- Must visit
Uffizi Galleries
World-famous museum of Renaissance art with masterpieces by Botticelli, Leonardo, Michelangelo, and Raphael. Timed entry is strongly advised due to very high demand.
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The cheapest and fastest buses from Tampa, FL to Florence, SC
Showing times and prices for Jun 21
Cheapest price
$111
Average price
$159
Fastest journey
1 d 30 m
Average duration
1 d 2 h 43 m
Buses per day
2
Distance
741 km
Cheap tickets
The best way to find a cheap bus ticket from Tampa, FL to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Tampa, FL to Florence, SC will cost around $159 if you buy it on the day, but the cheapest tickets can be found for only $111.
Fast buses
Of the 2 buses that leave Tampa, FL for Florence, SC on Sun, Jun 21, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct buses cover the 741 km distance in an average of 1 d 2 h 43 m but if you time it right, some buses will get you there in just 1 d 30 m .
On Sun, Jun 21 the slowest buses will take 1 d 4 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
3:35 AM24h30Tampa, FL4:05 AMFlorence, SC$1111One-way0 transfers- 11:50 AM28h55Tampa, FL4:45 PMFlorence, SC$2071One-way0 transfers
- 3:35 AM24h30Tampa, FL4:05 AMFlorence, SC$1111One-way0 transfers
- 11:50 AM28h55Tampa, FL4:45 PMFlorence, SC$2071One-way0 transfers
Travel Information
Compare train and bus for Tampa, FL to Florence, SC
Omio recommends booking the train as it is the most popular option from Tampa, FL to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from $99. For those with little time consider booking a train which can get you there in 11h 45m. The ticket price range depends on the travel mode: a bus costs an average of $99, and a train costs an average of $105.
Distance: 460 miles (741 km)
Compare bus with
| Bus | Most popular Train | Driving |
|---|---|---|
$126 Average price Cheapest | $135 Average price | $101 Average price (fuel + tolls) |
13h 59m Average total duration 13h 29m Onboard + 30m Additional time* | 12h 15m Average total duration Fastest 11h 45m Onboard + 30m Additional time* | 7h 33m Average total duration (door-to-door) |
 Most popular bus company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Tampa, FL to Florence, SC is a bus with an average price of $126 (€103).
This is compared to other travel options from Tampa, FL to Florence, SC:
A bus is $9 (€7) less than a train for this route with tickets for a train from Tampa, FL to Florence, SC costing on average $135 (€110).
The fastest way to travel from Tampa, FL to Florence, SC is by train with an average journey time of 11h 45m.
Other travel options to Florence, SC take longer:
Bus takes on average 13h 29m.
It's helpful to compare your options as there are 2 ways to travel between Tampa, FL and Florence, SC including taking a train and bus.
We recommend using the train as it is the most popular way to get from Tampa, FL to Florence, SC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Tampa, FL to Florence, SC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:50AM | Arrival Time 05:25PM | Duration 15h35 | Departure days Thu, Fri | Cheapest price $99 |
Operator FlixBus | Departure Time 02:50AM | Arrival Time 06:25PM | Duration 15h35 | Departure days Fri | Cheapest price $99 |
Operator FlixBus | Departure Time 03:35AM | Arrival Time 04:05AM | Duration 24h30 | Departure days Sun | Cheapest price $111 |
Operator FlixBus | Departure Time 06:50AM | Arrival Time 11:45AM | Duration 28h55 | Departure days Fri | Cheapest price $124 |
Operator FlixBus | Departure Time 10:50AM | Arrival Time 03:45PM | Duration 28h55 | Departure days Wed | Cheapest price $118 |
Operator FlixBus | Departure Time 11:50AM | Arrival Time 04:45PM | Duration 28h55 | Departure days Sat | Cheapest price $207 |
Operator FlixBus | Departure Time 04:55PM | Arrival Time 01:30PM | Duration 20h35 | Departure days Fri | Cheapest price $147 |
Operator FlixBus | Departure Time 05:25PM | Arrival Time 01:30PM | Duration 20h05 | Departure days Fri | Cheapest price $147 |
Operator Greyhound | Departure Time 10:25PM | Arrival Time 12:05AM | Duration 25h40 | Departure days Fri | Cheapest price $125 |
Operator Flixbus USA | Departure Time 10:35PM | Arrival Time 01:25PM | Duration 14h50 | Departure days Tue, Sun | Cheapest price $101 |
