- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
The best way to find a cheap bus ticket from Baltimore, MD to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Baltimore, MD to Florence, SC will cost around $89 if you buy it on the day, but the cheapest tickets can be found for only $89.
It's difficult to get from Baltimore, MD to Florence, SC without transferring at least once.

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Buses from Baltimore, MD to Florence, SC run on average 1 times per day, taking around 10h 5m. Cheap bus tickets for this journey start at $72 if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:05, the last at 23:45. The fastest bus covers the 392 miles (632 km) distance in 8h 55m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Baltimore, MD to Florence, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:30AM | Arrival Time 09:45AM | Duration 9h15 | Departure days Thu | Cheapest price $67 |
Operator FlixBus | Departure Time 01:30AM | Arrival Time 10:45AM | Duration 9h15 | Departure days Mon, Sun | Cheapest price $79 |
Operator Flixbus USA | Departure Time 01:35AM | Arrival Time 11:45AM | Duration 10h10 | Departure days Mon, Thu | Cheapest price $101 |
Operator FlixBus | Departure Time 03:25AM | Arrival Time 03:45PM | Duration 12h20 | Departure days Mon, Sun | Cheapest price $110 |
Operator Greyhound | Departure Time 06:45AM | Arrival Time 04:45PM | Duration 10h00 | Departure days Fri | Cheapest price $152 |
Operator Flixbus USA | Departure Time 11:25PM | Arrival Time 11:45AM | Duration 12h20 | Departure days Tue, Thu | Cheapest price $89 |
Buses from Baltimore, MD to Florence, SC with FlixBus and Greyhound. Overnight buses available on this route with FlixBus and Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
Pulled pork barbecue is a Pee Dee staple, slow-smoked until tender and served with the region's tangy vinegar-pepper sauce.
Smoked pork ribs are common at local barbecue joints, seasoned simply and cooked low and slow for deep smoke flavor.
Shrimp and grits is a South Carolina classic: local shrimp over creamy grits, often enriched with bacon, gravy, or butter.
Upscale downtown restaurant serving refined Southern dishes, steaks, seafood, and cocktails in a polished space.
Casual local favorite for Carolina barbecue, ribs, and classic Southern sides in a relaxed family setting.
Popular casual spot known for barbecue plates, pulled pork, and generous Southern comfort food portions.
Moderate by U.S. small-city standards. Hotels are usually cheaper than major tourist cities, while dining and car-based transport remain fairly typical for the region.
Tip 15-20% at restaurants. Round up or add 10-15% for taxis if service is good. Small change is fine at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Florence, SC.
Find answers to the most common questions about traveling from Baltimore, MD to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

Most Baltimore, MD to Florence, SC buses use the Baltimore, Haines St (Baltimore Downtown Bus Station) to Florence, W Lucas St (TA Gas Station) station pair, with some services arriving at Florence, S Irby St (Greyhound Bus Stop). Use this guide to compare Baltimore, MD and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Baltimore, Haines St (Baltimore Downtown Bus Station) is 2 km from Baltimore city centre. Public transport options include:
Baltimore, Haines St (Baltimore Downtown Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available throughout the station. ATMs are available at Baltimore, Haines St (Baltimore Downtown Bus Station).
Ticket office support is available at Baltimore, Haines St (Baltimore Downtown Bus Station).
Available at Baltimore, Haines St (Baltimore Downtown Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Baltimore, Haines St (Baltimore Downtown Bus Station): Fully accessible for wheelchairs.
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Food and snacks available at the gas station.
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Check bus stations information for Baltimore, MD and Florence, SC, including where buses depart and arrive on this route.