Milwaukee, WI to Florence, SC bus with Greyhound

Sat, Sep 19
+ Add return
Greyhound
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
2,000+ travel companies
Greyhound
FlixBus
Alsa
BlaBlaCar Bus
Rede Expressos
2,000+ travel companies
QR-Code
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
rate4.9
42K ratings
Google Play
rate4.6
136K reviews

The cheapest and fastest buses from Milwaukee, WI to Florence, SC

Showing times, prices and bookable tickets for Sep 19

Cheapest price on Sep 19

$107

Average ticket price on Sep 19

$117

Fastest journey on Sep 19

1 d 7 h 25 m

Average journey duration on Sep 19

1 d 7 h 48 m

Buses on Sep 19

3

Distance

1210 km

Cheap tickets

The best way to find a cheap bus ticket from Milwaukee, WI to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Milwaukee, WI to Florence, SC will cost around $117 if you buy it on the day, but the cheapest tickets can be found for only $107.

Fast buses

It's difficult to get from Milwaukee, WI to Florence, SC without transferring at least 3 times.

  • FlixBusFlixBus · FlixBus+Greyhound+FlixBusFlixBus
    3:40 PM31h25
    Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI
    12:05 AMFlorence, W Lucas St (TA Gas Station), SC
    $1071One-way
    3 transfers
  • FlixBusFlixBus · FlixBus+Greyhound+FlixBusFlixBus
    3:20 PM31h45
    Milwaukee, Intermodal Station
    12:05 AMFlorence, W Lucas St (TA Gas Station), SC
    $1091One-way
    3 transfers
  • Greyhound · +FlixBusFlixBus · FlixBus
    8:30 PM32h15
    Milwaukee, Intermodal Station
    5:45 AMFlorence, W Lucas St (TA Gas Station), SC
    $1351One-way
    3 transfers

Travel Information

Compare train and bus for Milwaukee, WI to Florence, SC

Omio recommends booking the bus as it is the most popular option from Milwaukee, WI to Florence, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $225 For those with little time, consider booking a bus, which has an average total journey time of 28h 10m. Average ticket prices depend on the travel mode: a bus costs an average of $225, while a bus costs an average of $225.

Distance: 751 miles (1210 km)

Compare bus with

Most popular
Bus
Train
Driving

$225

Average price

Cheapest

$189

Average price

(fuel + tolls)

28h 10m

Average total duration

Fastest

27h 40m

Onboard

+

30m

Additional time*

14h 59m

Average total duration

(door-to-door)

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Milwaukee, WI to Florence, SC is a bus with an average price of $225.
The fastest way to travel from Milwaukee, WI to Florence, SC is by bus with an average journey time of 27h 40m.
It's helpful to compare your options as there are 2 ways to travel between Milwaukee, WI and Florence, SC including taking a train and bus.
We recommend using the bus as it is the most popular way to get from Milwaukee, WI to Florence, SC among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.

Tickets start at around $225 compared to roughly $189 in fuel and tolls — a saving of about $-35.99. The journey takes 27h 40m versus 14h 59m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.

Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.

Milwaukee, WI to Florence, SC Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound USA
Departure Time
06:30AM
Arrival Time
03:30PM
Duration
33h00
Departure days
Wed, Thu, Fri, Sun
Cheapest price
$233
Operator
Flixbus USA
Departure Time
09:00AM
Arrival Time
01:30PM
Duration
28h30
Departure days
Thu, Fri, Sun
Cheapest price
$225
Operator
Flixbus USA
Departure Time
11:50AM
Arrival Time
04:20PM
Duration
28h30
Departure days
Fri, Sun
Cheapest price
$286
Operator
FlixBus
Departure Time
03:20PM
Arrival Time
12:05AM
Duration
31h45
Departure days
Sat
Cheapest price
$109
Operator
FlixBus
Departure Time
03:40PM
Arrival Time
12:05AM
Duration
31h25
Departure days
Sat
Cheapest price
$107
Operator
Greyhound
Departure Time
08:30PM
Arrival Time
05:45AM
Duration
32h15
Departure days
Sat
Cheapest price
$135

Live departures

Milwaukee, WI to Florence, SC bus times

The table below shows live departures for Milwaukee, WI to Florence, SC buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Greyhound USA6:30 AM Milwaukee, WI
33h00
3:30 PM Florence, SC3 transfers
Flixbus USA9:00 AM Milwaukee, WI
28h30
1:30 PM Florence, SC2 transfers
Flixbus USA11:50 AM Milwaukee, WI
28h30
4:20 PM Florence, SC2 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Compare prices and tickets Milwaukee, WI to Florence, SC by train or bus

Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sat
Sep 19
Sun
Sep 20
Mon
Sep 21
Tue
Sep 22
Wed
Sep 23
Thu
Sep 24
Fri
Sep 25

Why should you book Milwaukee, WI to Florence, SC buses with Omio?

