- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
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Journey information
Overview: Bus from Milwaukee, WI to Florence, SC
USAUSA
Buses from Milwaukee, WI to Florence, SC run on average 3 times per day, taking around 26h 53m. Cheap bus tickets for this journey start at €88 if you book in advance.
The earliest bus runs at 05:35, the last at 19:15. The fastest bus covers the 751 miles (1210 km) distance in 25h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 751 miles (1210 km) |
Average bus duration 26h 53m |
Cheapest ticket price €88 |
Buses per day 3 |
Fastest bus 25h 0m |
First bus 5:35 AM |
Last bus 7:15 PM |
Cheapest Month Sep |
Cheapest Day Fri |
High Season Jul - Sep |
Low Season Apr - Jun |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Frequently asked questions about your Milwaukee, WI to Florence, SC trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Milwaukee, WI to Florence, SC.
Cheap bus tickets from Milwaukee, WI to Florence, SC can start from as little as €88 when you book in advance. The average bus ticket price for Milwaukee, WI to Florence, SC is €125 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The earliest bus from Milwaukee, WI to Florence, SC leaves at 5:35 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Milwaukee, WI to Florence, SC leaves at 7:15 PM.
There are 3 buses a day from Milwaukee, WI to Florence, SC which require at least one change with FlixBus, Greyhound. Schedules can vary on holidays or weekends with fewer buses.
Milwaukee, WI to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 03:25AM | Arrival Time 09:40AM | Duration 29h15 | Departure days Mon | Cheapest price €154 |
Operator Greyhound USA | Departure Time 06:30AM | Arrival Time 03:30PM | Duration 33h00 | Departure days Wed, Thu, Fri, Sat, Sun | Cheapest price €191 |
Operator Flixbus USA | Departure Time 09:00AM | Arrival Time 01:30PM | Duration 28h30 | Departure days Thu, Fri, Sat, Sun | Cheapest price €184 |
Operator Flixbus USA | Departure Time 11:50AM | Arrival Time 04:20PM | Duration 28h30 | Departure days Mon, Fri, Sat, Sun | Cheapest price €169 |
Operator FlixBus | Departure Time 12:10PM | Arrival Time 01:30PM | Duration 24h20 | Departure days Mon | Cheapest price €169 |
Operator Greyhound | Departure Time 08:30PM | Arrival Time 09:40AM | Duration 36h10 | Departure days Mon | Cheapest price €203 |
Live departures
Milwaukee, WI to Florence, SC bus times
The table below shows live departures for Milwaukee, WI to Florence, SC buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 FlixBus+ · +FlixBus | 11:50 AM Milwaukee, Intermodal Station | 24h40 | 1:30 PM Florence, S Irby St (Greyhound Bus Stop), SC | 4 transfers | |
| FlixBus+ · +FlixBus | 12:10 PM Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI | 24h20 | 1:30 PM Florence, S Irby St (Greyhound Bus Stop), SC | 4 transfers | |
| · · · | 8:30 PM Milwaukee, Intermodal Station | 36h10 | 9:40 AM Florence, S Irby St (Greyhound Bus Stop), SC | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Milwaukee, WI to Florence, SC buses with Omio?
FlixBus as well as Greyhound offer buses services from Milwaukee, WI to Florence, SC.
Omio is an official ticket reseller for all your travel options from Milwaukee, WI to Florence, SC.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Milwaukee, WI to Florence, SC.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Milwaukee, WI to Florence, SC.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Milwaukee, WI to Florence, SC.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Milwaukee, WI to Florence, SC.
Bus providers: FlixBus, Greyhound from Milwaukee, WI to Florence, SCYou can travel by bus between Milwaukee, WI to Florence, SC with FlixBus, Greyhound for as low as €88. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
25h 0m
Cheapest FlixBus Price
€88
FlixBus frequency
2 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
26h 50m
Cheapest Greyhound Price
€102
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Companies, tickets, and onboard amenities between Milwaukee, WI and Florence, SC
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
When taking a bus from Milwaukee, WI to Florence, SC, you can count on FlixBus, Greyhound for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Milwaukee, WI and Florence, SC and compare the amenities they offer before buying a bus ticket.
Yes, the following accessibility options are available when taking the bus from Milwaukee, WI to Florence, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Milwaukee, WI to Florence, SC for bus company FlixBus, Greyhound.
Whether you can cancel your bus ticket from Milwaukee, WI to Florence, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company {providersWithBike}.
Yes, there is food available to purchase on board the bus from Milwaukee, WI to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Milwaukee, WI to Florence, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Milwaukee, WI to Florence, SC:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Milwaukee, WI to Florence, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Milwaukee, WI to Florence, SC with the following bus company: FlixBus, Greyhound
Yes, there are USB plugs on board the bus from Milwaukee, WI to Florence, SC with the following bus company: FlixBus, Greyhound.
Yes, there is Wifi on board the bus from Milwaukee, WI to Florence, SC with the following bus company: FlixBus, Greyhound.
