- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
The best way to find a cheap bus ticket from Daytona Beach, FL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Daytona Beach, FL to Florence, SC will cost around $78 if you buy it on the day, but the cheapest tickets can be found for only $78.
It's difficult to get from Daytona Beach, FL to Florence, SC without transferring at least once.

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Buses from Daytona Beach, FL to Florence, SC run on average 2 times per day, taking around 7h 33m. Cheap bus tickets for this journey start at $53 (€44) if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:15, the last at 16:50. The fastest bus covers the 352 miles (567 km) distance in 7h 15m.
Distance 352 miles (567 km) |
Average bus duration 7h 33m |
Cheapest ticket price $53 (€44) |
Buses per day 2 |
Direct buses 1 |
Fastest bus 7h 15m |
First bus 5:15 AM |
Last bus 4:50 PM |
Cheapest Month Jul |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Apr - Jun |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Daytona Beach, FL to Florence, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 06:55PM | Arrival Time 01:25PM | Duration 18h30 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $78 |
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
Pulled pork barbecue is a Pee Dee staple, slow-smoked until tender and served with the region's tangy vinegar-pepper sauce.
Smoked pork ribs are common at local barbecue joints, seasoned simply and cooked low and slow for deep smoke flavor.
Shrimp and grits is a South Carolina classic: local shrimp over creamy grits, often enriched with bacon, gravy, or butter.
Upscale downtown restaurant serving refined Southern dishes, steaks, seafood, and cocktails in a polished space.
Casual local favorite for Carolina barbecue, ribs, and classic Southern sides in a relaxed family setting.
Popular casual spot known for barbecue plates, pulled pork, and generous Southern comfort food portions.
Moderate by U.S. small-city standards. Hotels are usually cheaper than major tourist cities, while dining and car-based transport remain fairly typical for the region.
Tip 15-20% at restaurants. Round up or add 10-15% for taxis if service is good. Small change is fine at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Florence, SC.
Find answers to the most common questions about traveling from Daytona Beach, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

Most Daytona Beach, FL to Florence, SC buses use the Daytona Beach, Cornerstone Blvd ("Tanger Outlets" parking lot) to Florence, W Lucas St (TA Gas Station) station pair. Use this guide to compare Daytona Beach, FL and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Daytona Beach, S Ridgewood Ave (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available inside the station. ATMs are available at Daytona Beach, S Ridgewood Ave (Greyhound Bus Station).
Ticket office support is available at Daytona Beach, S Ridgewood Ave (Greyhound Bus Station).
Available at Daytona Beach, S Ridgewood Ave (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Daytona Beach, S Ridgewood Ave (Greyhound Bus Station): Wheelchair accessible entrance and facilities.
Daytona Beach, Cornerstone Blvd ("Tanger Outlets" parking lot) is 7 km from Daytona Beach city centre. Public transport options include:
Daytona Beach, Cornerstone Blvd ("Tanger Outlets" parking lot) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Restaurants available inside the Tanger Outlets.
Wi-Fi is available at Daytona Beach, Cornerstone Blvd ("Tanger Outlets" parking lot). ATMs are aTMs available at the Tanger Outlets.
Ticket office support is available at Daytona Beach, Cornerstone Blvd ("Tanger Outlets" parking lot).
Available at Daytona Beach, Cornerstone Blvd ("Tanger Outlets" parking lot): Parking, Taxis, WC.
Accessibility facilities are available at Daytona Beach, Cornerstone Blvd ("Tanger Outlets" parking lot): Wheelchair accessible pathways available.
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Food and snacks available at the gas station.
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Check bus stations information for Daytona Beach, FL and Florence, SC, including where buses depart and arrive on this route.
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