- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Indianapolis, IN to St. Louis, MO
Showing times and prices for Aug 01
Cheapest price
$47
Average price
$68
Fastest journey
4 h 20 m
Average duration
5 h 2 m
Buses per day
6
Distance
370 km
Cheap tickets
The best way to find a cheap bus ticket from Indianapolis, IN to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Indianapolis, IN to St. Louis, MO will cost around $68 if you buy it on the day, but the cheapest tickets can be found for only $47.
Fast buses
Of the 6 buses that leave Indianapolis, IN for St. Louis, MO on Sat, Aug 01, 6 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Aug 01 the direct buses cover the 370 km distance in an average of 5 h 2 m but if you time it right, some buses will get you there in just 4 h 20 m .
On Sat, Aug 01 the slowest buses will take 6 h 21 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
1:05 AM4h20Indianapolis, IN5:25 AMSt. Louis, MO$471One-way0 transfers- 3:25 PM4h55Indianapolis, IN8:20 PMSt. Louis, MO$491One-way0 transfers
- 4:25 PM4h55Indianapolis, IN9:20 PMSt. Louis, MO$511One-way0 transfers
- 12:05 AM4h40Indianapolis, IN4:45 AMSt. Louis, MO$571One-way0 transfers
11:40 AM6h21Indianapolis, IN6:01 PMSt. Louis, MO$941One-way0 transfers
- 1:05 AM4h20Indianapolis, IN5:25 AMSt. Louis, MO$471One-way0 transfers
- 12:05 AM4h40Indianapolis, IN4:45 AMSt. Louis, MO$571One-way0 transfers
- 4:25 PM4h55Indianapolis, IN9:20 PMSt. Louis, MO$511One-way0 transfers
- 3:25 PM4h55Indianapolis, IN8:20 PMSt. Louis, MO$491One-way0 transfers
- 11:40 AM6h21Indianapolis, IN6:01 PMSt. Louis, MO$941One-way0 transfers
Travel Information
Compare train, bus, and flight for Indianapolis, IN to St. Louis, MO
Omio recommends booking the bus as it is the most popular option from Indianapolis, IN to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $33. For those with little time consider booking a bus which can get you there in 5h 22m. The ticket price range depends on the travel mode: a bus costs an average of $33, and a flight costs an average of $135.
Distance: 229 miles (370 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$54 Average price Cheapest | $124 Average price | $332 Average price | $50 Average price (fuel + tolls) |
5h 52m Average total duration Fastest 5h 22m Onboard + 30m Additional time* | 8h 58m Average total duration 8h 28m Onboard + 30m Additional time* | 11h 43m Average total duration 8h 43m Onboard + 3h 0m Additional time* | 3h 31m Average total duration (door-to-door) |
Most popular bus company | Most popular train company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Indianapolis, IN to St. Louis, MO is a bus with an average price of $54 (€44).
This is compared to other travel options from Indianapolis, IN to St. Louis, MO:
A bus is $70 (€57) less than a train for this route with tickets for a train from Indianapolis, IN to St. Louis, MO costing on average $124 (€101).
A bus is $278 (€228) less than a flight for this route with tickets for a flight from Indianapolis, IN to St. Louis, MO costing on average $332 (€272).
The fastest way to travel from Indianapolis, IN to St. Louis, MO is by bus with an average journey time of 5h 22m.
Other travel options to St. Louis, MO take longer:
Train takes on average 8h 28m.
Flight takes on average 8h 43m.
It's helpful to compare your options as there are 3 ways to travel between Indianapolis, IN and St. Louis, MO including taking a train, bus, and flight.