Complete guide to Florence, SC
Things to do in Florence, SC
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
- Must visit
Galleria dell'Accademia
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
- Recommended
Museo dell'Opera del Duomo
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
- Must visit
Piazza della Signoria
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
- Must visit
Piazzale Michelangelo
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
- Recommended
Boboli Gardens
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
- Gluten-free
Pee Dee Pulled Pork BBQ
Pulled pork barbecue is a Pee Dee staple, slow-smoked until tender and served with the region's tangy vinegar-pepper sauce.
- Gluten-free
Smoked Pork Ribs
Smoked pork ribs are common at local barbecue joints, seasoned simply and cooked low and slow for deep smoke flavor.
- Gluten-free
Shrimp and Grits
Shrimp and grits is a South Carolina classic: local shrimp over creamy grits, often enriched with bacon, gravy, or butter.
Victors
Upscale downtown restaurant serving refined Southern dishes, steaks, seafood, and cocktails in a polished space.
Wholly Smokin' Downtown
Casual local favorite for Carolina barbecue, ribs, and classic Southern sides in a relaxed family setting.
Holt Bros BBQ
Popular casual spot known for barbecue plates, pulled pork, and generous Southern comfort food portions.
$ US Dollar
Moderate by U.S. small-city standards. Hotels are usually cheaper than major tourist cities, while dining and car-based transport remain fairly typical for the region.
Average meal costs
- Budget
- $8-12 for fast food or casual takeout.
- Mid-range
- $15-25 per person for a casual sit-down meal.
- Fine dining
- $35+ per person for upscale restaurants.
- Coffee
- $3-5 for regular coffee or latte.
Tipping culture
Tip 15-20% at restaurants. Round up or add 10-15% for taxis if service is good. Small change is fine at cafes.
Plan your visit to Florence, SC
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Florence, SC.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
FAQs: Bus from Milwaukee, WI to Florence, SC
Find answers to the most common questions about traveling from Milwaukee, WI to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
It's helpful to compare your options as there are 2 ways to travel between Milwaukee, WI and Florence, SC including taking a train and bus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
popular bus stations
Popular bus stations from Milwaukee, WI to Florence, SC
Most Milwaukee, WI to Florence, SC buses use the Milwaukee, Intermodal Station to Florence, W Lucas St (TA Gas Station) station pair. Use this guide to compare Milwaukee, WI and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Milwaukee
Arrival bus stations in Florence
Which Milwaukee, WI station do buses to Florence, SC leave from?
Buses from Milwaukee, WI to Florence, SC leave from Milwaukee, Intermodal Station. The station is 0 miles (1 km) from Milwaukee, WI city centre at Milwaukee, 433 W St. Paul Avenue, Milwaukee, WI 53203, USA.
Milwaukee, Intermodal StationMilwaukee, 433 W St. Paul Avenue, Milwaukee, WI 53203, USA
City-centre transport
Getting to Milwaukee, Intermodal Station from Milwaukee city centre
Milwaukee, Intermodal Station is 1 km from Milwaukee city centre. Public transport options include:
Bus57 · 4m · €4 · every ~4 min
Wisconsin Coach Lines · 6m · €3
Milwaukee, Intermodal Station bus station facilities and services
Milwaukee, Intermodal Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Cafe and vending machines available.
Wi-Fi and ATMs
Wi-Fi available in waiting areas. ATMs are aTM machines available inside the station.
Tickets and information
Ticket office support is available at Milwaukee, Intermodal Station.
Parking, taxis and toilets
Available at Milwaukee, Intermodal Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Milwaukee, Intermodal Station: ADA compliant with elevators and ramps.
Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop)Main Terminal, 5300 S Howell Ave, Milwaukee, WI 53207, USA
City-centre transport
Getting to Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) from Milwaukee city centre
Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) is 10 km from Milwaukee city centre. Public transport options include:
BusWisconsin Coach Lines · 10m · €5
Gre · 19m · €3 · every ~8 min
Gre · 27m · €3 · every ~8 min
Gre · 29m · €3 · every ~8 min
Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) bus station facilities and services
Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food options are available within the airport terminal.
Wi-Fi and ATMs
Wi-Fi is available at Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop). ATMs are aTMs are available in the airport terminal.
Tickets and information
Ticket office support is available at Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop).
Parking, taxis and toilets
Available at Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop): The station is accessible with facilities for disabled passengers.
Which Florence, SC station do buses from Milwaukee, WI arrive at?
Buses from Milwaukee, WI to Florence, SC arrive at Florence, W Lucas St (TA Gas Station). Florence, W Lucas St (TA Gas Station) is 3 miles (6 km) from Florence, SC city centre.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
TRUE
Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Bus stations for Milwaukee, WI to Florence, SC
Check bus stations information for Milwaukee, WI and Florence, SC, including where buses depart and arrive on this route.
When departing from Milwaukee, WI , you have various bus station options to start your journey from including Milwaukee, Intermodal Station, Milwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop) . When arriving in Florence, SC , you can end your journey in bus stations like Florence, W Lucas St (TA Gas Station) .Passengers board the bus most frequently from Milwaukee, Intermodal Station, which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Florence, W Lucas St (TA Gas Station), located 6 away from the city centre.
Most popular bus connections from Milwaukee, WI
More options for your journey from Milwaukee, WI to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Milwaukee, WI
Most popular bus connections to Florence, SC
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