- Must visit
Uffizi Galleries
World-famous museum of Renaissance art with masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. Timed entry is strongly advised due to very high demand.
Cheapest price
$79
Average price
$79
Fastest journey
18 h 30 m
Average duration
18 h 30 m
Buses per day
1
Distance
567 km
The best way to find a cheap bus ticket from Daytona Beach, FL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Daytona Beach, FL to Florence, SC will cost around $79 if you buy it on the day, but the cheapest tickets can be found for only $79.
It's difficult to get from Daytona Beach, FL to Florence, SC without transferring at least once.


Omio recommends booking the bus as it is the most popular option from Daytona Beach, FL to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from $79. For those with little time consider booking a bus which can get you there in 18h 30m. The ticket price range depends on the travel mode: a bus costs an average of $79, and a bus costs an average of $79.
Distance: 352 miles (567 km)
Most popular Bus | Driving |
|---|---|
$79 Average price Cheapest | $81 Average price (fuel + tolls) |
19h 0m Average total duration Fastest 18h 30m Onboard + 30m Additional time* | 5h 52m Average total duration (door-to-door) |
Direct Options | Direct Options |
Other travel options to Florence, SC take longer:
Bus takes on average 18h 30m.
Tickets start at around $79 (€65) compared to roughly $81 (€66) in fuel and tolls — a saving of about $1 (€1). The journey takes 18h 30m versus 5h 52m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 06:55PM | Arrival Time 01:25PM | Duration 18h30 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price $79 |
The table below shows live departures for Daytona Beach, FL to Florence, SC buses for tomorrow, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:55 PM Daytona Beach, FL | 18h30 | 1:25 PM Florence, SC | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Daytona Beach, FL to Florence, SC run on average 2 times per day, taking around 18h 30m. Cheap bus tickets for this journey start at $79 (€65) if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:15, the last at 16:50. The fastest bus covers the 352 miles (567 km) distance in 18h 30m.
Distance 352 miles (567 km) |
Average bus duration 18h 30m |
Cheapest ticket price $79 (€65) |
Buses per day 2 |
Direct buses 1 |
Fastest bus 18h 30m |
First bus 5:15 AM |
Last bus 4:50 PM |
High Season Jan - Mar |
Low Season Jan - Mar |
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
World-famous museum of Renaissance art with masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. Timed entry is strongly advised due to very high demand.
Best known for Michelangelo’s David, this compact museum is one of Florence’s essential stops. Advance booking is commonly recommended because queues can be long.
Large palace museum complex with royal apartments, paintings, and design collections. Worth visiting for its scale, courtly interiors, and links to Medici history.
The monumental heart of Florence, surrounded by the cathedral, dome, baptistery, and bell tower. Essential for first-time visitors and classic city views.
Historic square lined with civic architecture and open-air sculptures. One of Florence’s liveliest public spaces and a key stop on any walking route.
The city’s most famous viewpoint, especially popular at sunset for sweeping skyline photos. A social media favorite and classic Florence panorama.
Slow-smoked pork shoulder, usually chopped or pulled and served with a tangy Southern barbecue sauce. It is a staple across the Carolinas and common in Florence-area smokehouses.
Cornmeal-coated catfish fillets fried until crisp, often served with hush puppies and slaw. This is a classic Pee Dee and broader South Carolina comfort dish.
Creamy stone-ground grits topped with shrimp, often with bacon, gravy, or a light sauce. A defining Lowcountry and South Carolina dish regularly found in Florence.
Established downtown barbecue spot specializing in smoked meats, Southern sides, and a casual local atmosphere.
Upscale, long-running Florence restaurant known for steaks, seafood, and polished Southern-American dining in an elegant setting.
Well-known casual seafood restaurant recognized for fried seafood platters, shrimp, fish, and regional comfort fare.
Costs are moderate for the U.S. Budget eats are easy to find, while hotels and fine dining can raise daily costs.
Tip 18-20% at restaurants. Tip USD 1-2 per drink at bars, round up or tip 10-15% for taxis, and tip hotel staff USD 2-5 for helpful service.
Find answers to the most common questions about traveling from Daytona Beach, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

Most Daytona Beach, FL to Florence, SC buses use the Daytona Beach, Cornerstone Blvd ("Tanger Outlets" parking lot) to Florence, S Irby St (Greyhound Bus Stop) station pair. Use this guide to compare Daytona Beach, FL and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need