- Must visit
Greenville County Museum of Art
Major art museum known for its Southern art collection and works by Andrew Wyeth and Jasper Johns. One of the city’s top cultural attractions.
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The cheapest and fastest buses from Orlando, FL to Greenville, SC
Showing times and prices for Jun 06
Cheapest price
$74
Average price
$96
Fastest journey
14 h 20 m
Average duration
14 h 33 m
Buses per day
2
Distance
709 km
Cheap tickets
The best way to find a cheap bus ticket from Orlando, FL to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Greenville, SC will cost around $96 if you buy it on the day, but the cheapest tickets can be found for only $74.
Fast buses
Of the 2 buses that leave Orlando, FL for Greenville, SC on Sat, Jun 06, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 06 the direct buses cover the 709 km distance in an average of 14 h 33 m but if you time it right, some buses will get you there in just 14 h 20 m .
On Sat, Jun 06 the slowest buses will take 14 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
11:00 AM14h20Orlando, FL1:20 AMGreenville, SC$741One-way0 transfers- 8:15 PM14h45Orlando, FL11:00 AMGreenville, SC$1171One-way0 transfers
- 11:00 AM14h20Orlando, FL1:20 AMGreenville, SC$741One-way0 transfers
- 8:15 PM14h45Orlando, FL11:00 AMGreenville, SC$1171One-way0 transfers
Travel Information
Compare bus, train, and flight for Orlando, FL to Greenville, SC
Omio recommends booking the flight as it is the most popular option from Orlando, FL to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $68. For those with little time consider booking a flight which can get you there in 1h 50m. The ticket price range depends on the travel mode: a bus costs an average of $68, and a train costs an average of $139.
Distance: 440 miles (709 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$127 Average price Cheapest | $198 Average price | $228 Average price | $101 Average price (fuel + tolls) |
10h 20m Average total duration 9h 50m Onboard + 30m Additional time* | 4h 50m Average total duration Fastest 1h 50m Onboard + 3h 0m Additional time* | 29h 13m Average total duration 28h 43m Onboard + 30m Additional time* | 7h 37m Average total duration (door-to-door) |
 Most popular bus company |  Most popular airline |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Orlando, FL to Greenville, SC is a bus with an average price of $127 (€104).
This is compared to other travel options from Orlando, FL to Greenville, SC:
A bus is $71 (€58) less than a flight for this route with tickets for a flight from Orlando, FL to Greenville, SC costing on average $198 (€161).
A bus is $100 (€82) less than a train for this route with tickets for a train from Orlando, FL to Greenville, SC costing on average $228 (€185).
The fastest way to travel from Orlando, FL to Greenville, SC is by flight with an average journey time of 1h 50m.
Other travel options to Greenville, SC take longer:
Bus takes on average 9h 50m.
Train takes on average 28h 43m.
It's helpful to compare your options as there are 3 ways to travel between Orlando, FL and Greenville, SC including taking a bus, train, and flight.
We recommend using the flight as it is the most popular way to get from Orlando, FL to Greenville, SC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Orlando, FL to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:40AM | Arrival Time 12:05PM | Duration 10h25 | Departure days Fri | Cheapest price $76 |
Operator FlixBus | Departure Time 02:55AM | Arrival Time 02:40PM | Duration 11h45 | Departure days Wed, Thu, Fri | Cheapest price $112 |
Operator FlixBus | Departure Time 03:55AM | Arrival Time 03:40PM | Duration 11h45 | Departure days Tue, Thu, Fri | Cheapest price $98 |
Operator FlixBus | Departure Time 08:45AM | Arrival Time 11:25PM | Duration 14h40 | Departure days Fri | Cheapest price $164 |
Operator FlixBus | Departure Time 11:00AM | Arrival Time 01:20AM | Duration 14h20 | Departure days Sat | Cheapest price $74 |
Operator FlixBus | Departure Time 01:00PM | Arrival Time 01:55AM | Duration 12h55 | Departure days Thu | Cheapest price $164 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 11:00AM | Duration 17h00 | Departure days Wed | Cheapest price $89 |
Operator FlixBus | Departure Time 07:00PM | Arrival Time 12:00PM | Duration 17h00 | Departure days Tue, Fri, Sun | Cheapest price $71 |
Operator FlixBus | Departure Time 08:15PM | Arrival Time 11:00AM | Duration 14h45 | Departure days Sat | Cheapest price $117 |
Operator FlixBus | Departure Time 09:15PM | Arrival Time 11:05AM | Duration 13h50 | Departure days Fri | Cheapest price $68 |
Live departures
Orlando, FL to Greenville, SC bus times
The table below shows live departures for Orlando, FL to Greenville, SC buses for tomorrow, Saturday, June 6. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 11:00 AM Orlando, FL | 14h20 | 1:20 AM Greenville, SC | 0 transfersDirect | |
| 8:15 PM Orlando, FL | 14h45 | 11:00 AM Greenville, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Orlando, FL to Greenville, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Orlando, FL to Greenville, SC buses with Omio?
Greyhound operates all buses services from Orlando, FL to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Orlando, FL to Greenville, SC.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Orlando, FL to Greenville, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Orlando, FL to Greenville, SC.
Journey information
Overview: Bus from Orlando, FL to Greenville, SC
USAUSA
Buses from Orlando, FL to Greenville, SC run on average 5 times per day, taking around 9h 50m. Cheap bus tickets for this journey start at $68 (€55) but you can travel from only $56 (€46) by flight.
