- Must visit
Greenville County Museum of Art
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
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The cheapest and fastest buses from Chicago, IL to Greenville, SC
Showing times and prices for Jun 19
Cheapest price
$111
Average price
$118
Fastest journey
19 h 45 m
Average duration
20 h 10 m
Buses per day
8
Distance
903 km
Cheap tickets
The best way to find a cheap bus ticket from Chicago, IL to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Greenville, SC will cost around $118 if you buy it on the day, but the cheapest tickets can be found for only $111.
Fast buses
It's difficult to get from Chicago, IL to Greenville, SC without transferring at least once.
FlixBus · FlixBus6:00 PM21h10Chicago, Greyhound Bus Station4:10 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1111One-way1 transfer- FlixBus+
1:00 PM20h40Chicago, Greyhound Bus Station10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1161One-way1 transfer - +FlixBus10:50 PM21h40Chicago, Greyhound Bus Station9:30 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1161One-way1 transfer
- +FlixBus11:10 PM21h20Chicago, Union Station (Amtrak), IL9:30 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1161One-way1 transfer
- · 10:15 AM19h45Chicago, Union Station (Amtrak), IL7:00 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1171One-way1 transfer
- · 10:15 AM19h45Chicago, Union Station (Amtrak), IL7:00 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1171One-way1 transfer
- · 6:10 AM20h05Chicago, Greyhound Bus Station3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1321One-way1 transfer
- · 9:55 AM20h05Chicago, Greyhound Bus Station7:00 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1171One-way1 transfer
- +FlixBus2:45 PM20h15Chicago, Greyhound Bus Station12:00 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$1171One-way1 transfer
- FlixBus+1:00 PM20h40Chicago, Greyhound Bus Station10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1161One-way1 transfer
Travel Information
Compare bus, train, and flight for Chicago, IL to Greenville, SC
Omio recommends booking the bus as it is the most popular option from Chicago, IL to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $141. For those with little time consider booking a flight which can get you there in 1h 56m. The ticket price range depends on the travel mode: a bus costs an average of $141, and a flight costs an average of $380.
Distance: 561 miles (903 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$141 Average price Cheapest | $241 Average price | $380 Average price | $135 Average price (fuel + tolls) |
17h 58m Average total duration 17h 28m Onboard + 30m Additional time* | 28h 49m Average total duration 28h 19m Onboard + 30m Additional time* | 4h 56m Average total duration Fastest 1h 56m Onboard + 3h 0m Additional time* | 10h 59m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Chicago, IL to Greenville, SC is a bus with an average price of $141 (€115).
This is compared to other travel options from Chicago, IL to Greenville, SC:
A bus is $100 (€81) less than a train for this route with tickets for a train from Chicago, IL to Greenville, SC costing on average $241 (€197).
A bus is $238 (€195) less than a flight for this route with tickets for a flight from Chicago, IL to Greenville, SC costing on average $380 (€310).
The fastest way to travel from Chicago, IL to Greenville, SC is by flight with an average journey time of 1h 56m.
Other travel options to Greenville, SC take longer:
Bus takes on average 17h 28m.
Train takes on average 28h 19m.
It's helpful to compare your options as there are 3 ways to travel between Chicago, IL and Greenville, SC including taking a bus, train, and flight.
We recommend using the bus as it is the most popular way to get from Chicago, IL to Greenville, SC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Chicago, IL to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:10AM | Arrival Time 03:15AM | Duration 20h05 | Departure days Everyday | Cheapest price $117 |
Operator Greyhound | Departure Time 09:55AM | Arrival Time 07:00AM | Duration 20h05 | Departure days Everyday | Cheapest price $117 |
Operator Greyhound | Departure Time 10:15AM | Arrival Time 07:00AM | Duration 19h45 | Departure days Everyday | Cheapest price $117 |
Operator FlixBus | Departure Time 01:00PM | Arrival Time 10:40AM | Duration 20h40 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $116 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 12:00PM | Duration 20h15 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price $117 |
Operator FlixBus | Departure Time 05:15PM | Arrival Time 04:10PM | Duration 21h55 | Departure days Thu | Cheapest price $160 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 04:10PM | Duration 21h10 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price $111 |
Operator Greyhound | Departure Time 10:50PM | Arrival Time 09:30PM | Duration 21h40 | Departure days Everyday | Cheapest price $116 |
Operator Greyhound | Departure Time 11:10PM | Arrival Time 09:30PM | Duration 21h20 | Departure days Everyday | Cheapest price $116 |
Live departures
Chicago, IL to Greenville, SC bus times
The table below shows live departures for Chicago, IL to Greenville, SC buses for today, Thursday, June 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| · | 6:10 AM Chicago, Greyhound Bus Station | 20h05 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| · | 9:55 AM Chicago, Greyhound Bus Station | 20h05 | 7:00 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| · | 10:15 AM Chicago, Union Station (Amtrak), IL | 19h45 | 7:00 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| FlixBus+ | 1:00 PM Chicago, Greyhound Bus Station | 20h40 | 10:40 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| +FlixBus | 2:45 PM Chicago, Greyhound Bus Station | 20h15 | 12:00 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| FlixBus · FlixBus · FlixBus | 5:15 PM Chicago, Greyhound Bus Station | 21h55 | 4:10 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| +FlixBus | 10:50 PM Chicago, Greyhound Bus Station | 21h40 | 9:30 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| +FlixBus | 11:10 PM Chicago, Union Station (Amtrak), IL | 21h20 | 9:30 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Chicago, IL to Greenville, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Chicago, IL to Greenville, SC buses with Omio?
FlixBus operates all buses services from Chicago, IL to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Chicago, IL to Greenville, SC.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Chicago, IL to Greenville, SC.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Chicago, IL to Greenville, SC.
