The cheapest and fastest buses from Orlando, FL to Greenville, SC
Cheapest price on Sep 05
$93
Average ticket price on Sep 05
$96
Fastest journey on Sep 05
10 h 10 m
Average journey duration on Sep 05
11 h 56 m
Buses on Sep 05
5
Distance
709 km
The best way to find a cheap bus ticket from Orlando, FL to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Greenville, SC will cost around $96 if you buy it on the day, but the cheapest tickets can be found for only $93.
It's difficult to get from Orlando, FL to Greenville, SC without transferring at least once.
FlixBus+
10:55 PM11h45Orlando, N John Young Pkwy (Greyhound Bus Station)10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$931One-way1 transfer
FlixBus · FlixBus9:30 AM12h00Orlando, N John Young Pkwy (Greyhound Bus Station)9:30 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$931One-way1 transfer
FlixBus+
2:00 PM13h15Orlando, The Florida Mall, FL3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$961One-way1 transfer
FlixBus+
2:45 PM12h30Orlando, N John Young Pkwy (Greyhound Bus Station)3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$981One-way1 transfer
FlixBus+
8:50 PM10h10Orlando, N John Young Pkwy (Greyhound Bus Station)7:00 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1001One-way1 transfer
FlixBus+
8:50 PM10h10Orlando, N John Young Pkwy (Greyhound Bus Station)7:00 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$1001One-way1 transfer
FlixBus+
10:55 PM11h45Orlando, N John Young Pkwy (Greyhound Bus Station)10:40 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$931One-way1 transfer
FlixBus · FlixBus9:30 AM12h00Orlando, N John Young Pkwy (Greyhound Bus Station)9:30 PMGreenville, Woodruff Rd ("Raceway" gas station), SC$931One-way1 transfer
FlixBus+
2:45 PM12h30Orlando, N John Young Pkwy (Greyhound Bus Station)3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$981One-way1 transfer
FlixBus+
2:00 PM13h15Orlando, The Florida Mall, FL3:15 AMGreenville, Woodruff Rd ("Raceway" gas station), SC$961One-way1 transfer
Travel Information
Compare bus, train, and flight for Orlando, FL to Greenville, SC
Omio recommends booking the flight as it is the most popular option from Orlando, FL to Greenville, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $104 For those with little time, consider booking a flight, which has an average total journey time of 5h 12m. Average ticket prices depend on the travel mode: a bus costs an average of $104, while a flight costs an average of $462.
Distance: 440 miles (709 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$104 Average price Cheapest | $462 Average price | $407 Average price | $104 Average price (fuel + tolls) |
12h 17m Average total duration 11h 47m Onboard + 30m Additional time* | 5h 12m Average total duration Fastest 3h 12m Onboard + 2h 0m Additional time* | 25h 32m Average total duration 25h 2m Onboard + 30m Additional time* | 7h 37m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Orlando, FL to Greenville, SC:
A bus is $303 (€245) less than a train for this route with tickets for a train from Orlando, FL to Greenville, SC costing on average $407 (€329).
A bus is $358 (€289) less than a flight for this route with tickets for a flight from Orlando, FL to Greenville, SC costing on average $462 (€373).
Other travel options to Greenville, SC take longer:
Bus takes on average 11h 47m.
Train takes on average 25h 2m.
