- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
Journey information
Overview: Bus from Orlando, FL to Florence, SC
USAUSA
Buses from Orlando, FL to Florence, SC run on average 2 times per day, taking around 9h 29m. Cheap bus tickets for this journey start at $66 if you book in advance.
There are 1 buses per day. The earliest bus runs at 04:00, the last at 23:40. The fastest bus covers the 402 miles (647 km) distance in 8h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 402 miles (647 km) |
Average bus duration 9h 29m |
Cheapest ticket price $66 |
Buses per day 2 |
Direct buses 1 |
Fastest bus 8h 10m |
First bus 4:00 AM |
Last bus 11:40 PM |
Cheapest Month Jun |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your Orlando, FL to Florence, SC trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Orlando, FL to Florence, SC.
Cheap bus tickets from Orlando, FL to Florence, SC can start from as little as $66 when you book in advance. The average bus ticket price for Orlando, FL to Florence, SC is $102 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from Orlando, FL to Florence, SC leaves at 4:00 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Orlando, FL to Florence, SC leaves at 11:40 PM.
Yes, there are 1 direct buses a day from Orlando, FL to Florence, SC with FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
Orlando, FL to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 04:00AM | Arrival Time 01:25PM | Duration 9h25 | Departure days Wed | Cheapest price $84 |
Operator FlixBus | Departure Time 08:00AM | Arrival Time 05:25PM | Duration 9h25 | Departure days Mon, Thu, Sat, Sun | Cheapest price $89 |
Operator FlixBus | Departure Time 09:00AM | Arrival Time 06:35PM | Duration 9h35 | Departure days Thu, Sat | Cheapest price $72 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 12:05AM | Duration 11h20 | Departure days Fri | Cheapest price $94 |
Operator FlixBus | Departure Time 03:40PM | Arrival Time 12:05AM | Duration 8h25 | Departure days Fri | Cheapest price $73 |
Operator FlixBus | Departure Time 07:40PM | Arrival Time 04:05AM | Duration 8h25 | Departure days Mon, Sat | Cheapest price $94 |
Live departures
Orlando, FL to Florence, SC bus times
The table below shows live departures for Orlando, FL to Florence, SC buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 7:40 PM Orlando, FL | 8h25 | 4:05 AM Florence, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Orlando, FL to Florence, SC buses with Omio?
FlixBus operates all buses services from Orlando, FL to Florence, SC.
Omio is an official ticket reseller for all your travel options from Orlando, FL to Florence, SC.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Orlando, FL to Florence, SC.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Orlando, FL to Florence, SC.
Bus providers: FlixBus from Orlando, FL to Florence, SCYou can travel by bus between Orlando, FL to Florence, SC with FlixBus for as low as $66. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
8h 10m
Cheapest FlixBus Price
$66
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Companies, tickets, and onboard amenities between Orlando, FL and Florence, SC
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from Orlando, FL to Florence, SC, you can count on FlixBus for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Orlando, FL and Florence, SC and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from Orlando, FL to Florence, SC:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Orlando, FL to Florence, SC for bus company FlixBus.
Whether you can cancel your bus ticket from Orlando, FL to Florence, SC depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from Orlando, FL to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Orlando, FL to Florence, SC:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Orlando, FL to Florence, SC:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Orlando, FL to Florence, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Orlando, FL to Florence, SC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Orlando, FL to Florence, SC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Orlando, FL to Florence, SC with the following bus company: FlixBus.
Complete guide to Florence, SC
Things to do in Florence, SC
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
- Must visit
Galleria dell'Accademia
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
- Recommended
Museo dell'Opera del Duomo
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
- Must visit
Piazza della Signoria
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
- Must visit
Piazzale Michelangelo
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
- Recommended
Boboli Gardens
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
- Gluten-free
Pee Dee Pulled Pork BBQ
Pulled pork barbecue is a Pee Dee staple, slow-smoked until tender and served with the region's tangy vinegar-pepper sauce.
- Gluten-free
Smoked Pork Ribs
Smoked pork ribs are common at local barbecue joints, seasoned simply and cooked low and slow for deep smoke flavor.
- Gluten-free
Shrimp and Grits
Shrimp and grits is a South Carolina classic: local shrimp over creamy grits, often enriched with bacon, gravy, or butter.