Operator Greyhound | Departure Time 10:35PM | Arrival Time 12:05AM | Duration 25h30 | Departure days Fri | Cheapest price $125 |
Live departures
Tampa, FL to Florence, SC bus times
The table below shows live departures for Tampa, FL to Florence, SC buses for today, Friday, June 19. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus · FlixBus+ | 4:55 PM Tampa, Marion Transit Center | 20h35 | 1:30 PM Florence, S Irby St (Greyhound Bus Stop), SC | 2 transfers | |
| FlixBus · FlixBus+ | 5:25 PM Tampa, USF Holly Drive (Central Plant), FL | 20h05 | 1:30 PM Florence, S Irby St (Greyhound Bus Stop), SC | 2 transfers | |
| FlixBus++FlixBus · FlixBus | 10:25 PM Tampa, USF Holly Drive (Central Plant), FL | 25h40 | 12:05 AM Florence, W Lucas St (TA Gas Station), SC | 3 transfers | |
| FlixBus++FlixBus · FlixBus | 10:35 PM Tampa, Marion Transit Center | 25h30 | 12:05 AM Florence, W Lucas St (TA Gas Station), SC | 3 transfers | |
| Saturday, June 20 | |||||
| 3:35 AM Tampa, FL | 24h30 | 4:05 AM Florence, SC | 0 transfersDirect | |
| 11:50 AM Tampa, FL | 28h55 | 4:45 PM Florence, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Tampa, FL to Florence, SC by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Sat
Jun 20
Jun 20
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Jun 21
Jun 21
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Why should you book Tampa, FL to Florence, SC buses with Omio?
Greyhound as well as FlixBus offer buses services from Tampa, FL to Florence, SC.
Omio is an official ticket reseller for all your travel options from Tampa, FL to Florence, SC.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Tampa, FL to Florence, SC.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are train and bus to ensure you get the best deal for traveling from Tampa, FL to Florence, SC.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Tampa, FL to Florence, SC.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Tampa, FL to Florence, SC.
Journey information
Overview: Bus from Tampa, FL to Florence, SC
USAUSA
Buses from Tampa, FL to Florence, SC run on average 6 times per day, taking around 13h 29m. Cheap bus tickets for this journey start at $99 (€81) if you book in advance.
The earliest bus runs at 00:05, the last at 22:35. The fastest bus covers the 460 miles (741 km) distance in 15h 35m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 460 miles (741 km) |
Average bus duration 13h 29m |
Cheapest ticket price $99 (€81) |
Buses per day 6 |
Fastest bus 15h 35m |
First bus 12:05 AM |
Last bus 10:35 PM |
Cheapest Month May |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Apr - Jun |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Greyhound, FlixBus from Tampa, FL to Florence, SCYou can travel by bus between Tampa, FL to Florence, SC with Greyhound, FlixBus for as low as $99 (€81). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
15h 35m
Cheapest Price
$99 (€81)
FlixBus frequency
5 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Duration
19h 35m
Cheapest Price
$145 (€119)
Greyhound frequency
2 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Florence
Things to do in Florence
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
- Must visit
Accademia Gallery
Best known for Michelangelo’s David, this compact museum is one of Florence’s essential stops. Advance booking is commonly recommended because queues can be long.
- Recommended
Palazzo Pitti
Large palace museum complex with royal apartments, paintings, and design collections. Worth visiting for its scale, courtly interiors, and links to Medici history.
- Must visit
Piazza del Duomo
The monumental heart of Florence, surrounded by the cathedral, dome, baptistery, and bell tower. Essential for first-time visitors and classic city views.
- Must visit
Piazza della Signoria
Historic square lined with civic architecture and open-air sculptures. One of Florence’s liveliest public spaces and a key stop on any walking route.
- Must visit
Piazzale Michelangelo
The city’s most famous viewpoint, especially popular at sunset for sweeping skyline photos. A social media favorite and classic Florence panorama.
- Gluten-free
Pulled Pork Barbecue
Slow-smoked pork shoulder, usually chopped or pulled and served with a tangy Southern barbecue sauce. It is a staple across the Carolinas and common in Florence-area smokehouses.