The earliest bus runs at 04:45, the last at 23:40. The fastest bus covers the 440 miles (709 km) distance in 10h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $56 (€46)
Distance 440 miles (709 km) |
Average bus duration 9h 50m |
Cheapest ticket price $68 (€55) |
Buses per day 5 |
Fastest bus 10h 25m |
First bus 4:45 AM |
Last bus 11:40 PM |
Cheapest Month May |
Cheapest Day Sat |
High Season Jan - Mar |
Low Season Jul - Sep |
Busiest Day Thu |
Least Busy Day Thu |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $56 (€46)
Bus providers: Greyhound from Orlando, FL to Greenville, SCYou can travel by bus between Orlando, FL to Greenville, SC with Greyhound for as low as $56 (€46). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
10h 25m
Cheapest Price
$76 (€62)
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Greenville
Things to do in Greenville
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
- Recommended
Upcountry History Museum
Regional history museum with rotating exhibitions on the Upstate’s people, industry, and culture. A strong choice for understanding Greenville beyond downtown.
- Recommended
Sigal Music Museum
Specialized museum displaying historic string, keyboard, and wind instruments from around the world. A lesser-known but distinctive Greenville stop.
- Must visit
Main Street
The core downtown street lined with shops, public art, plazas, and event spaces. It is Greenville’s main walking corridor and a top first stop.
- Must visit
Swamp Rabbit Trail
Multi-use greenway linking Greenville with nearby communities. Highly popular for walking and cycling, and one of the city’s most loved outdoor assets.
- Recommended
West End Historic District
Lively downtown district near Falls Park known for baseball, galleries, restored buildings, and a strong local atmosphere. Popular for strolling and photos.
- Gluten-free
South Carolina Barbecue
Slow-smoked pork, often chopped or pulled, served with the state's famous mustard-based 'Carolina Gold' sauce. It is a defining Upstate and statewide tradition.
- Vegetarian
Fried Green Tomatoes
Unripe green tomatoes sliced, breaded, and fried until crisp. A classic Southern starter found on many Greenville-area menus.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, often with bacon, gravy, or a rich butter sauce. A beloved Lowcountry and broader South Carolina favorite.
The Anchorage
Acclaimed neighborhood restaurant focused on seasonal Southern-influenced cooking, thoughtful plates, and a more polished dining experience.
Soby's New South Cuisine
A long-running downtown favorite serving refined Southern cuisine, including shrimp and grits and seasonal regional dishes, in a lively historic setting.
Jianna
Stylish downtown restaurant known for handmade pasta, oysters, and city views. It is one of Greenville's best-known upscale dining rooms.
United States Dollar
Costs are moderate by U.S. standards. Dining is reasonable, while hotels rise during events and peak weekends.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 20-35 per person at a casual sit-down restaurant.
- Fine dining
- USD 50-100+ per person at upscale restaurants.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% in restaurants; 20%+ for excellent service. Tip bartenders USD 1-2 per drink, taxis 10-15%, hotel staff USD 2-5, and round up for coffee if desired.
FAQs: Bus from Orlando, FL to Greenville, SC
Find answers to the most common questions about traveling from Orlando, FL to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Orlando, FL to Greenville, SC can start from as little as $68 (€55) when you book in advance. The average bus ticket price for Orlando, FL to Greenville, SC is $127 (€104) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Orlando, FL to Greenville, SC is 10h 25m to travel the 440 miles (709 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Orlando, FL to Greenville, SC leaves at 4:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Orlando, FL to Greenville, SC leaves at 11:40 PM.
There are 5 buses a day from Orlando, FL to Greenville, SC which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Orlando, FL to Greenville, SC, you can count on Greyhound for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Orlando, FL and Greenville, SC and compare the amenities they offer before buying a bus ticket.
A trip to Greenville, SC from Orlando, FL is worth doing but not as a day trip with a journey time of 10h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Orlando, FL to Greenville, SC is May.
It's helpful to compare your options as there are 3 ways to travel between Orlando, FL and Greenville, SC including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from Orlando, FL to Greenville, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Orlando, FL to Greenville, SC for bus company Greyhound.
Whether you can cancel your bus ticket from Orlando, FL to Greenville, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Orlando, FL to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Orlando, FL to Greenville, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Orlando, FL to Greenville, SC:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Orlando, FL to Greenville, SC.
You can reserve your seat on the bus from Orlando, FL to Greenville, SC with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Orlando, FL to Greenville, SC with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Orlando, FL to Greenville, SC with the following bus company: Greyhound.
Since neither Orlando, FL nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the flight as it is the most popular way to get from Orlando, FL to Greenville, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Orlando, FL to Greenville, SC
Orlando
Greenville
The major bus station for departures in Orlando is Orlando, N John Young Pkwy (Greyhound Bus Station). Find all the information you need to know about services, amenities and connections at Orlando, N John Young Pkwy (Greyhound Bus Station) for your trip from Orlando to Greenville.
Orlando, N John Young Pkwy (Greyhound Bus Station)
information
Orlando, The Florida Mall
information
The major bus station for arrivals in Greenville is Greenville, Woodruff Rd ("Raceway" gas station). Find all the information you need to know about services, amenities and connections at Greenville, Woodruff Rd ("Raceway" gas station) for your trip to Greenville from Orlando.
Greenville, Woodruff Rd ("Raceway" gas station)
information
Most popular bus connections from Orlando, FL
More options for your journey from Orlando, FL to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Orlando, FL
Most popular bus connections to Greenville, SC
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