- Must visit
Uffizi Galleries
World-famous museum of Renaissance art with masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. Timed entry is strongly advised due to very high demand.
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The cheapest and fastest buses from Orlando, FL to Florence, SC
Showing times and prices for Jun 20
Cheapest price
$73
Average price
$104
Fastest journey
8 h 25 m
Average duration
9 h 8 m
Buses per day
3
Distance
647 km
Cheap tickets
The best way to find a cheap bus ticket from Orlando, FL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Florence, SC will cost around $104 if you buy it on the day, but the cheapest tickets can be found for only $73.
Fast buses
Of the 3 buses that leave Orlando, FL for Florence, SC on Sat, Jun 20, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 20 the direct buses cover the 647 km distance in an average of 9 h 8 m but if you time it right, some buses will get you there in just 8 h 25 m .
On Sat, Jun 20 the slowest buses will take 9 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
9:00 AM9h35Orlando, FL6:35 PMFlorence, SC$731One-way0 transfers- 8:00 AM9h25Orlando, FL5:25 PMFlorence, SC$1131One-way0 transfers
- 7:40 PM8h25Orlando, FL4:05 AMFlorence, SC$1271One-way0 transfers
- 7:40 PM8h25Orlando, FL4:05 AMFlorence, SC$1271One-way0 transfers
- 8:00 AM9h25Orlando, FL5:25 PMFlorence, SC$1131One-way0 transfers
- 9:00 AM9h35Orlando, FL6:35 PMFlorence, SC$731One-way0 transfers
Travel Information
Compare train and bus for Orlando, FL to Florence, SC
Omio recommends booking the train as it is the most popular option from Orlando, FL to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from $73. For those with little time consider booking a bus which can get you there in 7h 55m. The ticket price range depends on the travel mode: a bus costs an average of $73, and a train costs an average of $67.
Distance: 402 miles (647 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
$104 Average price Cheapest | $149 Average price | $91 Average price (fuel + tolls) |
8h 25m Average total duration Fastest 7h 55m Onboard + 30m Additional time* | 10h 9m Average total duration 9h 39m Onboard + 30m Additional time* | 6h 28m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Orlando, FL to Florence, SC is a bus with an average price of $104 (€85).
This is compared to other travel options from Orlando, FL to Florence, SC:
A bus is $45 (€37) less than a train for this route with tickets for a train from Orlando, FL to Florence, SC costing on average $149 (€122).
The fastest way to travel from Orlando, FL to Florence, SC is by bus with an average journey time of 7h 55m.
Other travel options to Florence, SC take longer:
Train takes on average 9h 39m.
It's helpful to compare your options as there are 2 ways to travel between Orlando, FL and Florence, SC including taking a train and bus.
We recommend using the train as it is the most popular way to get from Orlando, FL to Florence, SC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about -2h -27m sooner (7h 55m by bus vs 6h 28m by car) and save roughly $-12.99 (€-10.64) compared to fuel and tolls ($104 (€85) vs $91 (€74)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by FlixBus.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Orlando, FL to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 04:00AM | Arrival Time 01:25PM | Duration 9h25 | Departure days Wed | Cheapest price $85 |
Operator FlixBus | Departure Time 04:45AM | Arrival Time 01:25PM | Duration 8h40 | Departure days Fri | Cheapest price $100 |
Operator FlixBus | Departure Time 08:00AM | Arrival Time 05:25PM | Duration 9h25 | Departure days Thu, Sat, Sun | Cheapest price $90 |
Operator FlixBus | Departure Time 09:00AM | Arrival Time 06:35PM | Duration 9h35 | Departure days Thu, Sat | Cheapest price $73 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 12:05AM | Duration 11h20 | Departure days Mon, Fri | Cheapest price $99 |
Operator FlixBus | Departure Time 03:40PM | Arrival Time 12:05AM | Duration 8h25 | Departure days Mon, Fri | Cheapest price $59 |
Operator FlixBus | Departure Time 07:40PM | Arrival Time 04:05AM | Duration 8h25 | Departure days Sat | Cheapest price $127 |
Live departures
Orlando, FL to Florence, SC bus times
The table below shows live departures for Orlando, FL to Florence, SC buses for tomorrow, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 8:00 AM Orlando, FL | 9h25 | 5:25 PM Florence, SC | 0 transfersDirect | |
| 9:00 AM Orlando, FL | 9h35 | 6:35 PM Florence, SC | 0 transfersDirect | |
| 7:40 PM Orlando, FL | 8h25 | 4:05 AM Florence, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Orlando, FL to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Jun 20
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Why should you book Orlando, FL to Florence, SC buses with Omio?
FlixBus operates all buses services from Orlando, FL to Florence, SC.
Omio is an official ticket reseller for all your travel options from Orlando, FL to Florence, SC.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Orlando, FL to Florence, SC.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Orlando, FL to Florence, SC.
Journey information
Overview: Bus from Orlando, FL to Florence, SC
USAUSA
Buses from Orlando, FL to Florence, SC run on average 4 times per day, taking around 7h 55m. Cheap bus tickets for this journey start at $73 (€60) but you can travel from only $67 (€55) by train.