Fried Catfish
Cornmeal-coated catfish fillets fried until crisp, often served with hush puppies and slaw. This is a classic Pee Dee and broader South Carolina comfort dish.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, often with bacon, gravy, or a light sauce. A defining Lowcountry and South Carolina dish regularly found in Florence.
Wholly Smokin' Downtown
Established downtown barbecue spot specializing in smoked meats, Southern sides, and a casual local atmosphere.
Victors
Upscale, long-running Florence restaurant known for steaks, seafood, and polished Southern-American dining in an elegant setting.
Tubb's Shrimp & Fish Co.
Well-known casual seafood restaurant recognized for fried seafood platters, shrimp, fish, and regional comfort fare.
United States Dollar
Costs are moderate for the U.S. Budget eats are easy to find, while hotels and fine dining can raise daily costs.
Average meal costs
- Budget
- USD 8-15 for fast food or a simple lunch.
- Mid-range
- USD 18-35 per person at a casual sit-down restaurant.
- Fine dining
- USD 50-100+ per person before drinks and tip.
- Coffee
- USD 3-6 for drip coffee or a latte.
Tipping culture
Tip 18-20% at restaurants. Tip USD 1-2 per drink at bars, round up or tip 10-15% for taxis, and tip hotel staff USD 2-5 for helpful service.
FAQs: Bus from Tampa, FL to Florence, SC
Find answers to the most common questions about traveling from Tampa, FL to Florence, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Tampa, FL to Florence, SC can start from as little as $99 (€81) when you book in advance. The average bus ticket price for Tampa, FL to Florence, SC is $126 (€103) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Tampa, FL to Florence, SC is 15h 35m to travel the 460 miles (741 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Tampa, FL to Florence, SC leaves at 12:05 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Tampa, FL to Florence, SC leaves at 10:35 PM.
There are 6 buses a day from Tampa, FL to Florence, SC which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Tampa, FL to Florence, SC, you can count on Greyhound, FlixBus for the best way to get you to Florence, SC. You can also check all possible bus companies who offer a service between Tampa, FL and Florence, SC and compare the amenities they offer before buying a bus ticket.
A trip to Florence, SC from Tampa, FL is worth doing but not as a day trip with a journey time of 15h 35m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Tampa, FL to Florence, SC is May.
It's helpful to compare your options as there are 2 ways to travel between Tampa, FL and Florence, SC including taking a train and bus.
Yes, there are bathrooms on board the bus from Tampa, FL to Florence, SC for bus company Greyhound, FlixBus.
Yes, the following accessibility options are available when taking the bus from Tampa, FL to Florence, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from Tampa, FL to Florence, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Tampa, FL to Florence, SC.
Yes, the following luggage options are included when booking a bus ticket from Tampa, FL to Florence, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Tampa, FL to Florence, SC:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Tampa, FL to Florence, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Tampa, FL to Florence, SC with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Tampa, FL to Florence, SC with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Tampa, FL to Florence, SC with the following bus company: Greyhound, FlixBus.
Since neither Tampa, FL nor Florence, SC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Tampa, FL to Florence, SC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Florence, SC, travelers should be cautious of petty crimes like pickpocketing and vehicle break-ins, especially in less crowded areas. It's advisable to stay in well-lit, populated places and avoid displaying valuables openly. Common scams include overcharging by taxi drivers and unofficial ticket sellers; always use licensed transportation and purchase tickets from authorized vendors. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Tampa, FL to Florence, SC
Tampa
Florence
The major bus station for departures in Tampa is Tampa, Marion Transit Center. Find all the information you need to know about services, amenities and connections at Tampa, Marion Transit Center for your trip from Tampa to Florence.
Tampa, Marion Transit Center
information
Tampa, USF Holly Drive (Central Plant)
information
The major bus station for arrivals in Florence is Florence, S Irby St (Greyhound Bus Stop). Find all the information you need to know about services, amenities and connections at Florence, S Irby St (Greyhound Bus Stop) for your trip to Florence from Tampa.
Florence, S Irby St (Greyhound Bus Stop)
information
Most popular bus connections from Tampa, FL
More options for your journey from Tampa, FL to Florence, SC
Here are some other resources that might have the information you need
Most popular buses to and from Florence, SC and Tampa, FL
Most popular bus connections to Florence, SC
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