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Greenville County Museum of Art
A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
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Travel Information
Compare bus and flight for Columbus, OH to Greenville, SC
Omio recommends booking the bus as it is the most popular option from Columbus, OH to Greenville, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €92 For those with little time, consider booking a flight, which has an average total journey time of 6h 2m. Average ticket prices depend on the travel mode: a bus costs an average of €92, while a flight costs an average of €505.
Distance: 354 miles (571 km)
Compare bus with
Most popular Bus | Flight | Driving |
|---|---|---|
€92 Average price Cheapest | €505 Average price | €73 Average price (fuel + tolls) |
18h 2m Average total duration 17h 32m Onboard + 30m Additional time* | 6h 2m Average total duration Fastest 4h 2m Onboard + 2h 0m Additional time* | 8h 4m Average total duration (door-to-door) |
 Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Columbus, OH to Greenville, SC is a bus with an average price of €92.
This is compared to other travel options from Columbus, OH to Greenville, SC:
A bus is €413 less than a flight for this route with tickets for a flight from Columbus, OH to Greenville, SC costing on average €505.
The fastest way to travel from Columbus, OH to Greenville, SC is by flight with an average journey time of 4h 2m.
Other travel options to Greenville, SC take longer:
Bus takes on average 17h 32m.
It's helpful to compare your options as there are 2 ways to travel between Columbus, OH and Greenville, SC including taking a bus and flight.
We recommend using the bus as it is the most popular way to get from Columbus, OH to Greenville, SC among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around €92 compared to roughly €73 in fuel and tolls — a saving of about €-18.53. The journey takes 17h 32m versus 8h 4m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Columbus, OH to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:50AM | Arrival Time 02:35PM | Duration 13h45 | Departure days Mon, Tue, Wed, Fri, Sun | Cheapest price €53 |
Operator Greyhound | Departure Time 04:50AM | Arrival Time 06:35PM | Duration 13h45 | Departure days Thu | Cheapest price €68 |
Operator Greyhound | Departure Time 05:20AM | Arrival Time 03:15AM | Duration 21h55 | Departure days Mon, Tue, Wed, Fri, Sun | Cheapest price €54 |
Operator Greyhound | Departure Time 09:45AM | Arrival Time 03:15AM | Duration 17h30 | Departure days Mon, Tue, Wed, Fri, Sun | Cheapest price €54 |
Operator Greyhound | Departure Time 10:30AM | Arrival Time 12:00PM | Duration 25h30 | Departure days Thu | Cheapest price €161 |
Operator Greyhound | Departure Time 11:00AM | Arrival Time 12:00PM | Duration 25h00 | Departure days Wed | Cheapest price €57 |
Operator FlixBus | Departure Time 11:00AM | Arrival Time 10:40AM | Duration 23h40 | Departure days Mon, Sun | Cheapest price €68 |
Operator Greyhound | Departure Time 02:00PM | Arrival Time 12:00PM | Duration 22h00 | Departure days Wed, Sun | Cheapest price €55 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 10:40AM | Duration 20h40 | Departure days Fri | Cheapest price €59 |
Operator FlixBus | Departure Time 05:20PM | Arrival Time 07:25PM | Duration 26h05 | Departure days Mon, Fri, Sun | Cheapest price €58 |
Compare prices and tickets Columbus, OH to Greenville, SC by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Columbus, OH to Greenville, SC buses with Omio?
Greyhound operates all buses services from Columbus, OH to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Columbus, OH to Greenville, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Columbus, OH to Greenville, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Columbus, OH to Greenville, SC.
Journey information
Overview: Bus from Columbus, OH to Greenville, SC
USAUSA
Buses from Columbus, OH to Greenville, SC run on average 5 times per day, taking around 17h 32m. Cheap bus tickets for this journey start at €60 if you book in advance.
The earliest bus runs at 00:50, the last at 22:15. The fastest bus covers the 354 miles (571 km) distance in 12h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 354 miles (571 km) |
Average bus duration 17h 32m |
Cheapest ticket price €60 |
Buses per day 5 |
Fastest bus 12h 40m |
First bus 12:50 AM |
Last bus 10:15 PM |
Cheapest Month Apr |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 14 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Columbus, OH to Greenville, SCYou can travel by bus between Columbus, OH to Greenville, SC with Greyhound, FlixBus for as low as €60. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
16h 5m
Cheapest FlixBus Price
€61
FlixBus frequency
3 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
12h 40m
Cheapest Greyhound Price
€60
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Greenville, SC
Things to do in Greenville, SC
Discover the best of Greenville, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville, SC trip today.
Greenville Center for Creative Arts
A contemporary art center showing regional and international artists through rotating exhibitions in a modern downtown gallery space.
Metropolitan Arts Council Gallery
A local gallery and arts space featuring exhibitions, classes, and community-focused programming in Greenville's Village area.
- Must visit
Falls Park on the Reedy
A signature downtown park with waterfalls, gardens, river trails, and lawns. It is Greenville's most popular public space for walking and views.
