- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
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The cheapest and fastest buses from Tampa, FL to Florence, SC
Showing times, prices and bookable tickets for Sep 20
Cheapest price on Sep 20
€90
Average ticket price on Sep 20
€130
Fastest journey on Sep 20
1 d 30 m
Average journey duration on Sep 20
1 d 2 h 43 m
Buses on Sep 20
2
Distance
741 km
Cheap tickets
The best way to find a cheap bus ticket from Tampa, FL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Tampa, FL to Florence, SC will cost around €130 if you buy it on the day, but the cheapest tickets can be found for only €90.
Fast buses
On Sun, Sep 20, we found 2 buses from Tampa, FL to Florence, SC, including 2 direct services.
On Sun, Sep 20 the direct buses cover the 741 km distance in an average of 1 d 2 h 43 m but if you time it right, some buses will get you there in just 1 d 30 m .
On Sun, Sep 20 the slowest buses will take 1 d 4 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
3:35 AM24h30Tampa, FL4:05 AMFlorence, SC€901One-way0 transfers- 11:50 AM28h55Tampa, FL4:45 PMFlorence, SC€1691One-way0 transfers
- 3:35 AM24h30Tampa, FL4:05 AMFlorence, SC€901One-way0 transfers
- 11:50 AM28h55Tampa, FL4:45 PMFlorence, SC€1691One-way0 transfers
Travel Information
Compare train and bus for Tampa, FL to Florence, SC
Omio recommends booking the train as it is the most popular option from Tampa, FL to Florence, SC among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €97 For those with little time, consider booking a train, which has an average total journey time of 11h 48m. Average ticket prices depend on the travel mode: a bus costs an average of €97, while a train costs an average of €142.
Distance: 460 miles (741 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
€97 Average price Cheapest | €142 Average price | €84 Average price (fuel + tolls) |
16h 21m Average total duration 15h 51m Onboard + 30m Additional time* | 11h 48m Average total duration Fastest 11h 18m Onboard + 30m Additional time* | 7h 33m Average total duration (door-to-door) |
Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Tampa, FL to Florence, SC is a bus with an average price of €97.
This is compared to other travel options from Tampa, FL to Florence, SC:
A bus is €44 less than a train for this route with tickets for a train from Tampa, FL to Florence, SC costing on average €142.
A bus is €442 less than a flight for this route with tickets for a flight from Tampa, FL to Florence, SC costing on average €539.
The fastest way to travel from Tampa, FL to Florence, SC is by flight with an average journey time of 4h 24m.
Other travel options to Florence, SC take longer:
Train takes on average 11h 18m.
Bus takes on average 15h 51m.
It's helpful to compare your options as there are 2 ways to travel between Tampa, FL and Florence, SC including taking a train and bus.
We recommend using the train as it is the most popular way to get from Tampa, FL to Florence, SC among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around €97 compared to roughly €84 in fuel and tolls — a saving of about €-13.50. The journey takes 15h 51m versus 7h 33m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Tampa, FL to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:50AM | Arrival Time 05:25PM | Duration 15h35 | Departure days Fri | Cheapest price €81 |
Operator FlixBus | Departure Time 02:50AM | Arrival Time 06:25PM | Duration 15h35 | Departure days Fri | Cheapest price €81 |
Operator FlixBus | Departure Time 03:35AM | Arrival Time 04:05AM | Duration 24h30 | Departure days Sun | Cheapest price €90 |
Operator FlixBus | Departure Time 06:50AM | Arrival Time 12:05AM | Duration 17h15 | Departure days Fri, Sun | Cheapest price €58 |
Operator FlixBus | Departure Time 11:50AM | Arrival Time 04:45PM | Duration 28h55 | Departure days Sat | Cheapest price €169 |
Operator Greyhound | Departure Time 10:25PM | Arrival Time 12:05AM | Duration 25h40 | Departure days Wed, Fri, Sun | Cheapest price €68 |
Operator Flixbus USA | Departure Time 10:35PM | Arrival Time 01:25PM | Duration 14h50 | Departure days Tue, Fri | Cheapest price €63 |
Operator Greyhound | Departure Time 10:35PM | Arrival Time 12:05AM | Duration 25h30 | Departure days Wed, Sun | Cheapest price €68 |
Live departures
Tampa, FL to Florence, SC bus times
The table below shows live departures for Tampa, FL to Florence, SC buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus+ +FlixBus · FlixBus | 10:25 PM Tampa, USF Holly Drive (Central Plant), FL | 25h40 | 12:05 AM Florence, W Lucas St (TA Gas Station), SC | 3 transfers | |
| FlixBus · FlixBus · FlixBus · FlixBus | 10:35 PM Tampa, Marion Transit Center | 25h30 | 12:05 AM Florence, W Lucas St (TA Gas Station), SC | 3 transfers | |
| Saturday, September 19 | |||||
| 3:35 AM Tampa, FL | 24h30 | 4:05 AM Florence, SC | 0 transfersDirect | |
| 11:50 AM Tampa, FL | 28h55 | 4:45 PM Florence, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Tampa, FL to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Sep 19
Sep 19
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Sep 20
Sep 20
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Sep 21
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Tue
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Sep 25
Why should you book Tampa, FL to Florence, SC buses with Omio?