We recommend using the bus as it is the most popular way to get from Indianapolis, IN to St. Louis, MO among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about -2h -51m sooner (5h 22m by bus vs 3h 31m by car) and save roughly $-4.33 (€-3.55) compared to fuel and tolls ($54 (€44) vs $50 (€41)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by Greyhound.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Indianapolis, IN to St. Louis, MO Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:05AM | Arrival Time 04:45AM | Duration 4h40 | Departure days Sat, Sun | Cheapest price $54 |
Operator Greyhound | Departure Time 01:05AM | Arrival Time 05:25AM | Duration 4h20 | Departure days Sat, Sun | Cheapest price $47 |
Operator Greyhound | Departure Time 04:50AM | Arrival Time 07:45AM | Duration 3h55 | Departure days Mon, Wed, Thu, Sun | Cheapest price $37 |
Operator Greyhound | Departure Time 05:00AM | Arrival Time 07:55AM | Duration 3h55 | Departure days Tue | Cheapest price $35 |
Operator Amtrak | Departure Time 06:40AM | Arrival Time 12:01PM | Duration 6h21 | Departure days Mon | Cheapest price $103 |
Operator Amtrak | Departure Time 10:40AM | Arrival Time 05:01PM | Duration 6h21 | Departure days Fri | Cheapest price $109 |
Operator Greyhound | Departure Time 11:05AM | Arrival Time 03:10PM | Duration 5h05 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $34 |
Operator Amtrak | Departure Time 11:40AM | Arrival Time 06:01PM | Duration 6h21 | Departure days Fri | Cheapest price $94 |
Operator Greyhound | Departure Time 03:05PM | Arrival Time 08:10PM | Duration 5h05 | Departure days Sat | Cheapest price $50 |
Operator Greyhound | Departure Time 03:15PM | Arrival Time 08:10PM | Duration 4h55 | Departure days Sat | Cheapest price $56 |
Operator Greyhound | Departure Time 03:25PM | Arrival Time 08:20PM | Duration 4h55 | Departure days Fri, Sat | Cheapest price $48 |
Operator Greyhound | Departure Time 04:25PM | Arrival Time 09:20PM | Duration 4h55 | Departure days Fri, Sat | Cheapest price $37 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 11:15PM | Duration 4h40 | Departure days Tue | Cheapest price $31 |
Operator Greyhound | Departure Time 07:55PM | Arrival Time 11:15PM | Duration 4h20 | Departure days Mon, Wed, Thu, Sun | Cheapest price $35 |
Live departures
Indianapolis, IN to St. Louis, MO bus times
The table below shows live departures for Indianapolis, IN to St. Louis, MO buses for today, Thursday, July 30. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 4:50 AM Indianapolis, Illinois St (Greyhound Bus Station) | 3h55 | 7:45 AM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
| 11:05 AM Indianapolis, Illinois St (Greyhound Bus Station) | 5h05 | 3:10 PM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
| 7:55 PM Indianapolis, Illinois St (Greyhound Bus Station) | 4h20 | 11:15 PM St. Louis, S 15th St (Civic center) | 0 transfersDirect | |
| Friday, July 31 | |||||
| 12:05 AM Indianapolis, IN | 4h40 | 4:45 AM St. Louis, MO | 0 transfersDirect | |
| 1:05 AM Indianapolis, IN | 4h20 | 5:25 AM St. Louis, MO | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets Indianapolis, IN to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Fri
Jul 31
Jul 31
Sat
Aug 01
Aug 01
Sun
Aug 02
Aug 02
Mon
Aug 03
Aug 03
Tue
Aug 04
Aug 04
Wed
Aug 05
Aug 05
Thu
Aug 06
Aug 06
Why should you book Indianapolis, IN to St. Louis, MO buses with Omio?
Greyhound operates all buses services from Indianapolis, IN to St. Louis, MO.
Omio is an official ticket reseller for all your travel options from Indianapolis, IN to St. Louis, MO.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Indianapolis, IN to St. Louis, MO.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Indianapolis, IN to St. Louis, MO.
Journey information
Overview: Bus from Indianapolis, IN to St. Louis, MO
USAUSA
Buses from Indianapolis, IN to St. Louis, MO run on average 4 times per day, taking around 5h 22m. Cheap bus tickets for this journey start at $33 (€27) if you book in advance.
