- Recommended
Greenville County Museum of Art
A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
The best way to find a cheap bus ticket from Chicago, IL to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Greenville, SC will cost around €86 if you buy it on the day, but the cheapest tickets can be found for only €81.
It's difficult to get from Chicago, IL to Greenville, SC without transferring at least once.
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Buses from Chicago, IL to Greenville, SC run on average 7 times per day, taking around 18h 14m. Cheap bus tickets for this journey start at €67 if you book in advance.
The earliest bus runs at 00:30, the last at 23:50. The fastest bus covers the 561 miles (903 km) distance in 15h 0m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Chicago, IL to Greenville, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 06:10AM | Arrival Time 03:15AM | Duration 20h05 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price €82 |
Operator Greyhound | Departure Time 09:55AM | Arrival Time 07:00AM | Duration 20h05 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price €82 |
Operator Greyhound | Departure Time 10:15AM | Arrival Time 07:00AM | Duration 19h45 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price €82 |
Operator FlixBus | Departure Time 01:00PM | Arrival Time 10:40AM | Duration 20h40 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price €81 |
Operator Greyhound | Departure Time 02:45PM | Arrival Time 12:35PM | Duration 20h50 | Departure days Wed | Cheapest price €82 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 12:35PM | Duration 17h35 | Departure days Thu, Sat, Sun | Cheapest price €84 |
Operator Greyhound | Departure Time 10:50PM | Arrival Time 09:30PM | Duration 21h40 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price €92 |
Operator Greyhound | Departure Time 11:10PM | Arrival Time 09:30PM | Duration 21h20 | Departure days Mon, Tue, Wed, Thu, Sat, Sun | Cheapest price €92 |
The table below shows live departures for Chicago, IL to Greenville, SC buses for today, Sunday, November 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
· | 6:10 AM Chicago, Greyhound Bus Station | 20h05 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
· | 9:55 AM Chicago, Greyhound Bus Station | 20h05 | 7:00 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
· | 10:15 AM Chicago, Union Station (Amtrak), IL | 19h45 | 7:00 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
FlixBus+![]() | 1:00 PM Chicago, Greyhound Bus Station | 20h40 | 10:40 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
FlixBus · FlixBus | 6:00 PM Chicago, Greyhound Bus Station | 21h10 | 4:10 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer |
Find all the dates and times for this journey
Buses from Chicago, IL to Greenville, SC with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Greenville, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville, SC trip today.
A major art museum in downtown Greenville with American art, Southern works, and rotating exhibitions in a bright riverfront setting.
A contemporary art center showing regional and international artists through rotating exhibitions in a modern downtown gallery space.
A local gallery and arts space featuring exhibitions, classes, and community-focused programming in Greenville's Village area.
A signature downtown park with waterfalls, gardens, river trails, and lawns. It is Greenville's most popular public space for walking and views.
Greenville's central street lined with shops, public art, and historic buildings. It is ideal for strolling between downtown attractions.
A swamp rabbit-themed riverside greenway popular for walking and cycling, linking downtown Greenville with parks and nearby districts.
South Carolina barbecue is slow-smoked pork, often chopped or pulled, and classically served with the state’s distinctive mustard-based sauce.
Shrimp and grits pairs creamy stone-ground grits with shrimp, often enriched with bacon or sausage. It is a Lowcountry staple found across Greenville.
Fried green tomatoes are tart unripe tomatoes breaded and fried. They are a beloved Southern side and common on Upstate menus.
Casual Greenville barbecue spot serving smoked meats, classic sides, and a relaxed neighborhood atmosphere.
Upscale downtown steakhouse and oyster bar with dry-aged beef, seafood, and an elegant supper-club feel.
Refined Southern restaurant known for seasonal plates, thoughtful cocktails, and a polished downtown setting.
Moderate for a U.S. city. Hotels and dining are usually cheaper than major metros, but car travel and limited transit can add to visitor costs.
Tip 18-20% at restaurants, more for excellent service. Taxis usually get 10-15%. Cafes often have tip jars; $1-2 is common for drinks.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Greenville, SC.
Find answers to the most common questions about traveling from Chicago, IL to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

Most Chicago, IL to Greenville, SC buses use the Chicago, Greyhound Bus Station to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Chicago, IL and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Snack shop and vending machines available
Free Wi-Fi in waiting area. ATMs are located near entrance.
Ticket office support is available at Chicago, Greyhound Bus Station.
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Multiple dining options are available inside the station.
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Ticket office support is available at Chicago, Union Station (Amtrak).
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Chicago, 95th Red Line Station is 14 km from Chicago city centre. Public transport options include:
Chicago, 95th Red Line Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Chicago, 95th Red Line Station. ATMs are available at Chicago, 95th Red Line Station.
Ticket office support is available at Chicago, 95th Red Line Station.
Available at Chicago, 95th Red Line Station: Parking, Taxis, WC.
Accessibility facilities are available at Chicago, 95th Red Line Station: Wheelchair accessible entrances available.
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Limited dining options available in adjacent areas.
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Check bus stations information for Chicago, IL and Greenville, SC, including where buses depart and arrive on this route.