Greyhound as well as FlixBus offer buses services from Tampa, FL to Florence, SC.
Omio is an official ticket reseller for all your travel options from Tampa, FL to Florence, SC.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Tampa, FL to Florence, SC.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Tampa, FL to Florence, SC.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Tampa, FL to Florence, SC.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Tampa, FL to Florence, SC.
Journey information
Overview: Bus from Tampa, FL to Florence, SC
USAUSA
Buses from Tampa, FL to Florence, SC run on average 2 times per day, taking around 15h 51m. Cheap bus tickets for this journey start at €57 if you book in advance.
The earliest bus runs at 00:05, the last at 22:35. The fastest bus covers the 460 miles (741 km) distance in 11h 20m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 460 miles (741 km) |
Average bus duration 15h 51m |
Cheapest ticket price €57 |
Buses per day 2 |
Fastest bus 11h 20m |
First bus 12:05 AM |
Last bus 10:35 PM |
Cheapest Month Aug |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Oct - Dec |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus, Greyhound from Tampa, FL to Florence, SCYou can travel by bus between Tampa, FL to Florence, SC with FlixBus, Greyhound for as low as €57. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
11h 20m
Cheapest FlixBus Price
€57
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
18h 35m
Cheapest Greyhound Price
€81
Greyhound frequency
1 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Florence, SC
Things to do in Florence, SC
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
- Must visit
Galleria dell'Accademia
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
- Recommended
Museo dell'Opera del Duomo
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
- Must visit
Piazza della Signoria
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
- Must visit
Piazzale Michelangelo
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
- Recommended
Boboli Gardens
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
FAQs: Bus from Tampa, FL to Florence, SC
Find answers to the most common questions about traveling from Tampa, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Tampa, FL to Florence, SC can start from as little as €57 when you book in advance. The average bus ticket price for Tampa, FL to Florence, SC is €97 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Tampa, FL to Florence, SC is 11h 20m to travel the 460 miles (741 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Tampa, FL to Florence, SC leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Tampa, FL to Florence, SC leaves at 10:35 PM.
There are 2 buses a day from Tampa, FL to Florence, SC which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Tampa, FL to Florence, SC, you can count on Greyhound, FlixBus for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Tampa, FL and Florence, SC and compare the amenities they offer before buying a bus ticket.
When departing from Tampa, FL , you have various bus station options to start your journey from including Tampa, Marion Transit Center, Tampa, USF Holly Drive (Central Plant), FL . When arriving in Florence, SC , you can end your journey in bus stations like Florence, W Lucas St (TA Gas Station), SC, Florence, S Irby St (Greyhound Bus Stop), SC .Passengers board the bus most frequently from Tampa, Marion Transit Center, which is located around away from the city centre, and they get off the bus at Florence, S Irby St (Greyhound Bus Stop), SC, located 0 away from the city centre.
A trip to Florence, SC from Tampa, FL is worth doing but not as a day trip with a journey time of 11h 20m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Tampa, FL to Florence, SC is August.
It's helpful to compare your options as there are 2 ways to travel between Tampa, FL and Florence, SC including taking a train and bus.
Yes, the following accessibility options are available when taking the bus from Tampa, FL to Florence, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Tampa, FL to Florence, SC for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Tampa, FL to Florence, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Tampa, FL to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Tampa, FL to Florence, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Tampa, FL to Florence, SC:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Tampa, FL to Florence, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Tampa, FL to Florence, SC with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Tampa, FL to Florence, SC with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Tampa, FL to Florence, SC with the following bus company: Greyhound, FlixBus.
