- Must visit
Greenville County Museum of Art
Well-regarded art museum known for American art, including important Andrew Wyeth works and Southern artists. One of the city’s standout cultural stops.
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Travel Information
Compare bus and flight for Rochester, NY to Greenville, SC
Omio recommends booking the flight as it is the most popular option from Rochester, NY to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $232. For those with little time consider booking a flight which can get you there in 3h 55m. The ticket price range depends on the travel mode: a bus costs an average of $232, and a flight costs an average of $458.
Distance: 628 miles (1011 km)
Compare bus with
| Bus | Most popular Flight | Driving |
|---|---|---|
$232 Average price Cheapest | $458 Average price | $162 Average price (fuel + tolls) |
34h 50m Average total duration 34h 20m Onboard + 30m Additional time* | 6h 55m Average total duration Fastest 3h 55m Onboard + 3h 0m Additional time* | 12h 11m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Rochester, NY to Greenville, SC is a bus with an average price of $232 (€190).
This is compared to other travel options from Rochester, NY to Greenville, SC:
A bus is $226 (€185) less than a flight for this route with tickets for a flight from Rochester, NY to Greenville, SC costing on average $458 (€374).
The fastest way to travel from Rochester, NY to Greenville, SC is by flight with an average journey time of 3h 55m.
Other travel options to Greenville, SC take longer:
Bus takes on average 34h 20m.
It's helpful to compare your options as there are 2 ways to travel between Rochester, NY and Greenville, SC including taking a bus and flight.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Rochester, NY to Greenville, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:15AM | Arrival Time 12:35PM | Duration 34h20 | Departure days Fri | Cheapest price $232 |
Operator FlixBus | Departure Time 06:55AM | Arrival Time 08:35AM | Duration 25h40 | Departure days Mon, Tue, Fri, Sat | Cheapest price $131 |
Operator FlixBus | Departure Time 12:05PM | Arrival Time 01:15PM | Duration 25h10 | Departure days Mon, Tue, Fri, Sat | Cheapest price $178 |
Operator FlixBus | Departure Time 06:55PM | Arrival Time 07:25PM | Duration 24h30 | Departure days Mon, Fri, Sat | Cheapest price $158 |
Operator FlixBus | Departure Time 11:35PM | Arrival Time 08:35AM | Duration 33h00 | Departure days Mon, Tue, Fri, Sat | Cheapest price $136 |
Live departures
Rochester, NY to Greenville, SC bus times
The table below shows live departures for Rochester, NY to Greenville, SC buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 FlixBus · FlixBus+ | 6:55 PM Rochester, Pleasant St (Greyhound Stop), NY | 24h30 | 7:25 PM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
| FlixBus · FlixBus · FlixBus | 11:35 PM Rochester, Pleasant St (Greyhound Stop), NY | 33h00 | 8:35 AM Greenville, Woodruff Rd ("Raceway" gas station), SC | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Rochester, NY to Greenville, SC by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Rochester, NY to Greenville, SC
USAUSA
Buses from Rochester, NY to Greenville, SC run on average 4 times per day, taking around 34h 20m. Cheap bus tickets for this journey start at $232 (€190) if you book in advance.
The earliest bus runs at 07:10, the last at 22:00. The fastest bus covers the 628 miles (1011 km) distance in 34h 20m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 628 miles (1011 km) |
Average bus duration 34h 20m |
Cheapest ticket price $232 (€190) |
Buses per day 4 |
Fastest bus 34h 20m |
First bus 7:10 AM |
Last bus 10:00 PM |
Cheapest Month Aug |
Cheapest Day Fri |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 1 day |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to Greenville
Things to do in Greenville
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
- Recommended
Upcountry History Museum
Regional history museum with permanent and rotating exhibits on the people and stories of Upstate South Carolina. A strong choice for understanding Greenville’s local context.
- Recommended
Sigal Music Museum
Specialized museum displaying rare historic instruments from around the world. A distinctive local favorite for music, design, and cultural history.
- Must visit
Main Street
Greenville’s central downtown street lined with shops, public art, plazas, and event spaces. It is the main place to walk and experience the city atmosphere.
