- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
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The cheapest and fastest buses from Indianapolis, IN to St. Louis, MO
Showing times, prices and bookable tickets for Sep 14
Cheapest price on Sep 14
$42
Average ticket price on Sep 14
$42
Fastest journey on Sep 14
3 h 55 m
Average journey duration on Sep 14
4 h 33 m
Buses on Sep 14
3
Distance
370 km
Cheap tickets
The best way to find a cheap bus ticket from Indianapolis, IN to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Indianapolis, IN to St. Louis, MO will cost around $42 if you buy it on the day, but the cheapest tickets can be found for only $42.
Fast buses
On Mon, Sep 14, we found 3 buses from Indianapolis, IN to St. Louis, MO, including 3 direct services.
On Mon, Sep 14 the direct buses cover the 370 km distance in an average of 4 h 33 m but if you time it right, some buses will get you there in just 3 h 55 m .
On Mon, Sep 14 the slowest buses will take 5 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
11:05 AM5h05Indianapolis, Illinois St (Greyhound Bus Station)3:10 PMSt. Louis, S 15th St (Civic center)$421One-way0 transfers- 7:35 PM4h40Indianapolis, Illinois St (Greyhound Bus Station)11:15 PMSt. Louis, S 15th St (Civic center)$421One-way0 transfers
- 5:00 AM3h55Indianapolis, Illinois St (Greyhound Bus Station)7:55 AMSt. Louis, S 15th St (Civic center)$431One-way0 transfers
- 5:00 AM3h55Indianapolis, Illinois St (Greyhound Bus Station)7:55 AMSt. Louis, S 15th St (Civic center)$431One-way0 transfers
- 7:35 PM4h40Indianapolis, Illinois St (Greyhound Bus Station)11:15 PMSt. Louis, S 15th St (Civic center)$421One-way0 transfers
- 11:05 AM5h05Indianapolis, Illinois St (Greyhound Bus Station)3:10 PMSt. Louis, S 15th St (Civic center)$421One-way0 transfers
Travel Information
Compare train, bus, and flight for Indianapolis, IN to St. Louis, MO
Omio recommends booking the bus as it is the most popular option from Indianapolis, IN to St. Louis, MO among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $54 For those with little time, consider booking a bus, which has an average total journey time of 4h 58m. Average ticket prices depend on the travel mode: a bus costs an average of $54, while a flight costs an average of $648.
Distance: 229 miles (370 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$54 Average price Cheapest | $208 Average price | $648 Average price | $51 Average price (fuel + tolls) |
4h 58m Average total duration Fastest 4h 28m Onboard + 30m Additional time* | 10h 39m Average total duration 10h 9m Onboard + 30m Additional time* | 6h 10m Average total duration 4h 10m Onboard + 2h 0m Additional time* | 3h 31m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Indianapolis, IN to St. Louis, MO is a bus with an average price of $54.
This is compared to other travel options from Indianapolis, IN to St. Louis, MO:
A bus is $153 less than a train for this route with tickets for a train from Indianapolis, IN to St. Louis, MO costing on average $208.
A bus is $594 less than a flight for this route with tickets for a flight from Indianapolis, IN to St. Louis, MO costing on average $648.
The fastest way to travel from Indianapolis, IN to St. Louis, MO is by flight with an average journey time of 4h 10m.
Other travel options to St. Louis, MO take longer:
Bus takes on average 4h 28m.
Train takes on average 10h 9m.
It's helpful to compare your options as there are 3 ways to travel between Indianapolis, IN and St. Louis, MO including taking a train, bus, and flight.