Journey information
Overview: Bus from Chicago, IL to Greenville, SC
USAUSA
Buses from Chicago, IL to Greenville, SC run on average 6 times per day, taking around 17h 28m. Cheap bus tickets for this journey start at $141 (€115) if you book in advance.
The earliest bus runs at 00:30, the last at 23:50. The fastest bus covers the 561 miles (903 km) distance in 20h 40m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 561 miles (903 km) |
Average bus duration 17h 28m |
Cheapest ticket price $141 (€115) |
Buses per day 6 |
Fastest bus 20h 40m |
First bus 12:30 AM |
Last bus 11:50 PM |
Cheapest Month Jul |
Cheapest Day Thu |
High Season Oct - Dec |
Low Season Jan - Mar |
Best time to book 7 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus from Chicago, IL to Greenville, SCYou can travel by bus between Chicago, IL to Greenville, SC with FlixBus for as low as $141 (€115). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
20h 40m
Cheapest Price
$141 (€115)
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Greenville
Things to do in Greenville
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
- Recommended
Upcountry History Museum
Regional history museum with permanent and rotating exhibits on the people and stories of Upstate South Carolina. A strong choice for understanding Greenville’s local context.
- Recommended
Sigal Music Museum
Specialized museum displaying rare historic instruments from around the world. A distinctive local favorite for music, design, and cultural history.
- Must visit
Main Street
Greenville’s central downtown street lined with shops, public art, plazas, and event spaces. It is the main place to walk and experience the city atmosphere.
- Must visit
Falls Park on the Reedy
Downtown park built around waterfalls, gardens, and river overlooks. It is Greenville’s signature public space and a top stop for first-time visitors.
- Must visit
Swamp Rabbit Trail
Popular multi-use greenway for walking and cycling, linking Greenville with nearby communities. Widely loved by locals and visitors for active sightseeing.
- Gluten-free
South Carolina Barbecue
Slow-smoked pork, often chopped or pulled, served with the state's signature mustard-based sauce. It is a defining Upstate and South Carolina tradition.
- Vegetarian
Fried Green Tomatoes
Slices of unripe tomato coated and fried until crisp, often served with remoulade or pimento cheese. A classic Southern starter common in Greenville restaurants.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, gravy, or bacon. This Lowcountry favorite is widely loved in Greenville as part of broader South Carolina cuisine.
The Anchorage
Well-regarded neighborhood restaurant focused on seasonal Southern-influenced American cooking with a polished but relaxed atmosphere.
Soby's
A long-running downtown Greenville favorite serving refined Southern cuisine in a lively, upscale setting. Known for shrimp and grits, brunch, and strong wine selections.
Smoke On The Water
Popular casual spot for barbecue, ribs, and Southern comfort food near Falls Park. Lively atmosphere and a good place to try local smoked meats.
United States Dollar
Moderate by U.S. standards: casual dining is affordable, while upscale downtown hotels and restaurants cost more.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual restaurant.
- Fine dining
- USD 50-100+ per person at upscale restaurants.
- Coffee
- USD 3-6 for a coffee drink.
Tipping culture
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff a few dollars, and round up for coffee only if desired.
FAQs: Bus from Chicago, IL to Greenville, SC
Find answers to the most common questions about traveling from Chicago, IL to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Chicago, IL to Greenville, SC can start from as little as $141 (€115) when you book in advance. The average bus ticket price for Chicago, IL to Greenville, SC is $141 (€115) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Chicago, IL to Greenville, SC is 20h 40m to travel the 561 miles (903 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Chicago, IL to Greenville, SC leaves at 12:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Chicago, IL to Greenville, SC leaves at 11:50 PM.
There are 6 buses a day from Chicago, IL to Greenville, SC which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Chicago, IL to Greenville, SC, you can count on FlixBus for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Chicago, IL and Greenville, SC and compare the amenities they offer before buying a bus ticket.
A trip to Greenville, SC from Chicago, IL is worth doing but not as a day trip with a journey time of 20h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Chicago, IL to Greenville, SC is July.
It's helpful to compare your options as there are 3 ways to travel between Chicago, IL and Greenville, SC including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from Chicago, IL to Greenville, SC:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Chicago, IL to Greenville, SC for bus company FlixBus.
Whether you can cancel your bus ticket from Chicago, IL to Greenville, SC depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Chicago, IL to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Chicago, IL to Greenville, SC:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Chicago, IL to Greenville, SC:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Chicago, IL to Greenville, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Chicago, IL to Greenville, SC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Chicago, IL to Greenville, SC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Chicago, IL to Greenville, SC with the following bus company: FlixBus.
Since neither Chicago, IL nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Chicago, IL to Greenville, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Chicago, IL to Greenville, SC
Most Chicago, IL to Greenville, SC buses use the Chicago, Greyhound Bus Station to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Chicago, IL and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Chicago
Arrival bus stations in Greenville
Chicago, Greyhound Bus Station
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Bus7 · 8m · $4 · every ~6 min
Chicago, Union Station (Amtrak)
City-centre transport
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Bus28, 151 · 7m · $4 · every ~13 min
Chicago, 95th Red Line Station
City-centre transport
Getting to Chicago, 95th Red Line Station from Chicago city centre
BusGreyhound US0100 · 20m · $2
29 · 47m · $4 · every ~11 min
29 · 48m · $4 · every ~11 min
SubwayRed Line · 24m · $6 · every ~23 min
Red Line · 25m · $6 · every ~23 min
Greenville, Woodruff Rd ("Raceway" gas station)
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Chicago, IL
Most popular bus connections to Greenville, SC
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