Travel Information
Compare train and bus for Roanoke, VA to Florence, SC
Omio recommends booking the train as it is the most popular option from Roanoke, VA to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from $281. For those with little time consider booking a train which can get you there in 25h 29m. The ticket price range depends on the travel mode: a bus costs an average of $281, and a train costs an average of $486.
Distance: 212 miles (342 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
$281 Average price Cheapest | $486 Average price |
43h 50m Average total duration 43h 20m Onboard + 30m Additional time* | 25h 59m Average total duration Fastest 25h 29m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Why should you book Roanoke, VA to Florence, SC buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Roanoke, VA to Florence, SC.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Roanoke, VA to Florence, SC.
Journey information
Overview: Bus from Roanoke, VA to Florence, SC
Buses from Roanoke, VA to Florence, SC run on average 1 times per day, taking around 43h 20m. Cheap bus tickets for this journey start at $281 (€228) if you book in advance.
The earliest bus runs at 12:35, the last at 12:35. The fastest bus covers the 212 miles (342 km) distance in 43h 20m.
Distance 212 miles (342 km) |
Average bus duration 43h 20m |
Cheapest ticket price $281 (€228) |
Buses per day 1 |
Fastest bus 43h 20m |
First bus 12:35 |
Last bus 12:35 |
High season Oct - Dec |
Low season Jul - Sep |
Bus providers: Greyhound from Roanoke, VA to Florence, SCYou can travel by bus between Roanoke, VA to Florence, SC with Greyhound for as low as $281 (€228). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Roanoke, VA to Florence, SC
Find answers to the most common questions about traveling from Roanoke, VA to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
Most popular bus connections from Roanoke, VA
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