
    information
    Columbus, West 12th Avenue (Ohio State University)
    information

    More options for your journey from Columbus, OH to Greenville, SC

    Here are some other resources that might have the information you need

    Trains from Columbus, OH to Greenville, SC
    Flights from Columbus, OH to Greenville, SC
    Tickets and more information for coaches to Columbus, OH
    Tickets and more information for coaches to Greenville, SC

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    HomeBusesBuses in USABus tickets to Greenville, SCColumbus, OH to Greenville, SC bus

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