There are 2 buses per day. The earliest bus runs at 04:00, the last at 23:40. The fastest bus covers the 402 miles (647 km) distance in 8h 25m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $67 (€55)
Distance 402 miles (647 km) |
Average bus duration 7h 55m |
Cheapest ticket price $73 (€60) |
Buses per day 4 |
Direct buses 2 |
Fastest bus 8h 25m |
First bus 4:00 AM |
Last bus 11:40 PM |
Cheapest Month Jul |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Apr - Jun |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $67 (€55)
Bus providers: FlixBus from Orlando, FL to Florence, SCYou can travel by bus between Orlando, FL to Florence, SC with FlixBus for as low as $67 (€55). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
8h 25m
Cheapest Price
$73 (€60)
FlixBus frequency
4 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Florence
Things to do in Florence
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
- Must visit
Accademia Gallery
Best known for Michelangelo’s David, this compact museum is one of Florence’s essential stops. Advance booking is commonly recommended because queues can be long.
- Recommended
Palazzo Pitti
Large palace museum complex with royal apartments, paintings, and design collections. Worth visiting for its scale, courtly interiors, and links to Medici history.
- Must visit
Piazza del Duomo
The monumental heart of Florence, surrounded by the cathedral, dome, baptistery, and bell tower. Essential for first-time visitors and classic city views.
- Must visit
Piazza della Signoria
Historic square lined with civic architecture and open-air sculptures. One of Florence’s liveliest public spaces and a key stop on any walking route.
- Must visit
Piazzale Michelangelo
The city’s most famous viewpoint, especially popular at sunset for sweeping skyline photos. A social media favorite and classic Florence panorama.
- Gluten-free
Pulled Pork Barbecue
Slow-smoked pork shoulder, usually chopped or pulled and served with a tangy Southern barbecue sauce. It is a staple across the Carolinas and common in Florence-area smokehouses.
Fried Catfish
Cornmeal-coated catfish fillets fried until crisp, often served with hush puppies and slaw. This is a classic Pee Dee and broader South Carolina comfort dish.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, often with bacon, gravy, or a light sauce. A defining Lowcountry and South Carolina dish regularly found in Florence.
Wholly Smokin' Downtown
Established downtown barbecue spot specializing in smoked meats, Southern sides, and a casual local atmosphere.
Victors
Upscale, long-running Florence restaurant known for steaks, seafood, and polished Southern-American dining in an elegant setting.
Tubb's Shrimp & Fish Co.
Well-known casual seafood restaurant recognized for fried seafood platters, shrimp, fish, and regional comfort fare.
United States Dollar
Costs are moderate for the U.S. Budget eats are easy to find, while hotels and fine dining can raise daily costs.
Average meal costs
- Budget
- USD 8-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual sit-down restaurant.
- Fine dining
- USD 50-100+ per person before drinks and tip.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% at restaurants. Tip USD 1-2 per drink at bars, round up or tip 10-15% for taxis, and tip hotel staff USD 2-5 for helpful service.
FAQs: Bus from Orlando, FL to Florence, SC
Find answers to the most common questions about traveling from Orlando, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Orlando, FL to Florence, SC can start from as little as $73 (€60) when you book in advance. The average bus ticket price for Orlando, FL to Florence, SC is $104 (€85) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Orlando, FL to Florence, SC is 8h 25m to travel the 402 miles (647 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Orlando, FL to Florence, SC leaves at 4:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Orlando, FL to Florence, SC leaves at 11:40 PM.
Yes, there are 2 direct buses a day from Orlando, FL to Florence, SC with FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Orlando, FL to Florence, SC, you can count on FlixBus for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Orlando, FL and Florence, SC and compare the amenities they offer before buying a bus ticket.
A trip to Florence, SC from Orlando, FL is worth doing but not as a day trip with a journey time of 8h 25m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Orlando, FL to Florence, SC is July.
It's helpful to compare your options as there are 2 ways to travel between Orlando, FL and Florence, SC including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Orlando, FL to Florence, SC:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Orlando, FL to Florence, SC for bus company FlixBus.
Whether you can cancel your bus ticket from Orlando, FL to Florence, SC depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Orlando, FL to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Orlando, FL to Florence, SC:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Orlando, FL to Florence, SC:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Orlando, FL to Florence, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Orlando, FL to Florence, SC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Orlando, FL to Florence, SC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Orlando, FL to Florence, SC with the following bus company: FlixBus.
Since neither Orlando, FL nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Orlando, FL to Florence, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Orlando, FL to Florence, SC
Most Orlando, FL to Florence, SC buses use the Orlando, N John Young Pkwy (Greyhound Bus Station) to Florence, S Irby St (Greyhound Bus Stop) station pair. Use this guide to compare Orlando, FL and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Orlando
Arrival bus stations in Florence
Orlando, N John Young Pkwy (Greyhound Bus Station)
City-centre transport
Getting to Orlando, N John Young Pkwy (Greyhound Bus Station) from Orlando city centre
Bus125 · 40m · $2 · every ~6 min
125 · 41m · $2 · every ~6 min
Orlando, The Florida MallOrlando Florida Mall Ave,Florida Mall Ave 1632,32809
City-centre transport
Getting to Orlando, The Florida Mall from Orlando city centre
Bus42 · 26m · $2 · every ~5 min
Florence, S Irby St (Greyhound Bus Stop)
Most popular bus connections from Orlando, FL
More options for your journey from Orlando, FL to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Orlando, FL
Most popular bus connections to Florence, SC
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