Since neither Tampa, FL nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Tampa, FL to Florence, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Tampa, FL to Florence, SC
Most Tampa, FL to Florence, SC buses use the Tampa, Marion Transit Center to Florence, W Lucas St (TA Gas Station) station pair, with some services arriving at Florence, S Irby St (Greyhound Bus Stop). Use this guide to compare Tampa, FL and Florence, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Tampa
Arrival bus stations in Florence
Which Tampa, FL station do buses to Florence, SC leave from?
Buses from Tampa, FL to Florence, SC leave from Tampa, Marion Transit Center. The station is 0 miles (1 km) from Tampa, FL city centre at Marion Transit Center, 1211 N Marion St, Tampa, FL 33602, USA.
Tampa, Marion Transit CenterMarion Transit Center, 1211 N Marion St, Tampa, FL 33602, USA
City-centre transport
Getting to Tampa, Marion Transit Center from Tampa city centre
Bus1, 5, 19, 30 · 3m · €4 · every ~15 min
Tampa, Marion Transit Center bus station facilities and services
Tampa, Marion Transit Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Tampa, Marion Transit Center. ATMs are available at Tampa, Marion Transit Center.
Tickets and information
Ticket office support is available at Tampa, Marion Transit Center.
Parking, taxis and toilets
Available at Tampa, Marion Transit Center: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Tampa, Marion Transit Center: Wheelchair accessible with ramps.
Tampa, USF Holly Drive (Central Plant)University of South Florida, Central Plant, 13302 USF Chestnut Dr, Tampa, FL 33620, USA
City-centre transport
Getting to Tampa, USF Holly Drive (Central Plant) from Tampa city centre
Tampa, USF Holly Drive (Central Plant) is 13 km from Tampa city centre. Public transport options include:
BusFlixBus 2421 · 26m · €1
9, 400 · 1h 3m · €4 · every ~7 min
6 · 1h 9m · €4 · every ~5 min
Tampa, USF Holly Drive (Central Plant) bus station facilities and services
Tampa, USF Holly Drive (Central Plant) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Tampa, USF Holly Drive (Central Plant). ATMs are available at Tampa, USF Holly Drive (Central Plant).
Tickets and information
Ticket office support is available at Tampa, USF Holly Drive (Central Plant).
Parking, taxis and toilets
Available at Tampa, USF Holly Drive (Central Plant): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Tampa, USF Holly Drive (Central Plant): Wheelchair accessible facilities.
Which Florence, SC station do buses from Tampa, FL arrive at?
Buses from Tampa, FL to Florence, SC most often arrive at Florence, W Lucas St (TA Gas Station). Some services arrive at Florence, S Irby St (Greyhound Bus Stop), so check your ticket before travel to confirm your Florence, SC arrival station.
Florence, W Lucas St (TA Gas Station)Florence, SC, USA
City-centre transport
Getting to Florence, W Lucas St (TA Gas Station) from Florence city centre
Florence, W Lucas St (TA Gas Station) is 6 km from Florence city centre. Public transport options include:
TRUE
Florence, W Lucas St (TA Gas Station) bus station facilities and services
Florence, W Lucas St (TA Gas Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Food and snacks available at the gas station.
Wi-Fi and ATMs
Wi-Fi is available at Florence, W Lucas St (TA Gas Station). ATMs are available at Florence, W Lucas St (TA Gas Station).
Tickets and information
Ticket office support is available at Florence, W Lucas St (TA Gas Station).
Parking, taxis and toilets
Available at Florence, W Lucas St (TA Gas Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, W Lucas St (TA Gas Station): Basic accessibility features available.
Florence, S Irby St (Greyhound Bus Stop)S Irby St, Florence, SC, USA
City-centre transport
Getting to Florence, S Irby St (Greyhound Bus Stop) from Florence city centre
TRUE
Florence, S Irby St (Greyhound Bus Stop) bus station facilities and services
Florence, S Irby St (Greyhound Bus Stop) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Florence, S Irby St (Greyhound Bus Stop). ATMs are available at Florence, S Irby St (Greyhound Bus Stop).
Tickets and information
Ticket office support is available at Florence, S Irby St (Greyhound Bus Stop).
Parking, taxis and toilets
Available at Florence, S Irby St (Greyhound Bus Stop): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Florence, S Irby St (Greyhound Bus Stop): Bus stop accessible for disabled persons.
Most popular bus connections from Tampa, FL
More options for your journey from Tampa, FL to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Tampa, FL
Most popular bus connections to Florence, SC
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