Durham, NC to Greenville, SC bus with FlixBus

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Travel Information

Compare bus, train, and flight for Durham, NC to Greenville, SC

Omio recommends booking the bus as it is the most popular option from Durham, NC to Greenville, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of CHF44 For those with little time, consider booking a flight, which has an average total journey time of 4h 47m. Average ticket prices depend on the travel mode: a bus costs an average of CHF44, while a flight costs an average of CHF379.

Distance: 211 miles (341 km)

Compare bus with

Most popular
Bus
Train
Flight
Driving

CHF44

Average price

Cheapest

CHF73

Average price

CHF379

Average price

CHF41

Average price

(fuel + tolls)

5h 35m

Average total duration

5h 5m

Onboard

+

30m

Additional time*

6h 28m

Average total duration

5h 58m

Onboard

+

30m

Additional time*

4h 47m

Average total duration

Fastest

2h 47m

Onboard

+

2h 0m

Additional time*

3h 39m

Average total duration

(door-to-door)

FlixBus

Most popular bus company

Amtrak

Most popular train company

American Airlines

Most popular airline

Your own car or car rental

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Durham, NC to Greenville, SC is a bus with an average price of CHF44.

This is compared to other travel options from Durham, NC to Greenville, SC:

A bus is CHF29 less than a train for this route with tickets for a train from Durham, NC to Greenville, SC costing on average CHF73.

A bus is CHF335 less than a flight for this route with tickets for a flight from Durham, NC to Greenville, SC costing on average CHF379.

The fastest way to travel from Durham, NC to Greenville, SC is by flight with an average journey time of 2h 47m.

Other travel options to Greenville, SC take longer:

Bus takes on average 5h 5m.

Train takes on average 5h 58m.

It's helpful to compare your options as there are 3 ways to travel between Durham, NC and Greenville, SC including taking a bus, train, and flight.
We recommend using the train as it is the most popular way to get from Durham, NC to Greenville, SC among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around CHF44 compared to roughly CHF41 in fuel and tolls — a saving of about CHF-3.09. The journey takes 5h 5m versus 3h 39m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

Durham, NC to Greenville, SC Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
04:55AM
Arrival Time
10:50AM
Duration
5h55
Departure days
Wed
Cheapest price
CHF41
Operator
FlixBus
Departure Time
07:55AM
Arrival Time
12:35PM
Duration
4h40
Departure days
Sat, Sun
Cheapest price
CHF38
Operator
FlixBus
Departure Time
08:30AM
Arrival Time
01:15PM
Duration
4h45
Departure days
Wed
Cheapest price
CHF49
Operator
Greyhound
Departure Time
08:55AM
Arrival Time
02:50PM
Duration
5h55
Departure days
Fri
Cheapest price
CHF46
Operator
Greyhound
Departure Time
02:20PM
Arrival Time
08:10PM
Duration
5h50
Departure days
Wed
Cheapest price
CHF40
Operator
FlixBus
Departure Time
06:40PM
Arrival Time
11:25PM
Duration
4h45
Departure days
Fri
Cheapest price
CHF58

Compare prices and tickets Durham, NC to Greenville, SC by bus, train, or flight

Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Thu
Sep 17
Fri
Sep 18
Sat
Sep 19
Sun
Sep 20
Mon
Sep 21
Tue
Sep 22
Wed
Sep 23

Why should you book Durham, NC to Greenville, SC buses with Omio?

FlixBus operates all buses services from Durham, NC to Greenville, SC.
Omio is an official ticket reseller for all your travel options from Durham, NC to Greenville, SC.

Why book with Omio vs FlixBus?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Durham, NC to Greenville, SC.

Why book with Omio over Wanderu or Trainline?

  • Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Durham, NC to Greenville, SC.

Journey information

Overview: Bus from Durham, NC to Greenville, SC

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Buses from Durham, NC to Greenville, SC run on average 4 times per day, taking around 5h 5m. Cheap bus tickets for this journey start at CHF37 if you book in advance.

There are 4 buses per day. The earliest bus runs at 03:55, the last at 22:00. The fastest bus covers the 211 miles (341 km) distance in 4h 40m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
211 miles (341 km)
Average bus duration
5h 5m
Cheapest ticket price
CHF37
Buses per day
4
Direct buses
4
Fastest bus
4h 40m
First bus
3:55 AM
Last bus
10:00 PM
Cheapest Month
Sep
Cheapest Day
Sun
High Season
Jan - Mar
Low Season
Jul - Sep
Best time to book
7 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: FlixBus, Greyhound from Durham, NC to Greenville, SCYou can travel by bus between Durham, NC to Greenville, SC with FlixBus, Greyhound for as low as CHF37. When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
4h 40m
Cheapest FlixBus Price
CHF41
FlixBus frequency
3 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Learn more about FlixBus

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
5h 55m
Cheapest Greyhound Price
CHF41
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Learn more about Greyhound

FAQs: Bus from Durham, NC to Greenville, SC

Find answers to the most common questions about traveling from Durham, NC to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Durham, NC to Greenville, SC can start from as little as CHF37 when you book in advance. The average bus ticket price for Durham, NC to Greenville, SC is CHF44 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Durham, NC to Greenville, SC is 4h 40m to travel the 211 miles (341 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Durham, NC to Greenville, SC leaves at 3:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Durham, NC to Greenville, SC leaves at 10:00 PM.
Yes, there are 4 direct buses a day from Durham, NC to Greenville, SC with FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Durham, NC to Greenville, SC, you can count on FlixBus for the best way to get you to Greenville, SC. You can also check all possible bus companies who offer a service between Durham, NC and Greenville, SC and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Durham Station, which is located around away from the city centre, and they get off the bus at Greenville, Woodruff Rd ("Raceway" gas station), SC, located 8 away from the city centre.
A trip to Greenville, SC from Durham, NC is worth doing but not as a day trip with a journey time of 4h 40m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Durham, NC to Greenville, SC is September.
It's helpful to compare your options as there are 3 ways to travel between Durham, NC and Greenville, SC including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from Durham, NC to Greenville, SC:
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Durham, NC to Greenville, SC for bus company FlixBus.
Whether you can cancel your bus ticket from Durham, NC to Greenville, SC depends on the bus companies:
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Durham, NC to Greenville, SC.
Yes, the following luggage options are included when booking a bus ticket from Durham, NC to Greenville, SC:
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Durham, NC to Greenville, SC:
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Durham, NC to Greenville, SC. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Durham, NC to Greenville, SC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Durham, NC to Greenville, SC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Durham, NC to Greenville, SC with the following bus company: FlixBus.
Since neither Durham, NC nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Durham, NC to Greenville, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Durham, NC to Greenville, SC

Most Durham, NC to Greenville, SC buses use the Durham, W Pettigrew St (Greyhound Bus Station) to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Durham, NC and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in Durham
Arrival bus stations in Greenville
Durham, W Pettigrew St (Greyhound Bus Station)Durham W Pettigrew St Bus Station,515 W Pettigrew St,27701
City-centre transport

Getting to Durham, W Pettigrew St (Greyhound Bus Station) from Durham city centre

Bus2, 9, 12, 12B · 5m · CHF1 · every ~12 min

More options for your journey from Durham, NC to Greenville, SC

Here are some other resources that might have the information you need

Return journeys for buses from Greenville, SC to Durham, NC
Trains from Durham, NC to Greenville, SC
Tickets and more information for coaches to Durham, NC
Tickets and more information for coaches to Greenville, SC

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