- Must visit
Greenville County Museum of Art
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
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Travel Information
Compare bus, train, and flight for Portland, OR to Greenville, SC
Omio recommends booking the flight as it is the most popular option from Portland, OR to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $268. For those with little time consider booking a flight which can get you there in 8h 24m. The ticket price range depends on the travel mode: a bus costs an average of $268, and a train costs an average of $335.
Distance: 2223 miles (3578 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$438 Average price Cheapest | $445 Average price | $2161 Average price | $540 Average price (fuel + tolls) |
77h 38m Average total duration 77h 8m Onboard + 30m Additional time* | 11h 24m Average total duration Fastest 8h 24m Onboard + 3h 0m Additional time* | 95h 21m Average total duration 94h 51m Onboard + 30m Additional time* | 39h 53m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Portland, OR to Greenville, SC is a bus with an average price of $438 (€358).
This is compared to other travel options from Portland, OR to Greenville, SC:
A bus is $7 (€6) less than a flight for this route with tickets for a flight from Portland, OR to Greenville, SC costing on average $445 (€364).
A bus is $1723 (€1410) less than a train for this route with tickets for a train from Portland, OR to Greenville, SC costing on average $2161 (€1768).
The fastest way to travel from Portland, OR to Greenville, SC is by flight with an average journey time of 8h 24m.
Other travel options to Greenville, SC take longer:
Bus takes on average 77h 8m.
Train takes on average 94h 51m.
It's helpful to compare your options as there are 3 ways to travel between Portland, OR and Greenville, SC including taking a bus, train, and flight.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Portland, OR to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:50AM | Arrival Time 11:05AM | Duration 80h15 | Departure days Fri | Cheapest price $268 |
Operator Greyhound | Departure Time 10:00AM | Arrival Time 12:00PM | Duration 74h00 | Departure days Wed | Cheapest price $607 |
Compare prices and tickets Portland, OR to Greenville, SC by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Portland, OR to Greenville, SC
USAUSA
Buses from Portland, OR to Greenville, SC run on average 2 times per day, taking around 77h 8m. Cheap bus tickets for this journey start at $268 (€220) if you book in advance.
The earliest bus runs at 02:00, the last at 22:00. The fastest bus covers the 2223 miles (3578 km) distance in 74h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 2223 miles (3578 km) |
Average bus duration 77h 8m |
Cheapest ticket price $268 (€220) |
Buses per day 2 |
Fastest bus 74h 0m |
First bus 2:00 AM |
Last bus 10:00 PM |
Cheapest Month Apr |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to Greenville
Things to do in Greenville
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
- Recommended
Upcountry History Museum
Regional history museum with permanent and rotating exhibits on the people and stories of Upstate South Carolina. A strong choice for understanding Greenville’s local context.
- Recommended
Sigal Music Museum
Specialized museum displaying rare historic instruments from around the world. A distinctive local favorite for music, design, and cultural history.
- Must visit
Main Street
Greenville’s central downtown street lined with shops, public art, plazas, and event spaces. It is the main place to walk and experience the city atmosphere.
- Must visit
Falls Park on the Reedy
Downtown park built around waterfalls, gardens, and river overlooks. It is Greenville’s signature public space and a top stop for first-time visitors.
- Must visit
Swamp Rabbit Trail
Popular multi-use greenway for walking and cycling, linking Greenville with nearby communities. Widely loved by locals and visitors for active sightseeing.
- Gluten-free
South Carolina Barbecue
Slow-smoked pork, often chopped or pulled, served with the state's signature mustard-based sauce. It is a defining Upstate and South Carolina tradition.
- Vegetarian
Fried Green Tomatoes
Slices of unripe tomato coated and fried until crisp, often served with remoulade or pimento cheese. A classic Southern starter common in Greenville restaurants.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, gravy, or bacon. This Lowcountry favorite is widely loved in Greenville as part of broader South Carolina cuisine.
The Anchorage
Well-regarded neighborhood restaurant focused on seasonal Southern-influenced American cooking with a polished but relaxed atmosphere.
Soby's
A long-running downtown Greenville favorite serving refined Southern cuisine in a lively, upscale setting. Known for shrimp and grits, brunch, and strong wine selections.
Smoke On The Water
Popular casual spot for barbecue, ribs, and Southern comfort food near Falls Park. Lively atmosphere and a good place to try local smoked meats.
United States Dollar
Moderate by U.S. standards: casual dining is affordable, while upscale downtown hotels and restaurants cost more.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual restaurant.
- Fine dining
- USD 50-100+ per person at upscale restaurants.
- Coffee
- USD 3-6 for a coffee drink.
Tipping culture
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff a few dollars, and round up for coffee only if desired.
FAQs: Bus from Portland, OR to Greenville, SC
Find answers to the most common questions about traveling from Portland, OR to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Portland, OR to Greenville, SC can start from as little as $268 (€220) when you book in advance. The average bus ticket price for Portland, OR to Greenville, SC is $438 (€358) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Portland, OR to Greenville, SC is 74h 0m to travel the 2223 miles (3578 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Portland, OR to Greenville, SC leaves at 2:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Portland, OR to Greenville, SC leaves at 10:00 PM.
A trip to Greenville, SC from Portland, OR is worth doing but not as a day trip with a journey time of 74h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Portland, OR to Greenville, SC is April.
It's helpful to compare your options as there are 3 ways to travel between Portland, OR and Greenville, SC including taking a bus, train, and flight.
No, there are no bathrooms on board the bus from Portland, OR to Greenville, SC.
No, the bus from Portland, OR to Greenville, SC has no accessibility options.
No, bikes are not allowed on board the bus from Portland, OR to Greenville, SC.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Portland, OR to Greenville, SC.
No, luggage for the bus from Portland, OR to Greenville, SC needs to be booked in addition.
No, there are no additional luggage options for the bus from Portland, OR to Greenville, SC.
Unfortunately, pets are not allowed on the bus from Portland, OR to Greenville, SC.
No, there are no USB plugs on board the bus from Portland, OR to Greenville, SC.
No, there is no WiFi on board the bus from Portland, OR to Greenville, SC.
Since neither Portland, OR nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Portland, OR to Greenville, SC
Portland
Greenville
The major bus station for departures in Portland is Portland, NW Station Way (Station Place Parking Garage). Find all the information you need to know about services, amenities and connections at Portland, NW Station Way (Station Place Parking Garage) for your trip from Portland to Greenville.
Portland, NW Station Way (Station Place Parking Garage)
information
The major bus station for arrivals in Greenville is Greenville, Woodruff Rd ("Raceway" gas station). Find all the information you need to know about services, amenities and connections at Greenville, Woodruff Rd ("Raceway" gas station) for your trip to Greenville from Portland.
Greenville, Woodruff Rd ("Raceway" gas station)
information
Most popular bus connections from Portland, OR
More options for your journey from Portland, OR to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Portland, OR
Most popular bus connections to Greenville, SC
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