We recommend using the bus as it is the most popular way to get from Indianapolis, IN to St. Louis, MO among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $54 compared to roughly $51 in fuel and tolls — a saving of about $-3.27. The journey takes 4h 28m versus 3h 31m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Indianapolis, IN to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 05:00AM | Arrival Time 07:55AM | Duration 3h55 | Departure days Everyday | Cheapest price $35 |
Operator Amtrak | Departure Time 06:40AM | Arrival Time 12:01PM | Duration 6h21 | Departure days Tue, Thu | Cheapest price $88 |
Operator Greyhound | Departure Time 11:05AM | Arrival Time 03:10PM | Duration 5h05 | Departure days Everyday | Cheapest price $33 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 11:15PM | Duration 4h40 | Departure days Everyday | Cheapest price $32 |
Live departures
Indianapolis, IN to St. Louis, MO bus times
The table below shows live departures for Indianapolis, IN to St. Louis, MO buses for today, Sunday, September 13. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 11:05 AM Indianapolis, Illinois St (Greyhound Bus Station) | 5h05 | 3:10 PM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
| 7:35 PM Indianapolis, Illinois St (Greyhound Bus Station) | 4h40 | 11:15 PM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
| Monday, September 14 | |||||
| 5:00 AM Indianapolis, Illinois St (Greyhound Bus Station) | 3h55 | 7:55 AM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Indianapolis, IN to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Indianapolis, IN to St. Louis, MO buses with Omio?
Greyhound operates all buses services from Indianapolis, IN to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from Indianapolis, IN to St. Louis, MO.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Indianapolis, IN to St. Louis, MO.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Indianapolis, IN to St. Louis, MO.
Journey information
Overview: Bus from Indianapolis, IN to St. Louis, MO
USAUSA
Buses from Indianapolis, IN to St. Louis, MO run on average 3 times per day, taking around 4h 28m. Cheap bus tickets for this journey start at $31 if you book in advance.
There are 3 buses per day. The earliest bus runs at 01:55, the last at 23:45. The fastest bus covers the 229 miles (370 km) distance in 3h 55m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 229 miles (370 km) |
Average bus duration 4h 28m |
Cheapest ticket price $31 |
Buses per day 3 |
Direct buses 3 |
Fastest bus 3h 55m |
First bus 1:55 AM |
Last bus 11:45 PM |
Cheapest Month Jul |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Sat |
Best time to book 2 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, Infobus, FlixBus from Indianapolis, IN to St. Louis, MOYou can travel by bus between Indianapolis, IN to St. Louis, MO with Greyhound, Infobus, FlixBus for as low as $31. When you search for schedules and tickets, Omio will show you the best journey
Infobus
About
Infobus is an international IT company that operates as an online service for finding and purchasing bus, train, and plane tickets, rather than being a bus company itself. Established in 2002, Infobus acts as an intermediary between passengers and various transport carriers, particularly helping smaller bus companies offer online booking services. They utilize their own "BusSystem" to manage routes and ticket sales globally. Infobus covers over 30 countries and 300 cities, offering a wide range of routes and daily departures. While amenities can vary by carrier, Infobus aims to provide affordable and convenient travel with features like online booking, 24/7 support, and prompt notifications.
Luggage & cancellation policy
Average Infobus Duration
4h 5m
Cheapest Infobus Price
$163
Infobus frequency
1 a day
Luggage included
One carry-on bag up to 5kg (40x20x25) and one checked bag up to 20kg (50x30x80).
Additional luggage
10€ per additional bag.
Cancellation Policy
You can cancel your ticket up to 24 hours before departure for a partial refund. Cancellations within 24 hours may incur a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Transport for wheelchairs and mobility aids.
Bikes
Bikes are allowed; may require prior reservation and an additional fee.
Pets
Small pets allowed in carriers; larger pets may require a separate ticket.
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
10h 35m
Cheapest FlixBus Price
$166
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
3h 55m
Cheapest Greyhound Price
$31
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis, MO
Things to do in St. Louis, MO
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
- Recommended
Missouri History Museum
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
- Recommended
Saint Louis Science Center
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
- Must visit
Gateway Arch National Park Grounds
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
- Must visit
Forest Park
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
- Recommended
Tower Grove Park
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
- Vegetarian
Toasted Ravioli
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
- Vegetarian
Gooey Butter Cake
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Bulrush
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Ted Drewes Frozen Custard
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Pappy's Smokehouse
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
United States dollar ($)
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-35 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person at upscale restaurants.