- Must visit
Falls Park on the Reedy
Downtown park built around waterfalls, gardens, and river overlooks. It is Greenville’s signature public space and a top stop for first-time visitors.
- Must visit
Swamp Rabbit Trail
Popular multi-use greenway for walking and cycling, linking Greenville with nearby communities. Widely loved by locals and visitors for active sightseeing.
- Gluten-free
South Carolina Barbecue
Slow-smoked pork, often chopped or pulled, served with the state's signature mustard-based sauce. It is a defining Upstate and South Carolina tradition.
- Vegetarian
Fried Green Tomatoes
Slices of unripe tomato coated and fried until crisp, often served with remoulade or pimento cheese. A classic Southern starter common in Greenville restaurants.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, gravy, or bacon. This Lowcountry favorite is widely loved in Greenville as part of broader South Carolina cuisine.
The Anchorage
Well-regarded neighborhood restaurant focused on seasonal Southern-influenced American cooking with a polished but relaxed atmosphere.
Soby's
A long-running downtown Greenville favorite serving refined Southern cuisine in a lively, upscale setting. Known for shrimp and grits, brunch, and strong wine selections.
Smoke On The Water
Popular casual spot for barbecue, ribs, and Southern comfort food near Falls Park. Lively atmosphere and a good place to try local smoked meats.
United States Dollar
Moderate by U.S. standards: casual dining is affordable, while upscale downtown hotels and restaurants cost more.
Average meal costs
- Budget
- USD 10-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual restaurant.
- Fine dining
- USD 50-100+ per person at upscale restaurants.
- Coffee
- USD 3-6 for a coffee drink.
Tipping culture
Tip 18-20% in restaurants; 20%+ for great service. Tip bartenders USD 1-2 per drink, taxis about 10-15%, hotel staff a few dollars, and round up for coffee only if desired.
FAQs: Bus from Rochester, NY to Greenville, SC
Find answers to the most common questions about traveling from Rochester, NY to Greenville, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Rochester, NY to Greenville, SC can start from as little as $232 (€190) when you book in advance. The average bus ticket price for Rochester, NY to Greenville, SC is $232 (€190) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Rochester, NY to Greenville, SC is 34h 20m to travel the 628 miles (1011 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Rochester, NY to Greenville, SC leaves at 7:10 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Rochester, NY to Greenville, SC leaves at 10:00 PM.
A trip to Greenville, SC from Rochester, NY is worth doing but not as a day trip with a journey time of 34h 20m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Rochester, NY to Greenville, SC is August.
It's helpful to compare your options as there are 2 ways to travel between Rochester, NY and Greenville, SC including taking a bus and flight.
No, the bus from Rochester, NY to Greenville, SC has no accessibility options.
No, there are no bathrooms on board the bus from Rochester, NY to Greenville, SC.
No, bikes are not allowed on board the bus from Rochester, NY to Greenville, SC.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Rochester, NY to Greenville, SC.
No, luggage for the bus from Rochester, NY to Greenville, SC needs to be booked in addition.
No, there are no additional luggage options for the bus from Rochester, NY to Greenville, SC.
Unfortunately, pets are not allowed on the bus from Rochester, NY to Greenville, SC.
No, there are no USB plugs on board the bus from Rochester, NY to Greenville, SC.
No, there is no WiFi on board the bus from Rochester, NY to Greenville, SC.
Since neither Rochester, NY nor Greenville, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, SC, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like downtown and popular events. Common scams include overcharging by unofficial taxi or ride-share drivers and fake charity solicitations. It is advisable to use authorized transportation services, avoid displaying valuables openly, and stay aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Rochester, NY to Greenville, SC
Most Rochester, NY to Greenville, SC buses use the Rochester, Pleasant St (Greyhound Stop) to Greenville, Woodruff Rd ("Raceway" gas station) station pair. Use this guide to compare Rochester, NY and Greenville, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Rochester
Arrival bus stations in Greenville
Rochester, Pleasant St (Greyhound Stop)
Greenville, Woodruff Rd ("Raceway" gas station)
More options for your journey from Rochester, NY to Greenville, SC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, SC and Rochester, NY
Most popular bus connections to Greenville, SC
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