The cheapest and fastest buses from Boston, MA to Florence, SC
Cheapest price
$222
Average price
$222
Fastest journey
1 d 25 m
Average duration
1 d 25 m
Buses per day
1
Distance
1182 km
The best way to find a cheap bus ticket from Boston, MA to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Boston, MA to Florence, SC will cost around $222 if you buy it on the day, but the cheapest tickets can be found for only $222.
It's difficult to get from Boston, MA to Florence, SC without transferring at least 2 times.


Travel Information
Compare train and bus for Boston, MA to Florence, SC
Omio recommends booking the train as it is the most popular option from Boston, MA to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from €81. For those with little time consider booking a train which can get you there in 16h 1m. The ticket price range depends on the travel mode: a bus costs an average of €81, and a train costs an average of €114.
Distance: 734 miles (1182 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
€81 Average price Cheapest | €219 Average price |
18h 5m Average total duration 17h 35m Onboard + 30m Additional time* | 16h 31m Average total duration Fastest 16h 1m Onboard + 30m Additional time* |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Boston, MA to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 04:45PM | Arrival Time 11:45AM | Duration 19h00 | Departure days Tue | Cheapest price $195 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 05:45AM | Duration 31h55 | Departure days Tue | Cheapest price $199 |
Compare prices and tickets Boston, MA to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Boston, MA to Florence, SC buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Boston, MA to Florence, SC.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Boston, MA to Florence, SC.
Why book with Omio over Wanderu?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Boston, MA to Florence, SC.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Boston, MA to Florence, SC.
Journey information
Overview: Bus from Boston, MA to Florence, SC
Buses from Boston, MA to Florence, SC run on average 2 times per day, taking around 17h 35m. Cheap bus tickets for this journey start at $102 (€81) if you book in advance.
The earliest bus runs at 00:05, the last at 20:55. The fastest bus covers the 734 miles (1182 km) distance in 19h 5m.
Distance 734 miles (1182 km) |
Average bus duration 17h 35m |
Cheapest ticket price $102 (€81) |
Buses per day 2 |
Fastest bus 19h 5m |
First bus 00:05 |
Last bus 20:55 |
Bus providers: Greyhound, FlixBus from Boston, MA to Florence, SCYou can travel by bus between Boston, MA to Florence, SC with Greyhound, FlixBus for as low as $102 (€81). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
FAQs: Bus from Boston, MA to Florence, SC
Find answers to the most common questions about traveling from Boston, MA to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Boston, MA to Florence, SC
More options for your journey from Boston, MA to Florence, SC
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