- Coffee
- $3-5 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
FAQs: Bus from Indianapolis, IN to St. Louis, MO
Find answers to the most common questions about traveling from Indianapolis, IN to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Indianapolis, IN to St. Louis, MO can start from as little as $31 when you book in advance. The average bus ticket price for Indianapolis, IN to St. Louis, MO is $54 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Indianapolis, IN to St. Louis, MO is 3h 55m to travel the 229 miles (370 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Indianapolis, IN to St. Louis, MO leaves at 1:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Indianapolis, IN to St. Louis, MO leaves at 11:45 PM.
Yes, there are 3 direct buses a day from Indianapolis, IN to St. Louis, MO with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Indianapolis, IN to St. Louis, MO, you can count on Greyhound for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between Indianapolis, IN and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
Passengers board the bus most frequently from Indianapolis, Illinois St (Greyhound Bus Station), which is located around away from the city centre, and they get off the bus at St. Louis, S 15th St (Civic center), located 0 away from the city centre.
A trip to St. Louis, MO from Indianapolis, IN is worth doing but not as a day trip with a journey time of 3h 55m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Indianapolis, IN to St. Louis, MO is July.
It's helpful to compare your options as there are 3 ways to travel between Indianapolis, IN and St. Louis, MO including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Indianapolis, IN to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Indianapolis, IN to St. Louis, MO for bus company Greyhound.
Whether you can cancel your bus ticket from Indianapolis, IN to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Indianapolis, IN to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from Indianapolis, IN to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Indianapolis, IN to St. Louis, MO:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Indianapolis, IN to St. Louis, MO.
You can reserve your seat on the bus from Indianapolis, IN to St. Louis, MO with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Indianapolis, IN to St. Louis, MO with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Indianapolis, IN to St. Louis, MO with the following bus company: Greyhound.
Since neither Indianapolis, IN nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Indianapolis, IN to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Indianapolis, IN to St. Louis, MO
Most Indianapolis, IN to St. Louis, MO buses use the Indianapolis, Illinois St (Greyhound Bus Station) to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Indianapolis, IN and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Indianapolis
Arrival bus stations in St. Louis
Which Indianapolis, IN station do buses to St. Louis, MO leave from?
Buses from Indianapolis, IN to St. Louis, MO leave from Indianapolis, Illinois St (Greyhound Bus Station). The station is 0 miles (1 km) from Indianapolis, IN city centre at 350 S Illinois St, Indianapolis, IN 46225, USA.
Indianapolis, Illinois St (Greyhound Bus Station)350 S Illinois St, Indianapolis, IN 46225, USA
City-centre transport
Getting to Indianapolis, Illinois St (Greyhound Bus Station) from Indianapolis city centre
TRUE
Indianapolis, Illinois St (Greyhound Bus Station) bus station facilities and services
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Fast food outlets are available.
Wi-Fi and ATMs
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Tickets and information
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Parking, taxis and toilets
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
Which St. Louis, MO station do buses from Indianapolis, IN arrive at?
Buses from Indianapolis, IN to St. Louis, MO arrive at St. Louis, S 15th St (Civic center). St. Louis, S 15th St (Civic center) is 0 miles (1 km) from St. Louis, MO city centre.
St. Louis, S 15th St (Civic center)S 15th St, St. Louis, MO, USA
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
St. Louis, S 15th St (Civic center) bus station facilities and services
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Tickets and information
Ticket office support is available at St. Louis, S 15th St (Civic center).
Parking, taxis and toilets
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Most popular bus connections from Indianapolis, IN
More options for your journey from Indianapolis, IN to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and Indianapolis, IN
Most popular bus connections to St. Louis, MO
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