- Must visit
Main Street
Greenville's central street lined with shops, public art, and historic buildings. It is ideal for strolling between downtown attractions.
- Recommended
Prisma Health Swamp Rabbit Trail
A swamp rabbit-themed riverside greenway popular for walking and cycling, linking downtown Greenville with parks and nearby districts.
FAQs: Bus from Columbus, OH to Greenville, SC
Find answers to the most common questions about traveling from Columbus, OH to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Columbus, OH to Greenville, SC can start from as little as €60 when you book in advance. The average bus ticket price for Columbus, OH to Greenville, SC is €92 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Columbus, OH to Greenville, SC is 12h 40m to travel the 354 miles (571 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Columbus, OH to Greenville, SC leaves at 12:50 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Columbus, OH to Greenville, SC leaves at 10:15 PM.
There are 5 buses a day from Columbus, OH to Greenville, SC which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Columbus, OH to Greenville, SC, you can count on Greyhound, FlixBus for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Columbus, OH and Greenville, SC and compare the amenities they offer before buying a bus ticket.
When departing from Columbus, OH , you have various bus station options to start your journey from including Columbus, E Mound St (Akili Christian High School), OH, Columbus, E Town St (Bus Station), OH . When arriving in Greenville, SC , you can end your journey in bus stations like Greenville, Woodruff Rd ("Raceway" gas station), SC .Passengers board the bus most frequently from Columbus, E Mound St (Akili Christian High School), OH, which is located around away from the city centre, and they get off the bus at Greenville, Woodruff Rd ("Raceway" gas station), SC, located 8 away from the city centre.
A trip to Greenville, SC from Columbus, OH is worth doing but not as a day trip with a journey time of 12h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Columbus, OH to Greenville, SC is April.
It's helpful to compare your options as there are 2 ways to travel between Columbus, OH and Greenville, SC including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Columbus, OH to Greenville, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Columbus, OH to Greenville, SC for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Columbus, OH to Greenville, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Columbus, OH to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Columbus, OH to Greenville, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Columbus, OH to Greenville, SC:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Columbus, OH to Greenville, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Columbus, OH to Greenville, SC with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Columbus, OH to Greenville, SC with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Columbus, OH to Greenville, SC with the following bus company: Greyhound, FlixBus.
Since neither Columbus, OH nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Columbus, OH to Greenville, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Columbus, OH to Greenville, SC
Most Columbus, OH to Greenville, SC buses use the Columbus, E Mound St (Akili Christian High School) to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Columbus, OH and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Columbus
Arrival bus stations in Greenville
Which Columbus, OH station do buses to Greenville, SC leave from?
Buses from Columbus, OH to Greenville, SC leave from Columbus, E Mound St (Akili Christian High School). The station is 0 miles (1 km) from Columbus, OH city centre at 600 Oakland Park Ave, Columbus, OH 43214, USA.
Columbus, E Mound St (Akili Christian High School)600 Oakland Park Ave, Columbus, OH 43214, USA
City-centre transport
Getting to Columbus, E Mound St (Akili Christian High School) from Columbus city centre
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Columbus, E Mound St (Akili Christian High School) bus station facilities and services
Columbus, E Mound St (Akili Christian High School) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Columbus, E Mound St (Akili Christian High School). ATMs are available at Columbus, E Mound St (Akili Christian High School).
Tickets and information
Ticket office support is available at Columbus, E Mound St (Akili Christian High School).
Parking, taxis and toilets
Available at Columbus, E Mound St (Akili Christian High School): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Columbus, E Mound St (Akili Christian High School): Wheelchair accessible buses available.
Columbus, E Town St (Bus Station)E Town St, Columbus, OH 43215, USA
City-centre transport
Getting to Columbus, E Town St (Bus Station) from Columbus city centre
TRUE
Columbus, E Town St (Bus Station) bus station facilities and services
Columbus, E Town St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Columbus, E Town St (Bus Station). ATMs are available at Columbus, E Town St (Bus Station).
Tickets and information
Ticket office support is available at Columbus, E Town St (Bus Station).
Parking, taxis and toilets
Available at Columbus, E Town St (Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Columbus, E Town St (Bus Station): Wheelchair accessible bus platforms.
Which Greenville, SC station do buses from Columbus, OH arrive at?
Buses from Columbus, OH to Greenville, SC arrive at Greenville, Woodruff Rd ("Raceway" gas station). Greenville, Woodruff Rd ("Raceway" gas station) is 4 miles (8 km) from Greenville, SC city centre.
Greenville, Woodruff Rd ("Raceway" gas station)Woodruff Rd, Greenville, SC, USA
City-centre transport
Getting to Greenville, Woodruff Rd ("Raceway" gas station) from Greenville city centre
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
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Greenville, Woodruff Rd ("Raceway" gas station) bus station facilities and services
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Limited dining options available in adjacent areas.
Wi-Fi and ATMs
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Tickets and information
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Parking, taxis and toilets
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Most popular bus connections from Columbus, OH
More options for your journey from Columbus, OH to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Columbus, OH
Most popular bus connections to Greenville, SC
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