Victors
Upscale downtown restaurant serving refined Southern dishes, steaks, seafood, and cocktails in a polished space.
Wholly Smokin' Downtown
Casual local favorite for Carolina barbecue, ribs, and classic Southern sides in a relaxed family setting.
Holt Bros BBQ
Popular casual spot known for barbecue plates, pulled pork, and generous Southern comfort food portions.
$ US Dollar
Moderate by U.S. small-city standards. Hotels are usually cheaper than major tourist cities, while dining and car-based transport remain fairly typical for the region.
Average meal costs
- Budget
- $8-12 for fast food or casual takeout.
- Mid-range
- $15-25 per person for a casual sit-down meal.
- Fine dining
- $35+ per person for upscale restaurants.
- Coffee
- $3-5 for regular coffee or latte.
Tipping culture
Tip 15-20% at restaurants. Round up or add 10-15% for taxis if service is good. Small change is fine at cafes.
Plan your visit to Florence, SC
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Florence, SC.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from Orlando, FL to Florence, SC
Find answers to the most common questions about traveling from Orlando, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 2 ways to travel between Orlando, FL and Florence, SC including taking a train and bus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
popular bus stations
Popular bus stations from Orlando, FL to Florence, SC
Most Orlando, FL to Florence, SC buses use the Orlando, N John Young Pkwy (Greyhound Bus Station) to Florence, W Lucas St (TA Gas Station) station pair, with some services arriving at Florence, S Irby St (Greyhound Bus Stop). Use this guide to compare Orlando, FL and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Orlando
Arrival bus stations in Florence
Which Orlando, FL station do buses to Florence, SC leave from?
Buses from Orlando, FL to Florence, SC leave from Orlando, N John Young Pkwy (Greyhound Bus Station). The station is 1 miles (3 km) from Orlando, FL city centre at 555 John Young Pkwy, Orlando, FL 32805, USA.
Orlando, N John Young Pkwy (Greyhound Bus Station)555 John Young Pkwy, Orlando, FL 32805, USA
City-centre transport
Getting to Orlando, N John Young Pkwy (Greyhound Bus Station) from Orlando city centre
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Bus125 · 40m · $3 · every ~6 min
125 · 41m · $3 · every ~6 min
Orlando, N John Young Pkwy (Greyhound Bus Station) bus station facilities and services
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Tickets and information
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Parking, taxis and toilets
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
Orlando, The Florida MallOrlando Florida Mall Ave,Florida Mall Ave 1632,32809
City-centre transport
Getting to Orlando, The Florida Mall from Orlando city centre
Bus42 · 26m · $3 · every ~5 min
Which Florence, SC station do buses from Orlando, FL arrive at?
Buses from Orlando, FL to Florence, SC most often arrive at Florence, W Lucas St (TA Gas Station). Some services arrive at Florence, S Irby St (Greyhound Bus Stop), so check your ticket before travel to confirm your Florence, SC arrival station.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
TRUE
Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Florence, S Irby St (Greyhound Bus Stop)S Irby St, Florence, SC, USA
City-centre transport
Getting to Florence, S Irby St (Greyhound Bus Stop) from Florence city centre
TRUE
Florence, S Irby St (Greyhound Bus Stop) bus station facilities and services
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Tickets and information
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Parking, taxis and toilets
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Bus stations for Orlando, FL to Florence, SC
Check bus stations information for Orlando, FL and Florence, SC, including where buses depart and arrive on this route.
When departing from Orlando, FL , you have various bus station options to start your journey from including Orlando, N John Young Pkwy (Greyhound Bus Station), Orlando, The Florida Mall . When arriving in Florence, SC , you can end your journey in bus stations like Florence, W Lucas St (TA Gas Station), Florence, S Irby St (Greyhound Bus Stop) .Passengers board the bus most frequently from Orlando, N John Young Pkwy (Greyhound Bus Station), which is located around 1 miles (3 km) away from the city centre, and they get off the bus at Florence, W Lucas St (TA Gas Station), located 6 away from the city centre.
Most popular bus connections from Orlando, FL
More options for your journey from Orlando, FL to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Orlando, FL
Most popular bus connections to Florence, SC
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