Greyhound as well as FlixBus offer buses services from Milwaukee, WI to Florence, SC.
Omio is an official ticket reseller for all your travel options from Milwaukee, WI to Florence, SC.

Why book with Omio vs Greyhound?

  • Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Milwaukee, WI to Florence, SC.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Milwaukee, WI to Florence, SC.

Why book with Omio over Wanderu or Trainline?

  • Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Milwaukee, WI to Florence, SC.
  • Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Milwaukee, WI to Florence, SC.

Journey information

Overview: Bus from Milwaukee, WI to Florence, SC

USAUSA
USAUSA
Icon of bus

Buses from Milwaukee, WI to Florence, SC run on average 3 times per day, taking around 27h 40m. Cheap bus tickets for this journey start at $148 if you book in advance.

The earliest bus runs at 05:35, the last at 19:15. The fastest bus covers the 751 miles (1210 km) distance in 25h 0m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
751 miles (1210 km)
Average bus duration
27h 40m
Cheapest ticket price
$148
Buses per day
3
Fastest bus
25h 0m
First bus
5:35 AM
Last bus
7:15 PM
Cheapest Month
Jul
Cheapest Day
Fri
High Season
Jul - Sep
Low Season
Apr - Jun
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Bus providers: Greyhound, FlixBus from Milwaukee, WI to Florence, SCYou can travel by bus between Milwaukee, WI to Florence, SC with Greyhound, FlixBus for as low as $148. When you search for schedules and tickets, Omio will show you the best journey

FlixBus

About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
25h 0m
Cheapest FlixBus Price
$289
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Learn more about FlixBus

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
29h 15m
Cheapest Greyhound Price
$148
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Learn more about Greyhound

FAQs: Bus from Milwaukee, WI to Florence, SC

Find answers to the most common questions about traveling from Milwaukee, WI to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Milwaukee, WI to Florence, SC can start from as little as $148 when you book in advance. The average bus ticket price for Milwaukee, WI to Florence, SC is $225 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Milwaukee, WI to Florence, SC is 25h 0m to travel the 751 miles (1210 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Milwaukee, WI to Florence, SC leaves at 5:35 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Milwaukee, WI to Florence, SC leaves at 7:15 PM.
There are 3 buses a day from Milwaukee, WI to Florence, SC which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Milwaukee, WI to Florence, SC, you can count on Greyhound, FlixBus for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Milwaukee, WI and Florence, SC and compare the amenities they offer before buying a bus ticket.
When departing from Milwaukee, WI , you have various bus station options to start your journey from including Milwaukee, Intermodal Station, Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI . When arriving in Florence, SC , you can end your journey in bus stations like Florence, W Lucas St (TA Gas Station), SC .Passengers board the bus most frequently from Milwaukee, Intermodal Station, which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Florence, W Lucas St (TA Gas Station), SC, located 6 away from the city centre.
A trip to Florence, SC from Milwaukee, WI is worth doing but not as a day trip with a journey time of 25h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Milwaukee, WI to Florence, SC is July.
It's helpful to compare your options as there are 2 ways to travel between Milwaukee, WI and Florence, SC including taking a train and bus.
Yes, there are bathrooms on board the bus from Milwaukee, WI to Florence, SC for bus company Greyhound, FlixBus.
Yes, the following accessibility options are available when taking the bus from Milwaukee, WI to Florence, SC:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
  • FlixBus
    • Assistance
    • Priority boarding
    • Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Milwaukee, WI to Florence, SC depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
  • FlixBus
    • You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Milwaukee, WI to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Milwaukee, WI to Florence, SC:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
  • FlixBus
    • One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Milwaukee, WI to Florence, SC:
  • Greyhound
    • $15 per additional bag.
  • FlixBus
    • Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Milwaukee, WI to Florence, SC. The following conditions apply:
  • FlixBus
    • Small pets in carriers allowed
    • guide dogs travel for free.
You can reserve your seat on the bus from Milwaukee, WI to Florence, SC with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Milwaukee, WI to Florence, SC with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Milwaukee, WI to Florence, SC with the following bus company: Greyhound, FlixBus.
Since neither Milwaukee, WI nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Milwaukee, WI to Florence, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Milwaukee, WI to Florence, SC

Most Milwaukee, WI to Florence, SC buses use the Milwaukee, Intermodal Station to Florence, W Lucas St (TA Gas Station) station pair. Use this guide to compare Milwaukee, WI and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in Milwaukee
Arrival bus stations in Florence

Which Milwaukee, WI station do buses to Florence, SC leave from?

