- Must visit
Greenville County Museum of Art
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
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The cheapest and fastest buses from Columbus, OH to Greenville, SC
Showing times and prices for Jun 21
Cheapest price
$112
Average price
$123
Fastest journey
13 h 45 m
Average duration
19 h 22 m
Buses per day
8
Distance
571 km
Cheap tickets
The best way to find a cheap bus ticket from Columbus, OH to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Columbus, OH to Greenville, SC will cost around $123 if you buy it on the day, but the cheapest tickets can be found for only $112.
Fast buses
It's difficult to get from Columbus, OH to Greenville, SC without transferring at least once.
· +
FlixBus2:00 PM22h00Columbus, E Mound St (Akili Christian High School), OH12:00 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1121One-way2 transfers- · 12:50 AM13h45Columbus, E Mound St (Akili Christian High School), OH2:35 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1121One-way1 transfer
- FlixBus · FlixBus+11:00 AM23h40Columbus, E Town St (Bus Station), OH10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1141One-way2 transfers
- FlixBus+ · 9:45 AM17h30Columbus, E Town St (Bus Station), OH3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1191One-way2 transfers
- · · 5:20 AM21h55Columbus, E Mound St (Akili Christian High School), OH3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1201One-way2 transfers
- · 12:50 AM13h45Columbus, E Mound St (Akili Christian High School), OH2:35 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1121One-way1 transfer
- FlixBus+ · 9:45 AM17h30Columbus, E Town St (Bus Station), OH3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1191One-way2 transfers
- · +FlixBus11:50 PM21h40Columbus, E Mound St (Akili Christian High School), OH9:30 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1211One-way2 transfers
- · · 5:20 AM21h55Columbus, E Mound St (Akili Christian High School), OH3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1201One-way2 transfers
- · +FlixBus2:00 PM22h00Columbus, E Mound St (Akili Christian High School), OH12:00 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1121One-way2 transfers
Travel Information
Compare bus and flight for Columbus, OH to Greenville, SC
Omio recommends booking the bus as it is the most popular option from Columbus, OH to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $84. For those with little time consider booking a flight which can get you there in 4h 15m. The ticket price range depends on the travel mode: a bus costs an average of $84, and a flight costs an average of $313.
Distance: 354 miles (571 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
$153 Average price Cheapest | $375 Average price | $88 Average price (fuel + tolls) |
13h 35m Average total duration 13h 5m Onboard + 30m Additional time* | 7h 15m Average total duration Fastest 4h 15m Onboard + 3h 0m Additional time* | 8h 4m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Columbus, OH to Greenville, SC is a bus with an average price of $153 (€125).
This is compared to other travel options from Columbus, OH to Greenville, SC:
A bus is $222 (€182) less than a flight for this route with tickets for a flight from Columbus, OH to Greenville, SC costing on average $375 (€307).
The fastest way to travel from Columbus, OH to Greenville, SC is by flight with an average journey time of 4h 15m.
Other travel options to Greenville, SC take longer:
Bus takes on average 13h 5m.
It's helpful to compare your options as there are 2 ways to travel between Columbus, OH and Greenville, SC including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Columbus, OH to Greenville, SC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Columbus, OH to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:50AM | Arrival Time 02:35PM | Duration 13h45 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $104 |
Operator Greyhound | Departure Time 03:50AM | Arrival Time 01:55AM | Duration 22h05 | Departure days Thu | Cheapest price $89 |
Operator Greyhound | Departure Time 05:20AM | Arrival Time 03:15AM | Duration 21h55 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $108 |
Operator Greyhound | Departure Time 09:45AM | Arrival Time 03:15AM | Duration 17h30 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $112 |
Operator FlixBus | Departure Time 11:00AM | Arrival Time 10:40AM | Duration 23h40 | Departure days Mon, Sat, Sun | Cheapest price $114 |
Operator Greyhound | Departure Time 02:00PM | Arrival Time 12:00PM | Duration 22h00 | Departure days Thu, Fri, Sat, Sun | Cheapest price $104 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 01:15PM | Duration 23h15 | Departure days Mon, Tue | Cheapest price $136 |
Operator FlixBus | Departure Time 05:20PM | Arrival Time 07:25PM | Duration 26h05 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $149 |
Operator FlixBus | Departure Time 09:10PM | Arrival Time 07:25PM | Duration 22h15 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price $135 |
Operator Greyhound | Departure Time 11:50PM | Arrival Time 09:30PM | Duration 21h40 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $117 |
Live departures
Columbus, OH to Greenville, SC bus times
The table below shows live departures for Columbus, OH to Greenville, SC buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · · | 5:20 AM Columbus, E Mound St (Akili Christian High School), OH | 21h55 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| FlixBus+ · | 9:45 AM Columbus, E Town St (Bus Station), OH | 17h30 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| FlixBus · FlixBus+ | 11:00 AM Columbus, E Town St (Bus Station), OH | 23h40 | 10:40 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| · +FlixBus | 2:00 PM Columbus, E Mound St (Akili Christian High School), OH | 22h00 | 12:00 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| FlixBus · FlixBus · FlixBus | 5:20 PM Columbus, E Town St (Bus Station), OH | 26h05 | 7:25 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| FlixBus+ · | 9:10 PM Columbus, E Mound St (Akili Christian High School), OH | 22h15 | 7:25 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| · +FlixBus | 11:50 PM Columbus, E Mound St (Akili Christian High School), OH | 21h40 | 9:30 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| Sunday, June 21 | |||||
| · | 12:50 AM Columbus, E Mound St (Akili Christian High School), OH | 13h45 | 2:35 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Columbus, OH to Greenville, SC by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Columbus, OH to Greenville, SC buses with Omio?
