4.9
4.6The cheapest and fastest buses from Orlando, FL to Florence, SC
Cheapest price
Kč1804
Average price
Kč1804
Fastest journey
9 h 25 m
Average duration
9 h 25 m
Buses per day
1
Distance
647 km
The best way to find a cheap bus ticket from Orlando, FL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Florence, SC will cost around Kč1804 if you buy it on the day, but the cheapest tickets can be found for only Kč1804.
Of the 1 buses that leave Orlando, FL for Florence, SC on Wed, Aug 05, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 647 km distance in an average of 9 h 25 m but if you time it right, some buses will get you there in just 9 h 25 m .
On Wed, Aug 05 the slowest buses will take 9 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
4:00 AM9h25Orlando, FL1:25 PMFlorence, SCKč18041One-way0 transfers
- 4:00 AM9h25Orlando, FL1:25 PMFlorence, SCKč18041One-way0 transfers
Travel Information
Compare train and bus for Orlando, FL to Florence, SC
Omio recommends booking the train as it is the most popular option from Orlando, FL to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from Kč1549. For those with little time consider booking a bus which can get you there in 7h 55m. The ticket price range depends on the travel mode: a bus costs an average of Kč1549, and a train costs an average of Kč1411.
Distance: 402 miles (647 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
Kč2189 Average price Cheapest | Kč3137 Average price | Kč1915 Average price (fuel + tolls) |
8h 25m Average total duration Fastest 7h 55m Onboard + 30m Additional time* | 10h 9m Average total duration 9h 39m Onboard + 30m Additional time* | 6h 28m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Orlando, FL to Florence, SC:
A bus is Kč948 less than a train for this route with tickets for a train from Orlando, FL to Florence, SC costing on average Kč3137.
Other travel options to Florence, SC take longer:
Train takes on average 9h 39m.
You'll arrive about -2h -27m sooner (7h 55m by bus vs 6h 28m by car) and save roughly Kč-274.18 compared to fuel and tolls (Kč2189 vs Kč1915). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by FlixBus.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Orlando, FL to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 04:00AM | Arrival Time 01:25PM | Duration 9h25 | Departure days Wed | Cheapest price Kč1804 |
Operator FlixBus | Departure Time 04:45AM | Arrival Time 01:25PM | Duration 8h40 | Departure days Sun | Cheapest price Kč1829 |
Operator FlixBus | Departure Time 06:00AM | Arrival Time 05:30PM | Duration 11h30 | Departure days Sun | Cheapest price Kč1855 |
Operator FlixBus | Departure Time 08:00AM | Arrival Time 05:25PM | Duration 9h25 | Departure days Mon | Cheapest price Kč2172 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 12:05AM | Duration 11h20 | Departure days Thu, Fri, Sat, Sun | Cheapest price Kč1777 |
Operator FlixBus | Departure Time 03:40PM | Arrival Time 12:05AM | Duration 8h25 | Departure days Thu, Fri, Sat, Sun | Cheapest price Kč1468 |
Operator FlixBus | Departure Time 07:40PM | Arrival Time 04:05AM | Duration 8h25 | Departure days Mon | Cheapest price Kč2015 |
Compare prices and tickets Orlando, FL to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Aug 05
Aug 06
Aug 07
Aug 08
Aug 09
Aug 10
Aug 11
Why should you book Orlando, FL to Florence, SC buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Orlando, FL to Florence, SC.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Orlando, FL to Florence, SC.
Journey information
Overview: Bus from Orlando, FL to Florence, SC
USAUSA
Buses from Orlando, FL to Florence, SC run on average 4 times per day, taking around 7h 55m. Cheap bus tickets for this journey start at Kč1549 but you can travel from only Kč1411 by train.
There are 2 buses per day. The earliest bus runs at 04:00, the last at 23:40. The fastest bus covers the 402 miles (647 km) distance in 8h 25m.
Distance 402 miles (647 km) |
Average bus duration 7h 55m |
Cheapest ticket price Kč1549 |
Buses per day 4 |
Direct buses 2 |
Fastest bus 8h 25m |
First bus 4:00 AM |
Last bus 11:40 PM |
Cheapest Month Jul |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Apr - Jun |
Bus providers: FlixBus from Orlando, FL to Florence, SCYou can travel by bus between Orlando, FL to Florence, SC with FlixBus for as low as Kč1411. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Orlando, FL to Florence, SC
Find answers to the most common questions about traveling from Orlando, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Orlando, FL to Florence, SC
Most Orlando, FL to Florence, SC buses use the Orlando, N John Young Pkwy (Greyhound Bus Station) to Florence, S Irby St (Greyhound Bus Stop) station pair. Use this guide to compare Orlando, FL and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Getting to Orlando, N John Young Pkwy (Greyhound Bus Station) from Orlando city centre
Getting to Orlando, The Florida Mall from Orlando city centre
Most popular bus connections from Orlando, FL
More options for your journey from Orlando, FL to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Orlando, FL
Most popular bus connections to Florence, SC
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