- Must visit
Greenville County Museum of Art
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
Cheapest price
$94
Average price
$171
Fastest journey
14 h 5 m
Average duration
16 h 20 m
Buses per day
5
Distance
854 km
The best way to find a cheap bus ticket from Philadelphia, PA to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Philadelphia, PA to Greenville, SC will cost around $171 if you buy it on the day, but the cheapest tickets can be found for only $94.
Of the 5 buses that leave Philadelphia, PA for Greenville, SC on Mon, Jun 22, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Jun 22 the direct buses cover the 854 km distance in an average of 16 h 20 m but if you time it right, some buses will get you there in just 14 h 5 m .
On Mon, Jun 22 the slowest buses will take 20 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Omio recommends booking the train as it is the most popular option from Philadelphia, PA to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $79. For those with little time consider booking a flight which can get you there in 7h 0m. The ticket price range depends on the travel mode: a bus costs an average of $79, and a flight costs an average of $318.
Distance: 530 miles (854 km)
| Bus | Most popular Train | Flight |
|---|---|---|
$123 Average price Cheapest | $311 Average price | $485 Average price |
13h 13m Average total duration 12h 43m Onboard + 30m Additional time* | 14h 15m Average total duration 13h 45m Onboard + 30m Additional time* | 10h 0m Average total duration Fastest 7h 0m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Philadelphia, PA to Greenville, SC:
A bus is $188 (€154) less than a train for this route with tickets for a train from Philadelphia, PA to Greenville, SC costing on average $311 (€255).
A bus is $362 (€297) less than a flight for this route with tickets for a flight from Philadelphia, PA to Greenville, SC costing on average $485 (€397).
Other travel options to Greenville, SC take longer:
Bus takes on average 12h 43m.
Train takes on average 13h 45m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:00AM | Arrival Time 07:35PM | Duration 18h35 | Departure days Thu | Cheapest price $156 |
Operator Greyhound | Departure Time 02:00AM | Arrival Time 08:10PM | Duration 18h10 | Departure days Thu | Cheapest price $107 |
Operator FlixBus | Departure Time 05:00AM | Arrival Time 07:25PM | Duration 14h25 | Departure days Mon, Tue, Fri, Sat | Cheapest price $141 |
Operator Greyhound | Departure Time 05:50PM | Arrival Time 10:50AM | Duration 17h00 | Departure days Mon, Tue, Thu, Fri, Sat | Cheapest price $87 |
Operator FlixBus | Departure Time 06:30PM | Arrival Time 08:35AM | Duration 14h05 | Departure days Mon, Tue, Thu, Fri, Sat | Cheapest price $111 |
Operator FlixBus | Departure Time 07:20PM | Arrival Time 01:15PM | Duration 17h55 | Departure days Thu | Cheapest price $131 |
Operator Greyhound | Departure Time 09:50PM | Arrival Time 02:50PM | Duration 17h00 | Departure days Wed, Sun | Cheapest price $122 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 01:15PM | Duration 15h15 | Departure days Mon, Tue, Fri, Sat | Cheapest price $134 |
Operator Greyhound | Departure Time 10:30PM | Arrival Time 08:10PM | Duration 21h40 | Departure days Tue | Cheapest price $126 |
Operator FlixBus | Departure Time 10:30PM | Arrival Time 07:25PM | Duration 20h55 | Departure days Mon, Thu, Fri, Sat | Cheapest price $153 |
Operator Greyhound | Departure Time 10:50PM | Arrival Time 03:50PM | Duration 17h00 | Departure days Wed, Sun | Cheapest price $107 |
The table below shows live departures for Philadelphia, PA to Greenville, SC buses for today, Sunday, June 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:50 PM Philadelphia, PA | 17h00 | 2:50 PM Greenville, SC | 0 transfersDirect | |
![]() | 10:50 PM Philadelphia, PA | 17h00 | 3:50 PM Greenville, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Philadelphia, PA to Greenville, SC run on average 10 times per day, taking around 12h 43m. Cheap bus tickets for this journey start at $79 (€65) if you book in advance.
There are 1 buses per day. The earliest bus runs at 02:00, the last at 23:15. The fastest bus covers the 530 miles (854 km) distance in 15h 15m.
Distance 530 miles (854 km) |
Average bus duration 12h 43m |
Cheapest ticket price $79 (€65) |
Buses per day 10 |
Direct buses 1 |
Fastest bus 15h 15m |
First bus 2:00 AM |
Last bus 11:15 PM |
Cheapest Month Jan |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Jul - Sep |
Busiest Day Thu |
Least Busy Day Thu |
Best time to book 28 days |
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
Regional history museum with permanent and rotating exhibits on the people and stories of Upstate South Carolina. A strong choice for understanding Greenville’s local context.
Specialized museum displaying rare historic instruments from around the world. A distinctive local favorite for music, design, and cultural history.
Greenville’s central downtown street lined with shops, public art, plazas, and event spaces. It is the main place to walk and experience the city atmosphere.
Downtown park built around waterfalls, gardens, and river overlooks. It is Greenville’s signature public space and a top stop for first-time visitors.
Popular multi-use greenway for walking and cycling, linking Greenville with nearby communities. Widely loved by locals and visitors for active sightseeing.
Slow-smoked pork, often chopped or pulled, served with the state's signature mustard-based sauce. It is a defining Upstate and South Carolina tradition.
Slices of unripe tomato coated and fried until crisp, often served with remoulade or pimento cheese. A classic Southern starter common in Greenville restaurants.
Creamy stone-ground grits topped with shrimp, gravy, or bacon. This Lowcountry favorite is widely loved in Greenville as part of broader South Carolina cuisine.
Well-regarded neighborhood restaurant focused on seasonal Southern-influenced American cooking with a polished but relaxed atmosphere.
A long-running downtown Greenville favorite serving refined Southern cuisine in a lively, upscale setting. Known for shrimp and grits, brunch, and strong wine selections.
Popular casual spot for barbecue, ribs, and Southern comfort food near Falls Park. Lively atmosphere and a good place to try local smoked meats.
Moderate by U.S. standards: casual dining is affordable, while upscale downtown hotels and restaurants cost more.
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff a few dollars, and round up for coffee only if desired.
Find answers to the most common questions about traveling from Philadelphia, PA to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

Most Philadelphia, PA to Greenville, SC buses use the Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park) to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Philadelphia, PA and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need