The cheapest and fastest buses from Chicago, IL to Greenville, SC
Cheapest price
$157
Average price
$157
Fastest journey
20 h 5 m
Average duration
20 h 5 m
Buses per day
1
Distance
903 km
The best way to find a cheap bus ticket from Chicago, IL to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Greenville, SC will cost around $157 if you buy it on the day, but the cheapest tickets can be found for only $157.
Of the 1 buses that leave Chicago, IL for Greenville, SC on Fri, Mar 20, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Mar 20 the direct buses cover the 903 km distance in an average of 20 h 5 m but if you time it right, some buses will get you there in just 20 h 5 m .
On Fri, Mar 20 the slowest buses will take 20 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus, train, and flight for Chicago, IL to Greenville, SC
Omio recommends booking the bus as it is the most popular option from Chicago, IL to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $150. For those with little time consider booking a flight which can get you there in 5h 35m. The ticket price range depends on the travel mode: a bus costs an average of $150, and a train costs an average of $300.
Distance: 561 miles (903 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
$251 Average price Cheapest | $394 Average price | $329 Average price |
17h 58m Average total duration 17h 28m Onboard + 30m Additional time* | 28h 49m Average total duration 28h 19m Onboard + 30m Additional time* | 8h 35m Average total duration Fastest 5h 35m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Chicago, IL to Greenville, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 20
Mar 21
Mar 22
Mar 23
Mar 24
Mar 25
Mar 26
Why should you book Chicago, IL to Greenville, SC buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Chicago, IL to Greenville, SC.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Chicago, IL to Greenville, SC.
Journey information
Overview: Bus from Chicago, IL to Greenville, SC
Buses from Chicago, IL to Greenville, SC run on average 6 times per day, taking around 17h 28m. Cheap bus tickets for this journey start at $150 (€123) if you book in advance.
The earliest bus runs at 00:30, the last at 23:50. The fastest bus covers the 561 miles (903 km) distance in 20h 40m.
Distance 561 miles (903 km) |
Average bus duration 17h 28m |
Cheapest ticket price $150 (€123) |
Buses per day 6 |
Fastest bus 20h 40m |
First bus 00:30 |
Last bus 23:50 |
Bus providers: FlixBus from Chicago, IL to Greenville, SCYou can travel by bus between Chicago, IL to Greenville, SC with FlixBus for as low as $150 (€123). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Chicago, IL to Greenville, SC
Find answers to the most common questions about traveling from Chicago, IL to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Chicago, IL to Greenville, SC
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to Greenville, SC
Here are some other resources that might have the information you need