Tickets start at around $104 (€84) compared to roughly $104 (€84) in fuel and tolls — a saving of about $-0.36 (€-0.29). The journey takes 11h 47m versus 7h 37m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Orlando, FL to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 04:45AM | Arrival Time 07:35PM | Duration 14h50 | Departure days Mon, Thu, Fri, Sun | Cheapest price $80 |
Operator FlixBus | Departure Time 09:30AM | Arrival Time 09:30PM | Duration 12h00 | Departure days Everyday | Cheapest price $79 |
Operator FlixBus | Departure Time 12:30PM | Arrival Time 03:15AM | Duration 14h45 | Departure days Thu | Cheapest price $95 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 07:00AM | Duration 18h15 | Departure days Thu | Cheapest price $81 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 03:15AM | Duration 13h15 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 03:15AM | Duration 12h30 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 08:50PM | Arrival Time 07:00AM | Duration 10h10 | Departure days Everyday | Cheapest price $87 |
Operator FlixBus | Departure Time 10:55PM | Arrival Time 10:40AM | Duration 11h45 | Departure days Everyday | Cheapest price $79 |
Live departures
Orlando, FL to Greenville, SC bus times
The table below shows live departures for Orlando, FL to Greenville, SC buses for today, Friday, September 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+![]() | 8:50 PM Orlando, N John Young Pkwy (Greyhound Bus Station) | 10h10 | 7:00 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
FlixBus+![]() | 10:55 PM Orlando, N John Young Pkwy (Greyhound Bus Station) | 11h45 | 10:40 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
| Saturday, September 5 | |||||
FlixBus · FlixBus | 9:30 AM Orlando, N John Young Pkwy (Greyhound Bus Station) | 12h00 | 9:30 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
FlixBus+![]() | 2:00 PM Orlando, The Florida Mall, FL | 13h15 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
FlixBus+![]() | 2:45 PM Orlando, N John Young Pkwy (Greyhound Bus Station) | 12h30 | 3:15 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 1 transfer | |
Find all the dates and times for this journey
Compare prices and tickets Orlando, FL to Greenville, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Orlando, FL to Greenville, SC buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Orlando, FL to Greenville, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Orlando, FL to Greenville, SC.
Journey information
Overview: Bus from Orlando, FL to Greenville, SC
Buses from Orlando, FL to Greenville, SC run on average 5 times per day, taking around 11h 47m. Cheap bus tickets for this journey start at $69 (€56) if you book in advance.
The earliest bus runs at 04:45, the last at 23:40. The fastest bus covers the 440 miles (709 km) distance in 9h 35m.
Distance 440 miles (709 km) |
Average bus duration 11h 47m |
Cheapest ticket price $69 (€56) |
Buses per day 5 |
Fastest bus 9h 35m |
First bus 4:45 AM |
Last bus 11:40 PM |
Cheapest Month Jun |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Thu |
Least Busy Day Thu |
Best time to book 35 days |
Bus providers: FlixBus, Greyhound from Orlando, FL to Greenville, SCYou can travel by bus between Orlando, FL to Greenville, SC with FlixBus, Greyhound for as low as $69 (€56). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Orlando, FL to Greenville, SC
Find answers to the most common questions about traveling from Orlando, FL to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Orlando, FL to Greenville, SC
Most Orlando, FL to Greenville, SC buses use the Orlando, N John Young Pkwy (Greyhound Bus Station) to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Orlando, FL and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which Orlando, FL station do buses to Greenville, SC leave from?
Getting to Orlando, N John Young Pkwy (Greyhound Bus Station) from Orlando city centre
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Orlando, N John Young Pkwy (Greyhound Bus Station) bus station facilities and services
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Tickets and information
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Parking, taxis and toilets
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
Getting to Orlando, The Florida Mall from Orlando city centre
Which Greenville, SC station do buses from Orlando, FL arrive at?
Getting to Greenville, Woodruff Rd ("Raceway" gas station) from Greenville city centre
Greenville, Woodruff Rd ("Raceway" gas station) is 8 km from Greenville city centre. Public transport options include:
Greenville, Woodruff Rd ("Raceway" gas station) bus station facilities and services
Greenville, Woodruff Rd ("Raceway" gas station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Limited dining options available in adjacent areas.
Wi-Fi and ATMs
Wi-Fi is available at Greenville, Woodruff Rd ("Raceway" gas station). ATMs are available at Greenville, Woodruff Rd ("Raceway" gas station).
Tickets and information
Ticket office support is available at Greenville, Woodruff Rd ("Raceway" gas station).
Parking, taxis and toilets
Available at Greenville, Woodruff Rd ("Raceway" gas station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Greenville, Woodruff Rd ("Raceway" gas station): Basic access available for persons with disabilities.
Most popular bus connections from Orlando, FL
More options for your journey from Orlando, FL to Greenville, SC
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