Greyhound operates all buses services from Columbus, OH to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Columbus, OH to Greenville, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Columbus, OH to Greenville, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Columbus, OH to Greenville, SC.
Journey information
Overview: Bus from Columbus, OH to Greenville, SC
USAUSA
Buses from Columbus, OH to Greenville, SC run on average 5 times per day, taking around 13h 5m. Cheap bus tickets for this journey start at $84 (€68) if you book in advance.
The earliest bus runs at 00:50, the last at 22:15. The fastest bus covers the 354 miles (571 km) distance in 13h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 354 miles (571 km) |
Average bus duration 13h 5m |
Cheapest ticket price $84 (€68) |
Buses per day 5 |
Fastest bus 13h 45m |
First bus 12:50 AM |
Last bus 10:15 PM |
Cheapest Month Jul |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Columbus, OH to Greenville, SCYou can travel by bus between Columbus, OH to Greenville, SC with Greyhound for as low as $84 (€68). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
13h 45m
Cheapest Price
$84 (€68)
Greyhound frequency
5 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Greenville
Things to do in Greenville
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
- Recommended
Upcountry History Museum
Regional history museum with permanent and rotating exhibits on the people and stories of Upstate South Carolina. A strong choice for understanding Greenville’s local context.
- Recommended
Sigal Music Museum
Specialized museum displaying rare historic instruments from around the world. A distinctive local favorite for music, design, and cultural history.
- Must visit
Main Street
Greenville’s central downtown street lined with shops, public art, plazas, and event spaces. It is the main place to walk and experience the city atmosphere.
- Must visit
Falls Park on the Reedy
Downtown park built around waterfalls, gardens, and river overlooks. It is Greenville’s signature public space and a top stop for first-time visitors.
- Must visit
Swamp Rabbit Trail
Popular multi-use greenway for walking and cycling, linking Greenville with nearby communities. Widely loved by locals and visitors for active sightseeing.
- Gluten-free
South Carolina Barbecue
Slow-smoked pork, often chopped or pulled, served with the state's signature mustard-based sauce. It is a defining Upstate and South Carolina tradition.
- Vegetarian
Fried Green Tomatoes
Slices of unripe tomato coated and fried until crisp, often served with remoulade or pimento cheese. A classic Southern starter common in Greenville restaurants.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, gravy, or bacon. This Lowcountry favorite is widely loved in Greenville as part of broader South Carolina cuisine.
The Anchorage
Well-regarded neighborhood restaurant focused on seasonal Southern-influenced American cooking with a polished but relaxed atmosphere.
Soby's
A long-running downtown Greenville favorite serving refined Southern cuisine in a lively, upscale setting. Known for shrimp and grits, brunch, and strong wine selections.
Smoke On The Water
Popular casual spot for barbecue, ribs, and Southern comfort food near Falls Park. Lively atmosphere and a good place to try local smoked meats.
United States Dollar
Moderate by U.S. standards: casual dining is affordable, while upscale downtown hotels and restaurants cost more.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual restaurant.
- Fine dining
- USD 50-100+ per person at upscale restaurants.
- Coffee
- USD 3-6 for a coffee drink.
Tipping culture
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff a few dollars, and round up for coffee only if desired.
FAQs: Bus from Columbus, OH to Greenville, SC
Find answers to the most common questions about traveling from Columbus, OH to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Columbus, OH to Greenville, SC can start from as little as $84 (€68) when you book in advance. The average bus ticket price for Columbus, OH to Greenville, SC is $153 (€125) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Columbus, OH to Greenville, SC is 13h 45m to travel the 354 miles (571 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Columbus, OH to Greenville, SC leaves at 12:50 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Columbus, OH to Greenville, SC leaves at 10:15 PM.
There are 5 buses a day from Columbus, OH to Greenville, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Columbus, OH to Greenville, SC, you can count on Greyhound for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Columbus, OH and Greenville, SC and compare the amenities they offer before buying a bus ticket.
A trip to Greenville, SC from Columbus, OH is worth doing but not as a day trip with a journey time of 13h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Columbus, OH to Greenville, SC is July.
It's helpful to compare your options as there are 2 ways to travel between Columbus, OH and Greenville, SC including taking a bus and flight.
Yes, there are bathrooms on board the bus from Columbus, OH to Greenville, SC for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from Columbus, OH to Greenville, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Columbus, OH to Greenville, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Columbus, OH to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Columbus, OH to Greenville, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Columbus, OH to Greenville, SC:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Columbus, OH to Greenville, SC.
You can reserve your seat on the bus from Columbus, OH to Greenville, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Columbus, OH to Greenville, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Columbus, OH to Greenville, SC with the following bus company: Greyhound.
Since neither Columbus, OH nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Columbus, OH to Greenville, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Columbus, OH to Greenville, SC
Columbus
Greenville
The major bus station for departures in Columbus is Columbus, E Town St (Bus Station). Find all the information you need to know about services, amenities and connections at Columbus, E Town St (Bus Station) for your trip from Columbus to Greenville.
Columbus, E Town St (Bus Station)
information
The major bus station for arrivals in Greenville is Greenville, Woodruff Rd ("Raceway" gas station). Find all the information you need to know about services, amenities and connections at Greenville, Woodruff Rd ("Raceway" gas station) for your trip to Greenville from Columbus.
Greenville, Woodruff Rd ("Raceway" gas station)
information
Most popular bus connections from Columbus, OH
More options for your journey from Columbus, OH to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Columbus, OH
Most popular bus connections to Greenville, SC
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