Buses from Milwaukee, WI to Florence, SC leave from Milwaukee, Intermodal Station. The station is 0 miles (1 km) from Milwaukee, WI city centre at Milwaukee, 433 W St. Paul Avenue, Milwaukee, WI 53203, USA.
Milwaukee, Intermodal StationMilwaukee, 433 W St. Paul Avenue, Milwaukee, WI 53203, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to Milwaukee, Intermodal Station from Milwaukee city centre

Milwaukee, Intermodal Station is 1 km from Milwaukee city centre. Public transport options include:

Bus57 · 4m · $5 · every ~4 min
Wisconsin Coach Lines · 6m · $4

Milwaukee, Intermodal Station bus station facilities and services

Milwaukee, Intermodal Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Cafe and vending machines available.

Wi-Fi and ATMs

Wi-Fi available in waiting areas. ATMs are aTM machines available inside the station.

Tickets and information

Ticket office support is available at Milwaukee, Intermodal Station.

Parking, taxis and toilets

Available at Milwaukee, Intermodal Station: Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at Milwaukee, Intermodal Station: ADA compliant with elevators and ramps.

Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop)Main Terminal, 5300 S Howell Ave, Milwaukee, WI 53207, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) from Milwaukee city centre

Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) is 10 km from Milwaukee city centre. Public transport options include:

BusWisconsin Coach Lines · 10m · $6
Gre · 19m · $4 · every ~8 min
Gre · 27m · $4 · every ~8 min
Gre · 29m · $4 · every ~8 min

Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) bus station facilities and services

Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Food options are available within the airport terminal.

Wi-Fi and ATMs

Wi-Fi is available at Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop). ATMs are aTMs are available in the airport terminal.

Tickets and information

Ticket office support is available at Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop).

Parking, taxis and toilets

Available at Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop): Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop): The station is accessible with facilities for disabled passengers.

More options for your journey from Milwaukee, WI to Florence, SC

Here are some other resources that might have the information you need

Tickets and more information for coaches to Milwaukee, WI
Tickets and more information for coaches to Florence, SC

Most popular buses to and from Florence, SC and Milwaukee, WI

Bus Boston, MA - Florence, SC
Bus New York, NY - Florence, SC
Bus Washington, DC - Florence, SC
Bus Philadelphia, PA - Florence, SC
Bus Orlando, FL - Florence, SC
Bus Miami, FL - Florence, SC
Bus Tampa, FL - Florence, SC
Bus Newark, NJ - Florence, SC
Bus Baltimore, MD - Florence, SC
Bus Pittsburgh, PA - Florence, SC
Bus Charlotte, NC - Florence, SC
Bus Syracuse, NY - Florence, SC
Bus Raleigh, NC - Florence, SC
Bus Albany, NY - Florence, SC
Bus Jacksonville, FL - Florence, SC
Bus Fort Lauderdale, FL - Florence, SC
Bus Richmond, VA - Florence, SC
Bus Wilmington, DE - Florence, SC
Bus Providence, RI - Florence, SC
Bus Savannah, GA - Florence, SC
Bus Daytona Beach, FL - Florence, SC
Bus Greensboro, NC - Florence, SC
Bus Milwaukee, WI - Boston, MA
Bus Milwaukee, WI - New York, NY
Bus Milwaukee, WI - Los Angeles, CA
Bus Milwaukee, WI - Chicago, IL
Bus Milwaukee, WI - Washington, DC
Bus Milwaukee, WI - Las Vegas, NV
Bus Milwaukee, WI - San Diego, CA
Bus Milwaukee, WI - Philadelphia, PA
Bus Milwaukee, WI - Seattle, WA
Bus Milwaukee, WI - Orlando, FL
Bus Milwaukee, WI - Dallas, TX
Bus Milwaukee, WI - Atlanta, GA
Bus Milwaukee, WI - Portland, OR
Bus Milwaukee, WI - Phoenix, AZ
Bus Milwaukee, WI - Tampa, FL
Bus Milwaukee, WI - San Francisco, CA
Bus Milwaukee, WI - Houston, TX
Bus Milwaukee, WI - San Antonio, TX
Bus Milwaukee, WI - Denver, CO
Bus Milwaukee, WI - Newark, NJ
Bus Milwaukee, WI - Baltimore, MD
Bus Milwaukee, WI - New Orleans, LA
HomeBusesBuses in USABus tickets to Florence, SCMilwaukee, WI to Florence, SC bus

The Omio App Makes Travel Planning Easy

We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.

ios-badge
android-badge
Hand With Phone