- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
Cheapest price on Sep 19
$112
Average ticket price on Sep 19
$151
Fastest journey on Sep 19
11 h 15 m
Average journey duration on Sep 19
13 h 26 m
Buses on Sep 19
4
Distance
759 km
The best way to find a cheap bus ticket from Philadelphia, PA to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Philadelphia, PA to Florence, SC will cost around $151 if you buy it on the day, but the cheapest tickets can be found for only $112.
On Sat, Sep 19, we found 4 buses from Philadelphia, PA to Florence, SC, including 4 direct services.
On Sat, Sep 19 the direct buses cover the 759 km distance in an average of 13 h 26 m but if you time it right, some buses will get you there in just 11 h 15 m .
On Sat, Sep 19 the slowest buses will take 17 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Omio recommends booking the train as it is the most popular option from Philadelphia, PA to Florence, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $164 For those with little time, consider booking a flight, which has an average total journey time of 5h 57m. Average ticket prices depend on the travel mode: a bus costs an average of $164, while a flight costs an average of $784.
Distance: 471 miles (759 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$164 Average price Cheapest | $318 Average price | $784 Average price | $116 Average price (fuel + tolls) |
12h 8m Average total duration 11h 38m Onboard + 30m Additional time* | 11h 31m Average total duration 11h 1m Onboard + 30m Additional time* | 5h 57m Average total duration Fastest 3h 57m Onboard + 2h 0m Additional time* | 9h 33m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Philadelphia, PA to Florence, SC:
A bus is $154 less than a train for this route with tickets for a train from Philadelphia, PA to Florence, SC costing on average $318.
A bus is $620 less than a flight for this route with tickets for a flight from Philadelphia, PA to Florence, SC costing on average $784.
Other travel options to Florence, SC take longer:
Train takes on average 11h 1m.
Bus takes on average 11h 38m.
Tickets start at around $164 compared to roughly $116 in fuel and tolls — a saving of about $-48.60. The journey takes 11h 38m versus 9h 33m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:30AM | Arrival Time 03:45PM | Duration 15h15 | Departure days Fri | Cheapest price $196 |
Operator Greyhound | Departure Time 02:00AM | Arrival Time 03:45PM | Duration 13h45 | Departure days Sun | Cheapest price $181 |
Operator Greyhound | Departure Time 03:00AM | Arrival Time 04:45PM | Duration 13h45 | Departure days Tue | Cheapest price $198 |
Operator FlixBus | Departure Time 05:15PM | Arrival Time 10:45AM | Duration 17h30 | Departure days Sat | Cheapest price $160 |
Operator FlixBus | Departure Time 06:30PM | Arrival Time 05:45AM | Duration 11h15 | Departure days Fri, Sun | Cheapest price $103 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 09:45AM | Duration 11h55 | Departure days Wed | Cheapest price $107 |
Operator Flixbus USA | Departure Time 10:00PM | Arrival Time 11:45AM | Duration 13h45 | Departure days Tue | Cheapest price $142 |
Operator FlixBus | Departure Time 10:30PM | Arrival Time 03:45PM | Duration 17h15 | Departure days Wed, Thu, Sat | Cheapest price $149 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 10:45AM | Duration 11h15 | Departure days Sat | Cheapest price $112 |
The table below shows live departures for Philadelphia, PA to Florence, SC buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 6:30 PM Philadelphia Bus Station | 11h15 | 5:45 AM Florence, W Lucas St (TA Gas Station), SC | 1 transfer | |
| Saturday, September 19 | |||||
![]() | 2:00 AM Philadelphia, PA | 13h45 | 3:45 PM Florence, SC | 0 transfersDirect | |
![]() | 5:15 PM Philadelphia, PA | 17h30 | 10:45 AM Florence, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Philadelphia, PA to Florence, SC run on average 2 times per day, taking around 11h 38m. Cheap bus tickets for this journey start at $109 if you book in advance.
The earliest bus runs at 00:05, the last at 23:20. The fastest bus covers the 471 miles (759 km) distance in 10h 20m.
Distance 471 miles (759 km) |
Average bus duration 11h 38m |
Cheapest ticket price $109 |
Buses per day 2 |
Fastest bus 10h 20m |
First bus 12:05 AM |
Last bus 11:20 PM |
Cheapest Month Jul |
Cheapest Day Fri |
High Season Jul - Sep |
Low Season Jan - Mar |
Best time to book 4 days |
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
Find answers to the most common questions about traveling from Philadelphia, PA to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

Most Philadelphia, PA to Florence, SC buses use the Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park) to Florence, S Irby St (Greyhound Bus Stop) station pair, with some services arriving at Florence, W Lucas St (TA Gas Station). Use this guide to compare Philadelphia, PA and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park) is 2 km from Philadelphia city centre. Public transport options include:
Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park). ATMs are available at Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park).
Ticket office support is available at Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park).
Available at Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park): Parking, Taxis, WC.
Accessibility facilities are available at Philadelphia, Spring Garden St / N 2nd St (Madison War Memorial Park): The bus stop is accessible with ramps.
Philadelphia, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Snack bars and vending machines are available.
Free Wi-Fi available in the waiting area. ATMs are an ATM is available near the entrance.
Ticket office support is available at Philadelphia, Greyhound Bus Station.
Available at Philadelphia, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility facilities are available at Philadelphia, Greyhound Bus Station: The station is wheelchair accessible with ramps and elevators.
Philadelphia, Schuylkill Ave (Cira Centre South) is 1 km from Philadelphia city centre. Public transport options include:
Philadelphia, Schuylkill Ave (Cira Centre South) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available in the waiting area. ATMs are available at Philadelphia, Schuylkill Ave (Cira Centre South).
Ticket office support is available at Philadelphia, Schuylkill Ave (Cira Centre South).
Available at Philadelphia, Schuylkill Ave (Cira Centre South): Parking, Taxis, WC.
Accessibility facilities are available at Philadelphia, Schuylkill Ave (Cira Centre South): Wheelchair accessible area.
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Food and snacks available at the gas station.
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
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