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Journey information
Overview: Bus from Fort Myers, FL to Florence, SC
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 537 miles (865 km) |
First bus 03:18 |
Last bus 19:05 |
Key Takeaways
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
FAQs: Bus from Fort Myers, FL to Florence, SC
Find answers to the most common questions about traveling from Fort Myers, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

The first bus from Fort Myers, FL to Florence, SC leaves at 3: 18AM. Plan your trip with the Journey Planner from Omio.
The last bus from Fort Myers, FL to Florence, SC leaves at 5: 57PM.
A day trip to Florence, SC from Fort Myers, FL is worth doing with a journey time of min each way. Check with Omio app the best way to travel.
No, the bus from Fort Myers, FL to Florence, SC has no accessibility options.
No, there are no bathrooms on board the bus from Fort Myers, FL to Florence, SC.
No, bikes are not allowed on board the bus from Fort Myers, FL to Florence, SC.
To find the cheapest bus tickets for your trip from Fort Myers, FL to Florence, SC, follow these tips:
Start your search now and compare ticket prices to find the best deal!
Yes, there is food available to purchase on board the bus from Fort Myers, FL to Florence, SC.
No, luggage for the bus from Fort Myers, FL to Florence, SC needs to be booked in addition.
No, there are no additional luggage options for the bus from Fort Myers, FL to Florence, SC.
Unfortunately, pets are not allowed on the bus from Fort Myers, FL to Florence, SC.
No, there are no USB plugs on board the bus from Fort Myers, FL to Florence, SC.
No, there is no WiFi on board the bus from Fort Myers, FL to Florence, SC.
popular bus stations
Popular bus stations from Fort Myers, FL to Florence, SC
Fort Myers
Florence
The major bus station for departures in Fort Myers is Fort Myers, Rosa Parks Transit Center. Find all the information you need to know about services, amenities and connections at Fort Myers, Rosa Parks Transit Center for your trip from Fort Myers to Florence.
Fort Myers, Rosa Parks Transit Center
information
The major bus station for arrivals in Florence is Florence, S Irby St (Greyhound Bus Stop). Find all the information you need to know about services, amenities and connections at Florence, S Irby St (Greyhound Bus Stop) for your trip to Florence from Fort Myers.
Florence, S Irby St (Greyhound Bus Stop)
information
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