There are 3 buses per day. The earliest bus runs at 01:55, the last at 23:45. The fastest bus covers the 229 miles (370 km) distance in 3h 55m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 229 miles (370 km) |
Average bus duration 5h 22m |
Cheapest ticket price $33 (€27) |
Buses per day 4 |
Direct buses 3 |
Fastest bus 3h 55m |
First bus 1:55 AM |
Last bus 11:45 PM |
Cheapest Month Feb |
Cheapest Day Sun |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Sun |
Least Busy Day Sat |
Best time to book 1 day |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound from Indianapolis, IN to St. Louis, MOYou can travel by bus between Indianapolis, IN to St. Louis, MO with Greyhound for as low as $33 (€27). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
3h 55m
Cheapest Price
$33 (€27)
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to St. Louis, MO
Things to do in St. Louis, MO
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
- Recommended
Missouri History Museum
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
- Recommended
Saint Louis Science Center
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
- Must visit
Gateway Arch National Park Grounds
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
- Must visit
Forest Park
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
- Recommended
Tower Grove Park
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
- Vegetarian
St. Louis-Style Pizza
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
- Vegetarian
Toasted Ravioli
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
- Vegetarian
Gooey Butter Cake
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Bulrush
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Ted Drewes Frozen Custard
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Pappy's Smokehouse
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
United States dollar ($)
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $20-35 per person for a mid-range restaurant meal.
- Fine dining
- $60+ per person at upscale restaurants.
- Coffee
- $3-5 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
FAQs: Bus from Indianapolis, IN to St. Louis, MO
Find answers to the most common questions about traveling from Indianapolis, IN to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Indianapolis, IN to St. Louis, MO can start from as little as $33 (€27) when you book in advance. The average bus ticket price for Indianapolis, IN to St. Louis, MO is $54 (€44) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Indianapolis, IN to St. Louis, MO is 3h 55m to travel the 229 miles (370 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Indianapolis, IN to St. Louis, MO leaves at 1:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Indianapolis, IN to St. Louis, MO leaves at 11:45 PM.
Yes, there are 3 direct buses a day from Indianapolis, IN to St. Louis, MO with Greyhound. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Indianapolis, IN to St. Louis, MO, you can count on Greyhound for the best way to get you to St. Louis, MO. You can also check all possible bus companies who offer a service between Indianapolis, IN and St. Louis, MO and compare the amenities they offer before buying a bus ticket.
A trip to St. Louis, MO from Indianapolis, IN is worth doing but not as a day trip with a journey time of 3h 55m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Indianapolis, IN to St. Louis, MO is February.
It's helpful to compare your options as there are 3 ways to travel between Indianapolis, IN and St. Louis, MO including taking a train, bus, and flight.
Yes, there are bathrooms on board the bus from Indianapolis, IN to St. Louis, MO for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from Indianapolis, IN to St. Louis, MO:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Indianapolis, IN to St. Louis, MO depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Indianapolis, IN to St. Louis, MO.
Yes, the following luggage options are included when booking a bus ticket from Indianapolis, IN to St. Louis, MO:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Indianapolis, IN to St. Louis, MO:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Indianapolis, IN to St. Louis, MO.
You can reserve your seat on the bus from Indianapolis, IN to St. Louis, MO with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Indianapolis, IN to St. Louis, MO with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Indianapolis, IN to St. Louis, MO with the following bus company: Greyhound.
Since neither Indianapolis, IN nor St. Louis, MO are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Indianapolis, IN to St. Louis, MO among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In St. Louis, MO, travelers should be cautious in certain neighborhoods with higher crime rates, especially after dark. Common safety concerns include petty theft, pickpocketing, and occasional scams targeting visitors near popular attractions like the Gateway Arch. It’s advisable to stay in well-populated areas, avoid displaying valuables openly, and use reputable transportation services to minimize risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Indianapolis, IN to St. Louis, MO
Most Indianapolis, IN to St. Louis, MO buses use the Indianapolis, Illinois St (Greyhound Bus Station) to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Indianapolis, IN and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Indianapolis
Arrival bus stations in St. Louis
Indianapolis, Illinois St (Greyhound Bus Station)
Indianapolis, E Washington St / N Delaware St (City/County Building)
St. Louis, S 15th St (Civic center)
City-centre transport
Getting to St. Louis, S 15th St (Civic center) from St. Louis city centre
TrainMlb, Mlr · 4m · $4 · every ~14 min
Bus19, 32, 40 · 8m · $1 · every ~9 min
Most popular bus connections from Indianapolis, IN
More options for your journey from Indianapolis, IN to St. Louis, MO
Here are some other resources that might have the information you need
Most popular buses to and from St. Louis, MO and Indianapolis, IN
Most popular bus connections to St. Louis, MO
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
